Clinical trials: Alcohol Consumption, open to volunteers
Alcohol Related Liver Disease, Orthotopic Liver Transplantation
Risk and Protective Factors for Relapse to Alcohol Use in Patients With Liver Disease Undergoing Liver Transplantation
This is an observational, monocentric study, consisting of both a retrospective and a prospective component. The aim of the study is to identify risk and protective factors for alcohol relapse in patients with alcohol-related…
- Trial name
- NCT06749990
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Binge Drinking
The Brain, the Bug, and the Binge: the Interplay Between Binge Drinking, Gut Microbiota, and Brain Functioning
Adolescence and youth are periods of significant maturational changes which seems to involve greater susceptibility to disruptive events in the brain such as binge drinking (BD).
- Trial name
- NCT05946083
- Testing
- Inulin Intervention, Maltodextrin Intervention
- Where
- Portugal
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Minho
Hazardous Drinking, Harmful Alcohol Use
Telephone-Based Acceptance and Commitment Therapy for Young Adult Hazardous Drinkers
The goal of this clinical trial is to learn if telephone-based Acceptance and Commitment Therapy (ACT) works to help young adults with hazardous or harmful alcohol use quit drinking.
- Trial name
- NCT07621822
- Testing
- Telephone-Based Acceptance and Commitment Therapy (ACT), Waitlist control with Telephone-Based Social Support
- Volunteers
- 288 people
- Sponsor
- The Hong Kong Polytechnic University
Alcohol Use Disorder
HD-tACS for Alcohol Use Disorder
This study aims to systematically explore the effectiveness of accelerated HD-tACS in treating AUD, particularly its efficacy in reducing alcohol craving and preventing relapse in AUD patients.
- Trial name
- NCT07808190
- Testing
- HD-tACS
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Shanghai Mental Health Center
Alcohol Use Disorder
Evaluating the Effectiveness of Implementation Intentions to Strengthen Approach-avoidance Training
Approach Bias Modifcation corresponds to computerized interventions designed to change a cognitive bias (i.e., the approach bias) that may contribute to the maintenance of Alcohol Use Disorder.
- Trial name
- IMBA (NCT06211959)
- Testing
- Approach Bias Modification with Implementation Intentions
- Where
- France
- Volunteers
- 112 people
- Sponsor
- Clinique de la Mitterie
Alcohol Use Disorder
Enhancing Prospective Thinking in Early Recovery (HOME)
The goal of this clinical trial is to use a novel virtual reality intervention to test for efficacy in reducing alcohol use and increasing abstinence, with concomitant increases in future self-identification, future time…
- Trial name
- HOME (NCT06302413)
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Indiana University
Depression - Major Depressive Disorder, Alcohol Use Disorder
ACT_for Alcohol Use Disorder and Depression
Alcohol use disorders (AUDs) and depressive disorders frequently coexist, complicating the clinical management of patients suffering from them.
- Trial name
- NCT06620276
- Testing
- Acceptance and Commitment Therapy, Ketamine
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Suvorexant for Treatment of AUD and PTSD
This study is to determine if suvorexant (SUV) will reduce insomnia in 76 men and women veteran and non-veterans between the ages 21-65 with posttraumatic stress disorder (PTSD) symptoms and alcohol use disorder (AUD).
- Conditions
- Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD), Insomnia
- Trial name
- SUV (NCT06679062)
- Testing
- Suvorexant
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Anxiety Disorders and Symptoms, PTSD and Trauma-related Symptoms
Personalizing Treatment Delivery
Anxiety and anxiety-related disorders frequently co-occur with alcohol use problems resulting in an enormous humanitarian and economic cost to society.
- Conditions
- Anxiety Disorders and Symptoms, PTSD and Trauma-related Symptoms, Alcohol; Use, Problem; Alcohol Use Disorder
- Trial name
- NCT05821634
- Testing
- Personalized intervention condition: Cognitive behavioral therapy skills, Therapeutic control condition: Cognitive behavioral therapy skills, Tracking control condition: Supportive counseling
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Rutgers, The State University of New Jersey
Alcohol Use Disorder, Alcohol-associated Liver Disease
Pomegranate Dietary Supplements in AUD and ALD
The goal of this project is to determine an individual's ability to generate active gut microbial metabolites called urolithins upon consumption of pomegranate dietary supplements.
