Clinical trials: Alcohol-Related Disorders
Alcoholism, Smoking
Smoking Cessation in Alcoholism Treatment
This study is designed to increase understanding of the processes that affect the treatment outcome of individuals with both alcohol and nicotine dependence.
- Trial name
- NCT00000454
- Testing
- nicotine replacement patch
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Yale University
Alcoholic Liver Disease
Long Term Effect of Aggressive Nutritional Management on Survival in Patients With Alcoholic Liver Disease
Patient found to be malnourished after the nutritional evaluation would be randomized in the two groups of the study. The control group would receive standard nutritional counseling from a trained dietician where as those in the…
- Trial name
- NCT02140294
- Testing
- Polymeric nutritional supplements, Standard Nutrional Treatment
- Where
- India
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Alcohol Use Disorder, Risky Health Behavior
A Female-Specific CBT Group for Veteran Women With Alcohol Use Disorder in VA Primary Care Settings
The purpose of this study is to evaluate a Female-Specific Cognitive Behavioral Therapy (CBT) Group as treatment for Alcohol Use Disorder among Veteran women.
- Trial name
- NCT06118346
- Testing
- Female-Specific Cognitive Behavioral Therapy (FS-CBT), Usual Care
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- University of Massachusetts, Worcester
Alcohol Use Disorder, Alcohol Dependence
The Impact of Heavy Alcohol Use on Saliva and Oral Health
Background: People with alcohol use disorder (AUD) have a higher rate of dental and gum disease. Poor oral health can increase the risk of other diseases, such as diabetes and stroke.
- Trial name
- NCT06684483
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Alcohol-associated Liver Disease
A Cross-sectional Study on the Association of Peptidoglycan Fragments Derived From Gut Microbiota With Alcohol Liver Disease
alcohol-associated liver disease (ALD) is a leading cause of cirrhosis, yet the role of gut microbiota-derived peptidoglycan (PG) metabolites in liver injury remains unclear.
- Trial name
- NCT07284862
- Testing
- An observational, non-interventional study design.
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Alcohol Use Disorder
Pilot Trial to Evaluate PROblem Solving Therapy and APPLE Watch for College Students
The goals of this Pilot Trial are to test the preliminary efficacy of Problom-Solving Therapy (PST)-APPLE Watch in a 2-arm pilot Randomized Control Trial (RCT), vs education only-control to reduce alcohol use disorder symptoms…
- Trial name
- NCT06333288
- Testing
- PST-APPLE Watch group, Education-only control group
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Psychotic Disorders, Substance Use
Peer Approaches to Substances in Early Psychosis Programs: A Pilot Study of a Peer-Led Intervention
The aim of the study is to pilot a peer-provided, manualized intervention to increase the proportion of young people with first episode psychosis who reduce or stop substance use and improve psychiatric and functional outcomes.
- Trial name
- PAS-EPP (NCT04517279)
- Testing
- Peer Approach to Substances in Early Psychosis Programs, Usual Care Peer Services
- Where
- 15 sites in United States
- Volunteers
- 113 people
- Sponsor
- University of Texas at Austin
Prevention Harmful Effects
Computerized Alcohol Screening for Children and Adolescents (cASCA) in Primary Care
The purpose of this study is to assess the psychometric properties of a brief screening questionnaire for alcohol problems among 9- to 18-year-old patients in pediatricians' offices, and to pilot test a personalized…
- Trial name
- cASCA (NCT02233946)
- Testing
- computer-facilitated brief intervention
- Where
- 5 sites in United States
- Volunteers
- 871 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Alcohol Use Disorder
Image-guided, Robot Navigated Transcranial Magnetic Stimulation (IR-TMS) for Alcohol Use Disorder (AUD)
This study is testing a new treatment called IR-TMS (image-guided, robot navigated transcranial magnetic stimulation) to see if it can help people who drink too much alcohol to reduce the amount they drink.
- Trial name
- NCT06648642
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Alcohol or Other Drugs Use
Brief Substance Use Intervention for Youth in Teen Court
Youth involved in the juvenile justice system have multiple problems, including an earlier onset of alcohol and drug use and higher rates of alcohol and drug use than their peers in the general population.
