Clinical trials: Alcohol Use Disorder (AUD)
Alcohol Consumption, Heavy Drinker
Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers
The purpose of this research study is to find out about the effects of a drug called mavoglurant on alcohol consumption.
- Conditions
- Alcohol Consumption, Heavy Drinker, Alcohol Use Disorder (AUD)
- Trial name
- NCT06136195
- Testing
- Mavoglurant
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Yale University
Alcohol Use Disorder (AUD), Pharmacist-Patient Relations
Alcohol Telemedicine Consultation in Primary Care (ATC)
This pragmatic, cluster-randomized trial in adult primary care clinics in a healthcare system with a diverse membership will examine the effectiveness of an innovative, multi-faceted intervention, the Addiction Telemedicine…
- Conditions
- Alcohol Use Disorder (AUD), Pharmacist-Patient Relations, Alcohol Problem
- Trial name
- ATC (NCT05252221)
- Testing
- ATC Intervention
- Where
- 2 sites in United States
- Volunteers
- 41,843 people
- Sponsor
- Kaiser Permanente
Alcohol Use Disorder (AUD)
Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)
Background: Glucagon-like peptide 1 (GLP-1) agonist drugs are used to treat diabetes and aid weight loss. They may also help reduce cravings for drugs and alcohol.
- Trial name
- NCT07559500
- Testing
- Tirzepatide, [11C]raclopride plus drug, [11C]NNC-112
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcoholism, Alcohol Use Disorder (AUD)
A Randomized, Double-blind Placebo-Controlled Pharmacogenetic Study of Topiramate in European-American Heavy Drinkers
The purpose of this study is to advance the effort to develop personalized pharmacotherapy for alcohol use disorders (AUDs). The investigators propose to conduct a 12-week, prospective, randomized clinical trial of the moderating…
- Trial name
- TOPG (NCT02371889)
- Testing
- Topiramate, Medical Management
- Where
- 2 sites in United States
- Volunteers
- 320 people
- Sponsor
- University of Pennsylvania
Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD)
Ketamine-Enhanced Therapy for Individuals With Alcohol Use Disorder and Depression: A Pilot Study (KET-DUAL)
To assess the safety, feasibility and preliminary efficacy of ketamine-enhanced therapy (KET) for alcohol use disorder (AUD) and comorbid major depressive disorder (MDD) in an open-label, single arm, pilot clinical trial.
- Conditions
- Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD), Comorbidities and Coexisting Conditions
- Trial name
- KET-DUAL (NCT07247370)
- Testing
- Ketamine, Cognitive Behavioural Therapy
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- South West Sydney Local Health District
Alcohol Use Disorder (AUD)
Brain Inflammation and Function in Alcoholism
Background: Brain inflammation due to high alcohol intake may affect thinking, memory, and concentration. Researchers want to measure this using positron emission tomography (PET).
- Trial name
- NCT02233868
- Testing
- connectivity, neuroinflammation, neurofunction
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder (AUD), Attentional Bias
Attentional Control Training for Treating Alcohol Use Disorder
Background: There is consistent evidence that community and clinical samples of individuals with an alcohol use disorder (AUD) have attentional biases toward alcohol cues.
- Trial name
- NCT05102942
- Testing
- Attentional Control Training Program
- Where
- Denmark
- Volunteers
- 268 people
- Sponsor
- University of Southern Denmark
Cognitive Cycling, Alcohol Use Disorder (AUD)
Prevention of Relapse Through Cognitive Cycling in Patients With Alcohol Use Disorder Following Alcohol Withdrawal
TUA-VelCo is a single-center randomized controlled superiority trial with blinded methodological assessment. Adult patients hospitalized for alcohol withdrawal and meeting the criteria for Alcohol Use Disorder (AUD) according to…
- Conditions
- Cognitive Cycling, Alcohol Use Disorder (AUD), Treatment
- Trial name
- TUA-VelCo (NCT07690423)
- Testing
- cognitive cycling
- Volunteers
- 128 people
- Sponsor
- Centre Hospitalier Esquirol
Alcohol Abstinence
Guanfacine to Reduce Relapse Risk in Women With Alcohol Use Disorder (AUD)
Guanfacine may preferentially reduce craving and improve cognitive control in women with Alcohol Use Disorder (AUD), compared to men.
- Trial name
- NCT03137082
- Testing
- Guanfacine XR 3mgs/daily
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Stony Brook University
Alcohol Use Disorder (AUD)
OEA for Young Adults With Alcohol Use Disorder
The goal of this clinical trial is to evaluate the effects of oleoylethanolamide (OEA) supplementation on inflammation, the oral microbiome, neurocognitive function, and alcohol use in young adults ages 18 to 25 with alcohol use…
- Trial name
- NCT07503782
- Testing
- oleoylethanolamide
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder (AUD)
Multimodal Intervention for GGT Reduction in Alcohol Use Disorder (GGT-AUD)
The aim of this clinical trial is to evaluate whether a combined nutraceutical and psychological intervention can reduce gamma-glutamyl transferase (GGT) levels in individuals with Alcohol Use Disorder (AUD).
