Clinical trials: Alcohol Drinking
Alcohol Use Disorder, Mild Traumatic Brain Injury
rTMS Target Identification for Functional Disability in AUD+mTBI
The objectives of this VA Merit application are to identify a neural target unique to Veterans with co-occurring alcohol use disorder and mild traumatic brain injury (AUD+mTBI) and to test the efficacy of this target as a…
- Trial name
- rTMS-TARGET-ID (NCT04043442)
- Testing
- Magventure MagProX100 with MagOption stimulator and Magpro Cool Coil B65 A/P
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder
Decreasing the Temporal Window in Individuals With Alcohol Use Disorder
In the absence of sufficient monetary resources, individuals must attend to immediate, minimum needs (e.g., food, shelter). This constricts one's temporal window and engenders neglect of the future.
- Trial name
- RP1B (NCT04128761)
- Testing
- Scarcity Narrative, Neutral Narrative
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Virginia Polytechnic Institute and State University
Substance Use Disorders, Substance Use
Harnessing Telemedicine to Improve Alcohol Use Disorder Outcomes in Primary Care Patients
The purpose of this trial is to test new programs to see if they might help people manage their health and health behaviors related to alcohol use and well-being.
- Conditions
- Substance Use Disorders, Substance Use, Substance Dependence
- Trial name
- NCT05410561
- Testing
- Enhanced Usual Care (EUC), TeleTx intervention
- Where
- 2 sites in United States
- Volunteers
- 277 people
- Sponsor
- University of Michigan
Excessive Alcohol Consumption
Chatbot-delivered Screening and Brief Intervention for Alcohol Reduction in Working-age Adults
Alcohol abuse led to 5.3% of all deaths and 5.1% of all disability-adjusted life years globally in 2016, representing a heavier public health burden than diabetes, tuberculosis or HIV/AIDS (as documented in the World Health…
- Trial name
- NCT06602882
- Testing
- chatbot-delivered screening and brief intervention
- Where
- Hong Kong
- Volunteers
- 300 people
- Sponsor
- The University of Hong Kong
Opioid Use Disorder, Alcohol Use Disorder
Comparing Treatments for HIV-Infected Opioid and Alcohol Users in an Integrated Care Effectiveness Study
The purpose of this study is to learn how best to treat substance use disorders in an HIV clinic setting. Specifically, the purpose of this pilot study is to learn if extended-release naltrexone (XR-NTX) would be a feasible and…
- Trial name
- CHOICES (NCT01908062)
- Testing
- Extended Release Naltrexone, Treatment As usual
- Where
- 2 sites in United States, Canada
- Volunteers
- 51 people
- Sponsor
- Oregon Health and Science University
Intimate Partner Violence (IPV), Sexual Violence
Evaluation of a Sexual Violence and Intimate Partner Violence Primary Prevention Program Implemented in Drinking Establishments
The goal of this project is to evaluate the effectiveness of Safe Night Out, a community-level primary violence prevention program offered in drinking establishments in the Sacramento region of California.
- Conditions
- Intimate Partner Violence (IPV), Sexual Violence, Alcohol, Safety
- Trial name
- NCT07434856
- Testing
- Safe Night Out Program, No Safe Night Out
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Alcohol Use, Smoking
ChoicesPlus: Reducing Alcohol- and Tobacco-Exposed Pregnancy
Choices Plus, a randomized controlled study, will determine the efficacy of the Project CHOICES intervention plus a referral to an evidence-based smoking cessation program in reducing the risk of alcohol- and tobacco-exposed…
- Conditions
- Alcohol Use, Smoking, Contraception
- Trial name
- ChoicesPlus (NCT01032772)
- Testing
- Choices Plus, Information
- Where
- 2 sites in United States
- Volunteers
- 261 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Alcohol Use Disorder
A Study of New Treatment for Excessive Alcohol Users by Electric Stimulation of Nerves Around Ear
Alcohol Use Disorders (AUD's) are a major health and social problem. Relapse is a rule rather than an exception in alcohol dependence, leading to poor outcomes. Craving are frequently associated with relapse.
- Trial name
- NCT04106739
- Testing
- Drug Relief V(version) 2.0 Auricular Percutaneous Electrical Neural Field Stimulation (PENFS)
- Where
- India
- Volunteers
- 44 people
- Sponsor
- DyAnsys, Inc.
Alcoholism, Alcohol Abuse
EMPOWER AUD Pivotal Trial
Multi-site, double-blinded, prospective, randomized, sham-controlled study
- Conditions
- Alcoholism, Alcohol Abuse, Alcohol Use Disorder
- Trial name
- NCT05948605
- Testing
- Empower Neuromodulation System
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Theranova, L.L.C.
Alcohol Drinking, Opioid Use, Unspecified
Opioid Modulation and Neural Reward Activation in Healthy Adults
This is a double blind study of the effects of opioid antagonism on the brain's reward response. The investigators will recruit participants to undergo two scans, one on active medication and one on placebo.
- Trial name
- NCT04854551
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Adolescent Drinking, Adolescent Substance Use
Optimizing and Advancing SBIRT in Schools
The goal of this clinical trial is to establish whether brief interventions for alcohol use can be delivered in schools for both indicated prevention and selected prevention, determine if an expanded workforce is an effective…
- Conditions
- Adolescent Drinking, Adolescent Substance Use, Risk Behavior, Health
- Trial name
- OASIS (NCT06206161)
- Testing
- Indicated Prevention, Clinical Staff, Selective Prevention, Expanded Paraprofessional Workforce
- Where
- United States
- Volunteers
- 21,000 people
- Sponsor
- Massachusetts General Hospital
Alcohol Use Disorder
Selective Attention in Alcohol Use Disorder
This study examines the selective attention to emotional- and alcohol- associated cues in alcohol- dependant and healthy participants.
- Trial name
- NCT03816527
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Healthy, Alcohol Drinking
Rimonabant to Reduce Alcohol Consumption
This study will examine whether Rimonabant, a drug that blocks cannabinoid-1 (CB1) receptors in the brain, affects alcohol consumption.
- Trial name
- NCT00075205
- Testing
- SR141716 (Rimonabant)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder
A Study to Assess the Pharmacokinetic Profile of Prazosin and Cyproheptadine
The study is an open-label, randomized,2-period, single dose, crossover study in 8 healthy male/female volunteers. Subjects will be randomized to the following sequences: (A) Period 1: KT110 - wash-out period - Period 2: Alpress…
- Trial name
- NCT06147622
- Testing
- Prazosin + cyproheptadine, KT110
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Kinnov Therapeutics
Physical Exercise
Can Exercise Rewire the Brain Addiction Circuitry?
The aim of the present study is to apply neuroimaging techniques to investigate how physical exercise may influence the addiction circuitry, ultimately reducing alcohol consumption and craving in youth binge drinkers.
- Trial name
- REWIRED (NCT06317753)
- Testing
- Aerobic Exercise, Agility-Cognitive Exercise, Stretching/relaxation
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Minho
Alcohol Use, Unspecified, Hookah Smoking
Effect of Concurrent Hookah and Alcohol Consumption on Smoking Topography and Toxicant Exposure
The purpose of the current study is to investigate in a prospective randomized cross-over trial, the impact of alcohol versus a placebo drink on smoking behavior and topography (duration and frequency of puffing), abuse…
- Trial name
- NCT03096860
- Testing
- Active alcohol consumption
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Problematic Alcohol Use
E-alcohol Therapy - an Evaluation of Alcohol Therapy Delivered Via Video Conference
The study evaluates whether the introduction of e-alcohol therapy (alcohol therapy delivered via video conference) can break with some of the barriers related to alcohol treatment and thereby appeal to people with a problematic…
- Trial name
- NCT03116282
- Testing
- E-alcohol therapy
- Where
- Denmark
- Volunteers
- 365 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Alcohol Use Disorder
Testing the Efficacy of an Online Integrated Treatment for Comorbid Alcohol Misuse and Emotional Problems
Considering the high comorbidity between alcohol use disorders and emotional problems, there is currently a need for accessible, integrated treatments designed to target both disorders simultaneously.
- Trial name
- NCT03406039
- Testing
- Integrated Online CBT and MI
- Where
- Canada
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Alcohol Use Disorder, Substance Use Disorders
Indigenous Recovery Planning for American Indians
This research project uses a Community-Based Participatory Research (CBPR) framework to test the efficacy of a culturally adapted relapse prevention intervention developed collaboratively by community partners from the Fort Peck…
- Trial name
- NCT05612061
- Testing
- Indigenous Recovery Planning
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Montana State University
Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Effect of Sublingual Formulation of Dexmedetomidine HCl (BXCL501) - Alcohol Interaction Study
The overall objective of the proposed study is to determine if Dexmedetomidine HCl (BXCL501) is safe for treatment of alcohol use disorder (AUD) with comorbid posttraumatic stress disorder (PTSD) and also shows potential signals…
- Trial name
- NCT04827056
- Testing
- Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 40µg, Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 80µg, Ethanol Infusion
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance