Clinical trials: Alcohol Dependency
Alcohol Use Disorder
Effect of CBT Microinterventions on Mechanisms of Behavior Change Among Adults With AUD
This proposed R21, Effect of CBT Microinterventions on Mechanisms of Behavior Change among Adults with AUD: Using Eye Tracking to Measure Pre-Post Cognitive Control, uses a translational team science approach to isolate and…
- Trial name
- NCT03661853
- Testing
- Control, Functional Analysis, Cognitive Restructuring
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- University of Massachusetts, Worcester
Alcoholism, Bipolar Disorder
Drug Treatment for Alcoholics With Bipolar Disorder
The purpose of this study is to test the effectiveness of sodium valproate (Depacon) in treating individuals with alcohol dependence and comorbid bipolar disorder.
- Trial name
- NCT00000439
- Testing
- sodium valproate
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder (AUD), Alcoholism
Role of Pavlovian Mechanisms for Control Over Substance Use
During the first funding period (1st FP), the investigators developed a novel full Pavlovian-to-instrumental transfer (PIT) task that allows assessing both, general and specific PIT to investigate whether specific PIT differs…
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders, Cannabis Use Disorder
- Trial name
- ReCoDe (NCT06701487)
- Testing
- fMRI imaging (BOLD), sMRI (structure), Pavlovian-to-instrumental transfer (PIT) paradigm
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technische Universität Dresden
Alcohol Abuse
Pilot Test of Computerized MET to Reduce Adolescent Alcohol Use
The goal of this project is to conduct a pilot study evaluating feasibility, acceptability, and estimating the effect size of a new computerized Motivational Enhancement Therapy (cMET) intervention for alcohol-involved adolescent…
- Trial name
- NCT01796158
- Testing
- cASBI+cMET, cASBI
- Where
- United States
- Sponsor
- Boston Children's Hospital
Depression - Major Depressive Disorder, Anxiety
Deaf CBT-TS to Reduce Suicide Risk
The goal of this clinical trial is to learn if a short, Zoom-based intervention, Cognitive Behavioral Therapy for Treatment-Seeking for Deaf Individuals (Deaf CBT-TS) can change beliefs about mental health treatment and increase…
- Conditions
- Depression - Major Depressive Disorder, Anxiety, PTSD - Post Traumatic Stress Disorder, Insomnia
- Trial name
- NCT07279363
- Testing
- Deaf CBT-TS
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Rochester
Alcohol Use Disorder
mHealth App for Changing Alcohol Use in Alaska Native American Indian People
For many people who have trouble with alcohol, peer support - the opportunity to share challenges, problem-solving strategies, and successes with supportive others - can be helpful.
- Trial name
- CIRCLE (NCT05326438)
- Testing
- CIRCLE mHealth app
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Southcentral Foundation
Alcohol Abuse, Craving
Using Neurofeedback to Understand the Relationship Between Stress and Alcohol Consumption
In this research project, the aim is to discover the role specific brain networks play in the relationship between stress reactions and the desire for alcohol and alcohol consumption.
- Conditions
- Alcohol Abuse, Craving, Psychosocial Stressor, Neural Stress Response
- Trial name
- NeuStress (NCT06247306)
- Testing
- ScanSTRESS fMRI-paradigm (Streit et al., 2014), real-time fMRI neurofeedback
- Where
- Germany
- Volunteers
- 102 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Alcoholism
Trial Testing the Effect of Strategies on Performance of Brief Intervention Programmes for Harmful Alcohol Consumption
The overall objective is to study if training and support, financial reimbursement and referral to an internet based brief intervention programme, singly or in combination, may increase implementation of evidence based methods of…
- Trial name
- ODHIN_RCT (NCT01501552)
- Testing
- Training and support (T&S), Financial incentive, E-SBI (online screening and brief intervention)
- Where
- 10 sites in Netherlands, Poland and 3 more
- Volunteers
- 120 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Alcohol Consumption, Alcoholic Intoxication
Naltrexone for Heavy Drinking in Young Adults
In this study, 140 heavy drinking young adults (aged 18-25) will be provided with brief counseling and either naltrexone, a medication that is FDA-approved for the treatment of alcohol dependence, or placebo over the course of 8…
- Conditions
- Alcohol Consumption, Alcoholic Intoxication, Alcoholism, Alcohol-induced Disorders
- Trial name
- NCT00568958
- Testing
- BASICS counseling, naltrexone
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Yale University
Alcohol-Related Disorders, Alcohol Problem
Identifying and Managing Alcohol-related Health Problems in General Practice
The overall purpose of the proposed research is to increase patients' and general practitioners' (GPs') awareness of alcohol as a relevant factor for a wide variety of health problems in general practice, and enable earlier help…
- Conditions
- Alcohol-Related Disorders, Alcohol Problem, Alcohol Drug Interaction, Alcohol Use Disorder
- Trial name
- NCT04725552
- Testing
- 'Change' - an e-health intervention
- Where
- 4 sites in Norway
- Volunteers
- 40 people
- Sponsor
- Helse Stavanger HF
Alcoholic Liver Disease, Alcoholic Fibrosis of Liver
Early Detection of Alcoholic Liver Disease
This is an observational study to identify the prevalence of advanced liver fibrosis among patients with excessive alcohol intake using a non-invasive method (FibroScan®) and to characterize the main environmental, genetic and…
- Conditions
- Alcoholic Liver Disease, Alcoholic Fibrosis of Liver, Alcoholic Cirrhosis, Excessive Drinking
- Trial name
- NCT04070508
- Sponsor
- University of Pittsburgh
Alcohol Abuse, Anxiety Disorders
The Measurement of Mood Variability and Sustained Attention in Women With Alcohol Dependence.
The purpose of this study is to measure daily mood changes and to find out whether these mood changes are related to the ability to maintain attention on a task.
- Conditions
- Alcohol Abuse, Anxiety Disorders, Mood Disorders
- Trial name
- NCT00230425
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Saskatchewan
Acquired Immunodeficiency Syndrome, Alcoholism
Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex Traits
We propose to conduct a multifactorial genetic study of cancer risk-related behaviors and other complex human characteristics. The main areas of interest are tobacco smoking, excess alcohol consumption, psychological traits, and…
- Conditions
- Acquired Immunodeficiency Syndrome, Alcoholism, HIV Infection, Neoplasm
- Trial name
- NCT00001500
- Where
- United States
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Sexual Assault and Rape, Risk Behavior
Piloting ProHealth: A Program for Male Soldiers on Sex, Dating and Alcohol-Use at Fort Bragg
The proposed project will provide data concerning dating and sexual interactions that occur on Fort Bragg, North Carolina, in addition to piloting a sexual assault prevention program through the use of social norms and bystander…
- Conditions
- Sexual Assault and Rape, Risk Behavior, Alcohol Abuse
- Trial name
- NCT03184298
- Testing
- Surveys, Interviews, Group Discussions
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Womack Army Medical Center
Alcoholism
Integrative Therapy in Alcoholism
The main aim of this project consists in the investigation of the interaction of behavior therapy and Acamprosate in the outpatient treatment of alcoholic patients in a randomized, prospective and (regarding study medication…
- Trial name
- NCT00159107
- Testing
- Acamprosate, Integrative behavior therapy
- Where
- Germany
- Volunteers
- 371 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Suicide, Suicide, Attempted
Drivers of Suicide Mobile App Study
The central purpose of this project is to evaluate and facilitate access to evidence-based best practices for individuals struggling with suicidal ideation and co-occurring behavioral problems, including alcohol misuse, and…
- Conditions
- Suicide, Suicide, Attempted, Suicidal Ideation, Alcohol Use Disorder
- Trial name
- NCT05427734
- Testing
- WisePath for Adults, Active-Control app + electronic wellness resources brochure
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- Evidence-Based Practice Institute, Seattle, WA
Alcohol Drinking
Naltrexone and Memantine Effects on Alcohol Drinking Behaviors
The purpose of this study is to evaluate the combined effects of the study medications naltrexone and memantine on alcohol drinking behaviors.
- Trial name
- NCT01519063
- Testing
- Naltrexone and memantine first
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Yale University
Alcohol Use Disorder
Brief Family Involved Treatment Telehealth
Improving alcohol use disorder (AUD) treatment among Veterans is a national public health problem. The rate of AUD among Veterans is twice that of civilians, with up to 50% of Veterans having AUD.
- Trial name
- B-FIT (NCT05674409)
- Testing
- Brief Family-Involved Treatment (B-FIT), Cognitive Behavioral Therapy for Alcohol Use Disorder (CBT for AUD)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Medical University of South Carolina
Alcohol Dependence
Treatment Strategy for Alcohol Use Disorders in Veterans With TBI
The purpose of this research study is to understand the effectiveness of valproate (a common mood stabilizer) to further reduce alcohol misuse when given in addition to attending an alcohol rehabilitation program as well as the…
- Trial name
- AUD (NCT01342549)
- Testing
- Valproate, Naltrexone
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder
Clinical Course of Alcohol Use Disorder Recovery
The goal of this single-arm clinical trial is to better understand the ways in which individuals seeking treatment recover from Alcohol Use Disorder (AUD).
- Trial name
- NCT05607290
- Testing
- Cognitive-Behavioral Treatment
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of South Florida