- Conditions
- Alcohol Use Disorder, Alcohol-associated Liver Disease, Alcoholic Cirrhosis, Healthy
- Trial name
- NCT07678567
- Testing
- Pomegranate Dietary Ssupplement
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Alcohol Use Disorder, Substance Use Disorders
Evaluating a One-Year Version of the Parent-Child Assistance Program
The proposed project seeks to achieve three objectives that will, collectively, evaluate the effectiveness of a one-year version of the Parent-Child Assistance Program (PCAP-1) -a model for a home visitation and case management…
- Conditions
- Alcohol Use Disorder, Substance Use Disorders, Alcohol Use Complicating Pregnancy, Unspecified Trimester, Drug Use Disorders
- Trial name
- PCAP-1 (NCT06163651)
- Testing
- Parent-Child Assistance Program - One-Year Version
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Oklahoma
Severe Alcoholic Hepatitis
LiverTREM-1: Hepatic TREM-1 Expression and Prognosis in Severe Alcoholic Hepatitis
Background \& Rationale Severe alcohol-related hepatitis (SAH) is a serious condition with a 3-month mortality rate of ~30%. Diagnosis and prognosis are complex due to non-specific and insensitive clinical, biological, and…
- Trial name
- Liver TREM-1 (NCT07176741)
- Testing
- TREM-1 expression (via immunohistochemistry) between SAH patients and controls
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
Alcohol Use Disorder
Pilot Study: Effects of Nimodipine on Alcohol Drinking
This is an open label trial aiming to recruit 5 non-treatment seeking adults with Alcohol Use Disorder. All will participate in an alcohol drinking paradigm (ADP) lab session at the Hospital Research Unit (HRU) at Yale-New Haven…
- Trial name
- NCT06900998
- Testing
- Nimodipine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Yale University
Healthy Volunteers
PK and Onset of Hezkue Oral Sildenafil Suspension After Alcohol Consumption
This is an open-label, randomized study evaluating the pharmacokinetics and onset performance of Hezkue® oral sildenafil suspension administered following moderate alcohol consumption in healthy adult subjects.
- Trial name
- NCT07302698
- Testing
- Hezkue Oral Sildenafil Suspension
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aspargo Labs, Inc
Risk Behavior, Alcohol Use Disorder
TRAC-ER Intervention to Reduce Risky Alcohol Use and HIV Risk
Ecological momentary interventions (EMI), which use phones to deliver messages to reduce alcohol use and related risk behaviors during or prior to drinking events, can help to address triggers in real-time.
- Conditions
- Risk Behavior, Alcohol Use Disorder, HIV Infections
- Trial name
- TRAC-ER (NCT05576350)
- Testing
- Smartphone Based Alcohol Monitoring (SAM), Tracking and Reducing Alcohol Consumption (TRAC), TRAC-ER
- Where
- 2 sites in United States
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Alcohol Use Disorder
Nutritional Intervention to Reduce Alcohol Consumption
To test whether the implementation of a modified ketogenic diet (KD) is efficient in reducing outcome measures in relation to alcohol consumption in patients with alcohol use disorder (AUD).
- Trial name
- NIRAC (NCT06787235)
- Testing
- Modified ketogenic diet, Individual nutritional consultation
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Bern
Alcohol Drinking, Suicide
mHealth-supported Skills Training for Alcohol-Related Suicidality Phase 3
Suicide is a high priority public health problem and an increasingly prevalent alcohol-related consequence. One-third of people who die by suicide consume alcohol at hazardous rates in the year preceding death.
- Trial name
- mSTARS (NCT05847582)
- Testing
- Standard inpatient psychiatric care, Inpatient Skills Training, mHealth-supported Skills Training for Alcohol-Related Suicidality (mSTARS)
- Volunteers
- 35 people
- Sponsor
- Duke University
Alcohol Use Disorder
Involvement of the Septal Nuclei of the Human Brain in Alcohol Use Disorder
Alcohol activates reward systems in different brain areas, i.e., the nucleus accumbens, dorsal striatum, extended amygdala, and prefrontal cortex.
- Trial name
- NCT06866379
- Testing
- Brain imaging
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Anders Fink-Jensen, MD, DMSci
Alcohol Use Disorder
Anxiety During Abstinence in AUD
The goal of this study is to better understand the underlying neurobiological basis of anxiety that emerges during abstinence in patients with alcohol use disorder (AUD). The main questions it aims to answer are: 1.
- Trial name
- NCT06793488
- Testing
- Disulfiram 250 mg, functional MRI
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Columbia University
Alcohol Use Disorder (AUD)
Evaluation of a Virtual Reality-based Version of the Multiple Errands Test in Alcohol Use Disorder
The goal of this study is to validate the virtual version of the Multiple Errands Test (V-MET) as a tool for assessing executive functions in patients with alcohol use disorder (AUD). More specifically, the project aims to: 1.
- Trial name
- EVIMETAL (NCT07593664)
- Testing
- Multiple Errand Test (MET), Virtual MET
- Where
- 2 sites in France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier