Clinical trials: Alcohol Use Disorders
Binge Drinking, Harmful Use of Alcohol
Efficacy of a Fully Automated Electronic Screening and Brief Intervention to Reduce Harmful Alcohol Consumption: A Randomized Clinical Trial
This epidemiological study (randomized clinical trial) aims to evaluate a digital Screening and Brief Intervention (e-SBI) system for reducing and preventing harmful alcohol consumption in patients treated by the Brazilian…
- Trial name
- PROSA e-SBI (NCT07675447)
- Testing
- screening and brief intervention, electronic screening and brief intervention tool (e-SBI) for reducing rate of harmful alcohol consumption (HAC)
- Where
- Brazil
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
Alcohol Use Disorder
Evaluating Cannabidiol as a Novel Anticraving Medication for Alcohol Use Disorder
This human laboratory study aims to assess the effects of cannabidiol on alcohol consumption and craving in participants with alcohol use disorder.
- Trial name
- NCT06512389
- Testing
- Oral solution
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Centre for Addiction and Mental Health
Healthy, Alcohol Use Disorder (Mild vs. Moderate to Heavy)
Modification of Pavlovian and Instrumental Learning in Human Addiction
The project aims at investigating modifications of environmental factors (i.e. cues and stress) relevant for learning mechanisms in addictive disorders.
- Trial name
- NCT04032587
- Testing
- Modified training version of the Approach / Avoidance Task (AAT, see Wiers et al., 2011), Mindfulness-based interventions (e.g. body scan)
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
HIV/AIDS, Alcohol Abuse
An Economic and Relationship-strengthening Intervention to Reduce Alcohol Use in Malawi
With a full-scale randomized control trial, the investigators will evaluate the efficacy and cost effectiveness of Mlambe, an economic and relationship-strengthening intervention that provides incentivized saving accounts…
- Trial name
- NCT06367348
- Testing
- Mlambe
- Where
- Malawi
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Use Disorder, Alcohol Use Disorder
Cytisine for Smoking Cessation
The goal of this clinical trial is to evaluate the safety and effectiveness of cytisine as a smoking cessation treatment in individuals with concurrent alcohol use disorder.
- Conditions
- Tobacco Use Disorder, Alcohol Use Disorder, Smoking Cessation
- Trial name
- NCT05729243
- Testing
- Cytisine
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
PTSD, Alcohol Use Disorder
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD
The primary study objective is to determine the efficacy of pregabalin administered orally for a period of 12 weeks in reducing risky drinking and symptoms of posttraumatic stress disorder who have selected genotypes at the…
- Trial name
- NCT02884908
- Testing
- Pregabalin plus BBCET
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Maryland, Baltimore
Binge Drinking
Combining Cognitive Training With tDCS to Enhance Memory Inhibition in Young Binge Drinkers
This study protocol aims to examine the behavioral and electroencephalographic (EEG) correlates of memory inhibition (MI) among college binge drinkers (BDs).
- Trial name
- NCT05237414
- Testing
- Active tDCS, Active CT
- Where
- Portugal
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Minho
Alcohol Use Disorder, Opioid Use Disorder
Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment
This study will help determine the feasibility and acceptability of a brief opioid-informed alcohol intervention in patients receiving prescribed buprenorphine for opioid use who are currently drinking alcohol.
- Conditions
- Alcohol Use Disorder, Opioid Use Disorder, Alcohol Use, Opioid Use
- Trial name
- Project BEST (NCT07342504)
- Testing
- Brief opioid-informed alcohol treatment
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Notre Dame
Stress Disorders, Post-Traumatic, Substance-Related Disorders
Concurrent Treatment for Substance Dependent Individuals With Post-Traumatic Stress Disorder (PTSD)
This treatment intervention trial is designed for men and women with substance dependence and comorbid Post-Traumatic Stress Disorder (PTSD).
- Trial name
- NCT01365247
- Testing
- Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure, Relapse Prevention Treatment, Active Monitoring Control Group
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- The City College of New York
Alcohol Use Disorder Cognitive Decline
Cognitive Training in the Treatment of AUD
Alcohol Use Disorders (AUDs) have a significant public health impact and are highly prevalent in Veterans. Alcohol related brain effects on neurocognition (attention, memory and executive function) reduce ability to benefit from…
- Trial name
- NCT02664038
- Testing
- Cognitive Remediation Training
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- VA Office of Research and Development
Alcohol Disorders
Open Label Pilot Study of Perampanel for the Treatment of Alcohol Use Disorder
The purpose of this research study is to test the safety, tolerability, and effectiveness of the drug Perampanel when used in persons who drink and wish to stop drinking. Perampanel has been approved by the U.S.
- Trial name
- NCT04502589
- Testing
- Perampanel Tablet, Disulfiram
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Virginia Commonwealth University
Domestic Violence, Post Traumatic Stress Disorder
Evaluation of a Trauma-Informed Partner Violence Intervention Program
The goal of this study is to conduct a randomized controlled trial (RCT) comparing outcomes between two programs to reduce intimate partner violence (IPV)- the Strength at Home (SAH) program and a standard, state-approved IPV…
- Trial name
- NCT06803043
- Testing
- SAH, TAU
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Boston University
Alcohol Use Disorder
Developing a Novel Human Laboratory Paradigm for AUD Medication Screening
The intent of the study is to develop two versions of the 'ability to resist' drinking model designed to screen Alcohol Use Disorder (AUD) medications.
- Trial name
- NCT06489782
- Testing
- Model 1, Model 2
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Use Disorder, Alcohol Abuse
CHERL, Connecting Primary Care Patients With Community Resources to Facilitate Behavior Change
The investigators want to find out if providing a Community Health Educator Referral Liaison (CHERL) helps practices help their patients change risky behaviors (tobacco use, physical inactivity, unhealthy diet, and risky…
- Conditions
- Tobacco Use Disorder, Alcohol Abuse, Lack of Physical Activity, Poor Diet
- Trial name
- NCT00269009
- Testing
- CHERL
- Where
- 3 sites in United States
- Sponsor
- Great Lakes Research Into Practice Network
Alcohol Use Disorder, Sexually Transmitted Diseases
Addressing Heavy Alcohol Use Consumption With Kudzu
Drinking multiple alcoholic drinks on a single occasion (binge drinking), has many negative health risks but interventions to address this behavior remain limited.
- Trial name
- A-HACK (NCT03709043)
- Testing
- Standardized kudzu, Sexually transmitted infection testing:, Medical Management (MM) counseling for alcohol use:
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Glenn-Milo Santos
PTSD, Alcohol Use Disorders
Integrative Risk Reduction and Treatment for Teen Substance Use Problems and PTSD
Adolescents receiving RRFT and their caregivers will report significantly fewer substance use problems (quantity of use, frequency of use, and abuse symptoms) during treatment and follow-up than control adolescents who receive…
- Conditions
- PTSD, Alcohol Use Disorders, Substance Use Disorders
- Trial name
- RRFT (NCT01751035)
- Testing
- Risk Reduction through Family Therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Medical University of South Carolina
Alcohol Dependence, Alcohol Abuse
Brief Alcohol Intervention in General Hospitals
The purpose of the study is to reveal the most promising procedure for implementing alcohol screening and intervention in general hospitals and to find out, if and to which extent non-specialist health professionals can be…
- Conditions
- Alcohol Dependence, Alcohol Abuse, At-Risk-Drinking, Heavy Episodic Drinking
- Trial name
- NCT00423904
- Testing
- Brief intervention
- Volunteers
- 1,035 people
- Sponsor
- University Medicine Greifswald
HIV/AIDS
The Outreach and Prevention at ALcohol Venues in East Africa Study (OPAL-East Africa- Aim 2) (OPAL-Aim 2)
This study will evaluate the effect of a brief alcohol counseling intervention on PrEP and PEP adherence among adults with heavy alcohol use at high risk for HIV, while gaining insights into the facilitators, barriers, and…
- Trial name
- OPAL-Aim 2 (NCT06036238)
- Testing
- Healthy Living Intervention (HLI), Standard of Care
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol Use Disorder
Testing CBT Models and Change Mechanisms for Alcohol Dependent Women
The study has 4 specific aims: (1) To modify our existing Individual Female Specific Cognitive Behavioral Therapy (I-FS-CBT) for Alcohol Use Disorder (AUD) approach to treat women with alcohol dependence in a group format, Group…
- Trial name
- WTPIII (NCT03589274)
- Testing
- I-FS-CBT, G-FS-CBT
- Volunteers
- 155 people
- Sponsor
- Rutgers, The State University of New Jersey
Alcohol Use Disorder
NIAAA Natural History Protocol
Background: About 17 million adults had an alcohol use disorder in 2012. Researchers want to follow people that have alcohol problems and want treatment, as well as those who do not want treatment and healthy volunteers.
- Trial name
- NCT02231840
- Where
- United States
- Volunteers
- 7,500 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)