Clinical trials: Alcohol Abuse/Dependence
Alcoholism
New Medications to Treat Alcohol Dependence
In the last decade, there has been an explosion of new knowledge of the neuroscientific basis of alcohol-seeking behavior. Briefly, medications that modulate mesolimbic dopamine pathways by facilitating gamma amino butyric…
- Trial name
- NCT00223639
- Testing
- Topiramate
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Bankole Johnson
Alcoholism, Alcohol Abuse
Dutasteride Treatment for the Reduction of Heavy Drinking in Men
This study will examine the safety and potential benefit of the medication dutasteride to help men reduce or stop drinking alcohol.
- Conditions
- Alcoholism, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT01758523
- Testing
- Dutasteride, sugar pill
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- UConn Health
Alcohol Abuse, Alcohol Dependence
Facilitating Aftercare for Alcohol Detox Patients
The purpose of this study is to determine whether peer visits (known as "12th Step Calls") and professional counselors (using "Motivational Enhancement Therapy") are effective helping alcoholics link to substance abuse treatment…
- Trial name
- NCT00513708
- Testing
- Motivation Enhancement Therapy (MET), Peer-Twelve Step Facilitation (P-TSF)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- State University of New York at Buffalo
Alcohol Abuse, Nicotine Dependence Tobacco Product
Reactions to E-cigs and Alcohol
The purpose of this study is to 1) examine cognitive acuity following e-cig use (as compared to no e-cig use), 2) examine motor coordination following beer and e-cig use (as compared to beer consumption only).
- Trial name
- NCT03449017
- Testing
- E-cig use
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Indiana University
Alcohol Drinking, Anxiety Disorders
Retraining Attention to Treat Alcohol Dependence and Social Anxiety
The purpose of this research is to test a computerized intervention for people with co-occurring social anxiety and alcohol dependence.
- Trial name
- AMP (NCT01886716)
- Testing
- Anxiety Attention Training, Alcohol Attention Training, Control Training
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of Cincinnati
Bipolar I or II Depression and Alcohol Abuse or Dependence
Open-Label Depakote ER in Patients With Bipolar I or II Depression and Alcohol Abuse or Dependence
The purpose of this study is to determine if Divalproex Sodium can be used to Treat and Prevent Depression in Patients with Bipolar Disorder who have Comorbid Alcohol Dependence/Abuse.
- Trial name
- NCT00204503
- Testing
- Depakote ER
- Where
- United States
- Sponsor
- The University of Texas Medical Branch, Galveston
Alcohol Dependence, Alcohol Consumption
ASAP Study - Hospital-Based Brief Intervention for Alcohol Problems
The objective of this project was to test whether screening and brief intervention for unhealthy alcohol use leads to improved alcohol-related outcomes (such as alcohol consumption and linkage to alcohol assistance) and is…
- Trial name
- NCT00183105
- Testing
- Brief Intervention (adaptation of motivational interviewing)
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Boston Medical Center
Behavior Therapy, Cocaine
The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Cocaine Abuse - 1
Although LAAM, a derivative of methadone, has been successfully used as an alternative to methadone maintenance in opioid addicts, its effect on concurrent opioid and cocaine abuse has not been ascertained.
- Conditions
- Behavior Therapy, Cocaine, Contingency Management, Heroin Dependence
- Trial name
- NCT00158288
- Testing
- LAAM
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Abuse, Alcohol Dependence
Remote Brief Intervention and Referrals to Treatment Service for Alcohol
The traditional paradigm that relies upon training physicians and nurses or uses on-site interventionists to perform screening, brief intervention, and referral to treatment (SBIRT) for alcohol has proven unsustainable in most…
- Trial name
- RBIRT (NCT02622984)
- Testing
- RBIRT, SBIRT
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Polaris Health Directions
Major Depressive Disorder, Alcohol Use Disorder
STAR*D Alcohol: Treatment of Depression Concurrent With Alcohol Abuse
The purpose of this study is to determine if having an alcohol use disorder affects recovery from depression, and also whether recovery from depression in patients who have alcohol use disorders is also accompanied by improvement…
- Trial name
- NCT00369746
- Testing
- citalopram
- Where
- United States
- Volunteers
- 674 people
- Sponsor
- New York State Psychiatric Institute
Alcohol Abuse, Alcohol-dependence
Treatment Settings for Those With an Alcohol Problem
A prior study in a tightly controlled clinical research environment found individuals with an alcohol use disorder (AUD) benefited more from inpatient (IP) than outpatient (OP) care, if they presented with high alcohol…
- Trial name
- NCT02986776
- Testing
- Inpatient Care, Outpatient Care
- Volunteers
- 176 people
- Sponsor
- State University of New York at Buffalo
Alcohol Abuse, Alcohol Dependence
A Comparison of Adolescent Group Therapy and Transitional Family Therapy for Adolescent Alcohol and Drug Abusers
The purpose of this study is to compare the effectiveness of two psychosocially-based, manual-driven, behavioral modalities. One of these is a standardized version of the established modality of Adolescent Group Therapy (AGT)…
- Conditions
- Alcohol Abuse, Alcohol Dependence, Cannabis Abuse, Cannabis Dependence
- Trial name
- NCT00484367
- Testing
- Adolescent group therapy, Transitional family therapy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- The Morton Center, Inc.
