Clinical trials: Alcohol Problems
Alcohol Use Disorder
Manipulating Ghrelin Signaling Via GOAT Inhibition in Alcohol Use Disorder
Background: People with alcohol use disorder (AUD) have trouble controlling their drinking. Medications can help some people with AUD but are not effective for many others.
- Trial name
- NCT03896516
- Testing
- GLWL-01
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol-Related Disorders, Alcohol Problem
Identifying and Managing Alcohol-related Health Problems in General Practice
The overall purpose of the proposed research is to increase patients' and general practitioners' (GPs') awareness of alcohol as a relevant factor for a wide variety of health problems in general practice, and enable earlier help…
- Conditions
- Alcohol-Related Disorders, Alcohol Problem, Alcohol Drug Interaction, Alcohol Use Disorder
- Trial name
- NCT04725552
- Testing
- 'Change' - an e-health intervention
- Where
- 4 sites in Norway
- Volunteers
- 40 people
- Sponsor
- Helse Stavanger HF
Alcohol Problem, Harm Reduction
Game-Based Intervention to Reduce Alcohol-Related Harms Among Sexual and Gender Minority Youth
This is a randomized controlled trial to examine the efficacy of a game-based intervention to reduce alcohol-related harms among sexual and gender minority youth.
- Conditions
- Alcohol Problem, Harm Reduction, Alcohol-Related Harm
- Trial name
- NCT06215664
- Testing
- Singularities Game, Food4Thought
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Alcohol Use Disorder
Testing the Efficacy of an Online Integrated Treatment for Comorbid Alcohol Misuse and Emotional Problems
Considering the high comorbidity between alcohol use disorders and emotional problems, there is currently a need for accessible, integrated treatments designed to target both disorders simultaneously.
- Trial name
- NCT03406039
- Testing
- Integrated Online CBT and MI
- Where
- Canada
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Alcohol Abuse
Attitudes & College Experiences
High volume drinking by young adults has proven resistant to long term change, so new approaches are needed. Given strong associations between alcohol-related attitudes and drinking behavior, the investigators adapt a…
- Trial name
- ACE (NCT04026633)
- Testing
- CAA, Control
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Brooklyn College of the City University of New York
Suicide, Attempted, Drug Use
Brief New Treatment for Suicide Attempts
Individuals with alcohol or drug use problems who are hospitalized for suicide attempt are at high risk for reattempt. This treatment development study adapts a promising outpatient intervention to prevent suicide reattempt in…
- Conditions
- Suicide, Attempted, Drug Use, Alcohol; Use, Problem
- Trial name
- NCT03300596
- Testing
- Brief intervention to prevent suicide attempt, Enhanced treatment as usual
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Rochester
Insomnia, Alcohol; Harmful Use
The Insomnia Treatment and Problems Study for Veterans
This project aims to evaluate improvement of insomnia as a mechanism of improvement in alcohol use outcomes.
- Trial name
- iTAP-V (NCT03804788)
- Testing
- Cognitive Behavioral Therapy for Insomnia, Sleep Hygeine
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Alcohol Drinking, Alcohol Problem Drinking
Parent Feedback Intervention Targeting Student Transitions and Alcohol Related Trajectories (+) Efficacy Study
FITSTART (Feedback Intervention Targeting Student Transitions and Risk Trajectories) is a parent-based social norms intervention that has been shown to reduce risky drinking in incoming first year students.This program uses…
- Conditions
- Alcohol Drinking, Alcohol Problem Drinking, Parenting
- Trial name
- FITSTART+ (NCT04549454)
- Testing
- FITSTART+ PBI, General Parenting Advice
- Where
- United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Loyola Marymount University
Alcohol Use Disorder, Opioid Use Disorder
Developing e-Covery, an App-based Intervention to Support Individuals With Co-occurring Problem Alcohol and Opioid Use
This project aims to improve the health of individuals engaged in co-occurring alcohol and opioid use by supporting the maintenance of behavior change initiated in substance use treatment.
- Trial name
- NCT05325788
- Testing
- e-Covery, Comparator Condition
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol-Related Disorders
Melatonin Use for Sleep Problems in Alcohol Dependent Patients
A double blind Randomized Controlled Trial with two arms will be used. Subjects with Alcohol use disorder and sleep problems will be recruited and assigned randomly to the active treatment Melatonin or Placebo arms.
- Trial name
- NCT03043443
- Testing
- Melatonin
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Centre for Addiction and Mental Health
Alcohol Abuse, Drug Abuse
Prevention and Reduction of Alcohol and Drug Problems in a Clinical Psychiatric Youth Population
In adolescents, mental health problems are frequently associated with substance misuse, even considered a risk factor for alcohol abuse and dependence.
- Conditions
- Alcohol Abuse, Drug Abuse, Mood Disorder, Anxiety Disorder
- Trial name
- NCT01595568
- Testing
- Personality-targeted interventions
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- St. Justine's Hospital
PTSD, Alcohol Use Disorder
Serotonin Selective Reuptake Inhibitor Treatment of Dual Diagnosis Post-traumatic Stress Disorder and Alcohol Problems
The investigators propose to conduct a clinical trial to evaluate sertraline treatment efficacy in a large sample of military veterans with a dual diagnosis of PTSD and Alcohol Use Disorder who are receiving Cognitive and…
- Trial name
- DDx (NCT02504931)
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Alcohol Drinking, Alcohol-Related Disorders
Effectiveness of a Case Management Intervention for Alcohol Use-Related Problems in Frequent Users of an Emergency Department
Alcohol use and its consequences represent an important public health problem. As well as alcohol dependence, hazardous drinking also contributes to a high burden in terms of morbidity and mortality.
- Trial name
- NCT04219748
- Testing
- Case Management
- Where
- Spain
- Volunteers
- 11 people
- Sponsor
- Hospital Clinic of Barcelona
HIV Infection, Alcohol Use
St. PETERsburg Pain and Alcohol Intervention With Naltrexone and Nalmefene
This study is a randomized controlled trial (RCT) to assess the feasibility, tolerability, and safety of using opioid receptor antagonists (naltrexone and nalmefene) to treat pain among HIV-infected persons with heavy alcohol use…
- Conditions
- HIV Infection, Alcohol Use, Pain
- Trial name
- PETER PAIN (NCT03278886)
- Testing
- Low dose naltrexone, Nalmefene
- Where
- Russia
- Volunteers
- 11 people
- Sponsor
- Boston Medical Center
Posttraumatic Stress Symptom, Alcohol Drinking
Testing the Impact of Thrive App Versions on Alcohol Use and Posttraumatic Stress After Recent Sexual Assault
The goal of this study is to find the most effective and efficient version of the THRIVE app. The THRIVE app is the first app-based preventative intervention that has been found to reduce alcohol misuse and posttraumatic stress…
- Conditions
- Posttraumatic Stress Symptom, Alcohol Drinking, Alcohol Problem
- Trial name
- NCT06444295
- Testing
- Activity scheduling, Cognitive restructuring, Coaching calls
- Where
- United States
- Volunteers
- 464 people
- Sponsor
- University of Washington
Alcohol Use Disorder, Insomnia
Online Cognitive Behavior Therapy for Comorbid Sleep Problems in Alcohol Use Disorder
The main goal is to study the effects of internet-delivered cognitive behavioural therapy with minimum guidance for comorbid sleep problems in alcohol use disorder, in routine addiction care.
- Conditions
- Alcohol Use Disorder, Insomnia, Sleep Disorder, Dyssomnias
- Trial name
- NCT04402619
- Testing
- Cognitive behavior therapy
- Where
- 2 sites in Sweden
- Volunteers
- 25 people
- Sponsor
- Karolinska Institutet
Substance Abuse Problem, Alcohol Abuse
Designing a Mobile App for Veterans With Substance Use Problems
The purpose of this study is to increase access for rural Veterans to evidence-based, person-centered, individually tailored treatment for alcohol use problems.
- Conditions
- Substance Abuse Problem, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT01812187
- Testing
- SHIFT Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michael E. DeBakey VA Medical Center
Adolescent Alcohol Use
Brief Motivational Interviewing +/- Mindfulness Training for Adolescent Alcohol Use in Pediatric Primary Care
Alcohol use is prevalent in U.S. adolescents and contributes to adverse health outcomes in this population. Care for adolescent alcohol use is lacking in most pediatric primary care settings (PPC).
- Trial name
- PCORIMINDSET (NCT07059078)
- Testing
- Brief Motivational Interviewing-based Alcohol Intervention, Smartphone App-delivered Mindfulness Training
- Where
- 13 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Johns Hopkins University
Arthritis, Asthma
Integrating Behavioral Health and Primary Care for Comorbid Behavioral and Medical Problems
Behavioral problems are part of many of the chronic diseases that cause the majority of illness, disability and death. Tobacco, diet, physical inactivity, alcohol, drug abuse, failure to take treatment, sleep problems, anxiety…
- Conditions
- Arthritis, Asthma, Chronic Obstructive Lung Disease, Diabetes
- Trial name
- IBHPC (NCT02868983)
- Testing
- Integration
- Where
- United States
- Volunteers
- 4,025 people
- Sponsor
- University of Vermont
Mental Health, Risk Reduction Behavior
Digital Self-help Support for Lifestyle Behavior Changes Among Primary Care Outpatients With Mental Health Problems
All patients, who have booked a first appointment with a psychologist or counselor at two primary care clinics, are asked to fill out a lifestyle screening questionnaire within the Electronic Medical Record (EMR) system.
- Conditions
- Mental Health, Risk Reduction Behavior, Primary Health Care
- Trial name
- NCT03691116
- Testing
- Digital Health Profile, Treatment as usual
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet