Clinical trials: Alcohol Withdrawal Syndrome
Alcohol Withdrawal Syndrome
Efficacy and Safety of Levetiracetam in the Inpatient Treatment of Alcohol Withdrawal Syndrome
The purpose of this study is to evaluate the efficacy and safety of levetiracetam for treating alcohol withdrawal syndrome (AWS) in inpatients (vs. placebo).
- Trial name
- NCT00146471
- Testing
- Levetiracetam
- Where
- 5 sites in Germany
- Volunteers
- 120 people
- Sponsor
- Charite University, Berlin, Germany
Alcohol Withdrawal, Nutrition Disorders
Riboflavin for Glutamate Reduction in Alcohol Withdrawal
This RCT intends to investigate the use of oral Riboflavin (Vitamin B2) for reduction of blood glutamate levels in the setting of acute alcohol withdrawal.
- Conditions
- Alcohol Withdrawal, Nutrition Disorders, Alcohol Use Disorder
- Trial name
- RGRAW (NCT04232800)
- Testing
- Riboflavin
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Alcohol Withdrawal
Phenobarbital for Acute Alcohol Withdrawal
Intravenous phenobarbital in combination with a symptom-guided standardized lorazepam-based alcohol withdrawal protocol will be associated with decreased need for ICU admission, continuous lorazepam infusion and will not be…
- Trial name
- NCT01184417
- Testing
- 10 mg/kg IV phenobarbital in 100 ml saline
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Jonathan Rosenson
Alcoholism, Alcohol Related Disorders
Laboratory Studies on Oxytocin for Treatment of Alcohol Use Disorder
This study will examine the utility of the neuropeptide oxytocin (OT) as a potential new medication for the treatment of Alcohol use disorder (AUD).
- Trial name
- NCT02407340
- Testing
- oxytocin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Johns Hopkins University
Alcohol Withdrawal Syndrome
Gabapentin for Alcohol Withdrawal Syndrome
The current "gold-standard" for the management of alcohol withdrawal syndrome (AWS) is symptom-triggered administration of benzodiazepines.
- Trial name
- NCT03012815
- Testing
- Gabapentin, Benzodiazepines, Divalproex Sodium
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Mayo Clinic
Alcohol Withdrawal
Osteopathic Treatment to Alcohol Withdrawal Syndrome
The alcohol withdrawal syndrome has a hierarchical symptomatology depending on the severity (minor, moderate or severe). These signs express a state of psychic, behavioral and physical deprivation.
- Trial name
- OSTEOOL (NCT03916939)
- Testing
- osteopathy, simulated osteopathy
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Alcohol Use Disorder, Alcohol Withdrawal
Digitally Assisted Recovery Coach
The aims of this proof-of-concept study are to determine the feasibility of 1) using a smartphone app ("Lifeguard") to facilitate engagement with a peer recovery coach, 2) monitoring post-detox using a modified Brief Addiction…
- Trial name
- NCT05393544
- Testing
- Digitally assisted peer recovery coach
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Alcohol Use Disorder, Alcohol Withdrawal
Effects of Ketone Supplementation on Acute Alcohol Withdrawal
The goal of this study is to study the effects of the ketone supplement Kenetik compared to placebo (an inactive beverage) on alcohol withdrawal symptoms during the 5 days of clinical alcohol withdrawal management treatment at…
- Conditions
- Alcohol Use Disorder, Alcohol Withdrawal, Alcohol Dependence, Ketosis
- Trial name
- NCT06173973
- Testing
- Kenetik; Ketone Concentrate
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Alcohol Withdrawal
Evaluation of Bilateral HF-rTMS on Abstinence in Alcohol Use Disorder Patients With Executive Dysfunction
High frequency repetitive transcranial magnetic stimulation (HF-rTMS) over dorsolateral prefrontal cortex (DLPFC) could correct defective executive functions over the hyperactive reward circuit through the meso-fronto-limbic…
- Trial name
- STIM-ALC (NCT04997330)
- Testing
- Active rTMS
- Where
- France
- Volunteers
- 95 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alcoholism, Alcohol Withdrawal
Outpatient Treatment of Alcohol Withdrawal Syndrome
The purpose of this study is to compare a fixed-schedule therapy versus a symptom-triggered therapy for alcohol withdrawal syndrome in medical outpatients.
