Clinical trials: Alcohol Dependence
Alcohol Dependence
Baclofen as Add-On to Standard Treatment of Alcohol- Dependent Patients
This is a study of Baclofen as an add-on to standard treatment for alcohol-dependent patients.
- Trial name
- NCT01002105
- Testing
- Baclofen, Control group
- Where
- Israel
- Volunteers
- 75 people
- Sponsor
- Sha'ar Menashe Mental Health Center
Alcoholism
Medication Development in Alcoholism: Investigating PPAR Agonists
The primary hypotheses under test are that alcohol dependent subjects treated with fenofibrate will report decreased craving for alcohol following cue-exposure in the laboratory and report less drinking post treatment relative to…
- Trial name
- NCT02158273
- Testing
- Sugar Pill, TRICOR (fenofibrate)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Scripps Research Institute
Housing Problems, Drug Use
ED-Home Pilot Study
This is a single-arm pilot study to test the feasibility of homelessness prevention and substance use interventions to be delivered to at-risk patients in the Bellevue Hospital emergency department (ED).
- Conditions
- Housing Problems, Drug Use, Alcohol; Use, Problem
- Trial name
- NCT03864341
- Testing
- Referral to homelessness prevention services, Substance use services, Follow-up
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Drug Dependence, Alcohol Dependence
Impact of Exercise and Affirmations (IntenSati) on Addiction-related Cognitive and Psychosocial Deficits
Addiction to illicit and prescribed drugs, alcohol and tobacco is associated with a panoply of brain changes that contribute to structural and micro-structural deficits, altered metabolism and neurotransmission, and related…
- Trial name
- NCT01171677
- Testing
- IntenSati
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Alcoholism
Levetiracetam XR in Very Heavy Drinkers
The primary objectives of this study are to assess the efficacy of levetiracetam XR in increasing the percentage of subjects with no heavy drinking days and in reducing the weekly percentage of heavy drinking days in subjects…
- Trial name
- NCIG 002 (NCT00970814)
- Testing
- BBCET, Levetiracetam XR, Sugar Pill
- Where
- 5 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder (AUD), Substance Use Disorders
The Anchor Study: Digitally Delivered Intervention for Reducing Problematic Substance Use
This study aims to validate W-SUDs as a digitally-delivered substance use disorder program through a fully-powered randomized control trial that will test the comparative efficacy of the mobile-app based substance use disorder…
- Trial name
- NCT04925570
- Testing
- W-SUDs, Digitally-delivered Psychoeducation
- Where
- United States
- Volunteers
- 258 people
- Sponsor
- Woebot Health
Alcoholic Intoxication, Neurobehavioral Manifestations
Residual Effects of Intoxication on Student Performance
The primary goal of the study is to assess the residual effects of heavy drinking on academic performance. The investigators will also explore whether these effects differ by family history of alcohol abuse and hangover symptoms…
- Trial name
- NCT00183170
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Boston University
Alcohol Dependence
Prometa Protocol for Alcohol Dependence
This is a placebo controlled trial (some people receive active and some people receive inactive medication) to evaluate the effectiveness of a new protocol to treat alcohol dependence.
- Trial name
- NCT00262639
- Testing
- Flumazenil and Gabapentin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical University of South Carolina
Alcoholism
Effects of Ghrelin on Alcohol Cue Reactivity and Craving
Only a few medications are approved for the treatment of alcohol dependence and there exists a substantial need for discovering ways to provide more effective treatments.
- Trial name
- NCT01190085
- Testing
- Ghrelin, Saline solution
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Brown University
Alcoholism
N-acetylcysteine in Alcohol Dependence
The present study is designed to find out if N-acetylcysteine works in reducing alcohol drinking and craving.
