Clinical trials: Alcohol-induced Disorders
Alcohol Drinking, Alcohol Intoxication
Mindfulness-Based Intervention and Transcranial Direct Current Brain Stimulation to Reduce Heavy Drinking
Alcohol use disorder (AUD) impacts millions of Americans and is associated with significant behavioral, social, economic, medical, and neurobiological dysfunction, yet current behavioral treatments for AUD are only modestly…
- Conditions
- Alcohol Drinking, Alcohol Intoxication, Alcoholism
- Trial name
- MBItDCS (NCT02861807)
- Testing
- Brain stimulation with mindfulness-based relapse prevention
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of New Mexico
Alcohol Use Disorder
Orexin Receptor Antagonists as Modulators of Threat Sensitivity in Individuals With Alcohol Use Disorder
The goal of this double-blind clinical trial is to further explore if, how, and for whom orexin antagonism modifies brain-behavior stress targets in moderate to severe alcohol use disorder (AUD).
- Trial name
- NCT05656534
- Testing
- Suvorexant
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Ohio State University
Alcohol Use Disorder, Insomnia
Daridorexant for People With Insomnia and Alcohol Use Disorder Study
The goal of this clinical trial is to see if a sleep medication, daridorexant (DTX), can help decrease drinking in people who have alcohol use disorder (AUD) and insomnia.
- Trial name
- DIAS (NCT07701928)
- Testing
- Daridorexant, Brief Counseling, MEMS and Medication Accounting
- Where
- United States
- Volunteers
- 205 people
- Sponsor
- Sterling McPherson
Alcohol Addiction
Disulfiram as a Modulator of Amyloid Precursor Protein-processing
A causal therapeutic approach for treatment of Alzheimer's disease has not been established so far. The protein ADAM10 represents a promising target for an A-beta peptide preventing strategy.
- Trial name
- DIMAP (NCT03212599)
- Testing
- Disulfiram
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Alcohol Use Disorder
Improving Outcomes Among Medical/Surgical Inpatients With Alcohol Use Disorders
This project aims to help Veterans who are in medical treatment and have untreated alcohol problems. First, the investigators adapted a Decision Aid that explains alcohol-related treatment options and their risks and benefits.
- Trial name
- NCT03258632
- Testing
- Drinking Options - Motivate, Shared Decisions, Telemonitor (DO-MoST)
- Where
- 2 sites in United States
- Volunteers
- 155 people
- Sponsor
- VA Office of Research and Development
HIV Infections, Alcohol Drinking
Boston Alcohol Research Collaboration on HIV/AIDS (ARCH) Cohort: The 4F Study
The purpose of this study is to follow a cohort of HIV-infected adults who have alcohol and/or drug use to: 1) test the associations between alcohol (and illicit drugs and polypharmacy (multiple prescribed medications)) and falls…
- Conditions
- HIV Infections, Alcohol Drinking, Substance-Related Disorders, Bone Diseases
- Trial name
- NCT03414411
- Where
- United States
- Volunteers
- 251 people
- Sponsor
- Boston University
HIV Infection, Alcohol Use
Boston Alcohol Research Collaboration on HIV/AIDS (ARCH) Cohort
The purpose of this study is to expand and continue a cohort of HIV-infected adults to establish the longitudinal Boston ARCH Cohort of 250 HIV-infected men and women with current substance dependence or ever injection drug use…
- Conditions
- HIV Infection, Alcohol Use, Bone Disease, Substance-Related Disorders
- Trial name
- NCT01740115
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Boston Medical Center
Alcohol Dependence
Duloxetine Versus Pregabalin for Alcohol Dependence
A 12-week, double-blind, placebo-controlled parallel group study will be conducted with 150 outpatients with alcohol dependence, with random assignment to pregabalin 300 mg/d, duloxetine 40 mg/d, or placebo in conjunction with…
- Trial name
- NCT00929344
- Testing
- Pregabalin, Duloxetine, Standardized behavioral therapy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The Scripps Research Institute
Alcohol Use Disorder
Citicoline in Youth Alcohol Use Disorder
The goal of this study is to evaluate how citicoline, an over-the-counter supplement, versus a placebo pill (i.e., an inactive pill) affects the immune system, brain, and cognition in adolescents who may use alcohol.
- Trial name
- NCT05870111
- Testing
- Citicoline (cytidine diphosphate-choline)
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Smoking Cessation, Alcohol-Related Disorders
Effectiveness of Bupropion for Smokers Recovering From Alcohol Dependence
Smoking is often a problem for alcohol dependent individuals. Many people who seek treatment for alcohol dependence are unable to quit smoking.