- Trial name
- NCT01464554
- Testing
- Usual care, Project Free Talk
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- RAND
Alcohol Use Disorder, Alcohol Abstinence
Feasibility of Telephone-based Acceptance and Commitment Therapy in Hong Kong Chinese Young Adults With Alcohol Use Disorder: A Pilot Study
Objective: The proposed study aims to develop a protocol of telephone-based Acceptance and Commitment Therapy (ACT) for Alcohol Use Disorder (AUD) and examine the feasibility of implementing such intervention among the Hong Kong…
- Trial name
- NCT07501130
- Testing
- ACT, Social support
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Alcohol Use Disorder
Clinical Outcome of a Patented Pharmaceutical Composition (KT-110) to Treat Alcohol Use Disorder While Avoiding Major Side Effects
Double-blind randomised, parallel-group, three-arm, multicentre, placebo-controlled study The primary objective is to demonstrate the superiority of the combination of Periactine® (cyproheptadine 8 mg/day or 12 mg/day) and…
- Trial name
- COCKTAIL (NCT04108104)
- Testing
- Cyproheptadine, Alpress LP
- Where
- 35 sites in France
- Volunteers
- 154 people
- Sponsor
- Kinnov Therapeutics
Alcoholism
Dietary Fiber Intake in Alcohol-dependent Patients
The alcohol problem affects 7.5% of the population in Europe and represents a major public health problem. Alcoholism is also a major cause of undernutrition.
- Trial name
- NCT03803709
- Testing
- inulin
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Université Catholique de Louvain
Alcohol Abuse, IPV
Wearable Technology and Alcohol-Facilitated Intimate Partner Violence
This project seeks to develop interactive treatment options to successfully reduce AUD and IPV concurrently. The purpose of the study is to examine the usability, feasibility, and acceptability of wearable activity trackers (like…
- Conditions
- Alcohol Abuse, IPV, Couples
- Trial name
- START (NCT05374798)
- Testing
- Heart Rate Variability-Biofeedback (HRV-B) via Smartwatch Device Intervention
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Medical University of South Carolina
Cannabis Use, Alcohol Use
Alcohol and Cannabis Co-Use and the Gut-Brain Axis
This observational study aims to improve our understanding of how legal market cannabis use impacts acute and long-term alcohol use, the microbiota-gut-brain-axis (MGBA), and neurobehavioral alcohol use phenotypes such as…
- Conditions
- Cannabis Use, Alcohol Use, Inflammation
- Trial name
- FRACTAL (NCT04998006)
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Depression, Alcohol Use Disorder
Usefulness of Supportive Text Messages in the Treatment of Depressed Alcoholics
Background: There is abundant evidence that rates of comorbidity between substance use and depression are high (1, 2) and the risk of poor outcome is higher among individuals with the dual disorder compared with those with a…
- Trial name
- NCT01037868
- Testing
- Supportive SMS text messages
- Where
- Ireland
- Volunteers
- 56 people
- Sponsor
- University of Dublin, Trinity College
Alcohol Dependence
Comparative Trial Of Disulfiram, Naltrexone And Acamprosate In The Treatment Of Alcohol Dependence
The aim of this study was to compare the effect of manual based cognitive therapy in adjunct of three different pharmacotherapy.
- Trial name
- DNA (NCT00435435)
- Testing
- Disulfiram, Acamprosate, Naltexone
- Where
- Finland
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Alcohol Dependence
Outpatient Psychotherapeutic Treatment for Alcohol Dependent Individuals With Comorbid Psychiatric Disorders
Research has shown that alcohol dependence often co-occurs with comorbid anxiety disorders and/or depression. Anxiety and depression influence the course and treatment of alcohol dependence and are a major risk factor for alcohol…
- Trial name
- NCT02141789
- Testing
- Outpatient Cognitive Behavioral Psychotherapy
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Konstanz
Alcohol Use Disorder (AUD)
The Efficacy and Neurobehavioural Mechanism of Cannabidiol (CBD) for Alcohol Dependence
The study will explore the psychophysiological and neurobiological and mechanisms of CBD in participants with alcohol use disorder
- Trial name
- NCT05387148
- Testing
- Cannabidiol (CBD)
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- South West Sydney Local Health District
Domestic Violence, Alcohol Abuse
Brief Intervention for Problem Drinking and Partner Violence
This study is a randomized controlled trial of a brief intervention for women Emergency Department patients with involvement in both Intimate Partner Violence (IPV) and problem drinking (defined as the full spectrum of hazardous…
- Trial name
- NCT01207258
- Testing
- Motivational Enhancement Therapy
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- University of Pennsylvania