Clinical trials: Alcohol Use, active
Alcohol Drinking, Opioid Use
Targeting Alcohol-Opioid Co-Use Among Young Adults Using a Novel MHealth Intervention
The goal of this treatment development project is to develop and pilot an adaptive mobile health (mHealth) intervention that targets the co-use of alcohol and opioids in young adults.
- Trial name
- NCT07663448
- Testing
- mHealth Intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brown University
Sexual Behavior, Alcohol Drinking
Young Adult Education on Alcohol & Health
The goal of this clinical trial is to test the effectiveness of our brief online program when compared to those who don't complete the program at all.
- Conditions
- Sexual Behavior, Alcohol Drinking, Condomless Sex
- Trial name
- NCT05620849
- Testing
- Online program
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV (Human Immunodeficiency Virus), Alcohol Misuse
PNF RCT to Decrease Alcohol Use and Increase HIV Prevention
Randomized controlled trial to test the preliminary efficacy and mediating mechanism of a personalized normative feedback intervention on behavioral intentions, heavy alcohol use, and HIV/STI prevention among adolescents and…
- Conditions
- HIV (Human Immunodeficiency Virus), Alcohol Misuse, STI
- Trial name
- NCT07731932
- Testing
- PNF - HIV norms, PNF - Alcohol use norms, PNF - HIV and alcohol use norms
- Where
- Uganda
- Volunteers
- 1,350 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Alcohol Misuse, Cannabis Misuse
Substance Use in Assault-Injured Young Adults
This study aims to improve a short motivational conversation to better help young adults who were injured in assaults and also use alcohol or cannabis.
- Trial name
- NCT07070414
- Testing
- Brief Negotiation Interview intervention (BNI) (adapted)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Sleep, Alcohol Misuse
Mechanisms of Cannabidiol and Sleep in the Context of Alcohol Use
The goal of this clinical trial is to learn if cannabidiol helps to improve sleep and decrease alcohol use. It will also learn about the safety of cannabidiol.
- Trial name
- CALM (NCT07527338)
- Testing
- Cannabidiol
- Volunteers
- 58 people
- Sponsor
- University of Colorado, Boulder
Dual Diagnosis, Risk Youth
Virtual Reality (VR-GINSO) as an Complement to Intervention for Alcohol and Cannabis Use in Youth in Residential Care
The goal of this RCT is to evaluate the effects of a virtual reality intervention on self-efficacy regarding alcohol and cannabis use among at-risk youth in various residential mental health treatment centers who have…
- Conditions
- Dual Diagnosis, Risk Youth, Antisocial Behavior
- Trial name
- VR-GINSO (NCT07834606)
- Testing
- Virtual Reality, Treatment as Usual (TAU)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Universidad Francisco de Vitoria
Alcohol Abuse, Craving
Using Neurofeedback to Understand the Relationship Between Stress and Alcohol Consumption
In this research project, the aim is to discover the role specific brain networks play in the relationship between stress reactions and the desire for alcohol and alcohol consumption.
- Conditions
- Alcohol Abuse, Craving, Psychosocial Stressor, Neural Stress Response
- Trial name
- NeuStress (NCT06247306)
- Testing
- ScanSTRESS fMRI-paradigm (Streit et al., 2014), real-time fMRI neurofeedback
- Where
- Germany
- Volunteers
- 102 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Suvorexant for Treatment of AUD and PTSD
This study is to determine if suvorexant (SUV) will reduce insomnia in 76 men and women veteran and non-veterans between the ages 21-65 with posttraumatic stress disorder (PTSD) symptoms and alcohol use disorder (AUD).
- Conditions
- Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD), Insomnia
- Trial name
- SUV (NCT06679062)
- Testing
- Suvorexant
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Alcohol Use Disorder (AUD)
LSD Treatment for Persons With Alcohol Use Disorder
Lysergic acid diethylamide (LSD) was investigated in numerous clinical trials during the 1950s and 1960s. Specifically, the use of LSD in the treatment of AUD was investigated extensively.
