Clinical trials: Alcohol-induced Disorders
Alcohol Withdrawal, Alcohol Dependence
Oxytocin Treatment of Alcohol Dependence
This study will test in individuals who have alcohol dependence (alcohol addiction) the hypotheses 1) that intranasal oxytocin treatment will decrease withdrawal symptoms during medical detoxification and 2) that intranasal…
- Trial name
- OT-ETOH2 (NCT02275611)
- Testing
- intranasal oxytocin spray
- Volunteers
- 13 people
- Sponsor
- University of North Carolina, Chapel Hill
Alcohol Dependence, Post-Traumatic Stress Disorder (PTSD)
Zonisamide in Addition to E-CPT-C for Veterans With PTSD and Comorbid Alcohol Dependence
This is a randomized, controlled trial with 50 veterans diagnosed with post-traumatic stress disorder (PTSD) and comorbid alcohol dependence.
- Trial name
- NCT01847469
- Testing
- Enhanced-Cognitive Processing Therapy-C (E-CPT-C), Zonisamide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Yale University
Alcohol Use Disorder
An Open-Label, Single Dose Study in Patients With Alcohol Use Disorder
An open-label, Phase 2a study to evaluate the safety, tolerability, and pharmacodynamic effects of a single intranasal dose of BPL-003 combined with relapse prevention psychological support, to explore the potential effects on…
- Trial name
- NCT05674929
- Testing
- BPL-003
- Where
- 2 sites in United Kingdom
- Volunteers
- 13 people
- Sponsor
- Beckley Psytech Limited
Fetal Alcohol Spectrum Disorders
Cognitive Training and tDCS for Children With FASD
This is a randomized placebo-controlled trial of cognitive training with transcranial direct current stimulation (tDCS) for children and adolescents (ages 10 - 16 years) with prenatal alcohol exposure (PAE).
- Trial name
- NCT03361293
- Testing
- Active tDCS, Cognitive training
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Minnesota
Insomnia
The Efficacy of CBT-I in Alcoholics & Its Effects on Remission & Relapse
Insomnia is a highly prevalent disorder in those recovering from alcoholism. It has been associated with anxiety and depressive symptoms, as well as an increased risk of relapse back to the drinking.
- Trial name
- NCT01987089
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development
Alcohol Dependence, Nicotine Dependence
New Treatment for Alcohol and Nicotine Dependence
This research study aims to test whether topiramate (a drug that is being used for seizure) will help individuals who have problems with both alcohol and nicotine.
- Trial name
- NCT01182766
- Testing
- Low-Dose Topiramate, High-Dose Topiramate
- Where
- 4 sites in United States
- Volunteers
- 236 people
- Sponsor
- University of Virginia
Bipolar Disorder, Alcohol Abuse
Efficacy and Tolerability of Topiramate in Treatment of Bipolar Mania and Alcohol Use in Adolescents and Young Adults
The purpose of this research study is to study the effects (both good and bad) of combining quetiapine and topiramate for treating symptoms of bipolar mania (an illness with periods of elation, excessive excitement, irritability…
- Trial name
- NCT00550394
- Testing
- Quetiapine and Topiramate
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Cincinnati
Alcoholism
Clinical Study of TripleA for Treatment of Alcohol Addiction in Outpatient Care
The primary objective is to investigate differences in the alcohol consumption pattern between alcohol addicts receiving conventional treatment and those who receive a combination of conventional treatment and TripleA.
- Trial name
- NCT03195894
- Testing
- TripleA
- Volunteers
- 115 people
- Sponsor
- Kontigo Care AB
Alcohol Dependence, Alcohol Abuse
ABT-436 for Alcohol Dependence
The primary efficacy endpoint examines the hypothesis that ABT-436 will decrease the weekly percentage of heavy drinking days during Study Weeks 2 through 12 (Days 8-84) as compared to placebo.
- Conditions
- Alcohol Dependence, Alcohol Abuse, Alcohol Use Disorders, Alcoholism
- Trial name
- NCT01613014
- Testing
- ABT-436
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Abuse
Study of Mobile Phone Delivered Intervention to Reduce Alcohol Consumption
In this study, the investigators will be developing and testing a mobile phone text message intervention to reduce alcohol use for people at risk of alcohol dependence.
- Trial name
- mROAD (NCT02158949)
- Testing
- mROAD
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Southern California
Alcohol Use Disorder
Treatment Parameters for the Empower Neuromodulation System (ENS)
The subject will be administered a treatment at a treatment location and then be asked if he/she believes it is the active treatment, sham treatment, or does not know.
- Trial name
- AUD1 (NCT03807544)
- Testing
- TENS
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Theranova, L.L.C.
Lysosomal Acid Lipase Deficiency
Clinical Study In Infants With Rapidly Progressive Lysosomal Acid Lipase Deficiency
This was an open-label, repeat-dose, study of sebelipase alfa in infants with rapidly progressive lysosomal acid lipase deficiency (LAL-D). Eligible participants received once-weekly infusions of sebelipase alfa for up to 3 years.
- Trial name
- NCT02193867
- Testing
- Sebelipase Alfa
- Where
- 5 sites in United States, Finland and 2 more
- Volunteers
- 10 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Alcohol Dependence
Aripiprazole Effects on Alcohol Drinking and Craving
The purpose of this study is to determine whether aripiprazole (marketed dopamine stabilizer) is effective in reducing of alcohol craving and drinking compared to placebo depending on participant's baseline level of impulsivity.
- Trial name
- NCT01292057
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Medical University of South Carolina
Alcohol Abuse
Buproprion for Binge Drinking
The present proposal is an innovative and translational clinical trial derived from exciting preclinical findings to test the hypothesis that treatment with the melanocortin activator bupropion can reduce binge drinking in…
- Trial name
- NCT03169244
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of North Carolina, Chapel Hill
Alcoholism, Alcohol Abuse
Dutasteride Treatment for the Reduction of Heavy Drinking in Men
This study will examine the safety and potential benefit of the medication dutasteride to help men reduce or stop drinking alcohol.
- Conditions
- Alcoholism, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT01758523
- Testing
- Dutasteride, sugar pill
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- UConn Health
Alcohol Abuse, Alcohol Dependence
Facilitating Aftercare for Alcohol Detox Patients
The purpose of this study is to determine whether peer visits (known as "12th Step Calls") and professional counselors (using "Motivational Enhancement Therapy") are effective helping alcoholics link to substance abuse treatment…
- Trial name
- NCT00513708
- Testing
- Motivation Enhancement Therapy (MET), Peer-Twelve Step Facilitation (P-TSF)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- State University of New York at Buffalo
Alcohol Use Disorder
Zonisamide Treatment of Alcohol Use Disorder: an Evaluation of Efficacy and Mechanism of Action
This is a randomized, placebo-controlled, double-blind, 16 week trial of the medication zonisamide for the treatment of heavy drinking alcoholic civilians.
- Trial name
- Z-Comp (NCT02900352)
- Testing
- Zonisamide
- Where
- 4 sites in United States
- Volunteers
- 156 people
- Sponsor
- Virginia Commonwealth University
Bipolar Disorder, Alcohol Drinking
Acute Alcohol Response In Bipolar Disorder: a fMRI Study
Alcohol use disorders (AUDs) affect up to 60% of individuals with bipolar disorder during their lifetime-a rate 3 to 5 times higher than what occurs in the general population.
- Conditions
- Bipolar Disorder, Alcohol Drinking, Alcohol Use Disorder
- Trial name
- BACS (NCT04063384)
- Testing
- alcohol beverage
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Alcohol Use Disorder, HIV-infection/Aids
Development of an Intervention to Reduce Heavy Drinking and Improve HIV Care Engagement Among Fisherfolk in Uganda
Fisherfolk are a high risk population for HIV and are prioritized to receive antiretroviral treatment (ART) in Uganda, but risky alcohol use among fisherfolk is a barrier to HIV care engagement; multilevel factors influence…
- Trial name
- NCT03919695
- Testing
- Kisoboka: Behavioral and Structural Intervention, Screening and Referral
- Where
- Uganda
- Volunteers
- 160 people
- Sponsor
- San Diego State University
Alcohol Dependence, Alcohol Use Disorder
Extended-release Naltrexone and Care Management for Alcohol Dependent Frequent Emergency Department Users
Our primary aim is to assess the feasibility of initiating treatment in the ED with extended-release naltrexone (XR-NTX) plus care management (CM) vs.
- Trial name
- NCT02445339
- Testing
- XR-NTX+CM (Extended-Release Naltrexone plus Care Management)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health