Clinical trials: Alcohol Disorders
Alcohol Dependence
A Single-center, Open-label, Single-dose Study Investigating the Safety, Tolerability, and Pharmacokinetic Properties of Nalmefene 10 mg Tablets in Healthy Japanese Male Subjects
The safety, tolerability, and pharmacokinetics of nalmefene at a single oral dose of 10 mg in healthy Japanese male subjects will be evaluated.
- Trial name
- NCT02679469
- Testing
- nalmefene hydrochloride 10 mg
- Where
- Japan
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Psychosis, Substance Use
Community Reinforcement and Family Training for Early Psychosis (CRAFT-EP) and Substance Use: A Pilot Study
The purpose of this study is to evaluate Community Reinforcement and Family Training for Early Psychosis (CRAFT-EP) for families experiencing early psychosis and substance use delivered exclusively or primarily via telehealth…
- Conditions
- Psychosis, Substance Use, Substance Use Disorders, Family
- Trial name
- NCT05380583
- Testing
- CRAFT-EP, TAU
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Alcoholism, Alcohol Withdrawal
Preventing Alcohol Withdrawal With Oral Baclofen
The purpose of this study is determine if the medication baclofen can prevent the symptoms of Alcohol Withdrawal Syndrome (AWS) in hospitalized patients who may be at risk for AWS.
- Trial name
- BACLOFEN III (NCT01937364)
- Testing
- Baclofen
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Essentia Health
Alcohol Use Disorder
Deep Brain Stimulation for Alcohol Use Disorder
The purpose of this clinical study is to investigate the safety, tolerability, and feasibility of Deep Brain Stimulation (DBS) of the limbic pallidum in participants with severe alcohol use disorder (AUD) who have advanced but…
- Trial name
- NCT05522751
- Testing
- DBS
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Khaled Moussawi
Insomnia, Alcohol Use, Unspecified
Research Evaluating Sleep & Trends for Universal Prevention
This study is designed to develop an integrated intervention to reduce alcohol and marijuana use and consequences and improve sleep among young adults with comorbid heavy episodic drinking, marijuana use, and sleep impairment.
- Conditions
- Insomnia, Alcohol Use, Unspecified, Marijuana Use
- Trial name
- REST-UP (NCT04783519)
- Testing
- Brief Behavioral Therapy for Insomnia (BBTI), Brief Alcohol Screening and Intervention for College Students (BASICS)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Washington
Alcohol-Related Disorders, Alcohol Dependence
Acamprosate to Reduce Symptoms of Alcohol Withdrawal
This study will examine whether a new drug called acamprosate can be helpful for alcohol withdrawal, a result of drinking high amounts of alcohol for long periods of time.
- Conditions
- Alcohol-Related Disorders, Alcohol Dependence, Alcoholism, Healthy Volunteer
- Trial name
- NCT00106106
- Testing
- NMR-spectroscopy, Oral acamprosate
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Alcohol Use Disorder
Pilot Human Lab Study of Lacosamide in Alcohol Use Disorder (AUD)
The overall goal of the proposed project is to improve the treatment of individuals with AUD. The investigators will conduct the first pilot human laboratory study to assess the effects of two doses of lacosamide on alcohol…
- Trial name
- ACGT (NCT03897348)
- Testing
- Lacosamide 100 mg, Lacosamide 200 mg
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Substance Use Disorders
Community Wise: An Innovative Multi-level Intervention to Reduce Alcohol and Illegal Drug Use
The current project seeks to implement the Multiphase Optimization Strategy (MOST) and Community Based Participatory Research (CBPR) principles to identify the most efficient, scalable, and sustainable combination of Community…
- Trial name
- NCT02951455
- Testing
- Critical Dialogue, Capacity Building Project, Quality of Life Wheel
- Where
- United States
- Volunteers
- 602 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Alcohol Use Disorder
The Effects of Exenatide, a GLP-1 Agonist, on Alcohol Self-Administration in Heavy Drinkers
A double-blind, randomized, placebo-controlled, crossover design trial was used to test the effect of exenatide on alcohol self-administration and craving following a priming dose of alcohol.
- Trial name
- NCT03645408
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Alcohol Use Disorder
Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate)
This study will evaluate the behavioral effects of alcohol during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.
