Clinical trials: Alcohol Drinking
Alcohol Dependence
A Multicenter, Randomized, Double-blind, Placebo-controlled, 3-parallel-group Comparison Trial to Investigate the Effect of Nalmefene on Alcohol Consumption Reduction in Patients With Alcohol Dependence (Phase 3 Trial)
The efficacy, safety, and dose-response of nalmefene hydrochloride at 10 mg and 20 mg in patients with alcohol dependence will be evaluated in a multicenter, randomized, double-blind, placebo-controlled, 3-parallel-group…
- Trial name
- NCT02364947
- Testing
- Nalmefene hydrochloride
- Where
- 7 sites in Japan
- Volunteers
- 678 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Alcohol Abuse, Posttraumatic Stress Disorder
Prazosin for Alcohol Dependence and Posttraumatic Stress Disorder
The purpose of this study is to determine whether the drug prazosin is effective for the treatment of alcohol dependency and symptoms of Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT01518972
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Alcohol Drinking
Neural and Behavioral Effects of Cognitive Bias Modification (CBM)
This study seeks to better understand mechanisms of behavior change for heavy drinkers who are interested in changing their drinking.
- Trial name
- NCT04430543
- Testing
- Cognitive Bias Modification
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Boston University Charles River Campus
Opioid Use, Alcohol Drinking
TACUNA (Traditions and Connections for Urban Native Americans)
This study responds to Request For Application-DA-19-035, HEAL (Helping End Addiction Long Term) initiative: Preventing OUD in Older Adolescents and Young Adults (ages 16-30) by developing and implementing a culturally centered…
- Conditions
- Opioid Use, Alcohol Drinking, Marijuana Use
- Trial name
- TACUNA (NCT04617938)
- Testing
- TACUNA plus Wellness Circle, Opioid Education Workshop
- Where
- 3 sites in United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- RAND
Alcohol Use Disorder
Human Laboratory Study of Varenicline for Alcohol Use Disorder
This study is a double-blind, randomized, placebo-controlled, parallel group, two-site study designed to assess the effects of varenicline as compared with placebo on responses to in vivo alcohol cue exposure in the human…
- Trial name
- NCT03035708
- Testing
- Varenicline
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Nicotine Dependence, Alcohol Use Disorder
Combining Varenicline and Naltrexone for Smoking Cessation
This study is a double-blind, randomized clinical trial using a two group medication design consisting of the combination of VAR (1 mg twice daily) + NTX (50 mg once daily) and VAR (1 mg twice daily) + PLA (matched to NTX), for…
- Trial name
- NCT02698215
- Testing
- Varenicline, Varenicline plus Naltrexone
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- University of California, Los Angeles
Traumatic Brain Injury (TBI), Hazardous and Harmful Alcohol Use
Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI
The goal of the proposed project is to improve the treatment of veterans with co-occurring traumatic brain injury (TBI) and hazardous or harmful alcohol use.
- Trial name
- VAT (NCT01750268)
- Testing
- Medical Management Counseling, Topiramate
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Francisco
Alcoholism
Sertraline Pharmacotherapy for Alcoholism Subtypes
The purpose of this study is to determine whether Sertraline, compared to placebo, is effective in the treatment of alcohol dependence as a function of the subtype of alcoholic patient being treated.
- Trial name
- NCT00368550
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- UConn Health
Schizophrenia, Schizoaffective Disorder
Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder
The proposed study is a 4-site, 12-week, novel, feasibility, investigation of patients who have co-occurring diagnoses of schizophrenia and current substance use disorder (alcohol, cocaine, heroin, or cannabis).
