Clinical trials: Alcohol Withdrawal
Alcohol Withdrawal, Alcohol Use Disorder
Using Transcutaneous Auricular Vagus Nerve Stimulation to Treat Acute Alcohol Withdrawal
The purpose of this study is to see if stimulation of the vagus nerve via a non-invasive device placed behind external ear can reduce physical and psychological discomfort during acute alcohol withdrawal in patients with alcohol…
- Trial name
- NCT04159909
- Testing
- Transcutaneous Nerve Stimulation
- Where
- United States
- Sponsor
- Northwell Health
Alcohol Withdrawal Syndrome
Alcohol Withdrawal Syndrome Treated With Adjunctive Phenobarbital or Ketamine
The goal of this study will aim to determine if adding phenobarbital or ketamine to a symptom-triggered benzodiazepine regimen decreases the rate of intensive care unit admissions during the treatment of alcohol withdrawal…
- Trial name
- PKAT (NCT03788889)
- Testing
- Ketamine, Phenobarbital, Lorazepam
- Sponsor
- Santa Barbara Cottage Hospital
Alcoholism, Alcohol Related Disorders
Laboratory Studies on Oxytocin for Treatment of Alcohol Use Disorder
This study will examine the utility of the neuropeptide oxytocin (OT) as a potential new medication for the treatment of Alcohol use disorder (AUD).
- Trial name
- NCT02407340
- Testing
- oxytocin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Johns Hopkins University
Alcohol Drinking, Cirrhosis
Observational Study on Patients With Baclofen Treatment for Alcohol-dependence in France
Baclofen is an agonist of the amino-butyricum B (GABA-B) receptor used for a long time in neurology to treat spastic contracture.
- Conditions
- Alcohol Drinking, Cirrhosis, Alcohol Withdrawal
- Trial name
- OBADE (NCT02835365)
- Where
- 8 sites in France
- Volunteers
- 218 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Alcohol Dependence
Gabapentin for Abstinence Initiation in Alcohol Dependence
Primary Hypotheses: 1. Gabapentin will significantly reduce alcohol consumption and promote abstinence as compared to placebo. The primary outcome measure will be the number of the heavy drinking days (defined as any day where…
- Trial name
- GAINS (NCT01141049)
- Testing
- Gabapentin
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- New York State Psychiatric Institute
Alcoholism, Alcohol Withdrawal
Outpatient Treatment of Alcohol Withdrawal Syndrome
The purpose of this study is to compare a fixed-schedule therapy versus a symptom-triggered therapy for alcohol withdrawal syndrome in medical outpatients.
- Trial name
- NCT00136617
- Testing
- chlordiazepoxide
- Where
- Denmark
- Volunteers
- 165 people
- Sponsor
- Hvidovre University Hospital
Alcohol Withdrawal Syndrome
Efficacy and Safety of Levetiracetam in the Inpatient Treatment of Alcohol Withdrawal Syndrome
The purpose of this study is to evaluate the efficacy and safety of levetiracetam for treating alcohol withdrawal syndrome (AWS) in inpatients (vs. placebo).
- Trial name
- NCT00146471
- Testing
- Levetiracetam
- Where
- 5 sites in Germany
- Volunteers
- 120 people
- Sponsor
- Charite University, Berlin, Germany
Alcohol Withdrawal
Study of Exploratory Plasmatic Markers of Alcohol Withdrawal
This research focuses on alcohol withdrawal in hospitals and its potential neurological consequences. Alcohol withdrawal is an event that induces physical symptoms, such as tremors, sweating, anxiety and requires medical support.
- Trial name
- STEP-AW (NCT05216705)
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Cognitive Cycling, Alcohol Use Disorder (AUD)
Prevention of Relapse Through Cognitive Cycling in Patients With Alcohol Use Disorder Following Alcohol Withdrawal
TUA-VelCo is a single-center randomized controlled superiority trial with blinded methodological assessment. Adult patients hospitalized for alcohol withdrawal and meeting the criteria for Alcohol Use Disorder (AUD) according to…
- Conditions
- Cognitive Cycling, Alcohol Use Disorder (AUD), Treatment
- Trial name
- TUA-VelCo (NCT07690423)
- Testing
- cognitive cycling
- Volunteers
- 128 people
- Sponsor
- Centre Hospitalier Esquirol
Insomnia, Alcohol Use Disorder
Suvorexant in the Management Comorbid Sleep Disorder and Alcohol Dependence
Suvorexant (trade name Belsomra) is an orexin receptor antagonist that has TGA approval for the treatment of insomnia, characterised by difficulties with sleep onset and/or sleep maintenance.
