Clinical trials: Alcohol Dependence
Drug Addiction, Executive Dysfunction
Bilateral Prefrontal Modulation in Alcoholism
In this study, eligible alcoholic inpatients recruited from a specialized clinic for addiction treatment, filling inclusion criteria and not showing any exclusion criteria, were randomized to receive the repetitive (10 sessions…
- Trial name
- tDCS_ALCOHOL (NCT02091284)
- Testing
- transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Federal University of Espirito Santo
Alcoholic Hepatitis
IL-1 Signal Inhibition in Alcoholic Hepatitis
Alcoholic hepatitis (AH) is a florid presentation of alcoholic liver disease characterized by liver failure in the context of recent and heavy alcohol consumption.
- Trial name
- ISAIAH (NCT03775109)
- Testing
- Canakinumab 150mg/ml solution for injection
- Where
- 16 sites in United Kingdom
- Volunteers
- 55 people
- Sponsor
- Imperial College London
Alcohol Drinking
Naltrexone and Memantine Effects on Alcohol Drinking Behaviors
The purpose of this study is to evaluate the combined effects of the study medications naltrexone and memantine on alcohol drinking behaviors.
- Trial name
- NCT01519063
- Testing
- Naltrexone and memantine first
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Yale University
Alcohol Dependence
Efficacy of Nalmefene in Patients With Alcohol Dependence
The purpose of the study is to evaluate the efficacy, safety and tolerability of nalmefene in the treatment of alcohol dependence.
- Trial name
- ESENSE2 (NCT00812461)
- Testing
- Nalmefene
- Where
- 57 sites in Belgium, Czechia and 5 more
- Volunteers
- 678 people
- Sponsor
- H. Lundbeck A/S
Cocaine Use Disorder, Alcohol Use Disorder
PPARγ Agonist Treatment for Cocaine Dependence
The purpose of this research study is to determine whether a medication called pioglitazone (trade name Actos) can reduce behavioral problems associated with cocaine use, improve brain structural changes associated with cocaine…
- Trial name
- NCT02774343
- Testing
- Pioglitazone, Therapy, Contingency Management
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center, Houston
Alcohol Abuse
CARES: A Mobile Health Program for Alcohol Risk Reduction
In this fast-track STTR, Phase 1 will develop and test a mobile phone app among 40 adult community college students. The app is designed to reduce risky drinking behaviors and improve user safety.
- Trial name
- NCT03927482
- Testing
- CARES mobile smart phone app, Check Your Drinking
- Where
- United States
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Alcohol Use Disorder, Couples
Oxytocin to Enhance Alcohol Behavioral Couple Therapy (ABCT)
Alcohol Behavioral Couples Therapy (ABCT) is a manualized 12-session, weekly psychosocial intervention that simultaneously reduces alcohol use disorder (AUD) severity and improves relationship functioning.
- Trial name
- NCT03846505
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Medical University of South Carolina
Opioid Use Disorder, Alcohol Use Disorder
Comparing Treatments for HIV-Infected Opioid and Alcohol Users in an Integrated Care Effectiveness Study
The purpose of this study is to learn how best to treat substance use disorders in an HIV clinic setting. Specifically, the purpose of this pilot study is to learn if extended-release naltrexone (XR-NTX) would be a feasible and…
- Trial name
- CHOICES (NCT01908062)
- Testing
- Extended Release Naltrexone, Treatment As usual
- Where
- 2 sites in United States, Canada
- Volunteers
- 51 people
- Sponsor
- Oregon Health and Science University
Substance Abuse
Telephone Coaching of Family Members of Veterans With Substance Abuse Problems
This project will develop and pilot test an enhanced, telephone "coaching" intervention to help family members concerned about a Veteran of the wars in Iraq or Afghanistan who needs to seek treatment for a substance abuse problem.
- Trial name
- VA-CRAFT (NCT03246646)
- Testing
- Coaching
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- VA Office of Research and Development
Alcoholism
Repurposing alpha1 Noradrenergic Antagonists for Alcoholism Treatment
Double-blind, placebo-controlled, cross-over design study examining the effects of a norepinephrine alpha1 receptor antagonist (prazosin) on stress reactivity in a laboratory stressor task.
- Trial name
- NCT02966340
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alcoholism, Nicotine Dependence
Varenicline and Alcohol in Inpatient Addictions Program (IAP)
The overall hypothesis of this line of research is that varenicline will decrease alcohol consumption and tobacco use and will increase alcohol and tobacco abstinence rates.
- Trial name
- NCT01169610
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Alcohol Use Disorder
Efficacy and Mechanisms of CBT4CBT for Alcohol Use Disorders
Evaluate the efficacy of CBT4CBT and clinician-delivered CBT relative to standard treatment for reducing alcohol use
- Trial name
- NCT02742246
- Testing
- Individual clinician-provided CBT, CBT4CBT
- Where
- 2 sites in United States
- Volunteers
- 99 people
- Sponsor
- Yale University
Alcohol Dependence
Efficacy of Nalmefene in Patients With Alcohol Dependence
The purpose of the study is to evaluate the efficacy, safety and tolerability of nalmefene in the treatment of alcohol dependence.
- Trial name
- ESENSE1 (NCT00811720)
- Testing
- Nalmefene
- Where
- 39 sites in Austria, Finland and 2 more
- Volunteers
- 598 people
- Sponsor
- H. Lundbeck A/S
Alcohol Dependence, Posttraumatic Stress Disorder (PTSD)
A Controlled Trial of Topiramate Treatment for Alcohol Dependence in Veterans With PTSD
The goal of this project is to improve the treatment of veterans with co-occurring alcohol dependence and posttraumatic stress disorder (PTSD).
- Trial name
- TAP2 (NCT01749215)
- Testing
- Topiramate, Medical Management
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- University of California, San Francisco
Posttraumatic Stress Disorder, Alcohol Use Disorders
Brief Restructuring Intervention Following Trauma Exposure
The broad aim of this study is to develop and test a brief intervention that can be implemented in the immediate weeks following sexual assault to decrease likelihood of developing posttraumatic stress disorder (PTSD) or alcohol…
- Trial name
- BRITE (NCT02808468)
- Testing
- Brief Cognitive Therapy
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Washington
Alcohol and Substance-Related Mental Disorders
Effectiveness of an Evidence-based Stepped Care System for Alcohol and Other Drug Use Problems Among Congolese Refugees in Zambia
This is a randomized controlled trial (RCT) evaluating the effectiveness of a screening, brief intervention, and referral to treatment (SBIRT) stepped-care system in reducing unhealthy AOD use among Congolese refugees and the…
- Trial name
- NCT05471921
- Testing
- SBIRT, Treatment as usual
- Where
- 2 sites in United States, Zambia
- Volunteers
- 400 people
- Sponsor
- Columbia University
Alcoholism, Alcohol Dependence
Gabapentin Treatment of Alcohol Dependence
Gabapentin treatment for alcohol dependence
- Trial name
- NCT00391716
- Testing
- Gabapentin 900mg, behavioral counseling, gabapentin 1800mg
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The Scripps Research Institute
Alcohol Dependence
A Study in the Treatment of Alcohol Dependence.
H8R-MC-HJAQ is a Phase 2, parallel, double-blind, randomized study comparing LY686017 with placebo in a 12-week trial that includes Medical Management.
- Trial name
- NCT00805441
- Testing
- LY686017
- Where
- 21 sites in United States
- Volunteers
- 190 people
- Sponsor
- Eli Lilly and Company
Alcohol Dependence
A Randomized Clinical Trial of Alcohol Care Management
A randomized study of Alcohol Care Management for the treatment of alcohol dependence in primary care settings.
- Trial name
- NCT00419315
- Testing
- Alcohol Care Management, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 163 people
- Sponsor
- US Department of Veterans Affairs
Alcohol Use Disorder
Alcohol Use and Mental Health - Pilot Test of Video-assisted Drinking Topography
The overall goal is to pilot test and establish a procedure for video-assisted alcohol topography and explore its utility as an indicator of alcohol use disorder.
- Trial name
- NCT03314454
- Testing
- Beer, Videotaped drinking session
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Florida