- Trial name
- LYTA (NCT05474989)
- Testing
- LSD
- Where
- 2 sites in Switzerland
- Volunteers
- 128 people
- Sponsor
- Felix Mueller
Alcohol Use Disorder
Emergency Department-Initiated Medications for Alcohol Use Disorder
The proposed study will be the first randomized clinical trial to evaluate a comprehensive Emergency Department (ED)-based intervention for moderate to severe Alcohol Use Disorder (AUD) combining Screening, Brief Intervention and…
- Trial name
- NCT05827159
- Testing
- Naltrexone Pill, Naltrexone Injection, Brief Negotiation Interview
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Yale University
Alcohol Drinking, Sexual Violence
Motivations, Attitudes, and Perceptions Study
The goal of this clinical trial is to compare the impact of providing participants with 1. A recently developed protocol for motivating bystanders to intervene to help others who are in sexual risk situations…
- Conditions
- Alcohol Drinking, Sexual Violence, Social Norms
- Trial name
- MAP (NCT05873413)
- Testing
- Motivate-the-Bystander, Motivate-the-Bystander+Alcohol, Attention-only Control
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Alcohol Use
Mechanistic Evaluation of Guanfacine on Drinking Behavior in Women and Men With Alcohol Use Disorders
For this protocol, the investigators plan to collect pilot data to examine sex differences in guanfacine's effect on 1) counteracting stress and stimulation based drinking behavior in the laboratory and 2) improving clinical…
- Trial name
- NCT03764098
- Testing
- Guanfacine ER
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Yale University
Mental Health
Trial Phase: Syndemic Adapted Medly Uganda
The purpose of this study is to evaluate the effectiveness of the Syndemic-Adapted Medly Uganda (SAMU) in improving mental health care among adults living with HIV and hypertension in Uganda.
- Trial name
- SAMU (NCT07525271)
- Testing
- Syndemic-Adapted Medly Uganda (SAMU)
- Where
- 3 sites in Uganda
- Volunteers
- 1,500 people
- Sponsor
- Yale University
Alcohol Use Disorder
Psilocybin-Assisted vs Ketamine-Assisted Psychotherapy for Alcohol Use Disorder
This pilot study will collect preliminary data that measures the effects of psilocybin-assisted psychotherapy vs ketamine-assisted psychotherapy on patients struggling with alcohol use.
- Trial name
- NCT05421065
- Testing
- Psilocybin, Ketamine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Peggy C Nopoulos
Alcohol Use Disorder (AUD)
Study of Tirzepatide for Recovery and Alcohol Use Management
This is a pilot, 4-week, double-blind, placebo-controlled, randomized trial of individuals with alcohol use disorder (AUD) to receive weekly injections of either tirzepatide (n=10) or matching placebo (n=10).
- Trial name
- STREAM (NCT06727331)
- Testing
- Tirzepatide
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Alcohol Drinking
Effects of Stereotype Threat on Impulsivity and Its Relation to Alcohol Use in African Americans: An fMRI Study
The purpose of this study is to investigate the behavioral and neural correlates of stress exposure. Results from this study will enrich the understanding of how sociocultural, behavioral, and neural factors combine to influence…
- Trial name
- NCT05675332
- Testing
- Task-based behavioral intervention
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Risky Health Behavior, Substance Use Disorders
The STop UNhealthy Substance Use Now Trial
The STop UNhealthy (STUN) Substance Use Now Trial (STUN II) is a multisite trial aiming to evaluate the comparative effectiveness of the following strategies for improving the implementation of screening and interventions for…
- Conditions
- Risky Health Behavior, Substance Use Disorders, Substance Abuse, Alcohol Use Disorder
- Trial name
- STUN II (NCT06524232)
- Testing
- Practice Facilitation (PF), Learning Collaborative (LC), Performance Incentives (PI)
- Where
- 3 sites in United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Chronic Pain, Unhealthy Alcohol Use
Integrated Digital Health Approach to Reduce Hazardous Alcohol Use and Chronic Pain Among Rural Populations
The current proposal seeks to test the benefit of a brief intervention combined with a digital program delivered though a smartphone app for reducing chronic pain and hazardous drinking among those in rural settings.
- Trial name
- NCT07804914
- Testing
- Mobile Intervention for Alcohol and Pain, Control Intervention
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Boston University Charles River Campus
Alcohol Use, Unspecified, Substance Use
ANCHORS Alcohol & Sexual Health Study: UH3 Project
80 young adult men will complete an initial survey and receive 1 of 2 types of alcohol and sexual health education and information to encourage prevention of alcohol-related problems, HIV and other sexually transmitted infections…
- Conditions
- Alcohol Use, Unspecified, Substance Use, Sex Behavior
- Trial name
- NCT04331704
- Testing
- PrEP acronym (pre-exposure prophylaxis), Initial Web Survey, Interactive Voice Response (IVR) monitoring
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Florida
Alcohol Use Disorder, Alcoholism
Naltrexone in AUD Reward Drinkers
This study is a phase IV, two-arm, randomized, double-blind, placebo-controlled study to assess whether individuals identified as primarily reward drinkers are significantly more likely to reduce heavy drinking if they receive…
- Trial name
- NCT05028062
- Testing
- XR-NTX 380 mg, intramuscular injection, Medical Management
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania