Clinical trials: Alcohol Disorders
Alcohol Drinking, Drug Abuse
Enhancing Housing First Programs With a Social Network Substance Use Intervention
Housing First programs are promising approaches to transitioning substance using chronically homeless adults to affordable housing.
- Conditions
- Alcohol Drinking, Drug Abuse, HIV
- Trial name
- NCT02140359
- Testing
- Motivational Network Interview
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- RAND
Prenatal Alcohol Exposure, Fetal Alcohol Spectrum Disorders
Families Moving Forward Bridges: An Early Intervention for Infants and Toddlers With PAE With or At-risk for FASD
This is an unblinded, feasibility study of an adapted positive parenting intervention to be carried out in a small sample (n=12 dyads) of young children with FASD and their primary caregiver in King County, WA.
- Trial name
- NCT06935461
- Testing
- Families Moving Forward Bridges
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Washington
Injuries, Alcohol Related Disorders
Brief Intervention to Reduce Injury in Minorities
The purpose of this study is to evaluate the effectiveness and ethnic differences of a brief alcohol intervention for injured patients.
- Trial name
- NCT00132262
- Testing
- Brief intervention based on motivational interviewing, Standard Care including referral for treatment
- Volunteers
- 1,493 people
- Sponsor
- The University of Texas Health Science Center, Houston
Alcohol Dependence
Defining the Clinical Role of Topiramate in the Treatment of Alcohol Dependence in Australia
To compare the clinical effectiveness, tolerability, and cost-effectiveness of topiramate to active control (naltrexone) on treatment outcomes for alcohol dependence in a double-blind randomised controlled trial.
- Trial name
- NCT03479086
- Testing
- Topiramate, Naltrexone
- Where
- Australia
- Volunteers
- 180 people
- Sponsor
- South West Sydney Local Health District
Alcohol Use Disorder, Alcohol Abuse
Neurocognitive and Neurobehavioral Mechanisms of Change Following Psychological Treatment for Alcohol Use Disorder
Alcohol Use Disorder (AUD) is a significant public health problem, with prevalence rates of 13.9% for current and 29.1% for lifetime diagnosis (Grant et al., 2015).
- Conditions
- Alcohol Use Disorder, Alcohol Abuse, Alcohol Drinking, Alcohol Dependence
- Trial name
- ABQTREAT (NCT03842670)
- Testing
- Cognitive Behavior Therapy, Mindfulness Based Relapse Prevention
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of New Mexico
Alcoholism
GSK1521498 Alcohol Interaction Study
The aim of the study is to assess the safety and tolerability of GSK1521498 in combination with alcohol and to determine the amount of GSK1521498 and alcohol in your blood after you have been given these together.
- Trial name
- NCT01366573
- Testing
- GSK1521498
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Alcoholic Liver Disease
Quantitative MRI for Non-invasive Assessment of Severity of Alcoholic Liver Disease (ALD)
The current goal in the treatment of Alcoholic Liver Disease (ALD) is to manage ALD-associated complications as there are no disease-specific therapies.
- Trial name
- NCT03113929
- Testing
- MRI
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Cleveland Clinic
Substance Use Disorder (SUD), Opioid Use Disorder
Disease Intervention Specialist (DIS) for SUD
This prospective observational study evaluates three Disease Intervention Specialist service models designed to proactively identify and support adults at risk for substance use disorder.
- Conditions
- Substance Use Disorder (SUD), Opioid Use Disorder, Alcohol Use Disorder (AUD), Drug Use
- Trial name
- DIS-SUD (NCT07875361)
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Ohio State University
Alcohol Dependence
A Study for the Treatment of Alcohol Dependence
The Primary objective of this study is to test whether LY2196044 can reduce the number of heavy drinking days per month in people with alcohol dependence.
- Trial name
- NCT00804570
- Testing
- LY2196044
- Where
- 17 sites in United States
- Volunteers
- 375 people
- Sponsor
- Eli Lilly and Company
Alcohol Dependency
Relapse Prevention in Alcohol Dependency by Transcranial Direct Current Stimulation Supported Cue Exposure Therapy
Relapse is a major risk in substance abuse disorders, which is closely related to craving for a substance, describing a strong urge for consumption.