- Conditions
- Schizophrenia, Schizoaffective Disorder, Substance Use Disorders
- Trial name
- NCT03526354
- Testing
- Brexpiprazole, Treatment as Usual
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Massachusetts, Worcester
Alcohol Use Disorder
Deep Brain Stimulation for Alcohol Use Disorder
The purpose of this clinical study is to investigate the safety, tolerability, and feasibility of Deep Brain Stimulation (DBS) of the limbic pallidum in participants with severe alcohol use disorder (AUD) who have advanced but…
- Trial name
- NCT05522751
- Testing
- DBS
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Khaled Moussawi
Alcohol Use Disorder
Frontal-Striatal Reward Circuit Neuromodulation and Alcohol Self-Administration
This will be a single site randomized, 2-session, within-subject cross-over design pilot study. 20 enrolled (of 30 consented) subjects reporting varying levels of binge and high intensity drinking, defined as at least 2 episodes…
- Trial name
- NCT04971681
- Testing
- Low frequency repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Indiana University
Alcohol Drinking
Calibration Study of a Blood Alcohol Level Smart Watch
This trial is designed to test the accuracy of a wristwatch blood alcohol level monitor relative to alcohol breath testing. An established human laboratory self-administration procedure will be followed.
- Trial name
- NCT03574181
- Testing
- Smartwatch to measure Blood Alcohol Level (BAL)
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Alcoholism
Varenicline for Alcohol Dependence
The primary objective of this study is to assess the efficacy of varenicline in reducing the proportion of heavy drinking days during the last 8 weeks of treatment in subjects with alcohol dependence confirmed by Diagnostic and…
- Trial name
- NCIG 003 (NCT01146613)
- Testing
- Varenicline
- Where
- 7 sites in United States
- Volunteers
- 200 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Social Anxiety Disorder, Social Phobia
Paroxetine for Comorbid Social Anxiety Disorder and Alcoholism
The purpose of the study is to determine whether an SSRI, paroxetine, improves social anxiety symptoms and alcohol use in individuals who drink to cope with social anxiety disorder.
- Conditions
- Social Anxiety Disorder, Social Phobia, Alcohol Use Disorder, Alcohol Abuse
- Trial name
- NCT00246441
- Testing
- Paroxetine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Medical University of South Carolina
Underage Drinking
Parental Research on Interventions for Social Media
The prevalence of underage alcohol use continues to be a public health concern. Numerous studies have reported associations between teen drinking tendencies and parental attitudes and beliefs, parental awareness of teen drinking…
- Trial name
- PRISM (NCT04333966)
- Testing
- Interactive Social Networking Site Parent Based Intervention, Active Control
- Where
- United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University of North Texas Health Science Center
Alcohol Drinking
Feasibility and Effectiveness of a Specialized Brief Intervention for Hazardous Drinkers in an Emergency Department.
Alcohol use and its consequences represent an important public health problem. As well as alcohol dependence, hazardous drinking also contributes to a high burden in terms of morbidity and mortality.
- Trial name
- PPAU (NCT03273283)
- Testing
- Brief Intervention
- Volunteers
- 200 people
- Sponsor
- Hospital Clinic of Barcelona
Major Depressive Disorder, Alcohol Use Disorder
Treatment of Young Adults With Comorbid AUD/MDD: A Pilot Medication Trial
Recent reports have shown that alcohol misuse is a particularly serious problem among the 18 to 25 year old age group. Previous medication trials with SSRI antidepressants among young adults with co-occurring depressive…
- Trial name
- YAAD-P (NCT02646449)
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Alcohol Drinking, Opioid Use, Unspecified
Opioid Modulation and Neural Reward Activation in Healthy Adults
This is a double blind study of the effects of opioid antagonism on the brain's reward response. The investigators will recruit participants to undergo two scans, one on active medication and one on placebo.
- Trial name
- NCT04854551
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
PTSD and Alcohol Use Disorder
Topiramate and Prolonged Exposure
Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) frequently co-occur, and having both disorders is associated with greater psychological and functional impairment than having either disorder alone.
- Trial name
- TOP (NCT03176953)
- Testing
- topiramate, prolonged exposure
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Alcohol, Drinking, Alcohol Use Disorder
Sustaining Patient-centered Alcohol-related Care
Alcohol use is the third greatest cause of disability and death for US adults. Care for unhealthy alcohol use is lacking in most primary care settings.
- Trial name
- SPARC (NCT02675777)
- Testing
- Quality Improvement Intervention
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente