Clinical trials: Alcohol-induced Disorders
Alcoholism
New Medications to Treat Alcohol Dependence
In the last decade, there has been an explosion of new knowledge of the neuroscientific basis of alcohol-seeking behavior. Briefly, medications that modulate mesolimbic dopamine pathways by facilitating gamma amino butyric…
- Trial name
- NCT00223639
- Testing
- Topiramate
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Bankole Johnson
Alcohol Dependence, Alcohol Use Disorder
Extended-release Naltrexone and Care Management for Alcohol Dependent Frequent Emergency Department Users
Our primary aim is to assess the feasibility of initiating treatment in the ED with extended-release naltrexone (XR-NTX) plus care management (CM) vs.
- Trial name
- NCT02445339
- Testing
- XR-NTX+CM (Extended-Release Naltrexone plus Care Management)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
Addiction, Substance, Alcohol Use Disorder
Validation of the French Version of the Prediction of the Alcohol Withdrawal Severity Scale (PAWSS)
The goal of this observational study is to validate the French version of the PAWSS scale in a population of patients with Alcohol Use Disorders.
- Conditions
- Addiction, Substance, Alcohol Use Disorder, Alcohol Dependence, Alcohol Withdrawal
- Trial name
- PAWSS-VF (NCT06675539)
- Testing
- French version PAWSS
- Where
- France
- Volunteers
- 545 people
- Sponsor
- Etablissement Public de Santé Barthélemy Durand
ALD - Alcoholic Liver Disease
Comparison of ALD, NASH, and Healthy Control Patients
The availability of biological samples from individuals with alcoholic liver disease (ALD), as well as samples from appropriate heavy drinking, yet healthy controls and non-drinking healthy controls, is an essential first step in…
- Trial name
- NCT03224949
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Substance Abuse, Substance Dependence
fMRI Study of a Dual Process Treatment Protocol With Substance Dependent Adults
The purpose of this study is to determine whether drug-dependent adults who participate in a dual processing relapse prevention treatment protocol that allows for sensory-based exposure experiences over 10-weeks in outpatient…
- Conditions
- Substance Abuse, Substance Dependence, Alcohol Abuse, Drug Use
- Trial name
- NCT01320748
- Testing
- Dual Processing, Relapse Prevention
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Inova Health Care Services
Stress Disorders, Post-Traumatic, Intimate Partner Violence
Addressing the Health Concerns of VA Women With Sexual Trauma
Lifetime sexual trauma (ST) (i.e., behaviors that range from unwanted sexual touching to attempted or completed rape) is a significant social and public health problem among women Veterans.
- Conditions
- Stress Disorders, Post-Traumatic, Intimate Partner Violence, Alcohol-Related Disorders
- Trial name
- SHE (NCT02957747)
- Testing
- SHE
- Where
- 2 sites in United States
- Volunteers
- 153 people
- Sponsor
- VISN 17 Center of Excellence
Stress Disorders, Post-Traumatic, Substance-Related Disorders
Concurrent Treatment for Substance Dependent Individuals With Post-Traumatic Stress Disorder (PTSD)
This treatment intervention trial is designed for men and women with substance dependence and comorbid Post-Traumatic Stress Disorder (PTSD).
- Trial name
- NCT01365247
- Testing
- Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure, Relapse Prevention Treatment, Active Monitoring Control Group
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- The City College of New York
Alcohol-Related Disorders, Alcohol Dependence
Acamprosate to Reduce Symptoms of Alcohol Withdrawal
This study will examine whether a new drug called acamprosate can be helpful for alcohol withdrawal, a result of drinking high amounts of alcohol for long periods of time.
- Conditions
- Alcohol-Related Disorders, Alcohol Dependence, Alcoholism, Healthy Volunteer
- Trial name
- NCT00106106
- Testing
- NMR-spectroscopy, Oral acamprosate
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Alcoholic Intoxication, Chronic
Effect of Psychoeducation on Motivation to Change in Traumatized Alcoholics
Many people suffering from alcohol dependence have a history of exposure to stressful life situations, such as childhood physical or emotional misuse.
- Trial name
- NCT01323738
- Testing
- Psychoeducation
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Konstanz
Alcohol Use Disorders
The Effect of a Interdisciplinary Alcohol Cessation Intervention
The effect of alcohol interventions seems to be related to the intensity of the interventions. In this study the investigators will assess the effect of a interdisciplinary "booster session" in primary care, given to patients who…
- Trial name
- NCT01208571
- Testing
- "Booster session"
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Helse Stavanger HF
Alcohol Use Disorder
StuDy AimED at Increasing AlCohol AbsTinEnce
The goal of this clinical trial is to test the feasibility \& acceptability of an integrated CM-PST intervention (in K99 phase) and preliminary efficacy (in R00 phase), vs.
