Clinical trials: Alcohol Use, open to volunteers
Opioid Use Disorder
Brief Digitally-Enhanced Intervention for Reducing Alcohol Use During MOUD
The goal of this clinical trial is to reduce heavy drinking and enhance medication for opioid use disorder (MOUD) outcomes in individuals receiving MOUD.
- Trial name
- NCT06718491
- Testing
- Managing Physical Reactions to Overwhelming Emotions (IMPROVE), Health Education Training (HET)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ohio State University
Alcohol Use Disorder
Pilot Study: Effects of Nimodipine on Alcohol Drinking
This is an open label trial aiming to recruit 5 non-treatment seeking adults with Alcohol Use Disorder. All will participate in an alcohol drinking paradigm (ADP) lab session at the Hospital Research Unit (HRU) at Yale-New Haven…
- Trial name
- NCT06900998
- Testing
- Nimodipine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Yale University
Effectiveness of Screening and Brief-Intervention, Unhealthy Alcohol Use
Screening and Brief-Intervention of Post-war Alcohol Consumption in Public Hospital Outpatients
Background: High prevalence of alcohol-consumption among conflict-affected population has been reported in some low-and-middle income countries.
- Trial name
- NCT06918106
- Testing
- Simple advice, Brief-counseling and brochure
- Where
- Ethiopia
- Volunteers
- 262 people
- Sponsor
- Aksum University
Alcohol Use Disorder
Guanfacine for Alcohol Use Disorder (AUD)
The investigators assess whether guanfacine extended release (GXR; 3mg/d) compared with placebo (PBO) will attenuate drinking and drinking-related factors in N=200 men and women with Alcohol Use Disorder (AUD) across 12-weeks.
- Trial name
- NCT06629259
- Testing
- Guanfacine Extended Release (XR)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Indiana University
Alcohol Use Disorder
Motivation for IV Alcohol Self-Administration in Humans
The goal of this translational study is to understand different reasons why people between the ages of 21 and 65 with alcohol use disorder are motivated to self-administer alcohol.
- Trial name
- NCT06494891
- Testing
- Intravenous Alcohol
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- University of California, Los Angeles
Alcohol Use Disorder, Insomnia
Daridorexant for People With Insomnia and Alcohol Use Disorder Study
The goal of this clinical trial is to see if a sleep medication, daridorexant (DTX), can help decrease drinking in people who have alcohol use disorder (AUD) and insomnia.
- Trial name
- DIAS (NCT07701928)
- Testing
- Daridorexant, Brief Counseling, MEMS and Medication Accounting
- Where
- United States
- Volunteers
- 205 people
- Sponsor
- Sterling McPherson
Alcohol Use Disorder (AUD)
Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)
Background: Glucagon-like peptide 1 (GLP-1) agonist drugs are used to treat diabetes and aid weight loss. They may also help reduce cravings for drugs and alcohol.
- Trial name
- NCT07559500
- Testing
- Tirzepatide, [11C]raclopride plus drug, [11C]NNC-112
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder (AUD)
Process-Based Psychological Processes in Alcohol Use Disorder: A Case-Control Study Using PBAT, PHQ-9, and GAD-7
This observational study investigates differences in psychological processes and emotional symptoms between individuals with Alcohol Use Disorder (AUD) and a non-clinical control group. PBAT, PHQ-9, and GAD-7 will be used.
- Trial name
- PBAT Addiction (NCT07551830)
- Where
- Romania
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
High Intensity Use of Urgent and Emergency Care, Emergency Medicine
High Intensity Use of Urgent and Emergency Care: A Mixed-Methods Study
This study aims to understand the health and social care needs and experiences of adults who frequently use urgent and emergency care services in Dorset.
- Conditions
- High Intensity Use of Urgent and Emergency Care, Emergency Medicine, Health Inequalities, Mental Health
- Trial name
- NCT07630012
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bournemouth University
Alcohol Use Disorder
A Study of Brenipatide in Participants With Alcohol Use Disorder
The purpose of this study is to see if brenipatide when compared to a placebo works and is safe for participants with Alcohol Use Disorder (AUD) and hazardous alcohol use.
- Trial name
- RENEW-ALC-2 (NCT07219953)
- Testing
- LY3537031
- Where
- 115 sites in United States, Belgium and 6 more
- Volunteers
- 1,100 people
- Sponsor
- Eli Lilly and Company
Alcohol Abuse, Substance Use
Adaptation and Evaluation of Bright Horizons
This study will test if a program called 'Bright Horizons' is effective at reducing binge substance use among adolescents. Bright Horizons is a culturally adapted intervention developed and tested through a partnership between…
- Trial name
- NCT05743699
- Testing
- Bright Horizons, Case Management
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Healthy Volunteers
PK and Onset of Hezkue Oral Sildenafil Suspension After Alcohol Consumption
This is an open-label, randomized study evaluating the pharmacokinetics and onset performance of Hezkue® oral sildenafil suspension administered following moderate alcohol consumption in healthy adult subjects.
- Trial name
- NCT07302698
- Testing
- Hezkue Oral Sildenafil Suspension
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aspargo Labs, Inc
Alcohol Use Disorder, Stress Reaction
Neurobehavioral Profiles of Adaptive Stress Responses in Individuals With Alcohol Use Disorder
The goal of this observational study is to investigate longitudinal stress response profiles and adaptive versus non-adaptive stress responses in alcohol use disorder.
- Conditions
- Alcohol Use Disorder, Stress Reaction, Social Stress, Craving
- Trial name
- A03 (NCT06105853)
- Testing
- Trier Social Stress Test, Barlab Cue-Exposure, Functional magnetic resonance imaging
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Alcohol Consumption, Heavy Drinker
Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers
The purpose of this research study is to find out about the effects of a drug called mavoglurant on alcohol consumption.
- Conditions
- Alcohol Consumption, Heavy Drinker, Alcohol Use Disorder (AUD)
- Trial name
- NCT06136195
- Testing
- Mavoglurant
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Yale University
HIV, Alcohol Consumption
Mentor Moms+ Study
The goal of this study is to adapt an existing evidence based intervention for use in pregnant and lactating people (PLP) who use alcohol.
- Trial name
- (MM+) (NCT06962592)
- Testing
- MM+, Enhanced HIV attention control (eSOC)
- Where
- 2 sites in South Africa
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Alcohol Drinking, Cannabis Use
Cannabis' Impact on Alcohol Consumption
This study employs a repeated measures experimental design to examine the effect of THC-dominant dose of cannabis and CBD-dominant dose of cannabis, relative to placebo, on subsequent drinking in an alcohol choice task in which…
- Conditions
- Alcohol Drinking, Cannabis Use, Cannabis, Alcohol Use Disorder
- Trial name
- NCT05389930
- Testing
- THC-dominant cannabis, CBD-dominant cannabis, Alcohol
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Brown University
Drinking, Alcohol
Influence of TMS on Attention Modulation
The purpose of this study is to help understand how attention processes influence brain engagement during emotion and social cognition. The investigators also want to know if these processes are associated with drinking alcohol.
- Trial name
- TAM (NCT05611502)
- Testing
- TMS
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Auburn University
Addiction, Substance, Alcohol Use Disorder
Validation of the French Version of the Prediction of the Alcohol Withdrawal Severity Scale (PAWSS)
The goal of this observational study is to validate the French version of the PAWSS scale in a population of patients with Alcohol Use Disorders.
- Conditions
- Addiction, Substance, Alcohol Use Disorder, Alcohol Dependence, Alcohol Withdrawal
- Trial name
- PAWSS-VF (NCT06675539)
- Testing
- French version PAWSS
- Where
- France
- Volunteers
- 545 people
- Sponsor
- Etablissement Public de Santé Barthélemy Durand
Heavy Drinking
Exploring the Effects of Brief Mindfulness Training With Vagal Nerve Stimulation on Alcohol Cue Reactivity Among Young Adult Heavy Drinkers
The present study will assess the acceptability and feasibility of a brief intervention designed to help young heavy drinkers reduce their alcohol consumption.
- Trial name
- NCT07516873
- Testing
- Active RAVANS, Brief Mindfulness-Based Intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Cambridge Health Alliance
Chronic Liver Disease, Alcohol Use Disorder
Nottingham Community Liver Biomarkers Cohort
Deaths due to advanced liver scarring (liver cirrhosis) continue to increase, and liver disease is now the 3rd leading cause of premature death in the United Kingdom.
- Conditions
- Chronic Liver Disease, Alcohol Use Disorder, Type 2 Diabetes, Persistently Elevated ALT
- Trial name
- NCT02037867
- Testing
- Fibrosis Biomarkers
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- University of Nottingham