Clinical trials: Alcohol Dependency
Alcoholism
Oxytocin in Alcohol Use Disorder
Background: Oxytocin is a naturally occurring substance in the body. Studies show that oxytocin may affect how the body responds to alcohol. Researchers believe oxytocin may be a possible treatment for alcoholism.
- Trial name
- NCT02711189
- Testing
- Oxytocin
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder, Alcohol Dependence
Altering Memories That Increase Risk of Relapse in Alcohol Use Disorders
The purpose of this study is to examine the effects of rapamycin (sirolimus) versus a placebo, an inactive substance, on responses to alcohol cues in individuals with alcohol use disorder.
- Trial name
- NCT03732248
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Alcohol Abuse, Alcohol Addiction
Guided and Unguided Internet Treatment for Problematic Alcohol Use
The purpose of this study was to determine whether a 10-week internet-based program based on cognitive behavioral therapy (CBT) is effective in the treatment of alcohol problems, and if having therapist guidance leads to greater…
- Trial name
- NCT02384304
- Testing
- Choice, Messages, Self help
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Psychosis, Alcohol Use Disorder
Piloting of an Intervention to Reduce Problematic Alcohol Use in Early Phase Psychosis Patients
A focus of research for youth and Emerging Adults with early phase psychosis (EPP) has been cannabis use. However, this focus has led to overlooking the possible negative influence of another legal recreational drug, alcohol.
- Trial name
- NCT05365347
- Testing
- Cognitive Enhancement Therapy (CET)
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Nova Scotia Health Authority
Alcohol-Related Disorders, Alcoholism
Comparing Combined Behavioral Intervention and Ericksonian Hypnotherapy for Alcohol Addiction
This clinical study is being conducted to compare the effectiveness of two psychological treatments for alcohol addiction: Combined Behavioral Intervention (CBI) and Ericksonian Hypnotherapy (EH).
- Conditions
- Alcohol-Related Disorders, Alcoholism, Substance-related Disorders
- Trial name
- NCT06916754
- Testing
- Combined Behavioral Intervention, Ericksonian Hypnotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Beykoz University
Alcoholism
Imaging Cannabinoid CB1 Receptors in Alcohol Dependence
The cannabinoid type 1 (CB1) receptor is a protein found in the brain that is involved with the effects of marijuana; it may also play a role in the effects of alcohol dependence and withdrawal.
- Trial name
- NCT00816439
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
College Drinking
Text-based Alcohol Prevention for First Year College Students
This project aims to combat excessive perceived norms that contribute to high volume drinking by young adults, which adversely affects health and academic achievement.
- Trial name
- NCT03864237
- Testing
- Alcohol texts, Attention control
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Use Disorder, Stress Reaction
Neurobehavioral Profiles of Adaptive Stress Responses in Individuals With Alcohol Use Disorder
The goal of this observational study is to investigate longitudinal stress response profiles and adaptive versus non-adaptive stress responses in alcohol use disorder.
- Conditions
- Alcohol Use Disorder, Stress Reaction, Social Stress, Craving
- Trial name
- A03 (NCT06105853)
- Testing
- Trier Social Stress Test, Barlab Cue-Exposure, Functional magnetic resonance imaging
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Posttraumatic Stress Disorder, Alcohol Use Disorders
CAP: Doxazosin in the Treatment of Co-Occurring PTSD and Alcohol Use Disorders
The proposed study will examine the efficacy of doxazosin in the treatment of PTSD and alcohol use disorder or substance use disorders.
- Trial name
- Doxazosin (NCT02500602)
- Testing
- doxazosin
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- VA Office of Research and Development
PTSD and Alcohol Use Disorder
Topiramate and Prolonged Exposure
Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) frequently co-occur, and having both disorders is associated with greater psychological and functional impairment than having either disorder alone.
- Trial name
- TOP (NCT03176953)
- Testing
- topiramate, prolonged exposure
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder
Harm Reduction With Pharmacotherapy (HaRP)
The goal of this study is to test the efficacy of extended-release naltrexone and harm reduction counseling in reducing alcohol-related harm among homeless people with alcohol dependence.
- Trial name
- HaRP (NCT01932801)
- Testing
- XR-NTX, HRC
- Where
- United States
- Volunteers
- 308 people
- Sponsor
- University of Washington
Alcohol Use Disorder
Spaced Versus Massed Alcohol Avoidance Task
Rationale: Alcohol-Avoidance Training (AAT) has been used successfully to strengthen avoidance-tendencies in patients with alcohol use disorder (AUD).
- Trial name
- NCT05631366
- Testing
- Alcohol Avoidance Training
- Where
- Netherlands
- Volunteers
- 234 people
- Sponsor
- W. Markus
Nicotine Dependence, Alcohol Dependence
Topiramate to Aid Smoking Cessation in Alcohol Dependent Men
The purpose of this study is to determine whether topiramate is effective as an aid to smoking cessation for recovering alcohol dependent men.
- Trial name
- NCT00802412
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder
PT150 Drug for Use in Alcohol Use Disorder
The goal of this study is to learn if PT150 can reduce the behavioral and physical effects of stress, alcohol, and alcohol use in people with alcohol use disorder.
- Trial name
- NCT06712602
- Testing
- alcohol, Stress-Induction, PT150
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Pop Test Oncology LLC
Alcohol Use Disorder
Counseling for Alcohol Problems in Pregnancy (CAP-Pre) Phase II
Purpose: This study is testing a new counseling program called Counselling for Alcohol Problems in Pregnancy or CAP-Pre, designed to help pregnant women in South Africa to reduce their alcohol use and improve their well-being.
- Trial name
- CAP-Pre (NCT06853873)
- Testing
- The Counselling for Alcohol Problems in Pregnancy (CAP-Pre) intervention
- Where
- South Africa
- Volunteers
- 40 people
- Sponsor
- Leibniz Institute for Prevention Research and Epidemiology - BIPS GmbH
Alcohol Use Disorder
Ketamine for the Treatment for Alcohol Use Disorder in the ED
The investigators' approach is to conduct a pilot double-blind, placebo-controlled randomized clinical trial with individuals with alcohol use disorder (AUD) seeking inpatient alcohol detoxification in the emergency department…
- Trial name
- NCT05661669
- Testing
- Ketamine, Saline
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
Alcohol Use Disorder
Online Relapse Prevention Therapy for Patients With Alcohol Use Disorder
Alcohol use disorder (AUD) is characterized by problematic alcohol use accompanied by clinically significant distress. This disorder is associated with high relapse rates, with one in five patients remaining abstinent 12 months…
- Trial name
- NCT05579210
- Testing
- Online relapse prevention therapy, Face to face relapse prevention therapy
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Dr. Nazanin Alavi
Alcohol Use Disorders
Telephone and Mail Intervention for Alcohol Use Disorders
Randomized controlled trial and benefit-cost study of a telephone and mail intervention for non-treatment-seeking primary care patients with alcohol abuse or dependence
- Trial name
- TAMI (NCT00204854)
- Testing
- telephone counseling
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- University of Wisconsin, Madison
Severe Alcoholic Hepatitis
LiverTREM-1: Hepatic TREM-1 Expression and Prognosis in Severe Alcoholic Hepatitis
Background \& Rationale Severe alcohol-related hepatitis (SAH) is a serious condition with a 3-month mortality rate of ~30%. Diagnosis and prognosis are complex due to non-specific and insensitive clinical, biological, and…
- Trial name
- Liver TREM-1 (NCT07176741)
- Testing
- TREM-1 expression (via immunohistochemistry) between SAH patients and controls
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
fMRI, Alcohol Drinking
Ghrelin for Alcohol Use in Non-Treatment-Seeking Heavy Drinkers
Background: Ghrelin is a hormone in the human body that is mostly produced by the stomach. It makes people feel hungry, and also is connected with the desire to drink alcohol.
- Conditions
- fMRI, Alcohol Drinking, Alcoholism
- Trial name
- NCT01779024
- Testing
- Ghrelin, fMRI, Alcohol
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)