Clinical trials: Alcohol Use Disorders
Obesity, Weight Loss, Alcohol Drinking
Alcohol in the Treatment of Obesity
This pilot study looks at the relationship of moderate alcohol consumption on weight loss.
- Trial name
- NCT00594074
- Testing
- white wine
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Duke University
Chronic Pain
Managing Chronic Pain in Veterans With Substance Use Disorders
The proposed project will provide crucial data on the effectiveness of a pain management intervention designed for veterans with co-occurring pain and substance use disorders.
- Trial name
- NCT00982410
- Testing
- cognitive-behavioral treatment, educational supportive group
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- US Department of Veterans Affairs
Alcohol Use Disorder, Alcoholism
Oxytocin and Naltrexone: Investigation of Combined Effects on Stress- and Alcohol Cue-induced Craving in Alcohol Use Disorder
Alcohol use disorder (AUD) is a chronic relapsing disorder. Alcohol craving, a hallmark symptom of AUD that drives relapse in patients, is only insufficiently treated by existing medication.
- Conditions
- Alcohol Use Disorder, Alcoholism, Alcohol Addiction
- Trial name
- ON-ICE (NCT05093296)
- Testing
- Oxytocin nasal spray, Naltrexone Pill
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Alcohol Use Disorder
The Role of Dopaminergic and Glutamatergic Neurotransmission for Dysfunctional Learning in Alcohol Use Disorders
The aim of this project is to assess reward- based learning behavior and its association with alterations in dopaminergic and glutamatergic transmission in detoxified alcohol-dependent patients and matched controls.
- Trial name
- LeADP5 (NCT02094196)
- Testing
- Alcohol detoxification
- Where
- 2 sites in Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Alcohol Abuse, Alcohol Drinking
Decreasing Alcohol Use Through Student Peer Leaders
Problematic alcohol use can lead to worse social and health related consequences for underserved minorities, requiring urgent intervention.
- Conditions
- Alcohol Abuse, Alcohol Drinking, Alcohol Use Disorder, Alcohol Problem
- Trial name
- NCT04579068
- Testing
- Screening and Brief Intervention of Problematic Alcohol Use
- Volunteers
- healthy volunteers welcome
- Sponsor
- Charles Drew University of Medicine and Science
Alcohol Use Disorder
Anxiety During Abstinence in AUD
The goal of this study is to better understand the underlying neurobiological basis of anxiety that emerges during abstinence in patients with alcohol use disorder (AUD). The main questions it aims to answer are: 1.
- Trial name
- NCT06793488
- Testing
- Disulfiram 250 mg, functional MRI
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Columbia University
Alcohol Use Disorders
Randomized Trial of Intensive Motivational Interviewing (IMI) to Improve Drinking Outcomes Among Women
A Phase II Randomized Clinical Trial (RCT) is proposed to compare a 9-session model of intensive motivational interviewing (IMI) to standard motivational interviewing techniques (SMI) among alcohol dependent women.
- Trial name
- NCT02272023
- Testing
- Intensive Motivational Interviewing, Single session of Motivational Interviewing
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Public Health Institute, California
Alcohol Use, Adolescent
Evaluating Caregiver Involvement in Primary Care-Based Brief Interventions for Adolescent Alcohol Use Problems
Intervention for mild severity alcohol use among U.S. teens is crucial, as alcohol is the most commonly used substance in this age group, yet few receive the necessary interventions.
- Conditions
- Alcohol Use, Adolescent, Mild Alcohol Use Disorder, Mild Substance Use Disorder
- Trial name
- NCT06593652
- Testing
- Teen Intervene - Adolescent Only, Teen Intervene with Caregiver Session, Family Check Up
- Where
- United States
- Volunteers
- 615 people
- Sponsor
- Indiana University
Major Depressive Disorder, Alcohol Use Disorder
Allogeneic Human Mesenchymal Stem Cell Infusion vs Placebo in Alcohol Use Disorder and Major Depression.
The purpose of this study is to look at the safety of a study treatment with stem cells in Alcohol Use Disorder And Major Depression (AUD-MD) subjects.
- Trial name
- Alaunus (NCT03265808)
- Testing
- allogeneic human mesenchymal stem cells (allo-hMSCs)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Ihsan M Salloum, MD, MPH
Alcohol Use Disorder, Posttraumatic Stress Disorder (PTSD)
Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders
The purpose of this study is to evaluate whether the combination of prazosin and naltrexone will decrease alcohol cravings and drinking in individuals who have problems with alcohol and have used alcohol at risky levels compare…
- Trial name
- PaN (NCT02322047)
- Testing
- Prazosin, Naltrexone
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Addiction, Addiction, Alcohol
The Efficacy of a Mobile Application in Reducing Craving and Lapse Risk in Alcohol and Stimulants Problematic Use
The aim of the study is to evaluate the effectiveness of long-term and short-term app-based self-guided psychological interventions to reduce craving and lapse risk in users with substance use disorder or problematic substance…
- Conditions
- Addiction, Addiction, Alcohol, Addiction, Substance
- Trial name
- NCT05434416
- Testing
- mobile app
- Where
- Poland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- PredictWatch
Alcohol Use Disorder, Alcohol Drinking
Human Laboratory Study of ASP8062 for Alcohol Use Disorder
The primary objective of this study is to evaluate the effects of ASP8062, 25 mg once a day and matched placebo, on alcohol cue-elicited alcohol craving during a human laboratory paradigm after 2 weeks of daily dosing among…
- Conditions
- Alcohol Use Disorder, Alcohol Drinking, Alcohol Use Disorder (AUD)
- Trial name
- NCT05096117
- Testing
- ASP8062
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
SCHIZOPHRENIA 1 (Disorder), Alcohol Use Disorder
Snoezelen Therapy in Adults With Alcohol Dependence and Adults With Schizophrenia
The purpose of the study: obtaining knowledge about the impact of Snoezelen® therapy on the health of adults suffering from schizophrenia and requiring permanent institutional care, adults suffering from schizophrenia and adults…
- Conditions
- SCHIZOPHRENIA 1 (Disorder), Alcohol Use Disorder, Alcohol Dependence (Primary Condition)
- Trial name
- NCT07748078
- Testing
- Snoezelen® therapy for 6 weeks, Snoezelen® therapy for 12 weeks
- Where
- 2 sites in Poland
- Volunteers
- 140 people
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Schizophrenia, Schizoaffective Disorder
Efficacy of Quetiapine in the Treatment of Patients With Schizophrenia and a Comorbid Substance Use Disorder
The purpose of this study is to examine the efficacy of quetiapine (Seroquel) in reducing substance use in persons diagnosed with schizophrenia.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Psychotic Disorder, Substance Abuse
- Trial name
- NCT00156715
- Testing
- Quetiapine
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Substance Use Disorders, Addiction, Alcohol
Evaluating the Effectiveness of Mobile Self-guided Psychological Interventions to Reduce Relapse in Substance Use Disorder
The aim of the study is to evaluate the effectiveness of mobile interventions in reducing craving and lapses in patients diagnosed with Substance Use Disorder.
- Conditions
- Substance Use Disorders, Addiction, Alcohol, Addiction, Substance
- Trial name
- NCT05730504
- Testing
- Mobile app-based self-guided interventions
- Where
- Poland
- Volunteers
- 400 people
- Sponsor
- PredictWatch
Stimulant Use, Alcohol Use Disorder
Neuromodulation and Cognitive Training for Substance Use Disorders
The relapsing nature of substance use disorder is a major obstacle to successful treatment. About 70% of those entering treatment will relapse within one year.
- Trial name
- NCT04426214
- Testing
- tDCS, Cognitive Training
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Minnesota
Alcohol Use Disorder, Obesity and Overweight
Tirzepatide for Alcohol Use Disorder
The objective of this Phase 2 randomized controlled trial is to evaluate the effects of weekly tirzepatide (vs. placebo) on alcohol consumption and cardiometabolic outcomes in adults with alcohol use disorder and overweight or…
- Conditions
- Alcohol Use Disorder, Obesity and Overweight, Alcohol
- Trial name
- NCT06994338
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Southern California
Alcohol Abuse, Alcohol Drinking
Substance Use Risk Education (SURE) Project
This project is designed to compare college drinking interventions on outcomes and cost-effectiveness. We plan to recruit 700 students with residence hall alcohol violations to participate in a randomized study to evaluate 3…
- Trial name
- NCT00289965
- Testing
- Counselor-administered Brief Motivational Intervention (BMI), Alcohol 101 Plus (interactive CD-ROM), AlcoholEdu (Internet-based tutorial)
- Where
- United States
- Volunteers
- 703 people, healthy volunteers welcome
- Sponsor
- Syracuse University
Insomnia, Alcohol Problem
A Timeline Study of Alcohol Use and Its Relationship to Insomnia
This study is an epidemiological and descriptive study of the lifetime relationship of insomnia to alcohol problems.
- Trial name
- NCT00580411
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol; Harmful Use, Binge Drinking
Computerized Brief Alcohol Intervention (BI) for Binge Drinking HIV At-Risk and Infected Women
African American (AA) women are disproportionately affected by HIV/AIDs. The major risk factor for HIV acquisition among AA women is high-risk heterosexual sex, including unprotected vaginal and anal sex, and sex with a high-risk…
- Conditions
- Alcohol; Harmful Use, Binge Drinking, Risk Behavior, HIV Infection
- Trial name
- NCT01125371
- Testing
- Computerized brief alcohol intervention + IVR booster calls, Computerized brief alcohol intervention, Attention Control
- Where
- United States
- Volunteers
- 439 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University