Clinical trials: Alcohol Disorders
Alcohol Intoxication
Prevalence of Chronic Inebriates to the Emergency Department and Suitability for Sobering House Services
This study is intended to evaluate the prevalence of chronically inebriated patients in the Emergeny Department (ED). Patients will be identified prospectively by screening all patients (24/7) presenting to the ED for one month.
- Trial name
- NCT01783223
- Where
- United States
- Volunteers
- 668 people
- Sponsor
- Hennepin Healthcare Research Institute
Alcohol Use Disorder
Guanfacine for Alcohol Use Disorder (AUD)
The investigators assess whether guanfacine extended release (GXR; 3mg/d) compared with placebo (PBO) will attenuate drinking and drinking-related factors in N=200 men and women with Alcohol Use Disorder (AUD) across 12-weeks.
- Trial name
- NCT06629259
- Testing
- Guanfacine Extended Release (XR)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Indiana University
Alaska Native Youth Aged 14 - 24, Suicide, Attempted
Suicide Intervention for Alaska Native Youth
Two interventions will be delivered virtually to American Indian/Alaska Native youth who have been hospitalized with suicidal attempt, suicidal ideation, or associated risk behaviors, including alcohol-related injury.
- Conditions
- Alaska Native Youth Aged 14 - 24, Suicide, Attempted, Suicidal Ideation, Alcohol Intoxication
- Trial name
- BeWeL (NCT05360888)
- Testing
- Tools for Life, Tools for Life + MISN
- Where
- 2 sites in United States
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- RAND
Substance Use Disorders, Substance Use
Harnessing Telemedicine to Improve Alcohol Use Disorder Outcomes in Primary Care Patients
The purpose of this trial is to test new programs to see if they might help people manage their health and health behaviors related to alcohol use and well-being.
- Conditions
- Substance Use Disorders, Substance Use, Substance Dependence
- Trial name
- NCT05410561
- Testing
- Enhanced Usual Care (EUC), TeleTx intervention
- Where
- 2 sites in United States
- Volunteers
- 277 people
- Sponsor
- University of Michigan
Alcohol Use Disorder
ED Initiated Oral Naltrexone for AUD
This study will recruit Emergency Department (ED) patients with moderate to severe alcohol use disorder (AUD) who are interested in initiating medication assisted treatment (MAT). The study is split into two phases.
- Trial name
- NCT04817410
- Testing
- Emergency Department Initiated Oral Naltrexone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Alcohol Abuse, Criminal Behavior
Mindfulness for Alcohol Abusing Offenders
Over half of state and federal prisoners meet clinical criteria for alcohol abuse or dependence, and after release from prison, over three-quarters of offenders are re-arrested within five years.
- Trial name
- MIT (NCT03883646)
- Testing
- Mindfulness, Relapse Prevention
- Where
- United States
- Volunteers
- 392 people
- Sponsor
- The Mind Research Network
HIV, Alcohol; Harmful Use
Using CBPR to Engage Hazardous Drinking Women in the HIV Prevention and Care Continuum
Unhealthy alcohol use among women with and at risk for HIV can interrupt critical steps in the HIV prevention and care continuum, is associated with HIV transmission risk behaviors, and contributes to health disparities.
- Conditions
- HIV, Alcohol; Harmful Use, Mental Health Disorder
- Trial name
- NCT04090723
- Testing
- CBI-CC with peer navigation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Alcohol Dependence, Alcohol Drinking
Characterization Imaging Instruments in Alcoholics and Non-Alcoholics
Background: People with alcoholism have differences in their brains compared with healthy people. People who are dependent on alcohol also perform differently on behavioral tasks.
- Conditions
- Alcohol Dependence, Alcohol Drinking, Alcohol-Related Disorders, Alcoholism
- Trial name
- NCT02108080
- Where
- United States
- Volunteers
- 389 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcoholic Cirrhosis
Alcohol Biomarker Study
Objective: To validate ethyl glucuronide in scalp hair, fingernail and urine as a biomarker for alcohol use in patients with alcoholic cirrhosis.
- Trial name
- NCT04363424
- Where
- Netherlands
- Volunteers
- 191 people
- Sponsor
- Maastricht University Medical Center
Alcohol Use Disorder
Multimodal Neuroimaging of Alcohol Cues, Cortisol Response, and Compulsive Motivation
This study proposes to examine both the peripheral and central nervous system responses when light social drinkers and binge/heavy social drinkers are exposed to visual ethanol cues, followed by oral ethanol.
- Trial name
- NCT04412824
- Testing
- Intravenous blood draw
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Auburn University
HIV, Chronic Pain
Telehealth for Pain and Unhealthy Drinking Among PLWH
This randomized controlled trial is a between-groups design to compare the Motivational and Cognitive Behavioral Management for Alcohol and Pain (MCBMAP) Intervention to a Brief Advice and Information Control condition.
- Conditions
- HIV, Chronic Pain, Unhealthy Alcohol Use
- Trial name
- NCT05503173
- Testing
- MCBMAP, Brief Advice and Information
- Where
- United States
- Volunteers
- 253 people
- Sponsor
- Boston University
Alcohol Use Disorder, Mild, Alcohol Use Disorder, Moderate
Substituting SMSs for Provider-delivered Care to Improve Alcohol Use Outcomes
The goal of this clinical trial is to test whether a technology-substituted intervention (mhGAP-Remote) derived from the World Health Organization's (WHO) Mental Health Gap Action Programme-Intervention Guide (mhGAP-IG) is…
- Trial name
- NCT05925270
- Testing
- mhGAP-Remote, mhGAP-Standard
- Where
- 3 sites in Lesotho
- Volunteers
- 255 people
- Sponsor
- University Hospital, Basel, Switzerland
Alcoholism
Naltrexone Maintenance Treatment of Alcoholism
The purpose of this study is to determine the long-term effectiveness of naltrexone treatment in alcohol-dependent patients who respond to short-term treatment.
- Trial name
- NCT00000450
- Testing
- Naltrexone Tablet
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- The Scripps Research Institute
Alcohol Dependence, Cocaine Dependence
Human Behavioral Pharmacology Laboratory (HBPL) Study of Varenicline's Impact on Cocaine and Alcohol Craving
This is a Phase II within-subjects double-blind placebo-controlled human laboratory study. The purpose of the study is to determine the efficacy of varenicline (Chantix) for reducing cue-induced cocaine and alcohol craving.
- Trial name
- NCT01151813
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pennsylvania
Bipolar Disorder, Alcohol Dependence
Quetiapine for Bipolar Disorder and Alcohol Dependence
The purpose of this study is to find out whether an investigational drug called quetiapine can treat bipolar disorder, improve mood and reduce alcohol use and craving.
- Trial name
- NCT00457197
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Texas Southwestern Medical Center
Gingivitis, Periodontitis
Efficacy of Essential Oil Mouthwash With and Without Alcohol: a 3-Day Plaque Accumulation Model
The daily removal of supragingival dental plaque is a major factor in the prevention of caries, gingivitis and periodontitis. Proper control of bacterial plaque is obtained through the mechanical removal of the biofilm by the…
- Trial name
- NCT01411618
- Testing
- free alcohol essential oil mouthwash
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of L'Aquila
Alcoholic Hepatitis
PROlonged Corticosteroid Treatment or N-ACetylcysteine for Severe Alcoholic Hepatitis
Only patients suffering from a severe form of alcoholic hepatitis (Maddrey's discriminant function greater than 32) require medical treatment.
- Trial name
- PROCORNAC (NCT06956482)
- Testing
- N-Acetylcysteine (NAC) Treatment, Prednisolone, Prednisolone 10mg
- Where
- France
- Volunteers
- 477 people
- Sponsor
- University Hospital, Lille
Alcohol Use Disorder
Sex Differences in the Response to Abstinence From Alcohol.
In laboratory animals, repeated cycles of abstinence from and return to alcohol drinking can lead to changes in alcohol intake. In a study of the effect of abstinence on drinking in humans, the investigators found evidence that…
- Trial name
- SPAR (NCT03827460)
- Testing
- Abstinence from alcohol, Usual drinking, Intravenous Alcohol
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Indiana University
Overactive Bladder, Urinary Urgency
Fluids Affecting Bladder Urgency and Lower Urinary Symptoms
This study evaluates whether eliminating certain ingredients (caffeine, alcohol, artificial sweeteners, acidic juices) consumed in beverages reduces bladder symptoms of urinary frequency and urgency.
- Conditions
- Overactive Bladder, Urinary Urgency, Urinary Bladder, Overactive, Urinary Incontinence, Urge
- Trial name
- FABULUS (NCT03625492)
- Testing
- Reducing Potentially Irritating Beverages, Adopting the USDA Healthy Eating Habits
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Michigan
Alcohol Dependence
Duloxetine Versus Pregabalin for Alcohol Dependence
A 12-week, double-blind, placebo-controlled parallel group study will be conducted with 150 outpatients with alcohol dependence, with random assignment to pregabalin 300 mg/d, duloxetine 40 mg/d, or placebo in conjunction with…
- Trial name
- NCT00929344
- Testing
- Pregabalin, Duloxetine, Standardized behavioral therapy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The Scripps Research Institute
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