- Trial name
- NCT00304707
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcoholism
Integrative Therapy in Alcoholism
The main aim of this project consists in the investigation of the interaction of behavior therapy and Acamprosate in the outpatient treatment of alcoholic patients in a randomized, prospective and (regarding study medication…
- Trial name
- NCT00159107
- Testing
- Acamprosate, Integrative behavior therapy
- Where
- Germany
- Volunteers
- 371 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Alcoholism
GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence
This Project will explore the hypothesis that individuals with a family history positive for alcohol dependence (without any current Axis I disorder, except nicotine dependence), experience an alteration in the reward "valence"…
- Trial name
- NCT00611767
- Testing
- Thiopental
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Dependence
Brain Derived Neurotrophic Factor Serum Levels Evolution During the Six Months After Alcohol Withdrawal
Alcohol dependence is accompanied by several neurological mechanisms involving neuronal plasticity and neoneurogenesis, requiring Brain Derived Neurotrophic factor (BDNF) synthesis.
- Trial name
- NCT01491347
- Where
- 4 sites in France
- Volunteers
- 389 people
- Sponsor
- Centre Hospitalier Esquirol
Alcohol Drinking, Alcohol Use Disorder
Improving Care for Unhealthy Alcohol Use in Primary Care
In order to improve the quality of alcohol-related care for those with unhealthy alcohol use, the current research will use an evidence-based implementation strategy, practice facilitation, at one VA primary care site to pilot…
- Trial name
- NCT04565899
- Testing
- Practice facilitation implementation intervention
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Substance Use Disorder (SUD), Alcohol Use Disorder (AUD)
Metabolome and Gut Microbiome Changes During Smoking Cessation in Long-term Drug Therapy in a Therapeutic Community
Theoretical Framework: Cigarette smoking is the leading preventable cause of death worldwide, with nicotine dependence notably common among individuals with Substance Use Disorders (SUD).
- Conditions
- Substance Use Disorder (SUD), Alcohol Use Disorder (AUD), Nicotine Addiction, Healthy Adult Participants
- Trial name
- NCT06803706
- Testing
- 6-weeks CBT smoking cessation programme, Long-term drug therapy within a therapeutic community
- Where
- 3 sites in Austria
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Sigmund Freud PrivatUniversitat
Binge Drinking, Harmful Use of Alcohol
Efficacy of a Fully Automated Electronic Screening and Brief Intervention to Reduce Harmful Alcohol Consumption: A Randomized Clinical Trial
This epidemiological study (randomized clinical trial) aims to evaluate a digital Screening and Brief Intervention (e-SBI) system for reducing and preventing harmful alcohol consumption in patients treated by the Brazilian…
- Trial name
- PROSA e-SBI (NCT07675447)
- Testing
- screening and brief intervention, electronic screening and brief intervention tool (e-SBI) for reducing rate of harmful alcohol consumption (HAC)
- Where
- Brazil
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
Alcohol Use Disorder
Virtual Reality (VR) NATURE - Alcohol Use Disorder (AUD)
This pilot randomized clinical trial will evaluate the feasibility, acceptability, and preliminary effectiveness of immersive Virtual Reality (VR) nature intervention among adults with at least moderate depression symptoms…
- Trial name
- NCT07413458
- Testing
- Virtual Reality (VR) -nature treatment, Survey completion
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Alcohol Dependence
Lifestyle Physical Activity Intervention for Depressed Alcohol Dependent Women
Building on the large body of evidence for the effect of exercise in decreasing depressive symptoms and the few preliminary findings of its effect on craving and drinking outcomes, the purpose of this study is to develop a…
- Trial name
- NCT02705898
- Testing
- LPA+Fitbit, HEC
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Butler Hospital
Alcohol Use Disorder
Inpatient Alcohol Detox & Psychotherapy
The aim of the study is to evaluate effectiveness of inpatient detoxification and psycho-therapeutic support, measured in terms of readiness to change and abstinence maintenance.
- Trial name
- NCT03988478
- Testing
- Detoxification & psychotherapeutic support
- Volunteers
- 109 people
- Sponsor
- Tribhuvan University, Nepal
Alcoholism
Naltrexone Treatment of Alcohol Dependence
The long-range goal of this ongoing research program is to find more effective treatments for alcohol dependence by combining medication with the appropriate psychosocial support.
- Trial name
- NCT00000452
- Testing
- naltrexone (Revia), Compliance Enhancement Tech., Cognitive Behavior Therapy
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)