Clinical trials: Alcohol-Related Liver Disease
Decompensated Cirrhosis, Hepatitis B Virus (HBV) Infection
A Study to Predict Recompensation in Patients With Decompensated Cirrhosis Using Spleen Stiffness and Simple Blood Tests
The goal of this observational study is to learn if spleen stiffness and other non-invasive markers can help predict recompensation in people with decompensated cirrhosis who are receiving effective treatment for the cause of…
- Conditions
- Decompensated Cirrhosis, Hepatitis B Virus (HBV) Infection, Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Alcohol-Related Liver Disease
- Trial name
- LEAD-2 (NCT07087041)
- Where
- 28 sites in China
- Volunteers
- 735 people
- Sponsor
- Beijing Friendship Hospital
Liver Diseases, Alcoholic
A Study to Investigate the Safety and Efficacy of Efimosfermin Alfa Compared With Placebo in Adult Participants With Alcohol-related Liver Disease (ALD)
This is a dose-ranging study to evaluate safety of efimosfermin alfa and to establish proof-of-concept that efimosfermin alfa therapy provides benefit in participants with ALD.
- Trial name
- ALLSTAR (NCT07791043)
- Testing
- Efimosfermin alfa
- Where
- 4 sites in United States, Argentina
- Volunteers
- 274 people
- Sponsor
- GlaxoSmithKline
Alcoholic Liver Diseases, Decompensated Cirrhosis
Biomarkers for the Prognosis of Decompensated Alcoholic Liver Disease
Fibroscan is a non invasive imaging investigation which measures liver stiffness, known to correlate well with liver scarring and cirrhosis on liver biopsy.
- Trial name
- BANDED (NCT01701687)
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University of Nottingham
Alcohol-related Liver Disease, Alcohol Dependence
Impact of COVID-19 Outbreak on the Alcohol Consumption in Patients With Alcohol-related Liver Disease (ICoLD)
The lockdown consequent to Coronavirus outbreak has had a differential impact on the drinking behaviour on the general population.
- Conditions
- Alcohol-related Liver Disease, Alcohol Dependence, Alcohol Withdrawal, Addiction, Alcohol
- Trial name
- NCT04876443
- Testing
- Study questionnaire
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- King's College Hospital NHS Trust
Alcoholic Hepatitis
GCSF in Alcoholic Hepatitis
Alcoholic hepatitis is related to very high mortality rate. About 40% of the patients are died within first 6 months after the detection of the clinical syndrome.
- Trial name
- NCT03703674
- Testing
- GCSF
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Carcinoma, Hepatocellular, Liver Cirrhosis, Alcoholic
A Study of Molecular and Genetic Factors for Liver Cancer in the Greater Baltimore Area
Background: Liver cancer is the third most deadly and fifth most common cancer worldwide. Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer, and it has grown more prevalent in the United States.
- Conditions
- Carcinoma, Hepatocellular, Liver Cirrhosis, Alcoholic, Hepatitis, Alcoholic, Hepatitis, Chronic
- Trial name
- NCT00913757
- Where
- 2 sites in United States
- Volunteers
- 1,871 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Liver Cirrhosis
Faecal Microbiota Transplantation for Liver Cirrhosis
The purpose is to investigate the effect of faecal microbiota transplantation (FMT) on complications, progression, and mortality of patients with liver cirrhosis.
- Trial name
- CHiFT (NCT04932577)
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 220 people
- Sponsor
- University of Aarhus
Alcoholic Cirrhosis
Study of Decompensated Alcoholic Cirrhosis Treatment by Stem Cells
The main purpose of this study is to evaluate the safety and tolerance of umbilical cord mesenchymal stem cells (UCMSCs) in patients with decompensated alcoholic cirrhosis, and to provide dose basis for subsequent clinical study…
- Trial name
- NCT05155657
- Testing
- Conventional therapy plus low dose UCMSCs treatment, Conventional therapy plus medium dose UCMSCs treatment, Conventional therapy plus high dose UCMSCs treatment
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Yantai Yuhuangding Hospital
Cirrhosis, End Stage Liver Disease
Mild Hypothermia and Acute Kidney Injury in Liver Transplantation
Acute kidney injury (AKI), or worsening kidney function, is a common complication after liver transplantation (20-90% in published studies).
- Conditions
- Cirrhosis, End Stage Liver Disease, Acute Kidney Injury, Liver Transplant; Complications
- Trial name
- MHALT (NCT03534141)
- Testing
- Esophageal cooling/warming device, Mild hypothermia, Normothermia
- Where
- 3 sites in United States
- Volunteers
- 175 people
- Sponsor
- University of California, San Francisco
Alcoholic Cirrhosis, Iron Overload
Phlebotomy and Risk of Hepatocellular Carcinoma in Patients With Compensated Alcoholic Cirrhosis
The main objective of the study is to assess in patients with compensated alcoholic cirrhosis and hepatic iron overload (HIO), as assessed by MRI, the effect of phlebotomy in order to lower and maintain serum ferritin below 50 µg…
- Trial name
- CIRROX (NCT01342705)
- Testing
- phlebotomy
- Where
- 14 sites in France
- Volunteers
- 17 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Diseases, Alcoholic, Fatty Liver
Personalized Transcranial Magnetic Stimulation (TMS) for Metabolic Dysfunction and Alcohol-Related Liver Disease
The goal of this clinical trial is to learn if repetitive Transcranial Magnetic Stimulation (rTMS), a non-invasive brain stimulation technique, works to treat Metabolic dysfunction-associated and alcohol-associated liver disease…
- Conditions
- Liver Diseases, Alcoholic, Fatty Liver, Metabolic Syndrome
- Trial name
- P-TMS MetALD (NCT07399600)
- Testing
- Individually Targeted rTMS, Conventional rTMS
- Where
- China
- Volunteers
- 105 people
- Sponsor
- The Affiliated Hospital of Hangzhou Normal University
Alcoholic Hepatitis
Short-term Survival in Patients With Severe Alcoholic Hepatitis Treated With Steroid Versus Pentoxifylline
Alcoholic hepatitis represents one of the more serious forms of alcoholic liver disease. Critically ill patients with alcoholic hepatitis have high morbidity and mortality rate.
- Trial name
- NCT01455337
- Testing
- pentoxifylline, Prednisolone
- Volunteers
- 126 people
- Sponsor
- Inje University
Severe Alcoholic Hepatitis
Metadoxine as a Therapy for Severe Alcoholic Hepatitis
The purpose of this study is to determine whether metadoxine is effective for improve survival and reduced oxidative stress in patients with severe alcoholic hepatitis.
- Trial name
- NCT02161653
- Testing
- Prednisone plus Metadoxine, Pentoxifylline plus Metadoxine
- Where
- Mexico
- Volunteers
- 135 people
- Sponsor
- Hospital General de Mexico
Hepatitis C, Transmission, Intravenous Drug Abuser
Acceptability of Simultaneous Screening for Viral Hepatitis B, C and HIV Among Drug Users in Non-conventional Structures
The principle is to propose dedicated monthly screening days bringing together the health personnel involved (hepatologist, addictologist, nurse in charge of the program, addictology nurse and social worker) and to propose…
- Conditions
- Hepatitis C, Transmission, Intravenous Drug Abuser, Addiction, Alcohol, Addiction Opiate
- Trial name
- SCANVIR (NCT05361603)
- Where
- France
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Alcoholic Hepatitis
Use of F-652 in Patients With Alcoholic Hepatitis
Alcoholic hepatitis is a syndrome of progressive inflammatory liver injury associated with long-term heavy intake of ethanol. The pathogenesis is not completely understood.
- Trial name
- TREAT 008 (NCT02655510)
- Testing
- F-652
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Alcohol Related Disorders
Hepatic Function in Alcoholics Following 5 Days of Acetaminophen Dosing
The study objective was to determine if liver injury develops in alcoholic patients during or following 5 days of therapeutic acetaminophen dosing.
- Trial name
- NCT00427206
- Testing
- acetaminophen (4g/day)
- Where
- 2 sites in United States, Canada
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Alcoholic Hepatitis
Short Course Steroids in Alcohol Associated Hepatitis
Alcohol-associated hepatitis (AAH) is one of the most severe manifestations of the spectrum of alcohol related liver disease (ARLD), with high morbidity and mortality.
- Trial name
- STASHII (NCT06919458)
- Testing
- Prednisolone 40 mg
- Where
- 2 sites in India
- Volunteers
- 151 people
- Sponsor
- Asian Institute of Gastroenterology, India
Alcoholic Hepatitis
Fecal Microbial Transplantation in Severe Alcoholic Hepatitis
1. A subtype of Alcoholic hepatitis (AH), named severe alcoholic hepatitis (SAH) is associated with high short-term mortality (J Hepatol, 2019) 2.
- Trial name
- FMTH7 (NCT04758806)
- Testing
- Fecal microbial transplantation
- Where
- Slovakia
- Volunteers
- 50 people
- Sponsor
- F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica
Alcoholism, Alcohol Abuse
Health Behavior Feedback Study for Veterans With Hepatitis C
The purpose of this study was to explore whether a brief (3 session) intervention would impact health behavior of veterans with hepatitis C.
- Conditions
- Alcoholism, Alcohol Abuse, Hepatitis C, Liver Disease
- Trial name
- NCT00229580
- Testing
- 3 session brief intervention with health behavior feedback, treatment as usual
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Washington
Severe Alcoholic Hepatitis
A Comparison of Fecal Microbiota Transplantation and Steroid Therapy in Patients With Severe Alcoholic Hepatitis.
Study population: Patients attending the Out Patient Department and admitted to Institute of Liver and Biliary Sciences. Study design: Prospective randomized controlled trial Study period: One year- January 2017- December 2018…
- Trial name
- NCT03091010
- Testing
- Fecal Microbiota Transplantation, Steroids
- Where
- India
- Volunteers
- 112 people
- Sponsor
- Institute of Liver and Biliary Sciences, India