Clinical trials: Alcohol-induced Disorders
Reduction in Heavy Drinking in Patients With HIV
Reducing Heavy Drinking to Optimize HIV/AIDS Treatment and Prevention
This is a double-blind placebo-controlled study to evaluate the effect of Naltrexone (NTX) and counseling on highly active antiretroviral treatment (HAART) medication adherence in a cohort of HIV-infected patients who report…
- Trial name
- DAWN (NCT01227044)
- Testing
- Naltrexone
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Yale University
Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome
Scaling Up: A Multi-Site Trial of e-SBI for Alcohol Use in Pregnancy
The purpose of this research study is to find out if pregnant women screening positive for alcohol risk like the brief alcohol intervention application that the investigators have developed (called the MommyCheckup, which is a…
- Conditions
- Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome, Fetal Alcohol Effect
- Trial name
- e-Health (NCT04332172)
- Testing
- General information, Baseline brief intervention, Remote online booster sessions
- Where
- United States
- Volunteers
- 384 people
- Sponsor
- Michigan State University
Alcohol Use Disorder, Post Traumatic Stress Disorder
Cannabidiol as a Treatment for AUD Comorbid With PTSD
This project aims to determine whether cannabidiol (CBD), a compound derived from the cannabis plant, is effective in treating alcohol use disorder (AUD) in individuals with comorbid posttraumatic stress disorder (PTSD).
- Trial name
- NCT03248167
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- NYU Langone Health
Acute Alcoholic Hepatitis
Novel Therapies in Moderately Severe Acute Alcoholic Hepatitis
This study is being done to find out whether a diet supplemented with a probiotic nutrient can improve alcoholic hepatitis and gut complications compared to routine standard care.
- Trial name
- NTAH-Mod (NCT01922895)
- Testing
- Lactobacillus Rhamnosus GG
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Texas Southwestern Medical Center
Alcohol Use Disorders
Oxytocin Suppresses Substance Use Disorders Associated With Chronic Stress
In comparison to the general population, military personnel and veterans are at increased risk of developing both substance use disorders (SUDs) and post-traumatic stress disorder (PTSD).
- Trial name
- NCT02058251
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Medical University of South Carolina
Hepatitis C, Alcohol Abuse
Web-based Intervention to Reduce Alcohol Use in Veterans With Hepatitis C
Many people who are infected with Hepatitis C misuse alcohol, which is even more dangerous for them than it is for a non-infected person.
- Trial name
- NCT01707030
- Testing
- Web-Based Brief Alcohol Intervention, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 138 people
- Sponsor
- VA Office of Research and Development
Alcoholism
Varenicline (Chantix™) for the Treatment of Alcohol Dependence
The purpose of this study is to determine the efficacy of varenicline (Chantix™) for the treatment of alcohol dependence.
- Trial name
- ChA (NCT00705523)
- Testing
- varenicline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Alcohol Dependence
Mindfulness Meditation for Health
The purpose of this 52-week clinical trial is to see if the meditation-based intervention, adjunctive to standard of care therapy, can reduce relapse and improve psychological health among adults recovering from alcohol…
- Trial name
- NCT01056484
- Testing
- Mindfulness Based Relapse Prevention for Alcohol Dependence, "Wait-list" control
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- University of Wisconsin, Madison
Major Depressive Disorder, Alcohol Use Disorder
Treatment of Young Adults With Comorbid AUD/MDD: A Pilot Medication Trial
Recent reports have shown that alcohol misuse is a particularly serious problem among the 18 to 25 year old age group. Previous medication trials with SSRI antidepressants among young adults with co-occurring depressive…
- Trial name
- YAAD-P (NCT02646449)
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Alcoholism
Understanding Treatment Response With Naltrexone Among White Alcoholics
This is a study involving treatment for alcohol dependence among males of European or Asian decent. The ultimate aim of this line of investigation is to further establish a genetic link between alcohol dependence and treatment by…
- Trial name
- DEFINE II (NCT00817089)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Pennsylvania
Severe Acute Alcoholic Hepatitis
To Assess Safety/Efficacy of ELAD in Subjects w/ Severe Acute Alcoholic Hepatitis (sAAH) and Lille Score Failure
The purpose of this study is to determine if treatment with the ELAD System is safe and effective in subjects with severe acute alcoholic hepatitis and Lille score failures (Lille score >0.45).
- Trial name
- NCT01829347
- Testing
- ELAD, Standard of Care treatment
- Where
- 39 sites in United States, Germany and 2 more
- Volunteers
- 18 people
- Sponsor
- Vital Therapies, Inc.
Alcohol Dependence
Aripiprazole Effects on Alcohol Drinking and Craving
The purpose of this study is to determine whether aripiprazole (marketed dopamine stabilizer) is effective in reducing of alcohol craving and drinking compared to placebo depending on participant's baseline level of impulsivity.
- Trial name
- NCT01292057
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Medical University of South Carolina
PTSD and Alcohol Use Disorder
Topiramate and Prolonged Exposure
Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) frequently co-occur, and having both disorders is associated with greater psychological and functional impairment than having either disorder alone.
- Trial name
- TOP (NCT03176953)
- Testing
- topiramate, prolonged exposure
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
HIV Infections, Alcoholism
Brief Therapy Intervention for Heavy/Hazardous Drinking in HIV-Positive Women
The purpose of this study is to determine whether two brief counseling sessions reduce drinking and improve health outcomes in HIV-positive women who drink at heavy/hazardous levels.
- Trial name
- NCT00127231
- Testing
- Brief alcohol intervention based on Project Treat, Standard care
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Johns Hopkins University
Alcoholism
Medication Development in Alcoholism: Acamprosate Versus Naltrexone
The purpose of this study is to develop and validate a human laboratory model for prediction of medication efficacy in clinical trials for relapse prevention in alcohol dependence.
- Trial name
- NCT00656630
- Testing
- Acamprosate, Naltrexone
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- The Scripps Research Institute
Alcohol Use Disorder
EMA/EMI for Psychiatrically Hospitalized Emerging Adults Who Drink to Cope
The goal of this proposed study is to evaluate an ecological momentary assessment plus an ecological momentary intervention (EMA+EMI) for emerging adults in a psychiatric partial hospitalization program who drink to cope with…
- Trial name
- NCT05074030
- Testing
- Personalized Normative Feedback, Coping-Motive Specific Personalized Feedback Intervention plus an Ecological Momentary Intervention (PFIcope+EMI)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Butler Hospital
Alcohol Abuse
Computer-delivered Screening and Brief Intervention for Alcohol Use in Pregnancy
The purpose of this study is to lay the ground work for a fully powered clinical trial of a computer-delivered screener and intervention for alcohol use during pregnancy. The pilot study will include: 1.
- Trial name
- NCT01643044
- Testing
- Computer-delivered, brief intervention on alcohol use
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Wayne State University
Alcohol Drinking, Alcohol Abuse
A Gamified, Social Media Inspired Personalized Normative Feedback Alcohol Intervention for Sexual Minority Women
Sexual minority women in the United States are more likely to drink alcohol, engage in heavy drinking, and experience alcohol-related problems than are heterosexual women.
- Conditions
- Alcohol Drinking, Alcohol Abuse, Alcohol; Harmful Use
- Trial name
- NCT03884478
- Testing
- Personalized Normative Feedback
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Loyola Marymount University
Alcohol Dependence
A Randomized Clinical Trial of Alcohol Care Management
A randomized study of Alcohol Care Management for the treatment of alcohol dependence in primary care settings.
- Trial name
- NCT00419315
- Testing
- Alcohol Care Management, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 163 people
- Sponsor
- US Department of Veterans Affairs
Alcohol Use Disorder
Medication Development for Protracted Abstinence in Alcoholism: CORT118335 Versus Placebo
The hypotheses under test are that subjects with alcohol use disorder (AUD) of moderate or greater severity treated with CORT118335 will report decreased craving for alcohol following alcohol exposure in the laboratory and report…
- Trial name
- NCT04466215
- Testing
- Miricorilant
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Scripps Research Institute