Clinical trials: Alcohol Disorders
Adolescent Substance Use
Guiding Good Choices for Health
This study evaluates the feasibility and effectiveness of implementing Guiding Good Choices (GGC), an anticipatory guidance curriculum for parents of early adolescents, in three large, integrated healthcare systems.
- Trial name
- GGC4H (NCT04040153)
- Testing
- Guiding Good Choices
- Where
- 3 sites in United States
- Volunteers
- 3,636 people, healthy volunteers welcome
- Sponsor
- University of Washington
Alcohol Use, Marijuana Use
Development and Testing of a Smartphone Application to Reduce Substance Use and Sexual Risk Among Homeless Young Adults
A pilot trial (N=60) will be conducted to test the feasibility and preliminary effectiveness of OnTrack (a smartphone application to self-monitor substance use and sexual behaviors among homeless young adults) plus a brief…
- Conditions
- Alcohol Use, Marijuana Use, Sexual Behavior
- Trial name
- NCT02530645
- Testing
- OnTrack, Treatment as Usual, Brief Motivational Interviewing
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- New York State Psychiatric Institute
Alcohol Abuse, Substance Abuse
Project BrEAtHe: A Culturally Tailored MBSR Intervention for Young Adult Black Men
The purpose of this study is to create a program focused on mindfulness and stress reduction specifically tailored to young adult Black males.
- Conditions
- Alcohol Abuse, Substance Abuse, Post Traumatic Stress Disorder
- Trial name
- BrEAtHe (NCT07009977)
- Testing
- self-guided mHealth app only, self-guided mHealth app + 'real-time' feedback
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- UConn Health
Alcohol Dependence
Endophenotyping With Functional Magnetic Resonance Imaging (fMRI)
The mesolimbic dopaminergic reward system is a key structure underlying addictive behaviour in alcohol addiction and is under control of prefrontal glutamatergic neurotransmission.
- Trial name
- NGFN PLUS TP13 (NCT01503931)
- Where
- Germany
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Hepatitis, Alcoholic
Efficacy and Safety of S-adenosyl-l-methionine in Treatment of Alcoholic Hepatitis With Cholestasis
To determine the efficacy and safety S-adenosyl-l-methionine in alcoholic hepatitis with cholestasis.
- Trial name
- NCT02024295
- Testing
- Ademethionine, Polyene Phosphatidyl choline
- Where
- 2 sites in China
- Volunteers
- 118 people
- Sponsor
- Zhejiang Hisun Pharmaceutical Co. Ltd.
Depression, Anxiety
The EARN-Health Trial of Financial Savings and Health
The current literature in social epidemiology and public health suggests that low financial savings has an unsurprising negative relationship with subjective well-being, and increases the odds of making visits to a healthcare…
- Conditions
- Depression, Anxiety, Alcohol Abuse, Tobacco Abuse
- Trial name
- EARN-Health (NCT02185612)
- Testing
- Savings program
- Where
- United States
- Volunteers
- 678 people, healthy volunteers welcome
- Sponsor
- Stanford University
Alcohol Abuse or Dependence
Guided Self-Change Prevention Program for Alcohol Abuse in Adolescents in Educational Settings
This study corresponds to a pretest-posttest randomized experimental design with two arms. Arm 1 includes Guided Self-Change program, and Arm 2 a psychoeducational program to promote healthy habits.
- Trial name
- PREVENALC (NCT05281172)
- Testing
- Guided Self-Change therapy (GSC), Psychoeducation program about healthy habits
- Where
- Spain
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Alcohol Use Disorder, Anxiety Disorder/Anxiety State
Stress Reactivity as a Determinant in Co-occurring Alcohol Use and Anxiety Disorder: Diagnosis and Alcohol Use Outcomes
Alcohol dependence is among the most common and costly public health problems affecting the nation. Among individuals with alcohol use disorder (AUD), those with (vs.
