Clinical trials: Alcohol Disorders
Alcoholism, Alcohol Abuse
Study of the Effectiveness of Quetiapine for the Treatment of Alcohol Dependency
The purpose of this study is to determine whether quetiapine fumarate extended release is effective in the treatment of alcohol dependence in very heavy drinkers.
- Trial name
- NCT00498628
- Testing
- Quetiapine fumarate
- Where
- 7 sites in United States
- Volunteers
- 224 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Human Immunodeficiency Virus, Alcohol-Related Disorders
Effectiveness & Implementation of a Behavioral Intervention for Adherence and Substance Use in HIV Care in South Africa
The purpose of this study is to test the effectiveness and implementation of a brief, integrated behavioral intervention for HIV medication adherence and substance use in the HIV care setting in South Africa.
- Conditions
- Human Immunodeficiency Virus, Alcohol-Related Disorders, Drug Use
- Trial name
- NCT03529409
- Testing
- Project Khanya
- Where
- 2 sites in United States, South Africa
- Volunteers
- 66 people
- Sponsor
- University of Maryland, College Park
Alcohol Reactivity
Effect of Varenicline on Fixed-Dose Alcohol Administration in Participants With Alcohol Use Disorders
The purpose of this study is the examine the effect of varenicline on cognition to a high dose (0.08 g/dL) of alcohol (vs. placebo alcohol) over the ascending and descending limb of the blood alcohol curve.
- Trial name
- NCT01000987
- Testing
- varenicline
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Yale University
Alcohol Abuse
Puerarin Effects on Alcohol Drinking
This research is designed to assess the impact of pretreatment with puerarin (NPI-031G), a major ingredient in the plant kudzu, on alcohol drinking.
- Trial name
- PAD (NCT00854724)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Alcohol or Other Drugs Use
HealthCall-S: A Pilot Study Targeting Concurrent Non-injection Drug Use and Alcohol in HIV Primary Care Clinics
This pilot study goal is to compare two different treatments to help HIV positive patients reduce their concurrent drinking and non-injection drug use.
- Trial name
- NCT02294318
- Testing
- HealthCall+Motivational Interviewing, Motivational Interviewing
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Alcohol Dependence
Prazosin to Reduce Stress-Induced Alcohol/Drug Craving and Relapse
To test the preliminary efficacy of 16.0 mg of Prazosin daily versus placebo in treatment seeking alcohol dependent individuals.
- Trial name
- NCT00585780
- Testing
- Prazosin Tablet
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Alcohol Use Disorder (AUD)
Brain Network Modulation and Alcohol Use
The investigators will use real-time fMRI neurofeedback to enhance participants' ability to control their ability to modulate alcohol valuation.
- Trial name
- RP2B (NCT04828577)
- Testing
- Real Time Neurofeedback
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Alcoholism, Sleep Initiation and Maintenance Disorders
The Effects of Quetiapine (Seroquel XR) on Sleep During Alcohol Abstinence
The primary purpose of this study is to determine how efficacy of quetiapine (seroquel XR) in improving the sleep in recovering alcohol dependent subjects.
- Trial name
- NCT00434876
- Testing
- Quetiapine XR
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Subhajit Chakravorty
Alcohol Dependence, Depression
Mecamylamine for the Treatment of Patients With Depression and Alcohol Dependence
The objective of this study is to evaluate the efficacy of mecamylamine (MEC, 10 mg/day) versus placebo in reducing depressive and alcohol symptoms in patients with depression and co-morbid alcohol dependence.
- Trial name
- NCT00563797
- Testing
- Mecamylamine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Alcoholism
Trial Investigating the Efficacy and Safety of SCH 900435 (Org 25935) in Relapse Prevention in Participants With Alcohol Dependence (P05718)
The purpose of this study is to assess the effects of SCH 900435 (Org 25935, MK-8435) on heavy drinking, safety and tolerability of SCH 900435 in participants with alcohol dependence.
- Trial name
- OD-H (NCT00764660)
- Testing
- SCH 900435
- Volunteers
- 141 people
- Sponsor
- Merck Sharp & Dohme LLC
Healthy
Alcohol Metabolism and Disease Risk in Asians
The primary pathway of alcohol metabolism involves two main enzymes, alcohol and aldehyde dehydrogenase. Several genes that encode these enzymes have variants that alter the rate of alcohol metabolism and increase levels of…
- Trial name
- R21AA28365 (NCT04967599)
- Testing
- Phenotype Feedback Intervention, Genotype Feedback Intervention
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Alcohol Drinking, Alcohol Intoxication
Family Based Prevention of Alcohol and Risky Sex for Older Teens
An online, interactive web-based program for older teens and their parents is designed to address teen alcohol use and teen relationships.
- Conditions
- Alcohol Drinking, Alcohol Intoxication, Alcohol Poison, Alcohol-Related Disorders
- Trial name
- NCT03521115
- Testing
- Smart Choices 4 Teens
- Where
- United States
- Volunteers
- 411 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation
Schizophrenia, Alcohol Use Disorder
A Study of ALKS 3831 in Subjects With Schizophrenia and Alcohol Use Disorder
This double-blind, randomized study will evaluate the efficacy, safety and tolerability of ALKS 3831 in subjects with schizophrenia and alcohol use disorder (AUD).
- Trial name
- NCT02161718
- Testing
- Samidorphan + olanzapine (ALKS 3831)
- Where
- 71 sites in United States, Bulgaria and 1 more
- Volunteers
- 300 people
- Sponsor
- Alkermes, Inc.
HIV, Alcoholism
Will Having Alcohol Treatment Improve Functioning?
The purpose of the study is to find out if a medication,naltrexone is helpful for HIV-infected women who sometimes drink too much.
- Trial name
- WHAT-IF (NCT01245647)
- Testing
- Naltrexone, 50mg, once per day for 4 months, Sugar pill, 50mg, once per day for 4 months
- Where
- 3 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Florida
Alcohol Dependence
Efficacy of Nalmefene in Patients With Alcohol Dependence
The purpose of the study is to evaluate the efficacy, safety and tolerability of nalmefene in the treatment of alcohol dependence.
- Trial name
- ESENSE1 (NCT00811720)
- Testing
- Nalmefene
- Where
- 39 sites in Austria, Finland and 2 more
- Volunteers
- 598 people
- Sponsor
- H. Lundbeck A/S
Alcohol Use Disorder, Nicotine Use Disorder
Neurobiology of Alcohol and Nicotine Co-Addiction
This proposal addresses the critical absence of information about the neurobiology of recovery from Alcohol Use Disorder (AUD) in alcohol and nicotine users.
- Trial name
- NAUD (NCT03338933)
- Testing
- magnetic resonance imaging (MRI)
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
PTSD, Alcohol Use Disorder
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD
The primary study objective is to determine the efficacy of pregabalin administered orally for a period of 12 weeks in reducing risky drinking and symptoms of posttraumatic stress disorder who have selected genotypes at the…
- Trial name
- NCT02884908
- Testing
- Pregabalin plus BBCET
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Maryland, Baltimore
Alcohol Abuse, Tobacco Use Disorder
Screening to Augment Referral to Treatment- Project START
The investigators propose to use obstetric-gynecological clinics to conduct a randomized clinical trial that would compare two SBIRTS (Screening, Brief Intervention, Referral and Treatment), delivered either by a trained nurse or…
- Conditions
- Alcohol Abuse, Tobacco Use Disorder, Marijuana Abuse, Substance-Related Disorders
- Trial name
- ProjectSTART (NCT01539525)
- Testing
- Motivational Interview, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 439 people
- Sponsor
- Yale University
Fetal Alcohol Spectrum Disorders
Feasibility Study of the My Health Coach App for Adults With FASD
The purpose of this study is to test a new smartphone "app" for adults with fetal alcohol spectrum disorder (FASD). The app is called My Health Coach.
- Trial name
- NCT05604014
- Testing
- My Health Coach
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- University of Rochester
Alcohol Dependence, Cocaine Dependence
Human Behavioral Pharmacology Laboratory (HBPL) Study of Varenicline's Impact on Cocaine and Alcohol Craving
This is a Phase II within-subjects double-blind placebo-controlled human laboratory study. The purpose of the study is to determine the efficacy of varenicline (Chantix) for reducing cue-induced cocaine and alcohol craving.
- Trial name
- NCT01151813
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pennsylvania