Clinical trials: Alcohol-dependence
Alcohol Dependence
Varenicline for Alcohol Dependence
The varenicline for alcohol dependence trial investigates the efficacy of varenicline versus placebo for maintaining abstinence in the postacute treatment of alcohol dependent subjects.
- Trial name
- NCT01071187
- Testing
- Varenicline
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Johannes Gutenberg University Mainz
Alcoholism
Acamprosate Treatment: Mechanisms of Action
This study will examine whether pretreatment with two doses of acamprosate for seven days prior to abstinence lessens the intensity of acute withdrawal from alcohol compared with a placebo.
- Trial name
- NCT00004552
- Testing
- acamprosate (Campral)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Yale University
Alcohol Withdrawal Syndrome
Efficacy and Safety of Levetiracetam in the Inpatient Treatment of Alcohol Withdrawal Syndrome
The purpose of this study is to evaluate the efficacy and safety of levetiracetam for treating alcohol withdrawal syndrome (AWS) in inpatients (vs. placebo).
- Trial name
- NCT00146471
- Testing
- Levetiracetam
- Where
- 5 sites in Germany
- Volunteers
- 120 people
- Sponsor
- Charite University, Berlin, Germany
Alcohol Abuse
Contingency Management Treatment Duration
310 alcohol abusing or dependent patients beginning intensive outpatient day treatment at community-based clinics will be randomly assigned to one of four conditions: (a) standard treatment as usual (ST) at the clinic without…
- Trial name
- Duration (NCT00732342)
- Testing
- Contingency Management
- Where
- 5 sites in United States
- Volunteers
- 310 people
- Sponsor
- UConn Health
Alcohol Use Disorder
ED Initiated Oral Naltrexone for AUD
This study will recruit Emergency Department (ED) patients with moderate to severe alcohol use disorder (AUD) who are interested in initiating medication assisted treatment (MAT). The study is split into two phases.
- Trial name
- NCT04817410
- Testing
- Emergency Department Initiated Oral Naltrexone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Liver Diseases, Alcoholic, Alcoholism
Integrated Stepped Care for Unhealthy Alcohol Use in HIV
The study is a series of 3 linked randomized clinical trials of 6 month duration, with a total of 12 month follow-up, to evaluate the effect of Integrated Stepped Care on drinking outcomes and HIV biologic markers (including VACS…
- Conditions
- Liver Diseases, Alcoholic, Alcoholism, HIV, Hepatitis C
- Trial name
- NCT01410123
- Testing
- Integrated Stepped Care (ISC), Treatment as Usual
- Where
- 5 sites in United States
- Volunteers
- 319 people
- Sponsor
- Yale University
Alcohol Dependence, Veterans
Long-Acting Injectable Naltrexone Treatment of Alcohol Dependence in Primary Care vs. in Specialized Chemical Dependence Treatment: A Pilot Trial
The goal of the proposed project is to improve the primary care treatment of veterans with alcohol dependence. Alcohol dependence is a common behavioral health problem among veterans treated in VA primary care clinics.
- Trial name
- NCT00461890
- Testing
- Injectable Naltrexone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Alcohol Use Disorder
Probiotic Study in Alcohol Recovery
Alcohol Use Disorder (AUD) is a common condition that can affect physical and mental health. Current treatments do not work for everyone, and new approaches are needed.
- Trial name
- NCT07510113
- Testing
- Probiotic Formula Capsule
- Where
- United Kingdom
- Volunteers
- 38 people
- Sponsor
- Loughborough University
Drug Dependence, Alcohol Dependence
Impact of Exercise and Affirmations (IntenSati) on Addiction-related Cognitive and Psychosocial Deficits
Addiction to illicit and prescribed drugs, alcohol and tobacco is associated with a panoply of brain changes that contribute to structural and micro-structural deficits, altered metabolism and neurotransmission, and related…
- Trial name
- NCT01171677
- Testing
- IntenSati
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Substance-Related Disorders
Medical Office Intervention for Adolescent Drug Use
The goal of this study is to assess the efficacy of a new intervention based on motivational enhancement therapy among adolescents with a history of substance use.
