Clinical trials: Alcohol Abuse/Dependence
Alcohol Dependence
Duloxetine Versus Pregabalin for Alcohol Dependence
A 12-week, double-blind, placebo-controlled parallel group study will be conducted with 150 outpatients with alcohol dependence, with random assignment to pregabalin 300 mg/d, duloxetine 40 mg/d, or placebo in conjunction with…
- Trial name
- NCT00929344
- Testing
- Pregabalin, Duloxetine, Standardized behavioral therapy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The Scripps Research Institute
Alcohol Drinking, Alcohol Use Disorder
Improving Care for Unhealthy Alcohol Use in Primary Care
In order to improve the quality of alcohol-related care for those with unhealthy alcohol use, the current research will use an evidence-based implementation strategy, practice facilitation, at one VA primary care site to pilot…
- Trial name
- NCT04565899
- Testing
- Practice facilitation implementation intervention
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alcohol Abuse, Alcohol Dependence
Anonymous Treatment on the Internet for Alcohol Dependence: A Randomised, Controlled Trial
Internet based self help program with or without support of a counselor is tested among anonymous Internet help seekers at an open access website.
- Conditions
- Alcohol Abuse, Alcohol Dependence, Harmful Alcohol Use, Alcohol Use Disorder
- Trial name
- NCT02377726
- Testing
- Alkoholhjälpen counselor support, eChange Alkoholhjälpen, Alkoholhjälpen
- Where
- Sweden
- Volunteers
- 1,170 people
- Sponsor
- Karolinska Institutet
Prevention of Drug Abuse and Dependency, Alcohol Abuse and Dependency
The Whole Day First Grade Program
This five-year prevention services application is concerned with preventing substance abuse, comorbid mental and behavioral disorders, and school failure.
- Conditions
- Prevention of Drug Abuse and Dependency, Alcohol Abuse and Dependency, High Risk Sex Behavior, Smoking Tobacco
- Trial name
- NCT00257088
- Testing
- whole day first grade program
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- American Institutes for Research
Alcohol Use Disorder (AUD), Alcohol Abuse
Neurobiological Effects of Transcranial Direct Current Stimulation Treatment in Alcohol Use Disorder
Background: Alcohol Use Disorder (AUD) is a complex psychiatric disorder, involving several brain areas and neurocircuits. Transcranial Direct Current Stimulation (tDCS) allows to stimulate superficial areas of brain using a weak…
- Conditions
- Alcohol Use Disorder (AUD), Alcohol Abuse, Alcohol Dependence, Alcohol-Related Disorders
- Trial name
- NCT04897295
- Testing
- Active transcranial Direct Current Stimulation
- Volunteers
- 30 people
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Alcohol Abuse or Dependence
FGF21 and Its Role in Alcohol Dependence
Plasma fibroblast growthfactor-21 (FGF21) responses to acute alcohol exposure will be evaluated in three groups: A: 15 individuals diagnosed with alcohol dependence (ICD10 code F10.2) and no alcoholic liver diseases, B: 15…
- Trial name
- AlcoDep (NCT03892369)
- Testing
- Ethanol
- Where
- Denmark
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Posttraumatic Stress Disorders, Combat Disorders
Integrated Treatment of OEF/OIF Veterans With PTSD & Substance Use Disorders
In comparison to the general population, U.S. military and Veterans are at an increased risk for developing both substance use disorders (SUD) and Post Traumatic Stress Disorder (PTSD).
- Conditions
- Posttraumatic Stress Disorders, Combat Disorders, Alcohol Dependence, Drug Dependence
- Trial name
- COPE (NCT01338506)
- Testing
- Concurrent Treatment with Prolonged Exposure (COPE)
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Medical University of South Carolina
Alcohol Drinking
Kappa-PET Imaging and Naltrexone in Alcohol Drinking Behaviors
The primary purpose of the study is to increase our knowledge of receptor function in the brains of people who are heavy drinkers and taking naltrexone (NTX), a medication that has been approved for the treatment of alcohol…
- Trial name
- NCT01625611
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Yale University
Substance Abuse, Substance Dependence
Continuing Care Following Drug Abuse Treatment: Linkage With Primary Care
This component of a larger Center of Research Excellence Grant improves treatment for drug abuse by developing effective linkages between specialty drug treatment and primary health care.
- Conditions
- Substance Abuse, Substance Dependence, Substance, Addiction, Alcohol Abuse
- Trial name
- Linkage (NCT01621711)
- Testing
- Linkage patient activation intervention
- Where
- United States
- Volunteers
- 504 people
- Sponsor
- Kaiser Permanente
Alcohol Dependence, Alcohol Abuse
Project Motion, A Study of Motivational Interviewing to Reduce Heavy or Problematic Drinking
The purpose of this pilot study is to investigate the critical components of motivational interviewing (MI), a psychotherapeutic intervention, in reducing heavy or problematic drinking.
- Trial name
- NCT00665249
- Testing
- Motivational Interviewing, Spirit-Only Motivational Interviewing, Self-Change
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Northwell Health
Drug Abuse, Alcohol Abuse
Trial of Computerized MET for Adolescent Substance Use
The purpose of this study is to test the effects of a computerized, self-directed Motivational Enhancement Therapy program for adolescent substance use (iMET), in comparison to clinician-delivered MET and Treatment As Usual…
- Conditions
- Drug Abuse, Alcohol Abuse, Nicotine Dependence
- Trial name
- NCT01784653
- Testing
- iMET, MET
- Where
- United States
- Sponsor
- Boston Children's Hospital
Alcohol Dependence, Alcohol Abuse
Motivation in Alcohol Treatment Facilities
The purpose of this study is to determine if and to what extend a composite measure of treatment motivation and behavior change motivation predicts alcohol treatment success.
- Trial name
- NCT00424112
- Where
- 2 sites in Germany
- Volunteers
- 450 people
- Sponsor
- University Medicine Greifswald
Alcohol Use Disorder, Posttraumatic Stress Disorder (PTSD)
Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders
The purpose of this study is to evaluate whether the combination of prazosin and naltrexone will decrease alcohol cravings and drinking in individuals who have problems with alcohol and have used alcohol at risky levels compare…
- Trial name
- PaN (NCT02322047)
- Testing
- Prazosin, Naltrexone
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Alcohol Abuse, Tobacco Dependence
cSBI-M for Young Military Personnel
The goal of this project is to test the efficacy of a computer-facilitated Screening and Brief Intervention system adapted for Military use (cSBI-M) in reducing substance use among 18- to 25-yr-old U.S. Navy and U.S.
- Conditions
- Alcohol Abuse, Tobacco Dependence, Substance Abuse
- Trial name
- NCT01847300
- Testing
- cSBI-M
- Where
- United States
- Sponsor
- Boston Children's Hospital
Alcohol Dependence, Alcohol Interaction
Clinical Trial to Evaluate the Safety of PT150 (Formerly ORG34517) When it is Taken Concurrently With Alcohol
The purpose of the clinical study is to compare pharmacodynamic and safety endpoints following an alcohol challenge prior to and concurrent with PT150 (study drug) treatment.
- Trial name
- NCT03548714
- Testing
- PT150, Beverage
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Pop Test Oncology LLC
Alcohol Dependence, Alcohol Abuse
Community Reinforcement and Family Training (CRAFT) for Treatment-resistant Individuals With Alcohol Use Disorders
The present study examines the efficacy of the Community Reinforcement and Family Training (CRAFT) for Concerned Significant Others (CSOs) of individuals with alcohol use disorders (AUDs) using a randomized waiting list (WL)…
- Trial name
- CRAFT (NCT02112396)
- Testing
- Community Reinforcement and Family Training
- Where
- Germany
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Luebeck
Post Traumatic Stress Disorders, Unsafe Sex
Cognitive Processing Intervention for Trauma, HIV/STI Risks, and Substance Use Among Native Women
Many American Indian (AI) women never receive services for serious mental health problems resulting from traumatic events, violence exposure and maltreatment.
- Conditions
- Post Traumatic Stress Disorders, Unsafe Sex, Substance Use Disorders
- Trial name
- NCT01849029
- Testing
- Cognitive Processing Therapy-Cognitive
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Washington
Alcohol Abuse, Alcohol Drinking
Tracking Mood: The Effects of Daily Mood Tracking VAS on Alcohol Consumption in Adult Heavy Drinkers
The study aims to investigate the effects that mood tracking may have on the alcohol consumption of adults who consume more than 20 UK units of alcohol per week, classifying as high-risk drinkers.
- Conditions
- Alcohol Abuse, Alcohol Drinking, Alcohol Use Disorder, Alcohol Dependence
- Trial name
- NCT06419647
- Testing
- Intervention
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Ilona Myllyniemi
Alcohol Dependence, Alcohol Abuse
ABT-436 for Alcohol Dependence
The primary efficacy endpoint examines the hypothesis that ABT-436 will decrease the weekly percentage of heavy drinking days during Study Weeks 2 through 12 (Days 8-84) as compared to placebo.
- Conditions
- Alcohol Dependence, Alcohol Abuse, Alcohol Use Disorders, Alcoholism
- Trial name
- NCT01613014
- Testing
- ABT-436
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder, Alcohol Drinking
Virtual Incentive Treatment for Alcohol
The overall objective of this program of research is to utilize phosphatidylethanol (PEth), a blood-based biomarker that can detect alcohol use for up to 28 days to deliver a feasible telehealth-based 26-week CM intervention.
- Conditions
- Alcohol Use Disorder, Alcohol Drinking, Alcohol Abuse, Alcohol Dependence
- Trial name
- VITA (NCT06265506)
- Testing
- Contingency Management, Computer Based Training for Cognitive Behavioral Therapy for AUD (CBT4CBT)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Washington State University