Alcohol Dependence, Alcohol Abuse
Brief Alcohol Intervention in General Hospitals
The purpose of the study is to reveal the most promising procedure for implementing alcohol screening and intervention in general hospitals and to find out, if and to which extent non-specialist health professionals can be…
- Conditions
- Alcohol Dependence, Alcohol Abuse, At-Risk-Drinking, Heavy Episodic Drinking
- Trial name
- NCT00423904
- Testing
- Brief intervention
- Volunteers
- 1,035 people
- Sponsor
- University Medicine Greifswald
Alcohol Dependence
Efficacy and Safety Evaluating Study of Odelepran for the Use in Patient With Alcohol Dependence
The purpose of this study was to assess efficacy and safety of the study drug Odelepran, 125 mg as compared to placebo in the treatment of alcohol dependence in adult outpatients.
- Trial name
- NCT03663374
- Testing
- Odelepan
- Where
- 22 sites in Kazakhstan, Russia
- Volunteers
- 644 people
- Sponsor
- R-Pharm
Alcohol Abuse, Alcohol Dependence
Ondansetron, Alcohol Use, and Alcohol-Related Symptoms In HIV+ Persons
The proposed randomized clinical trial will investigate a novel pharmacotherapy for hazardous drinking, HIV-infected men and women, using the serotonin receptor (5-HT3) antagonist ondansetron.
- Trial name
- NCT01254877
- Testing
- ondansetron
- Where
- United States
- Volunteers
- 357 people
- Sponsor
- Johns Hopkins University
Alcohol Abuse, Cannabis Abuse
Study Comparing Two Types of Psychotherapy for Treating Depression and Substance Abuse
The purpose of this study is to determine whether Integrated Cognitive Behavioral Therapy or Twelve Step Facilitation Therapy is most effective for treatment of dually diagnosed veterans with depressive and substance use…
- Conditions
- Alcohol Abuse, Cannabis Abuse, Major Depressive Disorder, Substance-Related Disorders
- Trial name
- NCT00108407
- Testing
- Integrated Cognitive Behavioral Therapy, Twelve Step Facilitation Therapy
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Major Depressive Disorder, Alcohol Abuse
Acamprosate Added to Escitalopram and Behavioral Treatment for Comorbid Depression and Alcoholism
This is a study about treatment for people who suffer from both major depression and alcohol abuse or dependence. The study will examine whether the addition of acamprosate to escitalopram and behavioral interventions will…
- Conditions
- Major Depressive Disorder, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT00452543
- Testing
- acamprosate, escitalopram, Medical management
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts General Hospital
Alcohol Use Disorder, Alcohol Dependence
Tech-Enabled CM for AUD at Scale
This Phase II Small Business Innovative Research (SBIR) project is a clinical effectiveness and cost-effectiveness random controlled trial (RCT) of DynamiCare Health's innovative smartphone/smart debit card remote digital…
- Conditions
- Alcohol Use Disorder, Alcohol Dependence, Drug Dependence
- Trial name
- NCT04581499
- Testing
- DynamiCare Motivation Support Program, Untreated or Routine Care Control Group
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- DynamiCare Health
Alcohol Drinking
Naltrexone and Memantine Effects on Alcohol Drinking Behaviors
The purpose of this study is to evaluate the combined effects of the study medications naltrexone and memantine on alcohol drinking behaviors.
- Trial name
- NCT01519063
- Testing
- Naltrexone and memantine first
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Yale University
Alcoholic Liver Disease, Alcoholic Fibrosis of Liver
Early Detection of Alcoholic Liver Disease
This is an observational study to identify the prevalence of advanced liver fibrosis among patients with excessive alcohol intake using a non-invasive method (FibroScan®) and to characterize the main environmental, genetic and…
- Conditions
- Alcoholic Liver Disease, Alcoholic Fibrosis of Liver, Alcoholic Cirrhosis, Excessive Drinking
- Trial name
- NCT04070508
- Sponsor
- University of Pittsburgh