Clinical trials: Alcohol Drinking
Social Skills, Self-Criticism
Development and Pilot Trial of an Intervention to Reduce Disclosure Recipients Negative Social Reactions and Victims Psychological Distress and Problem Drinking
The purpose of this randomized controlled trial is to evaluate an intervention, Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS).
- Conditions
- Social Skills, Self-Criticism, Post-traumatic Stress Disorder, Depression
- Trial name
- NCT03488927
- Testing
- Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS)
- Where
- United States
- Volunteers
- 1,268 people, healthy volunteers welcome
- Sponsor
- University of New Hampshire
Nicotine Dependence, Alcohol Use Disorder
Combining Varenicline and Naltrexone for Smoking Cessation
This study is a double-blind, randomized clinical trial using a two group medication design consisting of the combination of VAR (1 mg twice daily) + NTX (50 mg once daily) and VAR (1 mg twice daily) + PLA (matched to NTX), for…
- Trial name
- NCT02698215
- Testing
- Varenicline, Varenicline plus Naltrexone
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- University of California, Los Angeles
HIV, Alcohol Use
Improving HIV and Alcohol-Related Outcomes Among HIV+ Persons in Clinic Settings
Alcohol use is increasingly recognized as a key factor in morbidity and mortality among HIV-positive individuals and represents an important public health concern, given its associations with medication non-adherence, increases…
- Conditions
- HIV, Alcohol Use, Medication Adherence
- Trial name
- PLUS (NCT02390908)
- Testing
- Immediate PLUS intervention, Wait-list PLUS intervention
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
Alcoholism
High Dose Vitamin B1 to Reduce Abusive Alcohol Use
B1AS tests the hypothesis that increased vitamin B1 (thiamine) intake can repair brain systems damaged by alcohol and help people with alcohol problems control their alcohol use.
- Trial name
- B1AS (NCT00680121)
- Testing
- Benfotiamine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Kansas
Alcohol Drinking
Calibration Study of a Blood Alcohol Level Smart Watch
This trial is designed to test the accuracy of a wristwatch blood alcohol level monitor relative to alcohol breath testing. An established human laboratory self-administration procedure will be followed.
- Trial name
- NCT03574181
- Testing
- Smartwatch to measure Blood Alcohol Level (BAL)
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Heavy Drinking and Sexual Risk Behavior
Alcohol and Sex Risk Intervention for MSM Supplement
Open pilot trial to test the feasibility and efficacy of a brief intervention with text messaging to reduce sexual risk behavior and heavy drinking among MSM
- Trial name
- NCT03522948
- Testing
- Brief intervention with text messaging to reduce sexual risk and heavy drinking among MSM
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Alcohol Use Disorder, Depression
Zambia Common Elements Treatment Approach Pilot Study
This is a randomized controlled trial (RCT) evaluating the effectiveness of an alcohol brief intervention alone compared to the brief intervention plus an evidence-based psychotherapy (CETA) in reducing alcohol misuse and…
- Conditions
- Alcohol Use Disorder, Depression, Post-traumatic Stress Disorder, HIV/AIDS
- Trial name
- ZCAP (NCT03966885)
- Testing
- Brief Intervention, Common Elements Treatment Approach (CETA)
- Where
- Zambia
- Volunteers
- 160 people
- Sponsor
- Columbia University
Alcohol Drinking, Smoking
An Effectiveness Trial of Project ALERT
The purpose of this study is to replicate a longitudinal evaluation of Project ALERT, a substance abuse prevention program that targets middle school students.
- Conditions
- Alcohol Drinking, Smoking, Marijuana Smoking
- Trial name
- NCT00650585
- Testing
- Project ALERT
- Where
- United States
- Volunteers
- 8,338 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation
Alcohol Drinking, Adolescent, Drinking Behavior
Brief Intervention to Prevent Alcohol Socialization (BIPAS Alcohol)
Early alcohol socialization occurs within the family. This multi-level, high-reach, low-intensity intervention to prevent early alcohol use capitalizes on the influence of providers, immunization timing, and pediatric guidelines…
- Conditions
- Alcohol Drinking, Adolescent, Drinking Behavior, Drinking, Alcohol, Adolescent Behavior
- Trial name
- NCT05520333
- Testing
- BIPAS Alcohol
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cigarette Use, Alcohol Use Above Recommended Limits
Developing a Team-Delivered Intervention for Smoking and Hazardous Drinking for Primary Care Veterans With Cardiovascular Diseases
In this study, the investigators are interested in learning how patients feel about and are impacted by a new approach for the primary care team to use to talk to patients about heart disease and health behaviors.
- Conditions
- Cigarette Use, Alcohol Use Above Recommended Limits, Cardiovascular Risk Factors (e.g., Hypertension), Cardiovascular Diseases
- Trial name
- CARE (NCT05275582)
- Testing
- CARE
- Where
- 2 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder
Alcohol, Inflammation, and Mindfulness Study (AIM)
The goal of the AIM Study is to examine the effectiveness of Mindfulness Based Relapse Prevention (MBRP) versus Relapse Prevention (RP) for the treatment of Alcohol Use Disorders (AUD) by implementing an 8-week long intervention…
- Trial name
- NCT02994043
- Testing
- Mindfulness-Based Relapse Prevention Therapy, Relapse Prevention Therapy
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of Colorado, Denver
Alcohol Dependence, Problem Drinking
Alcohol Pharmacotherapy for HIV+ Prisoners
This is a randomized controlled trial of injectable intramuscular naltrexone (XR-NTX) versus intramuscular placebo among HIV-infected prisoners meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition…
- Conditions
- Alcohol Dependence, Problem Drinking, Hazardous Drinking, Human Immunodeficiency Virus
- Trial name
- INSPIRE (NCT01077310)
- Testing
- Vivitrol- Intramuscular naltrexone (depot-formulation)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Alcohol Use, Unspecified
Estradiol Effects on Alcohol Across the Menstrual Cycle
This study will provide the first rigorous integrative test of the hypothesis that rapid rises in estradiol (a female hormone) increase the rewarding and disinhibiting effects of alcohol and that such increased sensitivity…
- Trial name
- NCT04595682
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mark Fillmore
Traumatic Brain Injury (TBI), Hazardous and Harmful Alcohol Use
N-acetylcysteine Treatment of Alcohol Use Disorder In Veterans With TBI
The goal of the project is to improve the care of Veterans with mild traumatic brain injury (mTBI) and unhealthy alcohol use.
- Trial name
- NAC (NCT02791945)
- Testing
- Medical Management Counseling, N-acetylcysteine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Housing Problems, Drug Use
ED-Home Pilot Study
This is a single-arm pilot study to test the feasibility of homelessness prevention and substance use interventions to be delivered to at-risk patients in the Bellevue Hospital emergency department (ED).
- Conditions
- Housing Problems, Drug Use, Alcohol; Use, Problem
- Trial name
- NCT03864341
- Testing
- Referral to homelessness prevention services, Substance use services, Follow-up
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Alcohol Consumption
Testing Brief Personalized Feedback Integrating Lab-based Alcohol Cue Information
This study aims to develop a brief intervention that uses information from a lab-based cue reactivity protocol to create personalized feedback targeting high-risk alcohol use among young adults who drink alcohol.
- Trial name
- Project ACE (NCT05873556)
- Testing
- Lab-based Cue Reactivity Personalized Feedback Intervention (PFI)
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Washington
Alcohol Use Disorder
Pharmacogenomics and Pharmacometabolomics of Acamprosate Treatment Outcome
AUDs are difficult to treat, and relapse rates are high, with an estimated 80% of individuals with AUDs returning to alcohol use after completing addictions treatment.
- Trial name
- NCT03818191
- Testing
- Acamprosate
- Where
- 3 sites in United States
- Volunteers
- 288 people
- Sponsor
- Mayo Clinic
Alcohol Drinking, Alcohol Intoxication
Breathalyzer Validation Study
The proposed project will test three commercial cellphone breathalyzers against a police grade breathalyzer device.The study will test the accuracy of these smartphone breathalyzers at assessing Breath Alcohol Content (BrAC)…
- Trial name
- BVS (NCT04086576)
- Testing
- Alcohoot, BACtrack Mobile Pro, DRIVESAFE Evoc
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alcohol Use Disorder
Cannabidiol Effects on Blood Alcohol Level and Intoxication
The main objectives of this study were to test if 2 different doses of Cannabidiol (compared to placebo) alter 1) breath alcohol concentration, 2) craving and subjective responses to alcohol or 3) cognitive performance following…
- Trial name
- NCT06105138
- Testing
- 200mg Cannabidiol oral solution, 30mg Cannabidiol oral solution
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Posttraumatic Stress Disorder, Alcohol Use Disorders
Brief Restructuring Intervention Following Trauma Exposure
The broad aim of this study is to develop and test a brief intervention that can be implemented in the immediate weeks following sexual assault to decrease likelihood of developing posttraumatic stress disorder (PTSD) or alcohol…
- Trial name
- BRITE (NCT02808468)
- Testing
- Brief Cognitive Therapy
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Washington