Clinical trials: Alcohol Drinking, Adult Disease
HIV/AIDS
The Outreach and Prevention at ALcohol Venues in East Africa Study (OPAL-East Africa- Aim 1)
This study will test innovative interventions to increase uptake and use of biomedical HIV prevention options by engaging women and men at drinking venues in rural Kenya and Uganda in care, while gaining insights into the…
- Trial name
- OPAL-Aim 1 (NCT05862857)
- Testing
- HIV-focused mobilization, Multi-disease-focused mobilization
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 9,375 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol Use Disorder, Treatment
Development and Testing of a Just-in-Time Adaptive Smart Phone Intervention to Reduce Drinking Among Homeless Adults
Homeless adults are 8 times as likely to be alcohol dependent compared with adults in the general population, yet few studies have examined the precipitants of alcohol use in this vulnerable population.
- Conditions
- Alcohol Use Disorder, Treatment, Homelessness
- Trial name
- Smart-T (NCT03746808)
- Testing
- EMA + App/Treatment Messages
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of North Texas Health Science Center
Alcohol Use Disorder
EMA/EMI for Psychiatrically Hospitalized Emerging Adults Who Drink to Cope
The goal of this proposed study is to evaluate an ecological momentary assessment plus an ecological momentary intervention (EMA+EMI) for emerging adults in a psychiatric partial hospitalization program who drink to cope with…
- Trial name
- NCT05074030
- Testing
- Personalized Normative Feedback, Coping-Motive Specific Personalized Feedback Intervention plus an Ecological Momentary Intervention (PFIcope+EMI)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Butler Hospital
Alcohol Drinking, Problem Drinking
Testing Brief Personalized Feedback Integrating EMA Alcohol Cue Information
This study aims to develop a brief intervention that incorporates ecological momentary assessments (EMAs; i.e., four brief surveys per day for 17 days) to create personalized feedback targeting high-risk alcohol use among young…
- Trial name
- Project ACE (NCT05373706)
- Testing
- Alcohol Cue Reactivity Personalized Feedback Intervention
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Washington
Bipolar Disorder, Alcohol Abuse
Efficacy and Tolerability of Topiramate in Treatment of Bipolar Mania and Alcohol Use in Adolescents and Young Adults
The purpose of this research study is to study the effects (both good and bad) of combining quetiapine and topiramate for treating symptoms of bipolar mania (an illness with periods of elation, excessive excitement, irritability…
- Trial name
- NCT00550394
- Testing
- Quetiapine and Topiramate
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Cincinnati
Alcohol Consumption, Alcoholic Intoxication
Naltrexone for Heavy Drinking in Young Adults
In this study, 140 heavy drinking young adults (aged 18-25) will be provided with brief counseling and either naltrexone, a medication that is FDA-approved for the treatment of alcohol dependence, or placebo over the course of 8…
- Conditions
- Alcohol Consumption, Alcoholic Intoxication, Alcoholism, Alcohol-induced Disorders
- Trial name
- NCT00568958
- Testing
- BASICS counseling, naltrexone
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Yale University
Alcohol Use Disorder
Harm Reduction With Pharmacotherapy (HaRP)
The goal of this study is to test the efficacy of extended-release naltrexone and harm reduction counseling in reducing alcohol-related harm among homeless people with alcohol dependence.
- Trial name
- HaRP (NCT01932801)
- Testing
- XR-NTX, HRC
- Where
- United States
- Volunteers
- 308 people
- Sponsor
- University of Washington
Alcohol Drinking, Alcohol Intoxication
Evaluating Perceived Fitness to Drive While Intoxicated
The goal of this study is to conduct a laboratory-based pilot randomized control trial of smartphone-enabled breath alcohol monitoring on perceived fitness to drive a vehicle among intoxicated adults.
- Conditions
- Alcohol Drinking, Alcohol Intoxication, Perception, Self, Drinking, Alcohol
- Trial name
- NCT05028413
- Testing
- Participants Shown their Breath Alcohol Content Measurement
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Binge Drinking, Alcohol Drinking in College
Balanced Lifestyle for Undergraduate Excellence - Mobile (Project BLUEM)
The purpose of this study is to evaluate a text-message delivered approach for improving college adjustment and experience and reducing risky alcohol use in young adult college students.
