Clinical trials: Alcohol Abuse/Dependence
Alcohol Dependence, Chronic Hepatitis C
Study of the Effects of Motivational Enhancement Therapy on Alcohol Use in Chronic Hepatitis C Patients
The purpose of this study is to determine whether motivational enhancement therapy (MET) reduces alcohol use in a population of HCV-infected veterans who are currently drinking alcohol and have alcohol disorders.
- Trial name
- NCT00596960
- Testing
- Motivational Enhancement Therapy (MET), Health education
- Where
- 2 sites in United States
- Volunteers
- 139 people
- Sponsor
- US Department of Veterans Affairs
Alcohol Drinking, Alcohol Use Disorder
Effect of Theta Burst Stimulation on Alcohol Cue Reactivity
Alcohol Use Disorder (AUD) is prevalent, devastating, and difficult to treat. The intransigence of AUD is readily apparent in the Trauma Unit of Wake Forest University Baptist Hospital, wherein 23% of trauma related admissions…
- Conditions
- Alcohol Drinking, Alcohol Use Disorder, Trauma Injury, Alcohol Dependence
- Trial name
- NCT04223154
- Testing
- Real iTBS to the dlPFC
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Wake Forest University Health Sciences
Alcoholism, Alcohol Abuse
Study of the Effectiveness of Quetiapine for the Treatment of Alcohol Dependency
The purpose of this study is to determine whether quetiapine fumarate extended release is effective in the treatment of alcohol dependence in very heavy drinkers.
- Trial name
- NCT00498628
- Testing
- Quetiapine fumarate
- Where
- 7 sites in United States
- Volunteers
- 224 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Dependence
Ondansetron With Olanzapine for the Treatment of Alcohol Dependence: A Preliminary Clinical Trial
This study would like to test whether the combination of ondansetron and olanzapine will be superior to placebo at decreasing self-reported heavy drinking among early onset alcoholics.
- Trial name
- NCT00678457
- Testing
- Ondansetron, Olanzapine
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Alcohol Dependence
Stress, Hypothalamic-pituitary-adrenal (HPA) Dysfunction, and Relapse in Alcoholism
This proposal is part of the INIA Stress Consortium. This study will 1. explore the contributions of lifetime trauma, recent stress, and alcohol use on stress-hormone axis disruption in treatment seeking, one-month abstinent…
- Trial name
- NCT00744588
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Texas Southwestern Medical Center
Marijuana Use, Marijuana Dependence
Examining Effects of Domain Specific Episodic Future Thinking on Cannabis Use
The overarching goal of this online study is to compare the efficacy of six (weekly) sessions of Domain-Specific Episodic Future Thinking (DS-EFT) relative an active control condition on improving the ability to value future…
- Conditions
- Marijuana Use, Marijuana Dependence, Tobacco Use, Alcohol Use, Unspecified
- Trial name
- NCT05324813
- Testing
- Domain-Specific Episodic Future Thinking
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Michael Sofis
Alcohol Abuse, Alcohol Dependence
Development and Testing of Adolescent Twelve-Step Facilitation
This study is the first to develop and test in a randomized experimental design the efficacy of an integrated 12-step facilitation intervention tailored for young people.
- Conditions
- Alcohol Abuse, Alcohol Dependence, Drug Abuse, Drug Dependence
- Trial name
- NCT01449981
- Testing
- Integrated Twelve-Step Facilitation, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Massachusetts General Hospital
Substance Use Disorders, Opiate Dependence
The Effect of Self-Forgiveness on Self-Stigma in Addiction.
This study has an experimental design and will examine the difference in pre-test and post-test data on the Self-Forgiveness Dual Process Scale (SFDPS) (Griffin, Worthington, Davis, Hook, \& Maguen, 2018) and the Substance Abuse…
- Conditions
- Substance Use Disorders, Opiate Dependence, Opiate Withdrawal Syndrome, Opioid-use Disorder
- Trial name
- NCT03971097
- Testing
- Six Step Model of Self-Forgiveness, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Pittsburgh
Alcohol Dependence, Bipolar Disorder
Open Label Trial of Acamprosate in Bipolar Alcoholics
The purpose of this study is to determine whether acamprosate (Campral) is safe and effective in treating alcohol dependence in individuals with bipolar disorder.