- Trial name
- NCT05778734
- Testing
- CM-PST, CM only
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Alcohol Use Disorder, Depression
aTBS for Treatment of Depression in AUD
This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial magnetic stimulation device for improvement of depressive symptoms and drinking behavior in individuals with alcohol dependence.
- Trial name
- NCT03981185
- Testing
- Accelerated theta burst treatment
- Sponsor
- Stanford University
Alcohol Use Disorder, Depression
The Network Study: Soldiers Connecting for Work and Health
This study will examine the efficacy of an internet-based brief intervention designed to reduce risky behavior in Soldiers as they transition from Active Duty into the civilian workforce as a Veteran.
- Trial name
- NCT04463225
- Testing
- Internet-Delivered Brief Intervention
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Cornell University
Hazardous Drinking
Primary Care-based Facilitated Access to a Web Based Brief Intervention to Reduce Alcohol Consumption
Brief Interventions (BIs) for risky drinkers are an effective tool in primary care. Lack of time in daily practice has been identified as a barrier for the wide implementation of BI.
- Trial name
- EFAR-Spain (NCT02082990)
- Testing
- Face-to-Face Brief Intervention, Online Brief Intervention
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- Hospital Clinic of Barcelona
Alcohol Drinking Related Problems, Alcohol Use Disorders
Co-occurence of Mental Illness and Problematic Alcohol Use: an Internet-based Cognitive Behavior Therapy Intervention
The goal of this clinical trial is to learn if internet-based cognitive behavior therapy (ICBT ) works to treat co-occurent of problematic alcohol use and mental illness including mild to moderate symptoms of either depression…
- Conditions
- Alcohol Drinking Related Problems, Alcohol Use Disorders, Depressive Disorders, Mental Illness
- Trial name
- CoMiT (NCT06789250)
- Testing
- Internet-based cognitive behavior therapy
- Where
- 2 sites in Sweden
- Volunteers
- 240 people
- Sponsor
- Linkoeping University
Alcohol Use Disorder
Blended Treatment for Alcohol Use Disorder
Blended Treatment for Alcohol Use Disorder (BLEND-A) is a pragmatic, cluster randomized controlled trial to assess the clinical effectiveness and cost-effectiveness of implementing a blended treatment format that aims to reduce…
- Trial name
- BLEND-A (NCT04535258)
- Testing
- Blend-A
- Where
- Denmark
- Volunteers
- 1,800 people
- Sponsor
- University of Southern Denmark
Severe Alcoholic Hepatitis
Efficacy of G-CSF in the Management of Steroid Non-responsive Severe Alcoholic Hepatitis
After successful screening, first the investigators first treat patients of severe alcoholic hepatitis with steroids for 7 days.
- Trial name
- NCT01820208
- Testing
- G-CSF
- Where
- India
- Volunteers
- 28 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Alcohol Use Disorder
Brief Family-involved Treatment for Alcohol Use Disorder
Family-involved treatments for alcohol use disorders (AUDs) hold considerable promise to improve engagement and compliance with treatment and improve treatment outcomes.
- Trial name
- B-FIT (NCT05545644)
- Testing
- Brief Family-Involved Treatment for Alcohol Use Disorder
- Volunteers
- 35 people
- Sponsor
- University of New Mexico
HIV Antiretroviral Therapy (ART) Adherence, Alcohol Consumption
Pilot of an Intervention to Reduce Alcohol Use and Improve ART Adherence Among Men Living With HIV With Pregnant Partners in Uganda.
Hazardous alcohol use, which is common among men in Uganda, is a primary driver of both HIV risk and intimate partner violence (IPV) in this setting.
- Trial name
- Kisoboka Amaka (NCT06900634)
- Testing
- Kisoboka Amaka, Screening and Referral
- Where
- Uganda
- Volunteers
- 60 people
- Sponsor
- San Diego State University
Alcohol Drinking, Alcohol-Related Disorders
Feasibility and Potential Effectiveness of a Case Management Intervention for Alcohol Use-Related Problems in Frequent Users of an Emergency Department: a Pilot Study
Alcohol use and its consequences represent an important public health problem. As well as alcohol dependence, hazardous drinking also contributes to a high burden in terms of morbidity and mortality.
- Trial name
- MALUA_Freq_P (NCT04938258)
- Testing
- Intensive Case Management
- Where
- Spain
- Volunteers
- 5 people
- Sponsor
- Hospital Clinic of Barcelona
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