Clinical trials: Alcohol Disorders
Unhealthy Alcohol Use
Financial Incentives, Randomization With Stepped Treatment Trial
The investigators plan to determine the effectiveness of contingency management (CM) plus stepped care for unhealthy alcohol use in HIV-positive patients.
- Trial name
- FIRST (NCT03089320)
- Testing
- Contingency Management Counseling, Addiction Physician Management, Motivational Enhancement Therapy
- Where
- 7 sites in United States
- Volunteers
- 120 people
- Sponsor
- Yale University
Alcohol Dependence
Effectiveness of Naltrexone Versus Placebo to Reduce Craving for Alcohol With Evaluation of Genetic Variability.
The purpose of this study is to determine whether naltrexone (an opiate blocking agent approved for the treatment of alcohol dependence) is more effective in the reduction of alcohol craving and drinking compared to placebo in…
- Trial name
- NCT00366626
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Medical University of South Carolina
Alcohol Dependence, Posttraumatic Stress Disorder
Mechanisms of Change, Motivation, and Treatment Outcome in Alcohol Dependence - Posttraumatic Stress Disorder
The purpose of this study is to test if provision of an effective psychotherapy for Post-traumatic Stress Disorder (PTSD), prolonged exposure, can be tolerated in alcohol dependent patients with PTSD and if it is associated with…
- Trial name
- NCT01409707
- Testing
- Trauma-focused exposure therapy, Motivational enhancement + trauma-focused exposure therapy, Healthy lifestyles sessions
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Mississippi Medical Center
Alcoholism
Repurposing alpha1 Noradrenergic Antagonists for Alcoholism Treatment
Double-blind, placebo-controlled, cross-over design study examining the effects of a norepinephrine alpha1 receptor antagonist (prazosin) on stress reactivity in a laboratory stressor task.
- Trial name
- NCT02966340
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Breast Cancer, Psychology, Social
Effectiveness of Screening and Brief Interventions for Alcohol and Tobacco During Breast Cancer Treatment (ONKODETOX)
Despite scientific, clinical and political incentives, alcohol and/or tobacco screening and brief intervention (SBI) services are poorly implemented in oncology settings.
- Trial name
- ONKODETOX (NCT03371732)
- Testing
- Motivational Intervention group, Educational advises group
- Where
- France
- Volunteers
- 104 people
- Sponsor
- Institut Bergonié
TBI, Anxiety
Cranial Electrotherapy Stimulation (CES) Therapy
The primary aim of this proposed study is to gather preliminary data for CES use in treating PTSD and anxiety symptoms in OEF/OIF Veterans with PTSD and a history of TBI.
- Conditions
- TBI, Anxiety, PTSD, Depression
- Trial name
- CES (NCT02453347)
- Testing
- CES Therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Alcohol Use Disorder (AUD)
Study of DCR-AUD in Healthy Volunteers
DCR-AUD will be evaluated for safety, tolerability, pharmacokinetics, and pharmacodynamics in healthy volunteers.
- Trial name
- NCT05021640
- Testing
- DCR-AUD
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Alcohol Use Disorder
Harm Reduction With Pharmacotherapy (HaRP)
The goal of this study is to test the efficacy of extended-release naltrexone and harm reduction counseling in reducing alcohol-related harm among homeless people with alcohol dependence.
- Trial name
- HaRP (NCT01932801)
- Testing
- XR-NTX, HRC
- Where
- United States
- Volunteers
- 308 people
- Sponsor
- University of Washington
Alcohol Drinking, Anxiety Disorders
Retraining Attention to Treat Alcohol Dependence and Social Anxiety
The purpose of this research is to test a computerized intervention for people with co-occurring social anxiety and alcohol dependence.
- Trial name
- AMP (NCT01886716)
- Testing
- Anxiety Attention Training, Alcohol Attention Training, Control Training
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of Cincinnati
Alcohol Dependence, Posttraumatic Stress Disorder (PTSD)
A Controlled Trial of Topiramate Treatment for Alcohol Dependence in Veterans With PTSD
The goal of this project is to improve the treatment of veterans with co-occurring alcohol dependence and posttraumatic stress disorder (PTSD).