- Trial name
- NCT00330486
- Testing
- Acamprosate
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Medical University of South Carolina
Liver Disease Chronic, Cirrhosis
cACLD in Patients With Alcohol Use Disorder in the Hospital Detoxification Unit
The aim of this study is to conduct a quick assessment of potential liver damage caused by chronic alcohol consumption. Taking advantage of the patient's admission to a specialized detoxification unit, several tests will be…
- Conditions
- Liver Disease Chronic, Cirrhosis, Detoxification, Alcohol Abuse/Dependence
- Trial name
- HEP-UHD (NCT06838468)
- Testing
- Screening of compensated advance chronic liver disease
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Corporacion Parc Tauli
Alcohol Dependence, Problem Drinking
Alcohol Pharmacotherapy for HIV+ Prisoners
This is a randomized controlled trial of injectable intramuscular naltrexone (XR-NTX) versus intramuscular placebo among HIV-infected prisoners meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition…
- Conditions
- Alcohol Dependence, Problem Drinking, Hazardous Drinking, Human Immunodeficiency Virus
- Trial name
- INSPIRE (NCT01077310)
- Testing
- Vivitrol- Intramuscular naltrexone (depot-formulation)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Alcohol Abuse, Posttraumatic Stress Disorder
Prazosin for Alcohol Dependence and Posttraumatic Stress Disorder
The purpose of this study is to determine whether the drug prazosin is effective for the treatment of alcohol dependency and symptoms of Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT01518972
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Alcohol Abuse or Dependence
Guided Self-Change Prevention Program for Alcohol Abuse in Adolescents in Educational Settings
This study corresponds to a pretest-posttest randomized experimental design with two arms. Arm 1 includes Guided Self-Change program, and Arm 2 a psychoeducational program to promote healthy habits.
- Trial name
- PREVENALC (NCT05281172)
- Testing
- Guided Self-Change therapy (GSC), Psychoeducation program about healthy habits
- Where
- Spain
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Alcohol Dependence (Primary Condition), Alcohol Abuse
A Placebo-Controlled Trial of Memantine for Alcohol Dependence
The purpose of this study is to obtain a preliminary indication of the safety and effectiveness of oral memantine (40 mg/day) in alcohol dependent patients.
- Trial name
- NCT00246415
- Testing
- Memantine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Abuse/Dependence
Examining the Relationship Between Physical Activity Levels and Chronotype Tendencies in Individuals With Alcohol Dependence
Alcohol use disorders are characterized by excessive alcohol consumption and loss of control and are associated with high mortality and disease burden.
- Trial name
- NCT06850428
- Where
- Turkey (Türkiye)
- Volunteers
- 207 people
- Sponsor
- Gulhane School of Medicine
Alcohol Dependence
An Exploratory Study of Naltrexone Plus Aripiprazole for Alcohol Dependence
The principal aim of this exploratory study is to examine whether the addition of aripiprazole to naltrexone will enhance efficacy over naltrexone alone in a 16-week randomized, placebo-controlled clinical trial, in which all…
- Trial name
- NALAPZ (NCT00667875)
- Testing
- Naltrexone, Naltrexone + Aripiprazole
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Medical University of South Carolina
Cocaine-Related Disorders, Opioid-Related Disorders
The Therapeutic Workplace Initiation Study
The primary purpose of the study is to determine if the central feature of the Therapeutic Workplace, the abstinence reinforcement contingency, is critical to initiate cocaine abstinence in injection drug using methadone patients…
- Conditions
- Cocaine-Related Disorders, Opioid-Related Disorders, Heroin Dependence, Substance Abuse, Intravenous
- Trial name
- NCT00249470
- Testing
- Abstinence & Work, Work Only
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Johns Hopkins University
Alcoholism
Varenicline for Alcohol Dependence
The primary objective of this study is to assess the efficacy of varenicline in reducing the proportion of heavy drinking days during the last 8 weeks of treatment in subjects with alcohol dependence confirmed by Diagnostic and…
- Trial name
- NCIG 003 (NCT01146613)
- Testing
- Varenicline
- Where
- 7 sites in United States
- Volunteers
- 200 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Social Anxiety Disorder, Social Phobia
Paroxetine for Comorbid Social Anxiety Disorder and Alcoholism
The purpose of the study is to determine whether an SSRI, paroxetine, improves social anxiety symptoms and alcohol use in individuals who drink to cope with social anxiety disorder.
- Conditions
- Social Anxiety Disorder, Social Phobia, Alcohol Use Disorder, Alcohol Abuse
- Trial name
- NCT00246441
- Testing
- Paroxetine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder, Alcoholism
Safety and Effectiveness of the BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for Treatment and Reduction of Heavy Drinking in Individuals With of Alcohol Use Disorder (AUD)
The study will compare alcohol use in two groups of subjects. One group will be assigned to the Deep TMS treatment and the other group will be assigned to the sham treatment.
- Conditions
- Alcohol Use Disorder, Alcoholism, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT07216872
- Testing
- Deep TMS (DTMS)
- Where
- 11 sites in United States, Israel and 1 more
- Volunteers
- 186 people
- Sponsor
- Brainsway