- Trial name
- NCT02228486
- Testing
- tDCS, Cue Exposure Therapy
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- University Hospital Tuebingen
Alcohol Abuse
Reducing Unsafe Alcohol Use in HIV-Positive Individuals
The main aim of this study is to test an intervention to reduce unsafe drinking among HIV-positive primary care patients. The intervention consists of a brief motivational interview, which is combined with daily alcohol…
- Trial name
- NCT00371969
- Testing
- Enhanced Motivational Interview, Standard Motivational Interview or viewing DVD
- Where
- United States
- Volunteers
- 254 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Alcoholism, HIV Infection
Genetic Factors and Interrelationships for Sexual Orientation, Susceptibility to HIV and Kaposi's Sarcoma, Alcoholism and Psychological Traits, and Histocompatibility Antigens
We propose to test, by DNA linkage analysis of family pedigree members, the following interrelated hypotheses: 1) that sexual orientation is genetically influenced; 2) that the development of Kaposi's sarcoma and other outcomes…
- Conditions
- Alcoholism, HIV Infection, Homosexuality, Kaposi's Sarcoma
- Trial name
- NCT00001294
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Effect of Sublingual Formulation of Dexmedetomidine HCl (BXCL501) - Alcohol Interaction Study
The overall objective of the proposed study is to determine if Dexmedetomidine HCl (BXCL501) is safe for treatment of alcohol use disorder (AUD) with comorbid posttraumatic stress disorder (PTSD) and also shows potential signals…
- Trial name
- NCT04827056
- Testing
- Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 40µg, Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 80µg, Ethanol Infusion
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Alcohol Use Disorder, Contingency Management
CM Treatment for Alcohol Dependence Using New Technology
Contingency management (CM) is highly efficacious for reducing substance use, and recent data suggest that reinforcing attendance at treatment can significantly improve treatment outcomes.
- Trial name
- NCT02143037
- Testing
- prize contingency management for attending treatment, usual care
- Where
- 2 sites in United States
- Volunteers
- 114 people
- Sponsor
- UConn Health
Alcohol Dependence
A Study of Quetiapine and Mirtazapine for the Treatment of Alcohol Dependency
The purpose of the study is to test whether taking two medicines (quetiapine and mirtazapine) is better for helping people to decrease drinking than taking one medicine alone (quetiapine).
- Trial name
- NCT01165541
- Testing
- Mirtazapine, Quetiapine fumarate extended release (Quetiapine XR)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Endometriomas
Antimullerian Hormone in Endometriomas
The purpose of this multicenter study is to evaluate the ovarian reserve after alcohol sclerotherapy of endometriomas versus conventional surgery.
- Trial name
- NCT02669628
- Testing
- Surgical technique, Alcohol sclerotherapy
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Hospital Universitari de Bellvitge
Human Immunodeficiency Virus (HIV)
Alcohol Monitor Validation
This study will validate a wrist-worn alcohol monitor (BACtrack Skyn) in both laboratory and real-life settings.
- Trial name
- NCT03617705
- Testing
- Skyn Monitor Lab Session 1, Skyn Monitor Field Test with EMA App, Skyn Monitor Lab Session 2
- Where
- 2 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Florida
Evaluate the Association Between Certain Environmental Exposures (e.g. Cigarette Smoking, Alcohol Drinking, Betel Nut Chewing…) and Head and Neck Cancers, Assess the Effect of Genetic Factors, Including Both SNP and Copy Number Variation (CNV) Through Analysis of Both Main Effect and Gene-gene Interaction
International Cancer of the Head and Neck, Genetics and Environment (InterCHANGE) Study
Our overall objective is to understand the role of lifestyle factors, genetics and HPV infection in the development and prognosis of head and neck cancer particularly in Asia.
- Trial name
- InterCHANGE (NCT01972802)
- Where
- Taiwan
- Volunteers
- 900 people
- Sponsor
- National Taiwan University Hospital
Alcoholism
Individualized Assessment and Treatment for Alcoholism II
The object of this study is to develop a treatment for alcohol use disorders that is more effective than current CB treatments. Through a 2009 R-21 pilot project the investigators developed a cognitive-behavioral (CB) treatment…
- Trial name
- IATP2 (NCT03233802)
- Testing
- Individualized Assess & Treatment (IATP), Packaged Cognitive-Behavioral (PCBT), Case Management (CaseM)
- Where
- United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- UConn Health
Alcohol and Tobacco/Cannabis Use
FASD Prevention R33
This R33 application proposes to adapt and test an evidence-based behavioral intervention to decrease polysubstance use (i.e., alcohol and tobacco/cannabis) during pregnancy and lactation and prevent adverse clinical outcomes…
- Trial name
- R33 (NCT07828275)
- Testing
- Intervention, Usual Care
- Where
- South Africa
- Volunteers
- 184 people
- Sponsor
- Philadelphia College of Osteopathic Medicine
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