Clinical trials: Alcohol-induced Disorders
Alcohol Abuse
Computer-delivered Screening and Brief Intervention for Alcohol Use in Pregnancy
The purpose of this study is to lay the ground work for a fully powered clinical trial of a computer-delivered screener and intervention for alcohol use during pregnancy. The pilot study will include: 1.
- Trial name
- NCT01643044
- Testing
- Computer-delivered, brief intervention on alcohol use
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Wayne State University
HIV Antiretroviral Therapy (ART) Adherence, Alcohol Abuse
Reducing Hazardous Alcohol Use and Optimizing Treatment as Prevention Among Men Living With HIV in Risk Environments
The investigators developed the Kisoboka ("It is possible") Intervention to address limitations of existing evidence-based interventions to optimize treatment as prevention among men living with HIV who drink alcohol at hazardous…
- Conditions
- HIV Antiretroviral Therapy (ART) Adherence, Alcohol Abuse, HIV Infection, Alcohol Use Disorder
- Trial name
- Kisoboka (NCT06771843)
- Testing
- Kisoboka, Behavioral Economics, Motivational Interviewing
- Where
- Uganda
- Volunteers
- 716 people
- Sponsor
- San Diego State University
Opioid-use Disorder, Opioid Abuse, in Remission
Mindfulness-Based Relapse Prevention for Opioid and Alcohol Use Disorders
A randomized controlled trial will examine mindfulness-based relapse prevention (MBRP) program outcomes for 240 individuals who have completed treatment for opioid or alcohol use disorders.
- Conditions
- Opioid-use Disorder, Opioid Abuse, in Remission, Alcohol Use Disorder, Alcohol Use Disorder, in Remission
- Trial name
- MBRP (NCT04278352)
- Testing
- Mindfulness Based Relapse Prevention
- Where
- 3 sites in United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Clemson University
Mental Health Disorder, Substance Abuse Drug
Tobacco Cessation Among Smokers Under Alcohol and/or Cannabis Treatment
Aims: To identify the predictors associated with smoking cessation in smokers under treatment for alcohol and/or cannabis treated in drug treatment centers (DTC).
- Conditions
- Mental Health Disorder, Substance Abuse Drug, Alcohol Abuse, Cannabis Use
- Trial name
- ACT-ATAC (NCT04841655)
- Where
- 2 sites in Spain
- Volunteers
- 1,625 people
- Sponsor
- Institut Català d'Oncologia
Liver Diseases, Alcoholic
A Study to Investigate the Safety and Efficacy of Efimosfermin Alfa Compared With Placebo in Adult Participants With Alcohol-related Liver Disease (ALD)
This is a dose-ranging study to evaluate safety of efimosfermin alfa and to establish proof-of-concept that efimosfermin alfa therapy provides benefit in participants with ALD.
- Trial name
- ALLSTAR (NCT07791043)
- Testing
- Efimosfermin alfa
- Where
- 4 sites in United States, Argentina
- Volunteers
- 274 people
- Sponsor
- GlaxoSmithKline
Alcohol Drinking, Alcohol Abuse
A Gamified, Social Media Inspired Personalized Normative Feedback Alcohol Intervention for Sexual Minority Women
Sexual minority women in the United States are more likely to drink alcohol, engage in heavy drinking, and experience alcohol-related problems than are heterosexual women.
- Conditions
- Alcohol Drinking, Alcohol Abuse, Alcohol; Harmful Use
- Trial name
- NCT03884478
- Testing
- Personalized Normative Feedback
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Loyola Marymount University
Anxiety, Depression
Research of Prevention and Intervention of Mental Health Problems
The purpose of this research is to establish a suitable community-based model for Chinese culture,to improve the community recognition of common mental disorders,as well as its treatment and control.
- Conditions
- Anxiety, Depression, Alcohol-abuse
- Trial name
- RPIMHP (NCT01422447)
- Testing
- regular intervention, community intervention
- Where
- 7 sites in China
- Volunteers
- 42,016 people
- Sponsor
- Shanghai Mental Health Center
Alcohol Dependence
A Randomized Clinical Trial of Alcohol Care Management
A randomized study of Alcohol Care Management for the treatment of alcohol dependence in primary care settings.
- Trial name
- NCT00419315
- Testing
- Alcohol Care Management, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 163 people
- Sponsor
- US Department of Veterans Affairs
Alcohol Use Disorder
Medication Development for Protracted Abstinence in Alcoholism: CORT118335 Versus Placebo
The hypotheses under test are that subjects with alcohol use disorder (AUD) of moderate or greater severity treated with CORT118335 will report decreased craving for alcohol following alcohol exposure in the laboratory and report…
- Trial name
- NCT04466215
- Testing
- Miricorilant
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Scripps Research Institute
Alcoholism
ALK21-003: Study of Medisorb® Naltrexone (VIVITROL®) in Alcohol-Dependent Adults
This was a Phase 3, multicenter, randomized, double-blind, placebo-controlled study conducted in subjects diagnosed with alcohol dependence as defined by the Diagnostic and Statistical Manual of Mental Disorders, 4th Ed.
- Trial name
- NCT01218958
- Testing
- Medisorb naltrexone 190 mg, Medisorb naltrexone 380 mg
- Volunteers
- 624 people
- Sponsor
- Alkermes, Inc.
Posttraumatic Stress Disorder (PTSD), Alcohol Use Disorder (AUD)
NAC for Treating Comorbid PTSD and SUD
As a result of sustained operations in Afghanistan and Iraq, there are an increasing number of U.S. military Veterans with substance use disorders and comorbid posttraumatic stress disorder (PTSD).
- Conditions
- Posttraumatic Stress Disorder (PTSD), Alcohol Use Disorder (AUD), Substance Use Disorder (SUD)
- Trial name
- DoD-NAC (NCT02911285)
- Testing
- N-acetylcysteine, Cognitive behavioral therapy
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Medical University of South Carolina
Alcohol Dependence
Aripiprazole Effects on Alcohol Reactivity and Consumption
The purpose of this study is to determine whether aripiprazole (marketed dopamine stabilizer) is effective in reducing of alcohol craving compared to placebo.
- Trial name
- NCT00183235
- Testing
- aripiprazole (up to 15 mg/day) for 8 days
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Alcoholic Liver Disease
Gut Mycobiome Profile in Alcoholic Liver Disease.
The fecal mycobiome, which refers to the community of fungi that resides in the human gut, is an important component of the gut microbiome.
- Trial name
- NCT05793190
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Alcoholism, Cocaine Dependence
Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol Dependence - 1
The purpose of this study is to see whether naltrexone is safe and useful in preventing alcohol relapse, as well as in decreasing craving for alcohol in people with a diagnosis of alcohol and cocaine dependence.
- Trial name
- NCT00218660
- Testing
- Naltrexone, BRENDA, CBT
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- University of Pennsylvania
Substance Use Disorders, Alcohol Abuse
Reinforcement of Abstinence and Continuing Care in Substance Abuse Treatment
The Contracts, Prompts, and Social Reinforcement (CPR) intervention was designed to address the continuing care adherence needs of veterans presenting for substance use disorder (SUD) treatment.
- Conditions
- Substance Use Disorders, Alcohol Abuse, Alcoholism, Substance Dependence
- Trial name
- NCT00288886
- Testing
- Contracting, Prompting and Reinforcement arm, Control arm
- Where
- 2 sites in United States
- Volunteers
- 183 people
- Sponsor
- US Department of Veterans Affairs
Alcoholism, Stress
Alcohol and Gender Effects on Stress Circuit Function
The purpose of this study is to look at the stress hormone response to medication-induced stress and a placebo (an inactive compound) in non-drinking, recovering male and female alcoholics, with a specific emphasis on the…
- Conditions
- Alcoholism, Stress, Alcohol Dependence
- Trial name
- NCT00226694
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Alcoholism
Project 4: Acute Effects of Alcohol on Learning and Habitization in Healthy Young Adults
This project aims to investigate how dysfunctional learning and habitization are affected by acute alcohol exposure, and whether individual differences in such alcohol effects can predict later development of Alcohol Use…
- Trial name
- LeAD_P4 (NCT01858818)
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Alcohol Use Disorder, Alcohol-related Liver Disease
Implementation of Mobile-based Programs for Alcohol Cessation in Treatment of Alcohol-associated Liver Disease
This protocol describes a randomized controlled trial testing the effectiveness and implementability of the CHESS Health Connections smartphone application among patients with alcohol-associated liver disease (ALD) at two medical…
- Trial name
- IMPACT-ALD (NCT06305624)
- Testing
- Connections App
- Where
- 3 sites in United States
- Volunteers
- 298 people
- Sponsor
- University of Wisconsin, Madison
Alcohol Use Disorder, Depression
Testing a Lifestyle Physical Activity Intervention for Women With Depression in Alcohol Treatment
The primary aim of this project is to test the efficacy of a technology-supported lifestyle physical activity (LPA) intervention for preventing relapse among women with depression engaged in alcohol treatment.
- Trial name
- HEART (NCT04667520)
- Testing
- Lifestyle Physical Activity (LPA), Fitbit Only
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Butler Hospital
Alcohol Dependence, Alcohol Abuse
Sweet Preference and Alcohol Craving
Purpose: The proposed 2-year investigation will be the first double-blind, placebo-controlled trial examining the hedonic response to sweet taste (HRST) as a phenotypic predictor of naltrexone (NTX) response in alcohol…
- Trial name
- SweetNal (NCT01296646)
- Testing
- Naltrexone, Brenda Therapy Sessions
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of North Carolina, Chapel Hill
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