- Trial name
- NCT00568087
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Nicotine Dependence, Alcohol Use Disorder
Combining Varenicline and Naltrexone for Smoking Cessation
This study is a double-blind, randomized clinical trial using a two group medication design consisting of the combination of VAR (1 mg twice daily) + NTX (50 mg once daily) and VAR (1 mg twice daily) + PLA (matched to NTX), for…
- Trial name
- NCT02698215
- Testing
- Varenicline, Varenicline plus Naltrexone
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- University of California, Los Angeles
Alcohol Use Disorder, Eligible to go Into the MRI Scanner
Clinical Intervention in Alcohol Use Disorder
Long-term abstinence from alcohol is supported by a compensatory mechanism in functional brain connectivity, a potential brain biomarker that could be an intervention target.
- Conditions
- Alcohol Use Disorder, Eligible to go Into the MRI Scanner, Short-term Abstinence From Alcohol Use (2 Week Abstinent)
- Trial name
- NCT02168400
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Minnesota
Alcoholism
Medication Development in Alcoholism: Acamprosate Versus Naltrexone
The purpose of this study is to develop and validate a human laboratory model for prediction of medication efficacy in clinical trials for relapse prevention in alcohol dependence.
- Trial name
- NCT00656630
- Testing
- Acamprosate, Naltrexone
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- The Scripps Research Institute
Alcohol Abuse
Sex Differences in Risk for Alcohol Abuse
This study will determine the neural and hormonal mechanisms underlying sex differences in sensitivity to the disinhibiting effects of alcohol in heavy drinkers.
- Trial name
- NCT04543942
- Testing
- Alcohol, Saline
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mark Fillmore
Alcohol Use Disorder
Frontal-Striatal Reward Circuit Neuromodulation and Alcohol Self-Administration
This will be a single site randomized, 2-session, within-subject cross-over design pilot study. 20 enrolled (of 30 consented) subjects reporting varying levels of binge and high intensity drinking, defined as at least 2 episodes…
- Trial name
- NCT04971681
- Testing
- Low frequency repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Indiana University
Alcohol Dependence, Chronic Hepatitis C
Study of the Effects of Motivational Enhancement Therapy on Alcohol Use in Chronic Hepatitis C Patients
The purpose of this study is to determine whether motivational enhancement therapy (MET) reduces alcohol use in a population of HCV-infected veterans who are currently drinking alcohol and have alcohol disorders.
- Trial name
- NCT00596960
- Testing
- Motivational Enhancement Therapy (MET), Health education
- Where
- 2 sites in United States
- Volunteers
- 139 people
- Sponsor
- US Department of Veterans Affairs
Alcohol Use Disorder
Cannabidiol in Youth Alcohol Use Disorder
The goal of this study is to test cannabidiol (CBD) as a potentially effective candidate medication for youth alcohol use disorder (AUD).
- Trial name
- NCT05317546
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Substance Use Disorders, Alcohol Abuse
Reinforcement of Abstinence and Continuing Care in Substance Abuse Treatment
The Contracts, Prompts, and Social Reinforcement (CPR) intervention was designed to address the continuing care adherence needs of veterans presenting for substance use disorder (SUD) treatment.
- Conditions
- Substance Use Disorders, Alcohol Abuse, Alcoholism, Substance Dependence
- Trial name
- NCT00288886
- Testing
- Contracting, Prompting and Reinforcement arm, Control arm
- Where
- 2 sites in United States
- Volunteers
- 183 people
- Sponsor
- US Department of Veterans Affairs
Alcohol Use Disorder, Alcohol Drinking
Pitolisant Effects on Alcohol Self-Administration in Heavy Drinkers
This is a double-blind, randomized, placebo-controlled, crossover design trial that will test the effect of pitolisant on alcohol self-administration and craving following a priming dose of alcohol.
- Trial name
- NCT04596267
- Testing
- Pitolisant
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Boston Medical Center
Smoking, Tobacco Dependence
Varenicline Treatment for Active Alcoholic Smokers
Alcohol dependence is a significant and prevalent public health problem affecting approximately 4% of the U.S. adult population.
- Conditions
- Smoking, Tobacco Dependence, Alcohol Dependence
- Trial name
- NCT01347112
- Testing
- Varenicline
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic