Clinical trials: Alcohol Use
Human Immunodeficiency Virus, Alcohol-Related Disorders
Effectiveness & Implementation of a Behavioral Intervention for Adherence and Substance Use in HIV Care in South Africa
The purpose of this study is to test the effectiveness and implementation of a brief, integrated behavioral intervention for HIV medication adherence and substance use in the HIV care setting in South Africa.
- Conditions
- Human Immunodeficiency Virus, Alcohol-Related Disorders, Drug Use
- Trial name
- NCT03529409
- Testing
- Project Khanya
- Where
- 2 sites in United States, South Africa
- Volunteers
- 66 people
- Sponsor
- University of Maryland, College Park
Suicide, Suicide, Attempted
Drivers of Suicide Mobile App Study
The central purpose of this project is to evaluate and facilitate access to evidence-based best practices for individuals struggling with suicidal ideation and co-occurring behavioral problems, including alcohol misuse, and…
- Conditions
- Suicide, Suicide, Attempted, Suicidal Ideation, Alcohol Use Disorder
- Trial name
- NCT05427734
- Testing
- WisePath for Adults, Active-Control app + electronic wellness resources brochure
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- Evidence-Based Practice Institute, Seattle, WA
Bipolar Disorder, Alcoholism
Aripiprazole for Bipolar Disorder and Alcohol Use Disorder
The investigators will conduct a 12-week, randomized, double-blind, parallel-group, placebo-controlled study of aripiprazole in 132 persons with Alcohol Use Disorder (AUD) and bipolar I or II disorder, currently depressed or…
- Conditions
- Bipolar Disorder, Alcoholism, Alcohol Abuse
- Trial name
- NCT02918370
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Texas Southwestern Medical Center
Alcohol Use Disorders (AUD)
Mifepristone for the Prevention of Relapses of Alcohol Drinking
The goal of this study is to determine if, under stress, alcohol drinking is reduced using mifepristone
- Trial name
- NCT02243709
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Brown University
Alcohol Consumption
Mechanisms for Alcohol Treatment Change [MATCH] Study
A 5-arm randomized trial to determine what components of a text message intervention are necessary to reduce hazardous drinking among young adults and mechanisms through which these changes occur.
- Trial name
- MATCH (NCT02918565)
- Testing
- Drinking Cognition Feedback (DCF), Alcohol Risk Feedback (ARF), Adaptive Goal Support (AGS)
- Where
- United States
- Volunteers
- 1,131 people
- Sponsor
- University of Pittsburgh
AOD Use, Abuse, and Dependence
Intranasal Oxytocin and Social Cognition, Implicit Preferences and Craving in Alcohol Drinkers
This is a randomized, placebo controlled, double blind crossover study of the effects of intranasal oxytocin on social cognition, implicit preferences and craving in moderate to heavy social alcohol drinkers.
- Trial name
- NCT01829516
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol Consumption
Network Support for Alcohol Treatment 2
The Network Support project is part of an ongoing effort to improve treatment for alcohol dependent patients. The Network Support Project is designed to help patients change their social network from one that reinforces drinking…
- Trial name
- NCT01129804
- Testing
- Coping Skills Training
- Where
- United States
- Volunteers
- 193 people
- Sponsor
- UConn Health
Alcohol Consumption
Effect of Heavy Alcohol Consumption on Farnesoid X Receptor (FXR) Signaling
The main purpose of this study is to see whether heavy drinking will interfere with a specific pathway, called FXR signaling in the liver.
- Trial name
- NCT02654236
- Testing
- 10 mg Obeticholic Acid (OCA)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Suthat Liangpunsakul
Alcohol Use Disorder (AUD)
Brain Network Modulation and Alcohol Use
The investigators will use real-time fMRI neurofeedback to enhance participants' ability to control their ability to modulate alcohol valuation.
- Trial name
- RP2B (NCT04828577)
- Testing
- Real Time Neurofeedback
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Alcohol Use Disorder
Effects of Cannabidiol in Alcohol Use Disorder
The goal of the proposed project is to begin rigorous study of the clinically relevant effects of non-psychoactive phytocannabinoid cannabidiol (CBD) in patients with severe alcohol use disorder (AUD).