- Trial name
- NCT00136617
- Testing
- chlordiazepoxide
- Where
- Denmark
- Volunteers
- 165 people
- Sponsor
- Hvidovre University Hospital
Alcohol Withdrawal
Metabolism of Chlordiazepoxide in the Treatment of Alcohol Withdrawal Symptoms
The aim of this study is to elucidate if CYP-phenotypes, variations in CYP-genotypes and dose of chlordiazepoxide is correlated to chlordiazepoxide plasma concentrations in patients admitted to Intensive Care or High Dependency…
- Trial name
- NCT05563350
- Testing
- Blood samples
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Alcoholism
Comparing Gabapentin and Lorazepam for Treating Alcohol Withdrawal
This study will evaluate a safe and useful medication for outpatient detoxification that is as effective as benzodiazepines in the short-term, and more effective in the protracted withdrawal period.
- Trial name
- NCT00011297
- Testing
- gabapentin (Neurontin), lorazepam (Ativan)
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Withdrawal Syndrome
MAGnesium Adjunction in Alcohol Withdrawal Syndrome: a Multicenter Assessment (MAGMA)
This study examine the efficacy of oral magnesium supplementation as an adjuvant therapy for decreasing intensity of alcohol withdrawal symptoms among inpatients requiring pharmacological treatment of their AWS.
- Trial name
- MAGMA (NCT03033823)
- Testing
- Magnesium
- Where
- 11 sites in France
- Volunteers
- 105 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Seizure, Alcohol Related
Efficacy of Keppra in Acute Alcohol Related Seizure Control--A Pilot Study
Pilot study to evaluate efficacy of Keppra (levetiracetam) for seizure control in patients with alcohol related seizures.
- Trial name
- NCT00627133
- Testing
- levetiracetam
- Where
- United States
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder, Addiction
Motivational Interviews Post Hospitalisation on Maintaining AbstiNence for 1 Year après le Sevrage en Alcool
The aim of this clinical study is to evaluate the efficacy of reinforced inpatient aftercare versus usual care on the percentage of days of abstinence during the first year following withdrawal in adults with alcohol use…
- Conditions
- Alcohol Use Disorder, Addiction, Alcohol Withdrawal, Motivational Interviews
- Trial name
- IMMANENCE (NCT06618755)
- Testing
- Experimental group : PSH (usual care) with motivational interviewing
- Where
- France
- Volunteers
- 104 people
- Sponsor
- University Hospital, Montpellier
Alcohol Withdrawal, Psychophysiologic Reaction
Auricular Vagal Stimulation in Alcohol Craving
Background: The cause of the vegetative symptoms is a sympathetic driven misbalance of the autonomous nervous system. To restore vegetative balance in alcohol withdrawal syndrome new neuro-modulatory methods, such as percutaneous…
- Trial name
- VNS_CRAV (NCT05131334)
- Testing
- auriStim, for auricular vagal stimulation
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Alcohol Dependence
Prometa Protocol for Alcohol Dependence
This is a placebo controlled trial (some people receive active and some people receive inactive medication) to evaluate the effectiveness of a new protocol to treat alcohol dependence.
- Trial name
- NCT00262639
- Testing
- Flumazenil and Gabapentin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical University of South Carolina
Alcohol Drinking, Cirrhosis
Observational Study on Patients With Baclofen Treatment for Alcohol-dependence in France
Baclofen is an agonist of the amino-butyricum B (GABA-B) receptor used for a long time in neurology to treat spastic contracture.
- Conditions
- Alcohol Drinking, Cirrhosis, Alcohol Withdrawal
- Trial name
- OBADE (NCT02835365)
- Where
- 8 sites in France
- Volunteers
- 218 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Alcohol Withdrawal
Study of Exploratory Plasmatic Markers of Alcohol Withdrawal
This research focuses on alcohol withdrawal in hospitals and its potential neurological consequences. Alcohol withdrawal is an event that induces physical symptoms, such as tremors, sweating, anxiety and requires medical support.
- Trial name
- STEP-AW (NCT05216705)
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Alcohol Use Disorder, Alcohol Withdrawal
Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder
The goal of this clinical trial is to learn the effects of ketone supplement compared to placebo on alcohol withdrawal symptoms during a 4 day alcohol withdrawal management treatment in adults with moderate to severe alcohol use…
- Conditions
- Alcohol Use Disorder, Alcohol Withdrawal, Ketosis
- Trial name
- KSAW (NCT06559995)
- Testing
- ketone supplement "D-beta-hydroxybutryric acid and R-1,3 butanediol" 12g of ketones,, magnetic resonance imaging session
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania