Clinical trials: Alcohol Use Disorder, open to volunteers
Alcohol Use Disorder
Towards a Targeted Ultrasound Neuromodulation Intervention for Alcohol Abuse Disorders
This study explores the potential of transcranial ultrasound stimulation (TUS) as an innovative therapeutic approach for individuals with Alcohol Use Disorder.
- Trial name
- TUS-AUD (NCT06894966)
- Testing
- low intensity transcranial focused ultrasound stimulation (TUS)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Plymouth
Alcohol Use Disorder, Alcohol Withdrawal
Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder
The goal of this clinical trial is to learn the effects of ketone supplement compared to placebo on alcohol withdrawal symptoms during a 4 day alcohol withdrawal management treatment in adults with moderate to severe alcohol use…
- Conditions
- Alcohol Use Disorder, Alcohol Withdrawal, Ketosis
- Trial name
- KSAW (NCT06559995)
- Testing
- ketone supplement "D-beta-hydroxybutryric acid and R-1,3 butanediol" 12g of ketones,, magnetic resonance imaging session
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Bipolar Disorder, Alcohol Use Disorder
N-Acetylcysteine for Bipolar and Alcohol Use Disorders
This study will evaluate N-acetylcysteine (NAC) in adults with bipolar disorder and alcohol use disorder. Participants will be randomly assigned to receive NAC or matched placebo for 28 days.
- Trial name
- NCT07913542
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Medical University of South Carolina
Substance-Related Disorders
The Road to Recovery Initiative (R2RI)
Despite substance use causing significant harms and cost to our health care system, British Columbia's (BC) current addiction treatment system remains under-resourced and fragmented.
- Trial name
- R2RI (NCT06639373)
- Testing
- Specialized clinical service access
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- BC Centre on Substance Use
Alcohol Use Disorder (AUD)
LSD Treatment for Persons With Alcohol Use Disorder
Lysergic acid diethylamide (LSD) was investigated in numerous clinical trials during the 1950s and 1960s. Specifically, the use of LSD in the treatment of AUD was investigated extensively.
- Trial name
- LYTA (NCT05474989)
- Testing
- LSD
- Where
- 2 sites in Switzerland
- Volunteers
- 128 people
- Sponsor
- Felix Mueller
Liver Transplant Recipient, Alcohol Use Disorders (AUD)
Intervention for Alcohol Use Disorder Recovery After Liver Transplantation
The goal of this clinical trial is to learn if it is feasible and acceptable to use a recovery coach and an online sober active community to help with alcohol use disorder after liver transplant.
- Trial name
- ILTARP (NCT07214259)
- Testing
- Online Sober Active Community, Recovery coach
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Leigh Anne Dageforde
Alcohol Use Disorder, Cannabis Use Disorder
Phenotyping Patients With Alcohol and Cannabis Use Disorders Using the Addictions Neuroclinical Assessment
This 2-arm study will recruit participants with 1) alcohol use disorder and 2) cannabis use disorder for a 12-week cognitive behavioral therapy, following a thorough baseline assessments on executive function, incentive salience…
- Trial name
- NCT05855668
- Testing
- CBT
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- Centre for Addiction and Mental Health
Opioid Use Disorder, Overdose, Drug
The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study
The goal of this clinical trial is to develop and test the CROSSROADS intervention. CROSSROADS is designed for people who have recently survived an opioid and/or stimulant-related non-fatal overdose and had contact with staff…
- Conditions
- Opioid Use Disorder, Overdose, Drug, Overdose, Substance Use (Drugs, Alcohol)
- Trial name
- CROSSROADS (NCT07216963)
- Testing
- Community Paramedic Standard of Care (CP SOC), CROSSROADS
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- Duke University
Alcohol Withdrawal, Alcohol Abstinence
Intravenous Acetate as an Adjunctive Treatment for Alcohol Withdrawal in Hospitalized Patients
Alcohol withdrawal syndrome is a highly morbid condition affecting a substantial percentage of patients hospitalized who have alcohol use disorders, estimated at 5-6% of all hospitalized patients.
