Clinical trials: Alcohol-induced Disorders
Alcohol Use Disorder
Semantic Networks in Alcohol Use Disorder Patients: Exploratory Study
Alcohol Use Disorder (AUD) is a major public health problem, characterized by a high rate of relapse. Chronic and excessive alcohol consumption notably induces frontal brain alterations and cognitive impairments such as executive…
- Trial name
- ALCOOLNET (NCT05636033)
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Opioid Agonist Treatment, Alcohol Use Disorder
Mobile Platform for Optimizing Wellness and Engagement in Recovery
This pilot study addresses the urgent public health crisis of co-occurring opioid and alcohol use disorders (OUD-AUD), leading causes of mortality in the United States, by testing a scalable digital contingency management (CM)…
- Conditions
- Opioid Agonist Treatment, Alcohol Use Disorder, Opioid Use Disorder
- Trial name
- MPOWER (NCT07178990)
- Testing
- Digital Contingency Management Intervention Arm, Digital Wellness Arm
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Intimate Partner Violence, Alcohol Use
Brief Intervention to Reduce Drinking Among Batterers
The goal of this project is to examine whether, relative to standard care, violence and alcohol use outcomes can be improved by a brief, motivationally based adjunct alcohol treatment for men enrolled in batterer intervention…
- Trial name
- NCT00539955
- Testing
- Standard Batterer Intervention, Brief Alcohol Intervention
- Where
- United States
- Volunteers
- 253 people
- Sponsor
- The University of Tennessee, Knoxville
Alcohol Abuse, Alcohol Dependence
Anonymous Treatment on the Internet for Alcohol Dependence: A Randomised, Controlled Trial
Internet based self help program with or without support of a counselor is tested among anonymous Internet help seekers at an open access website.
- Conditions
- Alcohol Abuse, Alcohol Dependence, Harmful Alcohol Use, Alcohol Use Disorder
- Trial name
- NCT02377726
- Testing
- Alkoholhjälpen counselor support, eChange Alkoholhjälpen, Alkoholhjälpen
- Where
- Sweden
- Volunteers
- 1,170 people
- Sponsor
- Karolinska Institutet
Alcohol Use Disorder
Does Oxytocin Alter Tolerance to or Motivation for Alcohol
This pilot study is intended to demonstrate feasibility and acquire preliminary data. If successful, this data could support a future project studying the effect of oxytocin on tolerance and alcohol seeking in humans.
- Trial name
- NCT05312008
- Testing
- Intranasal oxytocin
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Indiana University
Substance-Related Disorders, Alcohol-Related Disorders
Conflict Between Maternal Autonomy and Child Health in Substance-use
Qualitative project, comprising open-ended semi-structured interviews with healthcare workers, who provide antenatal care to substance-using women.
- Conditions
- Substance-Related Disorders, Alcohol-Related Disorders, Amphetamine-Related Disorders, Inhalant Abuse
- Trial name
- NCT02797990
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Prevention of Drug Abuse and Dependency, Alcohol Abuse and Dependency
The Whole Day First Grade Program
This five-year prevention services application is concerned with preventing substance abuse, comorbid mental and behavioral disorders, and school failure.
- Conditions
- Prevention of Drug Abuse and Dependency, Alcohol Abuse and Dependency, High Risk Sex Behavior, Smoking Tobacco
- Trial name
- NCT00257088
- Testing
- whole day first grade program
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- American Institutes for Research
Alcoholic Liver Disease
Ethanol Induces Skeletal Muscle Autophagy
In this study we plan to demonstrate that ethanol induces skeletal muscle autophagy to degrade MAA adducts.
- Trial name
- NCT03209791
- Testing
- Biopsies
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Unhealthy Alcohol Use, Alcohol Use Disorder
Relational Agent for Alcohol Screening and Treatment
This project will involve the development and initial evaluation of a promising computer-based intervention to improve the primary care management of risky alcohol use among Veterans.
- Conditions
- Unhealthy Alcohol Use, Alcohol Use Disorder, Alcohol Disorders
- Trial name
- RAAST (NCT02030288)
- Testing
- Relational Agent Intervention
- Where
- United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Bipolar Disorder
Senyo Health App - Comorbid Alcohol Use Disorder Treatment in Individuals With Bipolar Disorder Using a Telehealth Collaborative Care Platform
The purpose of this study is to examine the effectiveness of a digital integrated behavioral health (IBH) platform in improving alcohol use outcomes, including treatment retention and substance use frequency and severity in…
- Trial name
- NCT07556861
- Testing
- Senyo Health App
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Prescription Drug Abuse, Substance Abuse
A High School Program for Preventing Prescription Drug Misuse
This project will develop and evaluate a program to prevent prescription drug misuse in high school students
- Conditions
- Prescription Drug Abuse, Substance Abuse, Substance Use (Drugs, Alcohol)
- Trial name
- NCT03219190
- Testing
- LST High School Hybrid
- Where
- United States
- Volunteers
- 1,804 people, healthy volunteers welcome
- Sponsor
- National Health Promotion Associates, Inc.
Hepatorenal Syndrome
A Placebo-Controlled, Double-Blind Study to Confirm the Reversal of Hepatorenal Syndrome Type 1 With Terlipressin
This study is designed to evaluate the efficacy and safety of intravenous terlipressin versus placebo for the treatment of type 1 hepatorenal syndrome (HRS) in participants receiving standard of care albumin therapy.
- Trial name
- NCT01143246
- Testing
- Terlipressin
- Where
- 73 sites in United States, Canada
- Volunteers
- 196 people
- Sponsor
- Mallinckrodt
Alcohol Use Disorder
Pilot Human Laboratory Study of Alcohol Approach Bias Modification (AABM) for Alcohol Use Disorder (AUD)
The overall goal of the proposed project is to improve the treatment of individuals with Alcohol Use Disorder (AUD). We will conduct a pilot feasibility trial of Approach Bias Modification (AABM) training of heavy-drinking…
- Trial name
- ADP + AABM (NCT03898323)
- Testing
- Alcohol Approach Bias Modification
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol Dependence, Major Depression
Acamprosate in Alcoholics With Comorbid Anxiety or Depression
STUDY OBJECTIVES: The primary objective of this study is to compare the safety and efficacy of acamprosate versus placebo in the treatment of alcohol dependence in adults with co-occurring mood or anxiety disorders (specifically…
- Conditions
- Alcohol Dependence, Major Depression, Social Anxiety Disorder, Generalized Anxiety Disorder
- Trial name
- NCT00330174
- Testing
- Acamprosate
- Where
- 3 sites in United States
- Volunteers
- 90 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder
Counseling for Alcohol Problems in Pregnancy (CAP-Pre) Phase II
Purpose: This study is testing a new counseling program called Counselling for Alcohol Problems in Pregnancy or CAP-Pre, designed to help pregnant women in South Africa to reduce their alcohol use and improve their well-being.
- Trial name
- CAP-Pre (NCT06853873)
- Testing
- The Counselling for Alcohol Problems in Pregnancy (CAP-Pre) intervention
- Where
- South Africa
- Volunteers
- 40 people
- Sponsor
- Leibniz Institute for Prevention Research and Epidemiology - BIPS GmbH
Alcohol Dependence
ALK21-014: Efficacy and Safety of Medisorb® Naltrexone (VIVITROL®) After Enforced Abstinence
VIVITROL is indicated for the treatment of alcohol dependence in patients who are able to abstain from alcohol in an outpatient setting prior to initiation of treatment with VIVITROL.
- Trial name
- NCT00501631
- Testing
- VIVITROL 380 mg
- Volunteers
- 300 people
- Sponsor
- Alkermes, Inc.
Alcohol Use Disorder, Severe
Impact of Omega 3 in Alcohol Use Disorder
The goal of this clinical trial is to investigate the biological pathways underlying the beneficial effect of omega-3 polyunsaturated fatty acids (n-3 PUFA) on mental health in patients with alcohol use disorder.
- Trial name
- W3-AUD (NCT05899660)
- Testing
- Active Comparator: Omega-3
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Université Catholique de Louvain
Smoking, Alcohol Abuse
Dynamic Assessment and Referral System - Evaluation
The investigators study will use a randomized controlled design. Eligible and consenting participants will be randomly assigned to one of two conditions: (1) DARSSA Intervention condition, or (2) Minimal Intervention Control…
- Conditions
- Smoking, Alcohol Abuse, Drug Abuse
- Trial name
- DARSSA (NCT01153373)
- Testing
- Self-administered computerized assessment for tobacco, substance abuse, and alcohol use., Self-Administered Computerized Assessment and Counseling for Tobacco, Alcohol, and Substance Abuse
- Where
- United States
- Volunteers
- 758 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Prevention Harmful Effects
Computerized Alcohol Screening for Children and Adolescents (cASCA) in Primary Care
The purpose of this study is to assess the psychometric properties of a brief screening questionnaire for alcohol problems among 9- to 18-year-old patients in pediatricians' offices, and to pilot test a personalized…
- Trial name
- cASCA (NCT02233946)
- Testing
- computer-facilitated brief intervention
- Where
- 5 sites in United States
- Volunteers
- 871 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Alcohol Use Disorder, Couples
Oxytocin to Enhance Alcohol Behavioral Couple Therapy (ABCT)
Alcohol Behavioral Couples Therapy (ABCT) is a manualized 12-session, weekly psychosocial intervention that simultaneously reduces alcohol use disorder (AUD) severity and improves relationship functioning.
- Trial name
- NCT03846505
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Medical University of South Carolina
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