Clinical trials: Alcohol Disorders
Alcohol Abuse
Genetic and Neural Factors in Alcohol-Related Cognition
This study examines the genetic factors that impact cognitive processes and behavior after alcohol consumption. Participation in this project will contribute to a better understanding of cognitive factors that influence alcohol…
- Trial name
- NCT03725345
- Testing
- MRI Scanner
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Alcohol Dependence, Executive Dysfunction
Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex in Alcoholism
Alcohol dependency is the most frequent addiction leading to a massive burden of both, patients health, and economy. Present therapeutic concepts suffer from limited efficacy, and thus new innovative therapies are needed.
- Conditions
- Alcohol Dependence, Executive Dysfunction, Abnormal Craving for Drugs
- Trial name
- NCT01330394
- Testing
- transcranial Direct Current Stimulation
- Where
- 2 sites in Brazil
- Volunteers
- 33 people
- Sponsor
- Federal University of Espirito Santo
Alcohol Dependence
Oral vs. Injectable Naltrexone for Hospitalized Veterans With Alcohol Dependence
The over-arching goal of the proposed project is to understand the impact of medication adherence upon engagement in behavioral treatment for alcohol use disorders.
- Trial name
- NCT01856712
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Wisconsin, Madison
Neurobehavioral Manifestations, Drug Related Sleep Disturbance
Acute and Residual Effects of Caffeinated Beer
The aim of this study is to develop information about the acute and residual effects of a new product being targeted to young adults.
- Conditions
- Neurobehavioral Manifestations, Drug Related Sleep Disturbance, Alcohol Intoxication
- Trial name
- NCT00515294
- Testing
- Caffeinated Alcoholic Beer, Non-Caffeinated Alcoholic Beer, Caffeinated Non-Alcoholic Beer
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Boston University
Alcoholism, Schizophrenia
Facilitation of NMDA Receptor Function in Patients With Schizophrenia and Co-morbid Alcoholism
This placebo-controlled study is designed to evaluate the efficacy of glycine, an agonist of the glycine-B co-agonist site of the NMDA receptor, on alcohol consumption and craving as well as negative symptoms in schizophrenia.
- Trial name
- NCT00338598
- Testing
- Glycine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Alcohol Dependence, Stress Disorders, Post-Traumatic
Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD).
Prazosin is an alpha-1 adrenergic receptor antagonist that has been used successfully in the treatment of trauma nightmares and sleep disturbance in combat veterans with PTSD, and alcohol dependence.
- Trial name
- NCT00744055
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Yale University
Alcohol Use Disorder, Posttraumatic Stress Disorder (PTSD)
Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders
The purpose of this study is to evaluate whether the combination of prazosin and naltrexone will decrease alcohol cravings and drinking in individuals who have problems with alcohol and have used alcohol at risky levels compare…
- Trial name
- PaN (NCT02322047)
- Testing
- Prazosin, Naltrexone
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Alcoholism
Modulation of Pharmacologically Induced Alcohol Craving in Recently Detoxified Alcoholics
This study will determine if acamprosate, a drug approved to treat alcoholism, decreases alcohol cravings in alcohol-dependent subjects following infusions of yohimbine and mCPP.
- Trial name
- NCT00605904
- Testing
- Acamprosate, Yohimbine, mCPP
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Dependence
Gabapentin for Abstinence Initiation in Alcohol Dependence
Primary Hypotheses: 1. Gabapentin will significantly reduce alcohol consumption and promote abstinence as compared to placebo. The primary outcome measure will be the number of the heavy drinking days (defined as any day where…
- Trial name
- GAINS (NCT01141049)
- Testing
- Gabapentin
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- New York State Psychiatric Institute
Alcohol Use Disorder, Alcohol Dependence
RCT of Web-Based Behavioral Sleep Intervention for Individuals With Alcohol Use Disorder
Background: Many people with alcohol use disorders have a sleep problem called insomnia. One treatment is Cognitive Behavioral Therapy for Insomnia (CBT-I).
- Conditions
- Alcohol Use Disorder, Alcohol Dependence, Insomnia
- Trial name
- NCT03493958
- Testing
- Sleep Healthy Using the Internet (SHUTi)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Alcohol Use Disorder, Depression
Zambia Common Elements Treatment Approach Pilot Study
This is a randomized controlled trial (RCT) evaluating the effectiveness of an alcohol brief intervention alone compared to the brief intervention plus an evidence-based psychotherapy (CETA) in reducing alcohol misuse and…
- Conditions
- Alcohol Use Disorder, Depression, Post-traumatic Stress Disorder, HIV/AIDS
- Trial name
- ZCAP (NCT03966885)
- Testing
- Brief Intervention, Common Elements Treatment Approach (CETA)
- Where
- Zambia
- Volunteers
- 160 people
- Sponsor
- Columbia University
Alcoholism, Substance-related Disorders
Group Motivational Interviewing (GMI) For Homeless Veterans In VA Services
Homeless Veterans with substance use disorders (SUDs) are a major group served by VA and are heavily represented in VA housing. VA recently adopted a 'Housing First' approach emphasizing rapid housing placement to initiate…
- Conditions
- Alcoholism, Substance-related Disorders, Dual Diagnosis
- Trial name
- NCT02233738
- Testing
- Group Motivational Interviewing (GMI), Control Treatment Condition (CT)
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- VA Office of Research and Development
Alcohol-Related Disorders, Alcohol Drinking
Collaborative Care for Alcohol Use Disorders in the Patient-centered Medical Home
The purpose of this research study is to develop and test a care model to treat excessive drinking and alcohol use disorders in the primary care setting.
- Conditions
- Alcohol-Related Disorders, Alcohol Drinking, Alcoholism, Alcohol Abuse
- Trial name
- NCT02885311
- Testing
- Motivation Enhancement Therapy, Modified Behavioral Self-Control Therapy, Naltrexone
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Alcohol Disorders
Open Label Pilot Study of Perampanel for the Treatment of Alcohol Use Disorder
The purpose of this research study is to test the safety, tolerability, and effectiveness of the drug Perampanel when used in persons who drink and wish to stop drinking. Perampanel has been approved by the U.S.
- Trial name
- NCT04502589
- Testing
- Perampanel Tablet, Disulfiram
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Virginia Commonwealth University
HIV, Hypertension
SEARCH SAPPHIRE Phase A: A Multisectoral Strategy to Address Persistent Drivers of the HIV Epidemic in East Africa
The randomized trials in this record will assess effectiveness, fidelity and cost of prevention and treatment interventions for HIV and hypertension with the objective of informing a population-based study of multi-sectored…
- Conditions
- HIV, Hypertension, Alcohol Drinking, Maternal Child Health
- Trial name
- SAPPHIRE PhA (NCT04810650)
- Testing
- Mobility Dynamic Treatment Intervention, Health Living Intervention for Heavy Alcohol Users, Hypertension Linkage
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 2,233 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol Withdrawal, Alcohol Dependence
Oxytocin Treatment of Alcohol Dependence
This study will test in individuals who have alcohol dependence (alcohol addiction) the hypotheses 1) that intranasal oxytocin treatment will decrease withdrawal symptoms during medical detoxification and 2) that intranasal…
- Trial name
- OT-ETOH2 (NCT02275611)
- Testing
- intranasal oxytocin spray
- Volunteers
- 13 people
- Sponsor
- University of North Carolina, Chapel Hill
Alcohol Dependence, Post-Traumatic Stress Disorder (PTSD)
Zonisamide in Addition to E-CPT-C for Veterans With PTSD and Comorbid Alcohol Dependence
This is a randomized, controlled trial with 50 veterans diagnosed with post-traumatic stress disorder (PTSD) and comorbid alcohol dependence.
- Trial name
- NCT01847469
- Testing
- Enhanced-Cognitive Processing Therapy-C (E-CPT-C), Zonisamide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Yale University
Alcohol Use Disorder
An Open-Label, Single Dose Study in Patients With Alcohol Use Disorder
An open-label, Phase 2a study to evaluate the safety, tolerability, and pharmacodynamic effects of a single intranasal dose of BPL-003 combined with relapse prevention psychological support, to explore the potential effects on…
- Trial name
- NCT05674929
- Testing
- BPL-003
- Where
- 2 sites in United Kingdom
- Volunteers
- 13 people
- Sponsor
- Beckley Psytech Limited
Fetal Alcohol Spectrum Disorders
Cognitive Training and tDCS for Children With FASD
This is a randomized placebo-controlled trial of cognitive training with transcranial direct current stimulation (tDCS) for children and adolescents (ages 10 - 16 years) with prenatal alcohol exposure (PAE).
- Trial name
- NCT03361293
- Testing
- Active tDCS, Cognitive training
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Minnesota
Insomnia
The Efficacy of CBT-I in Alcoholics & Its Effects on Remission & Relapse
Insomnia is a highly prevalent disorder in those recovering from alcoholism. It has been associated with anxiety and depressive symptoms, as well as an increased risk of relapse back to the drinking.
- Trial name
- NCT01987089
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development