- Conditions
- Binge Drinking, Alcohol Drinking in College, Behavior, Drinking, Behavior and Behavior Mechanisms
- Trial name
- BLUEM (NCT04105725)
- Testing
- Brief Motivational Intervention+Substance-Free Activity Session, Alcohol + Nutrition Education Session
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Memphis
Major Depressive Disorder, Alcohol Use Disorder
Treatment of Young Adults With Comorbid AUD/MDD: A Pilot Medication Trial
Recent reports have shown that alcohol misuse is a particularly serious problem among the 18 to 25 year old age group. Previous medication trials with SSRI antidepressants among young adults with co-occurring depressive…
- Trial name
- YAAD-P (NCT02646449)
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Insomnia, Alcohol; Harmful Use
Insomnia Treatment and Problems (the iTAP Study)
This project aims to evaluate the efficacy of insomnia treatment in improving insomnia symptoms and alcohol-related problems among heavy-drinking young adults.
- Trial name
- iTAP (NCT03627832)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I), Sleep Hygiene
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Drinking, Alcohol
Multimodal Sleep Intervention Using Wearable Technology
This research study is examining three different components of a digital sleep intervention: web-based sleep health advice, sleep and alcohol smartphone diary self-monitoring, and personalized sleep and alcohol consumption…
- Trial name
- NCT03658954
- Testing
- Advice, Self-monitoring, Feedback
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yale University
Opioid Use, Alcohol Drinking
TACUNA (Traditions and Connections for Urban Native Americans)
This study responds to Request For Application-DA-19-035, HEAL (Helping End Addiction Long Term) initiative: Preventing OUD in Older Adolescents and Young Adults (ages 16-30) by developing and implementing a culturally centered…
- Conditions
- Opioid Use, Alcohol Drinking, Marijuana Use
- Trial name
- TACUNA (NCT04617938)
- Testing
- TACUNA plus Wellness Circle, Opioid Education Workshop
- Where
- 3 sites in United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- RAND
Nicotine Dependence, Alcohol Use
Pilot Study on Mindfulness for Tobacco and Alcohol in University Students
A. The study follows a randomized controlled design with approximately 60 smokers with a history of alcohol abuse age 18-29. The study will compare a 7-week mindfulness intervention to a matched 7-week education intervention to…
- Trial name
- NCT01679236
- Testing
- Mindfulness Training for Smokers, Interactive Learning for Smokers
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Wisconsin, Madison
Alcohol Use Disorder
Cannabidiol Effects on Blood Alcohol Level and Intoxication
The main objectives of this study were to test if 2 different doses of Cannabidiol (compared to placebo) alter 1) breath alcohol concentration, 2) craving and subjective responses to alcohol or 3) cognitive performance following…
- Trial name
- NCT06105138
- Testing
- 200mg Cannabidiol oral solution, 30mg Cannabidiol oral solution
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Insomnia, Alcohol Use, Unspecified
Research Evaluating Sleep & Trends for Universal Prevention
This study is designed to develop an integrated intervention to reduce alcohol and marijuana use and consequences and improve sleep among young adults with comorbid heavy episodic drinking, marijuana use, and sleep impairment.
- Conditions
- Insomnia, Alcohol Use, Unspecified, Marijuana Use
- Trial name
- REST-UP (NCT04783519)
- Testing
- Brief Behavioral Therapy for Insomnia (BBTI), Brief Alcohol Screening and Intervention for College Students (BASICS)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Washington
Alcohol Use Disorder
Broccoli Extract Supplementation in Older Adults With Alcohol Use Disorder
Chronic alcohol consumption leads to perturbations in gut microbiome balance (dysbiosis) and disruption of gut barrier integrity.
- Trial name
- NCT05902754
- Testing
- Generally Recognized as Safe - Sulforaphane
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans