Clinical trials: Alcohol Disorders
Alcohol Use Disorder (AUD)
Study of DCR-AUD in Healthy Volunteers
DCR-AUD will be evaluated for safety, tolerability, pharmacokinetics, and pharmacodynamics in healthy volunteers.
- Trial name
- NCT05021640
- Testing
- DCR-AUD
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Alcohol Use Disorder, Bipolar Disorder
Imaging GABAergic/Glutamatergic Drugs in Bipolar Alcoholics Alcoholics
The proposed 3-week, double-blind, crossover, proof of concept study aims to manipulate neurochemical dysfunctions characteristic of individuals with co-occurring BD and AUD (i.e., abnormally low prefrontal GABA and glutamate)…
- Trial name
- NCT03220776
- Testing
- N-Acetylcysteine, Gabapentin
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Medical University of South Carolina
Alcohol Drinking, Alcohol Problem Drinking
Parent Feedback Intervention Targeting Student Transitions and Alcohol Related Trajectories (+) Efficacy Study
FITSTART (Feedback Intervention Targeting Student Transitions and Risk Trajectories) is a parent-based social norms intervention that has been shown to reduce risky drinking in incoming first year students.This program uses…
- Conditions
- Alcohol Drinking, Alcohol Problem Drinking, Parenting
- Trial name
- FITSTART+ (NCT04549454)
- Testing
- FITSTART+ PBI, General Parenting Advice
- Where
- United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Loyola Marymount University
HIV Infections, Alcoholism
Brief Therapy Intervention for Heavy/Hazardous Drinking in HIV-Positive Women
The purpose of this study is to determine whether two brief counseling sessions reduce drinking and improve health outcomes in HIV-positive women who drink at heavy/hazardous levels.
- Trial name
- NCT00127231
- Testing
- Brief alcohol intervention based on Project Treat, Standard care
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Johns Hopkins University
Acute on Chronic Hepatic Failure, Acute Liver Failure
Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF
The study will evaluate the pharmacokinetics, pharmacodynamics, safety and preliminary efficacy of IDN-6556 in subjects with cirrhosis of the liver who are hospitalized for more than 24 hours due to acute deterioration of liver…
- Conditions
- Acute on Chronic Hepatic Failure, Acute Liver Failure, Liver Cirrhosis, Acute Alcoholic Hepatitis
- Trial name
- NCT01937130
- Testing
- IDN-6556
- Where
- 26 sites in United States, United Kingdom
- Volunteers
- 23 people
- Sponsor
- Conatus Pharmaceuticals Inc.
Alcohol Use Disorder
Effects of Pioglitazone on Stress Reactivity and Alcohol Craving
The purpose of this study is to examine the effects of pioglitazone on stress-induced relapse risk in a laboratory model and to examine the effects of pioglitazone on drinking, stress/anxiety, and alcohol craving in the natural…
- Trial name
- NCT05107765
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- The University of Texas Health Science Center, Houston
Alcohol Dependence, PTSD
Neuromodulation of Trauma Memories in PTSD & Alcohol Dependence
The purpose of this study is to examine the effect of propranolol versus placebo on craving, distress and cue reactivity to trauma and alcohol cues.
- Trial name
- NCT01055171
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Alcoholism
Efficacy and Safety of High Dose Baclofen for Alcohol Dependence
The proposed study will carefully test the hypothesis that a robust dose of baclofen (90 mg/day) has efficacy and is safe in individuals with alcohol dependence.
- Trial name
- NCT01980706
- Testing
- Baclofen
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of North Carolina, Chapel Hill
Drug Addiction, Executive Dysfunction
Bilateral Prefrontal Modulation in Alcoholism
In this study, eligible alcoholic inpatients recruited from a specialized clinic for addiction treatment, filling inclusion criteria and not showing any exclusion criteria, were randomized to receive the repetitive (10 sessions…
- Trial name
- tDCS_ALCOHOL (NCT02091284)
- Testing
- transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Federal University of Espirito Santo
Alcoholic Hepatitis
IL-1 Signal Inhibition in Alcoholic Hepatitis
Alcoholic hepatitis (AH) is a florid presentation of alcoholic liver disease characterized by liver failure in the context of recent and heavy alcohol consumption.
- Trial name
- ISAIAH (NCT03775109)
- Testing
- Canakinumab 150mg/ml solution for injection
- Where
- 16 sites in United Kingdom
- Volunteers
- 55 people
- Sponsor
- Imperial College London
Alcohol Drinking
Naltrexone and Memantine Effects on Alcohol Drinking Behaviors
The purpose of this study is to evaluate the combined effects of the study medications naltrexone and memantine on alcohol drinking behaviors.
- Trial name
- NCT01519063
- Testing
- Naltrexone and memantine first
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Yale University
Alcohol Dependence
Efficacy of Nalmefene in Patients With Alcohol Dependence
The purpose of the study is to evaluate the efficacy, safety and tolerability of nalmefene in the treatment of alcohol dependence.
- Trial name
- ESENSE2 (NCT00812461)
- Testing
- Nalmefene
- Where
- 57 sites in Belgium, Czechia and 5 more
- Volunteers
- 678 people
- Sponsor
- H. Lundbeck A/S
Aggression, Substance-Related Disorders
Preventing Violence Among Veterans in Substance Use Disorder Treatment
The purpose of this study is to examine the impact on both clinical (violence and substance use) outcomes and health services use (substance use disorder and mental health treatment) compared to standard SUD treatment (enhanced…
- Trial name
- NCT01337973
- Testing
- MI-CBT, MI-CBT+CC, E-TAU
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- VA Office of Research and Development
Acute Pancreatitis (AP), Gallstone Pancreatitis
Pentoxifylline Treatment in Acute Pancreatitis (AP)
The purpose of this study was to determine the effects (good and bad) of giving a drug called pentoxifylline to patients with acute pancreatitis.
- Conditions
- Acute Pancreatitis (AP), Gallstone Pancreatitis, Alcoholic Pancreatitis, Trauma Acute Pancreatitis
- Trial name
- AP (NCT02487225)
- Testing
- Pentoxifylline
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Mayo Clinic
Drug Use Disorders, Illicit Drug Use
Digital Treatments for Opioids and Other Substance Use Disorders in Primary Care
The DIGITS Trial addresses a critical knowledge gap: How to best implement digital treatments for opioids and other substance use disorders in primary care.
- Conditions
- Drug Use Disorders, Illicit Drug Use, Alcohol-Related Disorders, Opioid Use Disorder
- Trial name
- DIGITS (NCT05160233)
- Testing
- Standard implementation, Health Coaching, Practice Facilitation
- Where
- United States
- Volunteers
- 18,430 people
- Sponsor
- Kaiser Permanente
Cocaine Use Disorder, Alcohol Use Disorder
PPARγ Agonist Treatment for Cocaine Dependence
The purpose of this research study is to determine whether a medication called pioglitazone (trade name Actos) can reduce behavioral problems associated with cocaine use, improve brain structural changes associated with cocaine…
- Trial name
- NCT02774343
- Testing
- Pioglitazone, Therapy, Contingency Management
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center, Houston
Sexually Transmitted Infection (STI) Prevention, Unintended Pregnancy Prevention
Preventing Health Damaging Behaviors in Male and Female Army Recruits
Health damaging (risk) behaviors of young military personnel are reflections of health problems facing all young people in the U.S.
- Conditions
- Sexually Transmitted Infection (STI) Prevention, Unintended Pregnancy Prevention, Sexual Risk Reduction, Alcohol and Other Substance Use Prevention
- Trial name
- NCT01234103
- Testing
- Preventing Helath Damaging Health Behaviors in Male and Female Army Recruits
- Where
- United States
- Volunteers
- 933 people, healthy volunteers welcome
- Sponsor
- United States Department of Defense
Alcohol Abuse
CARES: A Mobile Health Program for Alcohol Risk Reduction
In this fast-track STTR, Phase 1 will develop and test a mobile phone app among 40 adult community college students. The app is designed to reduce risky drinking behaviors and improve user safety.
- Trial name
- NCT03927482
- Testing
- CARES mobile smart phone app, Check Your Drinking
- Where
- United States
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Alcohol Use Disorder, Couples
Oxytocin to Enhance Alcohol Behavioral Couple Therapy (ABCT)
Alcohol Behavioral Couples Therapy (ABCT) is a manualized 12-session, weekly psychosocial intervention that simultaneously reduces alcohol use disorder (AUD) severity and improves relationship functioning.
- Trial name
- NCT03846505
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Medical University of South Carolina
Opioid Use Disorder, Alcohol Use Disorder
Comparing Treatments for HIV-Infected Opioid and Alcohol Users in an Integrated Care Effectiveness Study
The purpose of this study is to learn how best to treat substance use disorders in an HIV clinic setting. Specifically, the purpose of this pilot study is to learn if extended-release naltrexone (XR-NTX) would be a feasible and…
- Trial name
- CHOICES (NCT01908062)
- Testing
- Extended Release Naltrexone, Treatment As usual
- Where
- 2 sites in United States, Canada
- Volunteers
- 51 people
- Sponsor
- Oregon Health and Science University