- Trial name
- NCT03252756
- Testing
- Phytocannabinoid cannabidiol (CBD)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- NYU Langone Health
Alcohol Use Disorder, Severe
Inpatient Single Dose Interventions for Alcohol Use Disorder
Every year, alcohol use disorder (AUD) generates millions of emergency department (ED) visits and hospital admissions, costing the U.S. health sector over $90 billion.
- Trial name
- NCT04562779
- Testing
- Naltrexone 380 MG, Ketamine Hydrochloride, Enhanced linkage
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Denver Health and Hospital Authority
Fetal Alcohol Spectrum Disorders
The Trajectory of Fetal Alcohol Spectrum Disorders (FASD) Across the Life Span: Continuing Prevention and Longitudinal Epidemiology
Screen women of childbearing age (15 - 44 years) for high risk drinking in antenatal clinics of the established research sites in the Western Cape Province of South Africa (SA).
- Trial name
- NCT04026620
- Testing
- Informational Pamphlet, Brief Motivational Enhancement Therapy (MET) Session
- Where
- South Africa
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Alcohol Use Disorder, Alcohol Misuse
Intranasal Oxytocin for the Treatment of Alcohol Use Disorder
Primary: The primary objective of the study is to compare the efficacy of intranasal oxytocin in reducing the weekly percentage of heavy drinking days over the 10 weeks of maintenance treatment among subjects with moderate to…
- Trial name
- NCT03878316
- Testing
- Instranasal Oxytocin
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Adolescent Drinking, Adolescent Problem Behavior
Mindfulness Mobile App to Reduce Adolescent Substance Use
Substance-abusing youth - especially those who are involved in the juvenile justice system - are at higher risk than nonusers for mental health problems, including depression, conduct problems, personality disorders, suicidal…
- Trial name
- Qlarity (NCT04027075)
- Testing
- Qlarity app users
- Where
- United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Alcohol Use Disorder, Posttraumatic Stress Disorder
Adapting and Piloting Behavioral Activation for Veterans With Alcohol Use Disorder and Posttraumatic Stress Disorder
The goal of this clinical trial is to compare an adaptation of Behavioral Activation, a behavioral intervention, to Relapse Prevention treatment, another behavioral intervention, in a sample of U.S.
- Trial name
- NCT06249386
- Testing
- Behavioral Activation (BA), Relapse Prevention (RP)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- RTI International
Alcohol Drinking
Imaging Glutamate Release From Alcohol
The goal of this research project is to determine the sensitivity of PET radioligands specific for targets in the glutamate system to an alcohol challenge.
- Trial name
- NCT04159688
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Use Disorder, PTSD
Cognitive Remediation for Alcohol Use Disorder and Posttraumatic Stress Disorder
The project will examine whether a computerized neuroscience-based cognitive training program can improve cognitive functioning and recovery outcomes among Veterans with Alcohol Use Disorder and co-occurring PTSD.
- Conditions
- Alcohol Use Disorder, PTSD, Cognitive Dysfunction
- Trial name
- NCT02929979
- Testing
- Cognitive Training
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alcohol-related Disorders, Post-traumatic Stress Disorder
Couple-Based Treatment for Alcohol Use Disorders and Post-Traumatic Stress Disorder
The purpose of this study is to develop and test a couple-based treatment for Veterans with an alcohol use disorder and post-traumatic stress disorder.
- Trial name
- CTAP (NCT00946322)
- Testing
- Couple-Based Treatment for Alcohol Use Disorders and PTSD
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- VA Office of Research and Development
Sexual Assault, College Drinking
Protecting Allies in Risky Situations
The current project will provide testing of a friend-based motivational interview (FMI) designed to reduce sexual assault risk. The study will address if the intervention minimizes the impact of alcohol on helping behavior, test…
- Conditions
- Sexual Assault, College Drinking, Behavioral Changes
- Trial name
- PAIRS (NCT04691492)
- Testing
- Friend-Based Motivational Interview
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Drug Use Disorders, Illicit Drug Use
An Initial Study of the Implementation of Digital Therapeutics for Substance Use Disorders in Primary Care
The DIGITS Trial addresses a critical knowledge gap: How to best implement digital treatments for opioids and other substance use disorders in primary care.
- Conditions
- Drug Use Disorders, Illicit Drug Use, Alcohol-Related Disorders
- Trial name
- DIGITS Pilot (NCT04907045)
- Testing
- Health Coaching, Practice Facilitation, Standard Implementation
- Where
- United States
- Volunteers
- 1,552 people
- Sponsor
- Kaiser Permanente