- Trial name
- NCT00229983
- Testing
- Motivational Enhancement Therapy
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Boston Children's Hospital
Opioid Agonist Treatment, Alcohol Use Disorder
Mobile Platform for Optimizing Wellness and Engagement in Recovery
This pilot study addresses the urgent public health crisis of co-occurring opioid and alcohol use disorders (OUD-AUD), leading causes of mortality in the United States, by testing a scalable digital contingency management (CM)…
- Conditions
- Opioid Agonist Treatment, Alcohol Use Disorder, Opioid Use Disorder
- Trial name
- MPOWER (NCT07178990)
- Testing
- Digital Contingency Management Intervention Arm, Digital Wellness Arm
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Alcohol Use Disorder, Alcohol Abuse
Talk Therapy by Phone to Promote Treatment for Alcohol Problems
A small percentage of individuals with alcohol use disorder (AUD) obtain alcohol-related care despite research showing that treatment is effective.
- Trial name
- NCT03758274
- Testing
- CBT by Phone to Promote Treatment, Reading the Subject a Pamphlet on Obtaining Alcohol Use Disorder Treatment
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Rochester
Alcohol Use Disorder, Risky Health Behavior
A Female-Specific CBT Group for Veteran Women With Alcohol Use Disorder in VA Primary Care Settings
The purpose of this study is to evaluate a Female-Specific Cognitive Behavioral Therapy (CBT) Group as treatment for Alcohol Use Disorder among Veteran women.
- Trial name
- NCT06118346
- Testing
- Female-Specific Cognitive Behavioral Therapy (FS-CBT), Usual Care
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- University of Massachusetts, Worcester
Alcohol Use Disorder
Decreasing the Temporal Window in Individuals With Alcohol Use Disorder
In the absence of sufficient monetary resources, individuals must attend to immediate, minimum needs (e.g., food, shelter). This constricts one's temporal window and engenders neglect of the future.
- Trial name
- RP1B (NCT04128761)
- Testing
- Scarcity Narrative, Neutral Narrative
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Virginia Polytechnic Institute and State University
Alcoholism, Smoking
Behavioral Counseling for Alcohol Dependent Smokers (Nicotine Patch)
This study is to evaluate the effectiveness of a mood management intervention on abstinent alcoholic smokers with a history of major depression.
- Trial name
- NCT00004551
- Testing
- nicotine replacement patch, mood management
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Mayo Clinic
Addiction, Alcohol, Addiction, Substance
Efficiency of Prevention Program Dedicated to Addictive Behaviors (PREVENTURE) of Vulnerable Teenagers
At the age of 17, in Brittany, 94.9% of adolescents have experimented alcohol consumption 78.1% within a month and 25.5% report repeated episodes of Intensive Punctual Alcohol.
- Trial name
- PREVADO (NCT04599270)
- Testing
- PREVENTURE Program, Routine care
- Where
- 5 sites in France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Brest
Alcohol Dependence
Endophenotyping With Functional Magnetic Resonance Imaging (fMRI)
The mesolimbic dopaminergic reward system is a key structure underlying addictive behaviour in alcohol addiction and is under control of prefrontal glutamatergic neurotransmission.
- Trial name
- NGFN PLUS TP13 (NCT01503931)
- Where
- Germany
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Alcohol Use Disorder
AABM to Decrease Problem Drinking and Impulsivity in Veterans With AUD: A Pilot Study
The proposed study is a pilot prospective, parallel groups, randomized, double blind, sham training-controlled, 9-session (over 3 weeks) clinical trial of AABM in 32 male and female veterans entering treatment for AUD at the VA…
- Trial name
- AABM (NCT02600832)
- Testing
- AABM Training
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Francisco
Alcohol-Related Disorders, Substance-Related Disorders
The Women's Recovery Group Study: Stage I Trial
The purpose of this study was to develop a gender-specific 12-session, manual-based relapse prevention group for women with substance use disorders (SUDs).
- Trial name
- NCT00230100
- Testing
- The Women's Recovery Group, mixed-gender Group Drug Counseling
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Mclean Hospital
Alcoholism
Assessing the Fit of Motivational Interviewing by Cultures With Adolescents
Hispanic adolescents experience more severe alcohol-related consequences due to their alcohol abuse and yet significantly fewer Hispanic adolescents receive alcohol treatment, particularly among justice-involved youth.
- Trial name
- AMICA (NCT01948700)
- Testing
- Motivational Interviewing, Education
- Where
- United States
- Volunteers
- 506 people
- Sponsor
- University of New Mexico