Clinical trials: Alcohol Drinking
Alcohol Use Disorder, Sexually Transmitted Diseases
Addressing Heavy Alcohol Use Consumption With Kudzu
Drinking multiple alcoholic drinks on a single occasion (binge drinking), has many negative health risks but interventions to address this behavior remain limited.
- Trial name
- A-HACK (NCT03709043)
- Testing
- Standardized kudzu, Sexually transmitted infection testing:, Medical Management (MM) counseling for alcohol use:
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Glenn-Milo Santos
Alcohol Use Disorder
Automated Reinforcement Management System (ARMS)
Alcohol abuse remains a significant cause of preventable morbidity and mortality in the US. Yet only 15% of those with alcohol use disorders receive treatment.
- Trial name
- ARMS (NCT04656925)
- Testing
- Contingency management
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Washington State University
Alcohol Use Disorder, Anxiety Disorders
Transdiagnostic CBT for Comorbid Alcohol Use and Anxiety Disorders
Almost 18 million US adults have alcohol use disorders (AUD), with one third of these individuals also diagnosed with anxiety disorders (AXD).
- Trial name
- NCT03230006
- Testing
- Unified Protocol for Transdiagnostic Treatment of Emotional Disorders, Take Control
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Boston University Charles River Campus
Underage Drinking
Parental Research on Interventions for Social Media
The prevalence of underage alcohol use continues to be a public health concern. Numerous studies have reported associations between teen drinking tendencies and parental attitudes and beliefs, parental awareness of teen drinking…
- Trial name
- PRISM (NCT04333966)
- Testing
- Interactive Social Networking Site Parent Based Intervention, Active Control
- Where
- United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University of North Texas Health Science Center
HIV Infection, Alcohol Use
St. PETERsburg Pain and Alcohol Intervention With Naltrexone and Nalmefene
This study is a randomized controlled trial (RCT) to assess the feasibility, tolerability, and safety of using opioid receptor antagonists (naltrexone and nalmefene) to treat pain among HIV-infected persons with heavy alcohol use…
- Conditions
- HIV Infection, Alcohol Use, Pain
- Trial name
- PETER PAIN (NCT03278886)
- Testing
- Low dose naltrexone, Nalmefene
- Where
- Russia
- Volunteers
- 11 people
- Sponsor
- Boston Medical Center
Alcohol Use
Evaluating a Brief Negotiational Intervention for Alcohol Use Among Injury Patients in Tanzania
A brief negotiational interview (BNI), administered in an Emergency Department setting for both hazardous and harmful drinkers has been shown to cost-effectively reduce a patient's alcohol intake and re-injury rate up to 3 years…
- Trial name
- BNI (NCT02828267)
- Testing
- Brief Negotiational Intervention, Standard Booster, Personalized Booster
- Where
- Tanzania
- Volunteers
- 75 people
- Sponsor
- Duke University
Alcohol-Related Disorders, Substance-Related Disorders
The Women's Recovery Group Study: Stage I Trial
The purpose of this study was to develop a gender-specific 12-session, manual-based relapse prevention group for women with substance use disorders (SUDs).
- Trial name
- NCT00230100
- Testing
- The Women's Recovery Group, mixed-gender Group Drug Counseling
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Mclean Hospital
Alcohol Abuse
Telephone Disease Management At-Risk Drinking (TDM II)
The aim of this study is to test for improvements in treatment outcomes for primary care patients with at-risk drinking when cared for using telephone disease management (TDM) compared to those treated with usual care.
- Trial name
- NCT00123409
- Testing
- Telephone disease management, Usual Care
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- US Department of Veterans Affairs
Alcohol Dependence
A Multicenter, Randomized, Double-blind, Placebo-controlled, 3-parallel-group Comparison Trial to Investigate the Effect of Nalmefene on Alcohol Consumption Reduction in Patients With Alcohol Dependence (Phase 3 Trial)
The efficacy, safety, and dose-response of nalmefene hydrochloride at 10 mg and 20 mg in patients with alcohol dependence will be evaluated in a multicenter, randomized, double-blind, placebo-controlled, 3-parallel-group…
- Trial name
- NCT02364947
- Testing
- Nalmefene hydrochloride
- Where
- 7 sites in Japan
- Volunteers
- 678 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Dating Violence, Alcohol Drinking
Evaluation of PRYSHM for LGBTQIA2S+ Youth
The overarching goal of the proposed project is to develop an innovative, online synchronous DV and AU prevention curriculum created specifically for SGMY (ages 15 to 18); conduct a pilot randomized controlled trial to assess its…
- Trial name
- PRYSHM (NCT05521906)
- Testing
- Promoting Resilient Youth with Strong Hearts and Minds (PRYSHM)
- Where
- United States
- Volunteers
- 314 people
- Sponsor
- University of Nebraska Lincoln
Alcohol Drinking
Measuring the Neuroimmune Response to Alcohol
This study uses positron emission tomography imaging of the 18-kDa translocator protein to measure the brain's immune response to alcohol.
- Trial name
- NCT04251221
- Testing
- Oral Alcohol Challenge
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Use Disorder
Pharmacogenomics and Pharmacometabolomics of Acamprosate Treatment Outcome
AUDs are difficult to treat, and relapse rates are high, with an estimated 80% of individuals with AUDs returning to alcohol use after completing addictions treatment.
- Trial name
- NCT03818191
- Testing
- Acamprosate
- Where
- 3 sites in United States
- Volunteers
- 288 people
- Sponsor
- Mayo Clinic
Alcohol Drinking, Craving
Cognitive Interference Task on Alcohol Craving and Consumption
The purpose of this study is to test a brief task of playing the game Tetris to reduce alcohol cravings and alcohol use. Women who are seen at primary care and recruited through the community will be asked to rate alcohol craving…
- Trial name
- NCT04924283
- Testing
- Tetris and Assessments, Assessment Only
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Human Immunodeficiency Virus Exposure, Alcohol; Harmful Use
Game Plan for PrEP
This small pilot randomized controlled trial will test whether a brief, web-based intervention inspired by the principles of motivational interviewing helps high-risk men who take pre-exposure prophylaxis (PrEP) moderate their…
- Trial name
- NCT04973267
- Testing
- Game Plan for PrEP, Attention-Matched Control Lifestyle Habits Videos
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Drinking
Calibration Study of a Blood Alcohol Level Smart Watch
This trial is designed to test the accuracy of a wristwatch blood alcohol level monitor relative to alcohol breath testing. An established human laboratory self-administration procedure will be followed.
- Trial name
- NCT03574181
- Testing
- Smartwatch to measure Blood Alcohol Level (BAL)
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Schizophrenia, Alcohol Use Disorder
A Study of ALKS 3831 in Subjects With Schizophrenia and Alcohol Use Disorder
This double-blind, randomized study will evaluate the efficacy, safety and tolerability of ALKS 3831 in subjects with schizophrenia and alcohol use disorder (AUD).
- Trial name
- NCT02161718
- Testing
- Samidorphan + olanzapine (ALKS 3831)
- Where
- 71 sites in United States, Bulgaria and 1 more
- Volunteers
- 300 people
- Sponsor
- Alkermes, Inc.
Alcohol Use Disorder
Broccoli Extract Supplementation in Older Adults With Alcohol Use Disorder
Chronic alcohol consumption leads to perturbations in gut microbiome balance (dysbiosis) and disruption of gut barrier integrity.
- Trial name
- NCT05902754
- Testing
- Generally Recognized as Safe - Sulforaphane
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Alcohol Use, Unspecified
Alcohol Biosensor Monitoring for Alcoholic Liver Disease
Successful treatment of alcohol associated liver disease (AALD) depends primarily on abstinence from alcohol. The investigators propose a randomized clinical trial of alcohol biosensor monitoring for patients with alcohol…
- Trial name
- NCT03533660
- Testing
- Feedback, Enhanced Usual Care
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Pittsburgh
Alcohol Use Disorder, Mild Traumatic Brain Injury
Pilot rTMS for AUD+mTBI
This is a pilot randomized controlled trial (RCT) for Veteran participants with alcohol use disorder co-occurring with mild traumatic brain injury and/or post-traumatic stress disorder.
- Conditions
- Alcohol Use Disorder, Mild Traumatic Brain Injury, Post-traumatic Stress Disorder
- Trial name
- TMS_AUD+mTBI (NCT03995173)
- Testing
- repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- VA Office of Research and Development
Alcohol-Related Disorders, Anxiety Disorders
Psychosocial and Medication Treatment for Anxiety in Alcoholism
The proposed project is written as a "typical clinical practice" test and is a fully-controlled trial of a combined anxiety-focused CBT and pharmacotherapy (venlafaxine; CBT-VEN) delivered for patients with comorbid alcohol-use…
- Trial name
- NCT00248612
- Testing
- Venlafaxine, CBT, Progressive muscle relaxation therapy (PMR)
- Where
- 2 sites in United States
- Volunteers
- 162 people
- Sponsor
- Boston Medical Center