- Trial name
- NCT03897062
- Testing
- Suvorexant 20 mg
- Where
- Australia
- Volunteers
- 22 people
- Sponsor
- The Florey Institute of Neuroscience and Mental Health
Alcohol Use Disorder
Ibudilast and Withdrawal-Related Dysphoria
Alcohol use disorder (AUD) is a prevalent and disabling psychiatric disorder with few, and only moderately efficacious, treatment options.
- Trial name
- NCT03489850
- Testing
- Ibudilast
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of California, Los Angeles
Alcohol Use Disorder
Non-invasive Vagal Nerve Stimulation in Alcohol Use Disorder
Alcohol use disorder (AUD) is a major health concern amongst Veterans as it causes poor health, lost days at work, impaired psychosocial functioning, and decreased quality of life.
- Trial name
- NCT05226130
- Testing
- Cervical transcutaneous vagus nerve stimulation (active comparator)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- VA Office of Research and Development
Alcohol Withdrawal, Alcohol Abstinence
Intravenous Acetate as an Adjunctive Treatment for Alcohol Withdrawal in Hospitalized Patients
Alcohol withdrawal syndrome is a highly morbid condition affecting a substantial percentage of patients hospitalized who have alcohol use disorders, estimated at 5-6% of all hospitalized patients.
- Conditions
- Alcohol Withdrawal, Alcohol Abstinence, Alcohol Use Disorder
- Trial name
- NCT07810946
- Testing
- Sodium Acetate
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Colorado, Denver
Alcohol Withdrawal Syndrome
Treatment of Alcohol Withdrawal in Hospital Patients
The purpose of this study is to test how tolerable and effective lorazepam is when used to treat alcohol withdrawal in hospital patients at risk for alcohol withdrawal.
- Trial name
- NCT00249366
- Testing
- Lorazepam (drug), Lorazepam
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- Virginia Commonwealth University
Alcoholics
Alcohol Abuse or Alcohol Withdrawal: Risk of Latent Scurvy
Scurvy, or latent scurvy, may be underestimated in developed countries, but continue to be described, often as case report. Little is known about the prevalence of vitamin C deficiency in a specific population as withdrawal…
- Trial name
- NCT03467022
- Testing
- Vitamin C
- Volunteers
- 47 people
- Sponsor
- SCP Battistelli
Alcohol Withdrawal
Evaluation of Bilateral HF-rTMS on Abstinence in Alcohol Use Disorder Patients With Executive Dysfunction
High frequency repetitive transcranial magnetic stimulation (HF-rTMS) over dorsolateral prefrontal cortex (DLPFC) could correct defective executive functions over the hyperactive reward circuit through the meso-fronto-limbic…
- Trial name
- STIM-ALC (NCT04997330)
- Testing
- Active rTMS
- Where
- France
- Volunteers
- 95 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alcohol Use Disorder, Alcohol Withdrawal
Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder
The goal of this clinical trial is to learn the effects of ketone supplement compared to placebo on alcohol withdrawal symptoms during a 4 day alcohol withdrawal management treatment in adults with moderate to severe alcohol use…
- Conditions
- Alcohol Use Disorder, Alcohol Withdrawal, Ketosis
- Trial name
- KSAW (NCT06559995)
- Testing
- ketone supplement "D-beta-hydroxybutryric acid and R-1,3 butanediol" 12g of ketones,, magnetic resonance imaging session
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Alcoholism
Baclofen to Prevent Agitation in Alcohol Addicted Patients in ICU
Background: Alcohol is the leading psychoactive substance consumed in France, with about 15 million regular consumers. The National institute on Alcohol Abuse and Alcoholism (NIAAA) considers alcohol abuse to be more than 14…
- Trial name
- BACLOREA (NCT02723383)
- Testing
- BACLOFEN
- Where
- 18 sites in France
- Volunteers
- 314 people
- Sponsor
- Nantes University Hospital
Alcohol Withdrawal Delirium
Treatment Of Alcohol Withdrawal Syndrome: Dexmedetomidine Vs Diazepam In A Hospital O'horán
The cessation of alcohol consumption of people suffering from alcohol abuse frequently leads to the development of an alcohol withdrawal syndrome (AWS).
- Trial name
- NCT03877120
- Testing
- Dexmedetomidine 0.004 MG/ML, Diazepam Injectable Solution
- Where
- Mexico
- Volunteers
- 2 people
- Sponsor
- Centro Medico Nacional La Raza, IMSS
Alcohol Withdrawal Syndrome
Clinical Quality Improvement of Benzodiazepine-Resistant Alcohol Withdrawal Syndrome
The overarching goal of this project is to improve the clinical quality of patients with Benzodiazepine-resistant alcohol withdrawal syndrome.
- Trial name
- NCT01652326
- Testing
- Diazepam
- Where
- United States
- Volunteers
- 792 people
- Sponsor
- University of Pittsburgh