- Trial name
- GGT-AUD (NCT07603726)
- Testing
- Alcohol Reduction Counseling, Nutraceutical Treatment, Psychological Intervention
- Where
- Romania
- Volunteers
- 197 people
- Sponsor
- Medical Center TOPMED
Alcohol Use Disorder
PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder
Background: People with alcohol use disorder (AUD) also often have bouts of depression called major depressive episodes (MDEs). People having MDEs have been found to have low levels of a protein called PDE4B in the brain.
- Trial name
- NCT06795581
- Testing
- 18F-PF-06445974, Oxazepam
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Mental Health (NIMH)
Alcohol Use Disorder (AUD)
Psilocybin for Treatment of Alcohol Use Disorder: a Feasibility Study
The purpose of this project is to assess the feasibility and safety of administering a single dose of psilocybin to patients diagnosed with alcohol use disorder (AUD).
- Trial name
- NCT04718792
- Testing
- Psilocybin
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Anders Fink-Jensen, MD, DMSci
Alcohol Use Disorder, Alcoholism
Safety and Effectiveness of the BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for Treatment and Reduction of Heavy Drinking in Individuals With of Alcohol Use Disorder (AUD)
The study will compare alcohol use in two groups of subjects. One group will be assigned to the Deep TMS treatment and the other group will be assigned to the sham treatment.
- Conditions
- Alcohol Use Disorder, Alcoholism, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT07216872
- Testing
- Deep TMS (DTMS)
- Where
- 11 sites in United States, Israel and 1 more
- Volunteers
- 186 people
- Sponsor
- Brainsway
Alcohol Use Disorder, Alcohol Dependence
The Impact of Heavy Alcohol Use on Saliva and Oral Health
Background: People with alcohol use disorder (AUD) have a higher rate of dental and gum disease. Poor oral health can increase the risk of other diseases, such as diabetes and stroke.
- Trial name
- NCT06684483
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Alcohol Use Disorder
Image-guided, Robot Navigated Transcranial Magnetic Stimulation (IR-TMS) for Alcohol Use Disorder (AUD)
This study is testing a new treatment called IR-TMS (image-guided, robot navigated transcranial magnetic stimulation) to see if it can help people who drink too much alcohol to reduce the amount they drink.
- Trial name
- NCT06648642
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Alcohol Use Disorder (AUD)
The Efficacy and Neurobehavioural Mechanism of Cannabidiol (CBD) for Alcohol Dependence
The study will explore the psychophysiological and neurobiological and mechanisms of CBD in participants with alcohol use disorder
- Trial name
- NCT05387148
- Testing
- Cannabidiol (CBD)
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- South West Sydney Local Health District
Alcohol Use Disorder
Study to Evaluate AD04 in Adults With Alcohol Use Disorder (AUD) and Selected Serotonin Transporter Polymorphisms
Randomized, multi-center, double-blind, parallel-group, placebo-controlled study. Eligible subjects will be randomized to receive either 0.33 mg AD04 or placebo orally twice-daily for 24 weeks in conjunction with brief…
- Trial name
- ONWARD (NCT04101227)
- Testing
- AD04 (ondansetron), Companion Diagnostic for Genetic Testing, Brief Psychological Counseling
- Where
- 25 sites in Bulgaria, Croatia and 5 more
- Volunteers
- 302 people
- Sponsor
- Adial Pharmaceuticals
Substance Use Disorder (SUD), Alcohol Use Disorder (AUD)
Metabolome and Gut Microbiome Changes During Smoking Cessation in Long-term Drug Therapy in a Therapeutic Community
Theoretical Framework: Cigarette smoking is the leading preventable cause of death worldwide, with nicotine dependence notably common among individuals with Substance Use Disorders (SUD).
- Conditions
- Substance Use Disorder (SUD), Alcohol Use Disorder (AUD), Nicotine Addiction, Healthy Adult Participants
- Trial name
- NCT06803706
- Testing
- 6-weeks CBT smoking cessation programme, Long-term drug therapy within a therapeutic community
- Where
- 3 sites in Austria
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Sigmund Freud PrivatUniversitat
Alcohol Use Disorder (AUD)
Brief Intervention and Fibroscan for Harmful Drinkers Presenting to the Emergency Department
The investigators plan to assess the feasibility of a randomised controlled trial of an innovative screening (Identification), Brief Intervention, Fibroscan and Self-Referral for Specialist Treatment (IBAFiRST) programme for high…
- Trial name
- IBAFiRST (NCT05720247)
- Testing
- Fibroscan, Brief Intervention
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Nottingham University Hospitals NHS Trust