- Trial name
- BED[IN]:36 (NCT03575403)
- Testing
- Alcohol, Duloxetine (60 MG), Methylphenidate
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Craig Rush
Alcohol Use Disorder, Couples
Oxytocin to Enhance Alcohol Behavioral Couple Therapy (ABCT)
Alcohol Behavioral Couples Therapy (ABCT) is a manualized 12-session, weekly psychosocial intervention that simultaneously reduces alcohol use disorder (AUD) severity and improves relationship functioning.
- Trial name
- NCT03846505
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Medical University of South Carolina
Thiamine Deficiency, Thiamine Deficiency; Sequelae
Prevalence of Thiamine Deficiency in Hospitalized Non-Alcoholic Veterans
Thiamine micronutrient deficiency (TD) can cause a variety of non-specific symptoms and leads to several thiamine deficiency disorders such as heart failure, polyneuropathy, Wernicke's Encephalopathy and generalized weakness and…
- Trial name
- NCT05480943
- Testing
- Thiamine repletion
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- VA Office of Research and Development
Bipolar Disorder, Alcohol Drinking
Acute Alcohol Response In Bipolar Disorder: a fMRI Study
Alcohol use disorders (AUDs) affect up to 60% of individuals with bipolar disorder during their lifetime-a rate 3 to 5 times higher than what occurs in the general population.
- Conditions
- Bipolar Disorder, Alcohol Drinking, Alcohol Use Disorder
- Trial name
- BACS (NCT04063384)
- Testing
- alcohol beverage
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Alcohol Use Disorder, Nicotine Use Disorder
Neurobiology of Alcohol and Nicotine Co-Addiction
This proposal addresses the critical absence of information about the neurobiology of recovery from Alcohol Use Disorder (AUD) in alcohol and nicotine users.
- Trial name
- NAUD (NCT03338933)
- Testing
- magnetic resonance imaging (MRI)
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder (AUD)
Study of DCR-AUD in Healthy Volunteers
DCR-AUD will be evaluated for safety, tolerability, pharmacokinetics, and pharmacodynamics in healthy volunteers.
- Trial name
- NCT05021640
- Testing
- DCR-AUD
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Hepatorenal Syndrome
A Placebo-Controlled, Double-Blind Study to Confirm the Reversal of Hepatorenal Syndrome Type 1 With Terlipressin
This study is designed to evaluate the efficacy and safety of intravenous terlipressin versus placebo for the treatment of type 1 hepatorenal syndrome (HRS) in participants receiving standard of care albumin therapy.
- Trial name
- NCT01143246
- Testing
- Terlipressin
- Where
- 73 sites in United States, Canada
- Volunteers
- 196 people
- Sponsor
- Mallinckrodt
Alcohol Use Disorder, Bipolar Disorder
Clinical Medication Development for Bipolar Disorder and Alcohol Use Disorders
Preclinical and clinical data as well as mechanistic justification have been presented suggesting citicoline and pregnenolone are each promising treatments for alcohol use in BPD.
- Conditions
- Alcohol Use Disorder, Bipolar Disorder, Schizoaffective Disorder Bipolar Type
- Trial name
- NCT02582905
- Testing
- Citicoline, Pregnenolone
- Where
- 3 sites in United States
- Volunteers
- 96 people
- Sponsor
- Sherwood Brown, MD, PhD
Alcohol Use Disorder
Cannabidiol in Youth Alcohol Use Disorder
The goal of this study is to test cannabidiol (CBD) as a potentially effective candidate medication for youth alcohol use disorder (AUD).
- Trial name
- NCT05317546
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Aggression, Substance-Related Disorders
Preventing Violence Among Veterans in Substance Use Disorder Treatment
The purpose of this study is to examine the impact on both clinical (violence and substance use) outcomes and health services use (substance use disorder and mental health treatment) compared to standard SUD treatment (enhanced…
- Trial name
- NCT01337973
- Testing
- MI-CBT, MI-CBT+CC, E-TAU
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- VA Office of Research and Development
Hepatitis, Alcoholic
Pentoxifylline for Acute Alcoholic Hepatitis (AAH)
The goal of this study is to demonstrate the effectiveness of pentoxifylline compared to placebo in AAH while studying putative mechanisms that are plausible and testable.
- Trial name
- NCT00205049
- Testing
- pentoxifylline
- Volunteers
- 4 people
- Sponsor
- University of Wisconsin, Madison