Clinical trials: Airway Remodelling
Airway Remodeling, Chronic Obstructive Pulmonary Disease
Effect of Tiotropium on Airway Remodeling in Patients With Early Stage COPD Accessed by Optical Coherence Tomography
This randomized, open-label, three-arm clinical trial evaluated the effects of tiotropium on airway remodeling in patients with GOLD stage 1 COPD using endobronchial optical coherence tomography (EB-OCT).
- Trial name
- NCT03842839
- Testing
- Tiotropium Inhalation Powder [Spiriva] 0.018mg, Salbutamol sulphate aerosol (Ventolin) 0.1mg
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Chronic Cough
Remodelling of the Lower Airways in Chronic Cough
The aim of the study is to assess if chronic cough leads to injury and remodelling of the airways. We plan to analyse bronchial injury and remodelling in patients with refractory chronic cough lasting longer than 12 month .
- Trial name
- NCT07659860
- Testing
- chest computed tomography and bronchoscopy
- Where
- 4 sites in Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Warsaw
Asthma, Copd
Effects of Smoking on Bronchial Epithelium
Asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory airway diseases affecting millions of people worldwide.
- Trial name
- NCT00849433
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
Asthma; Eosinophilic, Airway Remodeling
BenRalizumab Effect on Airway Remodeling in Severe asTHma
Response to biologic therapies in severe asthma is variable, with patients being either non-responders, responders or super-responders. There is currently no explanation for this broad variation in response.
- Trial name
- BREATH (NCT06288516)
- Testing
- Benralizumab 30 mg/ml
- Where
- Greece
- Volunteers
- 36 people
- Sponsor
- Aristotle University Of Thessaloniki
Asthma, COPD
The Effect of FP-025, on Allergen-induced Airway Responses in Mild Eosinophilic House Dust Mite (HDM)-Allergic Asthma.
This study is a Phase IIa, randomized, placebo-controlled, double-blind, 2-way crossover, 2-center (conducted in EU; The Netherlands) study in male and female subjects with stable, mild HDM-allergic asthma.
- Trial name
- NCT03858686
- Testing
- FP-025 capsules
- Where
- 2 sites in Netherlands
- Volunteers
- 27 people
- Sponsor
- Foresee Pharmaceuticals Co., Ltd.