Clinical trials: Alcohol Use Disorder
Sexually Transmitted Infection, Alcohol Use Complicating the Puerperium
Technology-Based Intervention for Reducing Sexually Transmitted Infections and Substance Use During Pregnancy
This proposed study is to test whether Health Check-up for Expectant Moms (HCEM), a computer-delivered screening and brief intervention (SBI) that simultaneously targets sexually transmitted infection (STI) risk and alcohol/drug…
- Conditions
- Sexually Transmitted Infection, Alcohol Use Complicating the Puerperium, Alcohol Use Complicating Pregnancy, Unspecified Trimester, Drug Use
- Trial name
- NCT03826342
- Testing
- Health Check-up for Expectant Moms, Time, attention, and information-matched control
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Michigan
Alcohol Use Disorder
Effectiveness of Zonisamide in Alcohol Dependent Veterans
This is a randomized, placebo-controlled, double-blind, 16 week trial of the medication zonisamide for the treatment of heavy drinking alcoholic Veterans.
- Trial name
- NCT02368431
- Testing
- Zonisamide
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder, Post Traumatic Stress Disorder
Cannabidiol as a Treatment for AUD Comorbid With PTSD
This project aims to determine whether cannabidiol (CBD), a compound derived from the cannabis plant, is effective in treating alcohol use disorder (AUD) in individuals with comorbid posttraumatic stress disorder (PTSD).
- Trial name
- NCT03248167
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- NYU Langone Health
Alcohol Drinking, Alcohol Intoxication
Family Based Prevention of Alcohol and Risky Sex for Older Teens
An online, interactive web-based program for older teens and their parents is designed to address teen alcohol use and teen relationships.
- Conditions
- Alcohol Drinking, Alcohol Intoxication, Alcohol Poison, Alcohol-Related Disorders
- Trial name
- NCT03521115
- Testing
- Smart Choices 4 Teens
- Where
- United States
- Volunteers
- 411 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation
Alcohol and Substance-Related Mental Disorders
Effectiveness of an Evidence-based Stepped Care System for Alcohol and Other Drug Use Problems Among Congolese Refugees in Zambia
This is a randomized controlled trial (RCT) evaluating the effectiveness of a screening, brief intervention, and referral to treatment (SBIRT) stepped-care system in reducing unhealthy AOD use among Congolese refugees and the…
- Trial name
- NCT05471921
- Testing
- SBIRT, Treatment as usual
- Where
- 2 sites in United States, Zambia
- Volunteers
- 400 people
- Sponsor
- Columbia University
Alcohol; Harmful Use, Binge Drinking
Computerized Brief Alcohol Intervention (BI) for Binge Drinking HIV At-Risk and Infected Women
African American (AA) women are disproportionately affected by HIV/AIDs. The major risk factor for HIV acquisition among AA women is high-risk heterosexual sex, including unprotected vaginal and anal sex, and sex with a high-risk…
- Conditions
- Alcohol; Harmful Use, Binge Drinking, Risk Behavior, HIV Infection
- Trial name
- NCT01125371
- Testing
- Computerized brief alcohol intervention + IVR booster calls, Computerized brief alcohol intervention, Attention Control
- Where
- United States
- Volunteers
- 439 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tobacco Use Cessation, Alcohol-related Disorders
Concurrent Alcohol and Smoking Treatment: Effects on Alcohol Relapse Risk
The majority of individuals with alcohol problems remain current smokers, and the negative health consequences of smoking among these individuals are substantial.
- Trial name
- NCT00861146
- Testing
- behavioral counseling plus contingency management
- Where
- 2 sites in United States
- Volunteers
- 151 people
- Sponsor
- Yale University
Alcohol Use Disorder
Pioglitazone for the Treatment of Alcohol Use Disorder
Alcohol Use Disorder (AUD) is common among Veterans but medication treatment is used infrequently and the impact of these treatments are small to moderate at best.
- Trial name
- PAUSE (NCT03864146)
- Testing
- Brief Behavioral Compliance Enhancement Treatment
- Where
- 2 sites in United States
- Volunteers
- 201 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder
Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy
The purpose of this study is to evaluate the safety and efficacy of dutasteride in reducing drinking and heavy drinking in men and women with alcohol use disorder.
- Trial name
- NCT04098302
- Testing
- Dutasteride Capsules
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- UConn Health
Alcohol Drinking, Alcohol Use Disorder
Understanding Alcohol Reward in Social Context
In this study, the investigators examine whether emotional and social reward from alcohol varies depending on the social context of consumption.
- Conditions
- Alcohol Drinking, Alcohol Use Disorder, Alcohol Intoxication, Alcohol; Harmful Use
- Trial name
- NCT03449095
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
PTSD, Alcohol Use Disorder
BioWare for AUD and PTSD
This study examines the ability of an innovative telehealth technology system to enhance Concurrent Treatment of PTSD and Substance Use Disorders using Prolonged Exposure (COPE) talk-therapy for individuals with posttraumatic…
- Trial name
- NCT05187364
- Testing
- COPE
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Medical University of South Carolina
Hazardous Alcohol Use
PrEP and Alcohol - Enhancing HIV Pre-Exposure Prophylaxis (PrEP)
The present investigation entails a pilot randomized controlled trial to explore whether a stand-alone, alcohol-reduction, brief intervention (with a module on substance use and depression) would be feasible, acceptable, and…
- Trial name
- NCT05097430
- Testing
- Alcohol-focused brief intervention
- Where
- 3 sites in Canada
- Volunteers
- 122 people
- Sponsor
- Centre for Addiction and Mental Health
Alcoholism
The Effects of Topiramate on Alcohol Use in Alcohol Dependent Subjects
This investigation will assess the effectiveness of topiramate in reducing ethanol consumption by alcohol dependent subjects. It also will seek to establish whether topiramate can be safely used in this population including…
- Trial name
- NCT00329407
- Testing
- Topiramate (Topamax)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Boston University
Acquired Immunodeficiency Syndrome, HIV/AIDS
Technological Intervention for Reducing Alcohol Use Among People Living With HIV/AIDS
While advances in medication have led to greatly improved outcomes for people living with HIV/AIDS, less than one-third of all people living with the disease are adherent enough to their medication to achieve viral suppression.
- Conditions
- Acquired Immunodeficiency Syndrome, HIV/AIDS, Alcohol Drinking
- Trial name
- TRAC (NCT03746600)
- Testing
- Project TRAC: Tracking and Reducing Alcohol Consumption
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Carolyn Lauckner
Alcohol Use Disorder, Inflammatory Response
An Inflammatory Challenge Using Endotoxin
The study design consists of a randomized, double-blind, placebo-controlled trial of low dose endotoxin. The low dose endotoxin challenge induces a transient systemic inflammatory response with normalization of cytokine levels…
- Conditions
- Alcohol Use Disorder, Inflammatory Response, Craving, Depressed Mood
- Trial name
- NCT04310423
- Testing
- Endotoxin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Bipolar Disorder, Alcohol Use Disorder
Ondansetron for Bipolar Disorder and Alcohol Use Disorders
The purpose of the study is to determine if ondansetron, as an add-on therapy, is associated with reduced depressive symptoms and alcohol use in outpatients with bipolar disorder (BPD), cyclothymic disorder, schizoaffective…
- Conditions
- Bipolar Disorder, Alcohol Use Disorder, Dual Diagnosis
- Trial name
- NCT02082678
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Texas Southwestern Medical Center
Cocaine-Related Disorders, Opioid-Related Disorders
The Therapeutic Workplace Initiation Study
The primary purpose of the study is to determine if the central feature of the Therapeutic Workplace, the abstinence reinforcement contingency, is critical to initiate cocaine abstinence in injection drug using methadone patients…
- Conditions
- Cocaine-Related Disorders, Opioid-Related Disorders, Heroin Dependence, Substance Abuse, Intravenous
- Trial name
- NCT00249470
- Testing
- Abstinence & Work, Work Only
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Johns Hopkins University
Posttraumatic Stress Disorder, Depression
Trauma Survivors Outcomes and Support Study IV
After traumatic injuries some people have difficulty returning to the routine of their everyday activities and may experience physical and emotional pain.
- Conditions
- Posttraumatic Stress Disorder, Depression, Suicide, Traumatic Brain Injury
- Trial name
- TSOS IV (NCT01625416)
- Testing
- Stepped Care Management
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- University of Washington
Alcohol Abuse, Alcohol Dependence
Ondansetron, Alcohol Use, and Alcohol-Related Symptoms In HIV+ Persons
The proposed randomized clinical trial will investigate a novel pharmacotherapy for hazardous drinking, HIV-infected men and women, using the serotonin receptor (5-HT3) antagonist ondansetron.
- Trial name
- NCT01254877
- Testing
- ondansetron
- Where
- United States
- Volunteers
- 357 people
- Sponsor
- Johns Hopkins University
Nicotine Dependence, Smoking
Varenicline for Smoking Cessation in Heavy Drinking Smokers
The purpose of this study is to determine whether extended pretreatment with varenicline (Chantix) is more efficacious for smoking cessation than standard pretreatment, how well varenicline is tolerated in heavy drinking smokers…
- Conditions
- Nicotine Dependence, Smoking, Heavy Drinking
- Trial name
- NCT00860028
- Testing
- Extended Varenicline Pretreatment, Short-term Varenicline Pretreatment
- Volunteers
- 30 people
- Sponsor
- Yale University