- Trial name
- TAP2 (NCT01749215)
- Testing
- Topiramate, Medical Management
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- University of California, San Francisco
Alcohol Drinking, Marijuana Smoking
Motivation and Skills for Delta-9-tetrahydrocannabinol/Ethanol (THC/ETOH+) Teens in Jail
This study will focus on treating substance abusing incarcerated teens using individually administered Motivational Interviewing (MI) followed by group Cognitive Behavior Therapy (CBT).
- Trial name
- SMART (NCT00506753)
- Testing
- MI/CBT, RT/SU
- Where
- United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Alcoholism
Managing Alcoholism in People Who Do Not Respond to Naltrexone
This is a study involving treatment for alcohol dependence (alcoholism). The study will combine motivational enhancement therapy and cognitive behavioral therapy (combined behavioral intervention, or CBI) and tests the benefits…
- Trial name
- EXTEND (NCT00115037)
- Testing
- Naltrexone, Medication Management (MM), Combined Behavioral Intervention (CBI)
- Where
- United States
- Volunteers
- 302 people
- Sponsor
- University of Pennsylvania
Acute Alcoholic Hepatitis
Novel Therapies in Moderately Severe Acute Alcoholic Hepatitis
This study is being done to find out whether a diet supplemented with a probiotic nutrient can improve alcoholic hepatitis and gut complications compared to routine standard care.
- Trial name
- NTAH-Mod (NCT01922895)
- Testing
- Lactobacillus Rhamnosus GG
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Texas Southwestern Medical Center
Alcohol Use Disorder, Post Traumatic Stress Disorder
Piloting "Signs of Safety": A Deaf-Accessible Therapy Toolkit for Alcohol Use Disorder and Trauma
The U.S. Deaf community - more than 500,000 Americans who communicate using American Sign Language (ASL) - experiences nearly triple the rate of lifetime problem drinking and twice the rate of trauma exposure as compared to the…
- Trial name
- NCT03845985
- Testing
- Seeking Safety + Signs of Safety toolkit
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Massachusetts, Worcester
Alcohol Use Disorder
Naltrexone for Individuals of East Asian Descent
This study will elucidate the pharmacogenetic effects of the Asn40Asp SNP of the OPRM1 gene on biobehavioral and neural markers of response to naltrexone in individuals of East Asian descent, an ethnic group most likely to…
- Trial name
- NCT02026011
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of California, Los Angeles
Opioid-use Disorder, Alcohol Use Disorder
Medication Development for Opioid and Alcohol Abuse
The present proposal will evaluate the ability of gabapentin maintenance to reduce the abuse liability of alcohol, oxycodone, and alcohol in combination with oxycodone in participants with both Opioid Use Disorder and Alcohol Use…
- Trial name
- NCT03205423
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- New York State Psychiatric Institute
Alcohol Use Disorder
Neural Mechanisms of Change During the Treatment of Alcohol Use Disorders With Prazosin
The study uses neurobiological measures through brain imaging, neuropsychological measures, and selfreport measures to try to understand how an effective treatment for alcoholism works.
- Trial name
- NCT01916941
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of New Mexico
Essential Tremor, Tremor
Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response
Essential Tremor (ET) is the most common tremor disorder, currently affecting an estimated 2.9 million Americans and leading to disability and decreased quality of life in 75% of cases.
- Trial name
- NCT02495883
- Testing
- Ethanol, Propranolol
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Major Depressive Disorder, Alcohol Use Disorder
STAR*D Alcohol: Treatment of Depression Concurrent With Alcohol Abuse
The purpose of this study is to determine if having an alcohol use disorder affects recovery from depression, and also whether recovery from depression in patients who have alcohol use disorders is also accompanied by improvement…
- Trial name
- NCT00369746
- Testing
- citalopram
- Where
- United States
- Volunteers
- 674 people
- Sponsor
- New York State Psychiatric Institute
Alcohol Use Disorder
Decreasing the Temporal Window in Individuals With Alcohol Use Disorder
In the absence of sufficient monetary resources, individuals must attend to immediate, minimum needs (e.g., food, shelter). This constricts one's temporal window and engenders neglect of the future.
- Trial name
- RP1B (NCT04128761)
- Testing
- Scarcity Narrative, Neutral Narrative
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Virginia Polytechnic Institute and State University