- Conditions
- Alcohol Use Disorder, Anxiety Disorder/Anxiety State, Stress Disorder, Hypothalamic Pituitary Adrenal
- Trial name
- NCT03056872
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Adolescent Drinking, Adolescent Problem Behavior
Mindfulness Mobile App to Reduce Adolescent Substance Use
Substance-abusing youth - especially those who are involved in the juvenile justice system - are at higher risk than nonusers for mental health problems, including depression, conduct problems, personality disorders, suicidal…
- Trial name
- Qlarity (NCT04027075)
- Testing
- Qlarity app users
- Where
- United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Depression - Major Depressive Disorder, Schizophenia Disorder
A Novel Blood Test as a Biomarker in Mental Health
This longitudinal, observational study aims to assess whether the characteristics of a novel blood peripheral biomarker can serve as indicators for depression and schizophrenia in patients at the Royal Columbian Hospital…
- Conditions
- Depression - Major Depressive Disorder, Schizophenia Disorder, Psychosis, Mania (Neurotic)
- Trial name
- LEADING-MH (NCT06856161)
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Fraser Health
Alcoholic Hepatitis
Alcoholic Hepatitis Network Observational Study
The purpose of this research study is to create a clinical database and bio-repository. To do this, we will obtain blood, urine, saliva, and stool samples (e.g., biological samples) and personal health information from you to use…
- Trial name
- NCT03850899
- Where
- 9 sites in United States
- Volunteers
- 1,133 people, healthy volunteers welcome
- Sponsor
- Indiana University
Alcohol Dependence, Depression
Mecamylamine for the Treatment of Patients With Depression and Alcohol Dependence
The objective of this study is to evaluate the efficacy of mecamylamine (MEC, 10 mg/day) versus placebo in reducing depressive and alcohol symptoms in patients with depression and co-morbid alcohol dependence.
- Trial name
- NCT00563797
- Testing
- Mecamylamine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
PTSD - Post Traumatic Stress Disorder, PTSD and Alcohol Use Disorder
Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisons
Addiction and trauma exposure are common among the 5.5 million people (1 in 47 adults) in the U.S. who are in prison or under supervision.
- Conditions
- PTSD - Post Traumatic Stress Disorder, PTSD and Alcohol Use Disorder, PTSD and Trauma-related Symptoms, Substance Use Disorder (SUD)
- Trial name
- STRIDES2 (NCT06923423)
- Testing
- Group Cognitive Processing Therapy (CPT), Control Group Individual trauma focused self-help via workbook
- Where
- 6 sites in United States
- Volunteers
- 640 people
- Sponsor
- University of Arkansas
Disease, Mental Disorders, Severe
Multifamily Group Psychoeducation for SUD's in Turkey
The aim of this study is to investigate the effects of multi-family group psychoeducation (MFGP) on the families of people living with a diagnosis of substance abuse disorder on patients and their families.
- Conditions
- Disease, Mental Disorders, Severe, Substance-Related Disorders, Substance Use Disorders
- Trial name
- NCT05564559
- Testing
- multifamily group psychoeducation
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Ege University
Alcoholic Hepatitis
Treatment of Alcohol-Related Hepatitis With Arginine
The purpose of this study is to test the effectiveness of the amino acid arginine in reducing liver injury in individuals with alcohol-related hepatitis.
- Trial name
- NCT00200746
- Testing
- Arginine
- Where
- United States
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Alcohol Use Disorder, Borderline Personality Disorder
Nalmefene in Alcohol Dependence and Borderline Personality Disorder
The objective is to study the effectiveness of Nalmefene in decreasing alcohol intake in subjects with alcohol use disorder and comorbid BPD.
- Trial name
- NCT02752503
- Testing
- Nalmefene
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Alcoholic Liver Cirrhosis, Ascites
Prevention of Decompensation in Liver Cirrhosis
The purpose of this study is to determine whether losartan, an angiotensin II blocker prevents the sodium retention in patients with liver cirrhosis and by that reduces the fluid retention.
- Trial name
- NCT00239096
- Testing
- losartan (drug)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Alcohol Abuse
Mentored Research on Improving Alcohol Brief Interventions in Medical Settings
The NIAAA estimates that 16% (40 million) of adults in the US are drinking at unsafe levels. More than 50% of alcohol health consequences occur in risky, non-dependent drinkers.
- Trial name
- NCT02978027
- Testing
- Brief Advice, NIAAA Clinician's Guide, Motivational Interviewing (MI)
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Alcohol Use Disorder With Insomnia
CBT-I Augmentation of Medication for Drinking in AUD
Alcohol Use Disorder (AUD) and insomnia are more prevalent in Veterans than in the general community. Furthermore, insomnia is comorbid in 36-91% of individuals with AUD and jeopardizes recovery by increasing their risk for…
- Trial name
- NCT04581603
- Testing
- Cognitive Behavioral Therapy for Insomnia, Sleep Hygiene Education
- Where
- 2 sites in United States
- Volunteers
- 82 people
- Sponsor
- VA Office of Research and Development
Bipolar I Disorder, Alcohol Dependence
Efficacy and Safety of Quetiapine Fumarate (SEROQUEL®) in the Treatment of Alcohol Dependency in Patients With Bipolar Disorder
The purpose of this study is to determine whether treatment with Quetiapine Fumarate (SEROQUEL) in conjunction with mood stabilizers (Lithium or Divalproex) for 12 weeks helps patients who have Bipolar I Disorder with Alcohol…
- Trial name
- NCT00114686
- Testing
- Quetiapine fumarate, lithium, divalproex
- Where
- 38 sites in United States
- Volunteers
- 350 people
- Sponsor
- AstraZeneca
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