Clinical trials: Alcohol Craving
Alcohol Use Disorder
Pioglitazone for the Treatment of Alcohol Use Disorder
Alcohol Use Disorder (AUD) is common among Veterans but medication treatment is used infrequently and the impact of these treatments are small to moderate at best.
- Trial name
- PAUSE (NCT03864146)
- Testing
- Brief Behavioral Compliance Enhancement Treatment
- Where
- 2 sites in United States
- Volunteers
- 201 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder, Posttraumatic Stress Disorder (PTSD)
Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders
The purpose of this study is to evaluate whether the combination of prazosin and naltrexone will decrease alcohol cravings and drinking in individuals who have problems with alcohol and have used alcohol at risky levels compare…
- Trial name
- PaN (NCT02322047)
- Testing
- Prazosin, Naltrexone
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Alcohol Drinking, Craving
Cognitive Interference Task on Alcohol Craving and Consumption
The purpose of this study is to test a brief task of playing the game Tetris to reduce alcohol cravings and alcohol use. Women who are seen at primary care and recruited through the community will be asked to rate alcohol craving…
- Trial name
- NCT04924283
- Testing
- Tetris and Assessments, Assessment Only
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Alcohol Drinking, Alcohol Drinking Related Problems
Effects of a New Behavioral Intervention on Alcohol Craving and Drinking
Background: Sights, sounds, and smells can be associated with alcohol and tempt people to drink. The connection between encountering cues and wanting to drink might be reduced by behavioral techniques, like giving the cues at…
- Trial name
- NCT02831049
- Testing
- Retrieval-extinction, Alcohol-related cues, Soft-drink related cues
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Use Disorder, Mild Traumatic Brain Injury
Pilot rTMS for AUD+mTBI
This is a pilot randomized controlled trial (RCT) for Veteran participants with alcohol use disorder co-occurring with mild traumatic brain injury and/or post-traumatic stress disorder.
- Conditions
- Alcohol Use Disorder, Mild Traumatic Brain Injury, Post-traumatic Stress Disorder
- Trial name
- TMS_AUD+mTBI (NCT03995173)
- Testing
- repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- VA Office of Research and Development
Alcoholism
A Study on the Biobehavioral Mechanisms of Baclofen and Alcohol Drinking
This pilot trial has the goal to demonstrate the feasibility of a study to test the effects of baclofen in a laboratory experiment using cue-reactivity and alcohol-self administration paradigms in non-treatment seeking…
- Trial name
- NCT01076283
- Testing
- Baclofen, Cyproheptadine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Brown University
Alcoholism
Study of the Medication Prazosin for Alcohol Dependence
The purpose of this study is to determine whether the drug prazosin is effective for the treatment of alcohol dependency.
- Trial name
- NCT00762710
- Testing
- Prazosin medication
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Alcohol Dependence, Alcohol Drinking
Role of Proinflammatory Signaling in Alcohol Craving
Background: Drinking too much alcohol can injure cells in the body. Inflammation is the body s reaction to injured cells. Studies show that inflammation can cause cravings for alcohol.
- Conditions
- Alcohol Dependence, Alcohol Drinking, Stress, Alcohol-Related Disorders
- Trial name
- NCT01631630
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Dependence
Effectiveness of Naltrexone Versus Placebo to Reduce Craving for Alcohol With Evaluation of Genetic Variability.
The purpose of this study is to determine whether naltrexone (an opiate blocking agent approved for the treatment of alcohol dependence) is more effective in the reduction of alcohol craving and drinking compared to placebo in…
- Trial name
- NCT00366626
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Medical University of South Carolina
Alcohol Dependence, Cocaine Dependence
Human Behavioral Pharmacology Laboratory (HBPL) Study of Varenicline's Impact on Cocaine and Alcohol Craving
This is a Phase II within-subjects double-blind placebo-controlled human laboratory study. The purpose of the study is to determine the efficacy of varenicline (Chantix) for reducing cue-induced cocaine and alcohol craving.
- Trial name
- NCT01151813
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pennsylvania
Alcohol Use Disorder
Effects of Pioglitazone on Stress Reactivity and Alcohol Craving (Pilot)
The purpose of this study is to assess the effect of pioglitazone on stress- and alcohol-related measures in treatment-seeking individuals with alcohol use disorder (AUD) and elevated levels of stress and anxiety.
- Trial name
- NCT03860753
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- The University of Texas Health Science Center, Houston
Alcohol Use Disorder
Decreasing the Temporal Window in Individuals With Alcohol Use Disorder
In the absence of sufficient monetary resources, individuals must attend to immediate, minimum needs (e.g., food, shelter). This constricts one's temporal window and engenders neglect of the future.
- Trial name
- RP1B (NCT04128761)
- Testing
- Scarcity Narrative, Neutral Narrative
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Virginia Polytechnic Institute and State University
Alcoholism, Cocaine Dependence
Prazosin for ETOH or Cocaine Craving
This double-blind placebo controlled crossover pilot trial will test the hypothesis that prazosin, an alpha-1 adrenergic receptor antagonist, reduces craving for their drug of choice in cocaine-dependent and alcohol-dependent…
- Trial name
- NCT00240227
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- US Department of Veterans Affairs
Alcoholism
Effects of Ghrelin on Alcohol Cue Reactivity and Craving
Only a few medications are approved for the treatment of alcohol dependence and there exists a substantial need for discovering ways to provide more effective treatments.
- Trial name
- NCT01190085
- Testing
- Ghrelin, Saline solution
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Brown University
Alcohol Use Disorder
Cannabidiol Effects on Blood Alcohol Level and Intoxication
The main objectives of this study were to test if 2 different doses of Cannabidiol (compared to placebo) alter 1) breath alcohol concentration, 2) craving and subjective responses to alcohol or 3) cognitive performance following…
- Trial name
- NCT06105138
- Testing
- 200mg Cannabidiol oral solution, 30mg Cannabidiol oral solution
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Alcohol Dependence, PTSD
Neuromodulation of Trauma Memories in PTSD & Alcohol Dependence
The purpose of this study is to examine the effect of propranolol versus placebo on craving, distress and cue reactivity to trauma and alcohol cues.
- Trial name
- NCT01055171
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder
Manipulating Ghrelin Signaling Via GOAT Inhibition in Alcohol Use Disorder
Background: People with alcohol use disorder (AUD) have trouble controlling their drinking. Medications can help some people with AUD but are not effective for many others.
- Trial name
- NCT03896516
- Testing
- GLWL-01
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Use Disorder
Increasing the Temporal Window in Individuals With Alcohol Use Disorder
Episodic future thinking (EFT) is based on the new science of prospection, which was first identified in a Science publication in 2007 and refers to pre-experiencing the future by simulation.
- Trial name
- RP1A (NCT04125238)
- Testing
- Episodic Future Thinking, Control Episodic Thinking
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Virginia Polytechnic Institute and State University
Alcohol Use Disorder, Liver Diseases
Biobehavioral Pathways Underlying Alcohol Use and Health
Alcohol-associated liver disease (ALD) and alcohol use disorder (AUD) are intersecting diseases that add substantially to the global burden of disease and mortality.
- Trial name
- NCT05135767
- Testing
- Brief Motivational Interviewing with Personalized Feedback
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Brown University
Alcohol Abstinence
Guanfacine to Reduce Relapse Risk in Women With Alcohol Use Disorder (AUD)
Guanfacine may preferentially reduce craving and improve cognitive control in women with Alcohol Use Disorder (AUD), compared to men.
- Trial name
- NCT03137082
- Testing
- Guanfacine XR 3mgs/daily
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Stony Brook University