- Conditions
- Alcohol Withdrawal, Alcohol Abstinence, Alcohol Use Disorder
- Trial name
- NCT07810946
- Testing
- Sodium Acetate
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Colorado, Denver
Hiv, Alcohol Use, Unspecified
Practice Facilitation as a Strategy to Improve Alcohol Treatment Adoption and Implementation in HIV Care
Despite availability of evidence-based alcohol reduction interventions (EBI), unhealthy alcohol use remains a barrier to HIV medication adherence, viral suppression and retention in HIV care and consequently HIV treatment as…
- Trial name
- NCT05241990
- Testing
- Practice Facilitation, Alcohol Stepped Care
- Where
- 3 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Alcohol Use Disorder
Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)
Background: Phosphodiesterase-4B (PDE4B) is a protein in the brain that may play a role in several mental health disorders. Researchers want to know if drinking alcohol increases the binding of a radioactive tracer to PDE4B in…
- Trial name
- NCT07027839
- Testing
- Intravenous Ethanol, 18F-PF-06445974
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression - Major Depressive Disorder, Schizophenia Disorder
A Novel Blood Test as a Biomarker in Mental Health
This longitudinal, observational study aims to assess whether the characteristics of a novel blood peripheral biomarker can serve as indicators for depression and schizophrenia in patients at the Royal Columbian Hospital…
- Conditions
- Depression - Major Depressive Disorder, Schizophenia Disorder, Psychosis, Mania (Neurotic)
- Trial name
- LEADING-MH (NCT06856161)
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Fraser Health
Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD)
Ketamine-Enhanced Therapy for Individuals With Alcohol Use Disorder and Depression: A Pilot Study (KET-DUAL)
To assess the safety, feasibility and preliminary efficacy of ketamine-enhanced therapy (KET) for alcohol use disorder (AUD) and comorbid major depressive disorder (MDD) in an open-label, single arm, pilot clinical trial.
- Conditions
- Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD), Comorbidities and Coexisting Conditions
- Trial name
- KET-DUAL (NCT07247370)
- Testing
- Ketamine, Cognitive Behavioural Therapy
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- South West Sydney Local Health District
Alcohol Use Disorder
Anxiety During Abstinence in AUD
The goal of this study is to better understand the underlying neurobiological basis of anxiety that emerges during abstinence in patients with alcohol use disorder (AUD). The main questions it aims to answer are: 1.
- Trial name
- NCT06793488
- Testing
- Disulfiram 250 mg, functional MRI
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Columbia University
Alcohol Use Disorder, Alcohol-associated Liver Disease
Implementation Facilitation Pilot for Alcohol Use Disorder (AUD) in Alcohol-associated Liver Disease (ALD)
The goal of this project is to improve provision of integrated medications for alcohol use disorder (MAUD) with brief counseling for patients with alcohol use disorder (AUD) and alcohol-associated liver disease (ALD) in…
- Trial name
- NCT07525258
- Testing
- Implementation Intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yale University
Substance Use (Drugs, Alcohol)
Adaptation of the Family Check-Up Online
Latinx people are the largest and fastest growing minority population in the U.S., yet most lack access to community responsive preventative interventions to reduce substance use among youth.
- Trial name
- NCT07025083
- Testing
- Adapted Family Check-Up Online, Original Family Check-Up Online
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Alcohol Use Disorder, Alcohol Dependence
The Impact of Heavy Alcohol Use on Saliva and Oral Health
Background: People with alcohol use disorder (AUD) have a higher rate of dental and gum disease. Poor oral health can increase the risk of other diseases, such as diabetes and stroke.
- Trial name
- NCT06684483
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Alcohol Use Disorder
Imaging CRF X NOP Interactions in Alcohol Use Disorder
This positron emission tomography imaging study uses [C-11]NOP-1A and hydrocortisone to image stress-modulating proteins in heavy drinking alcohol use disorder (AUD) subjects and healthy controls (HC).
- Trial name
- NCT07612631
- Testing
- Baseline [C-11]NOP-1A PET scan, Hydrocortisone, Post-hydrocortisone [C-11]NOP-1A PET scan
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Rajesh Narendran
Adolescent Alcohol Use, Mental Health Issue
Centralized Virtual SBIRT for Pediatric Primary Care
Adolescent alcohol and other drug (AOD) use is a significant public health problem which contributes to high levels of mortality, morbidity and healthcare costs in young people, and identification and early intervention for these…
- Conditions
- Adolescent Alcohol Use, Mental Health Issue, Alcohol Related Disorders, Adolescents
- Trial name
- NCT06486688
- Testing
- Centralized Virtual SBIRT
- Where
- United States
- Volunteers
- 22,320 people
- Sponsor
- Kaiser Permanente
Alcohol Use Disorder, Alcohol Drinking
Virtual Incentive Treatment for Alcohol
The overall objective of this program of research is to utilize phosphatidylethanol (PEth), a blood-based biomarker that can detect alcohol use for up to 28 days to deliver a feasible telehealth-based 26-week CM intervention.
- Conditions
- Alcohol Use Disorder, Alcohol Drinking, Alcohol Abuse, Alcohol Dependence
- Trial name
- VITA (NCT06265506)
- Testing
- Contingency Management, Computer Based Training for Cognitive Behavioral Therapy for AUD (CBT4CBT)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Washington State University