Clinical trials: Alcohol-induced Disorders
Alcohol Use Disorder, Stress Reaction
Psychobiology of Stress and Alcohol Craving
In this feasibility study the investigators are using a setup of stress-related body sensors including established as well as innovative sensor-based measures to identify predictor profiles for alcohol-related behavioral and…
- Conditions
- Alcohol Use Disorder, Stress Reaction, Social Stress, Craving
- Trial name
- NCT03810950
- Testing
- Trier Social Stress Test, Reading Newspaper, Barlab-Exposure
- Where
- Germany
- Volunteers
- 11 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Alcohol-dependence
The Effects of Treatment With Naltrexone in Alcohol and Cannabis-dependent Patients
Alcohol dependence is a major health problem worldwide and recently in Israel and it has major health care costs. Cannabis dependence is also a major health issue and many cannabis users find it difficult to quit.
- Trial name
- NCT01560013
- Testing
- Naltrexone
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Alcohol Dependence
Citalopram Effects on Craving and Dopamine Receptor Availability in Alcoholics
Alcohol use disorders (AUDs) are highly prevalent among U.S. civilians, and even more prevalent in the U.S. Veteran population. AUDs are frequently co-morbid with depressive symptoms in psychiatric clinical populations, resulting…
- Trial name
- CECDRAAD (NCT01657760)
- Testing
- citalopram
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Binge Drinking, Liver Injury
Metabolic Changes in Healthy Subjects with Acute Binge Drink
The goal of this double-blinded, randomized trial is to investigate the effects of acute binge drinking on liver function, liver fat content, and lipid metabolism in healthy young subjects.
- Conditions
- Binge Drinking, Liver Injury, Hepatic Steatosis
- Trial name
- MeABD (NCT06298318)
- Testing
- Vodka, water
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Zhejiang Chinese Medical University
Problem Drinking
Changing Impulsivity With Mindful Breathing Therapy to Reduce Problem Drinking
The investigators plan to establish the efficacy of a novel breathing-based mindfulness training (BBMT, a much simplified, easy-to-use version of standard MM) for problem drinking, and test whether impulsivity mediates this…
- Trial name
- BBMT (NCT02527720)
- Testing
- Mindfulness Therapy
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Alcohol Intoxication
Prevalence of Chronic Inebriates to the Emergency Department and Suitability for Sobering House Services
This study is intended to evaluate the prevalence of chronically inebriated patients in the Emergeny Department (ED). Patients will be identified prospectively by screening all patients (24/7) presenting to the ED for one month.
- Trial name
- NCT01783223
- Where
- United States
- Volunteers
- 668 people
- Sponsor
- Hennepin Healthcare Research Institute
Suicide, Alcohol Use Disorder
Qungasvik (Toolbox): Prevention of Alcohol/Suicide Risk in Alaska Native Youth
For the past 20+ years the investigators have focused on addressing two interrelated public health issues, alcohol use disorder (AUD) and suicide in Alaska.
- Trial name
- NCT05400135
- Testing
- Qungasvik (Tools for Life)
- Where
- United States
- Volunteers
- 542 people, healthy volunteers welcome
- Sponsor
- University of Alaska Fairbanks
Fetal Alcohol Spectrum Disorders
Improving Self Regulation in Children With Fetal Alcohol Syndrome Spectrum Disorders: A Neuroplastic Intervention
This study on children with fetal alcohol spectrum disorder (FASD) aims to (i) characterize their self-regulation deficits, a process important for controlling emotions and behavior, (ii) describe brain structure and function…
- Trial name
- NCT02457676
- Testing
- Alert Program for Self-Regulation
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Addiction, Addiction Disorders
Evaluation of the ADD'Pro Vocational Reintegration Program (ADD-PRO-EVAL)
The goal of this clinical trial is to evaluate whether an integrated medico-psychosocial vocational support program (ADD'Pro) can improve employment outcomes in adults with substance use disorders receiving care at a specialized…
- Conditions
- Addiction, Addiction Disorders, Substance Use Recovery, Return to Work
- Trial name
- ADD-PRO-EVAL (NCT07520617)
- Testing
- ADD'Pro Program, Standard Care (in control arm)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Alcohol Use Disorder, Mental Health Disorder
Integrating Combined Therapies for Persons With Co-occurring Disorders
The purpose of this study is to assess the effectiveness and implementability of ICT for co-occurring alcohol use and mental health disorders within community addiction treatment, as delivered by routine community addiction…
- Trial name
- ICT (NCT02598518)
- Testing
- Integrating Combined Therapies, Standard Care
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Stanford University
Alcoholism, Child Abuse, Sexual
Group Therapies for Reducing HIV-risk Behavior in Women Who Have Survived Childhood Sexual Abuse
This study will evaluate the effectiveness of trauma-focused group therapy for reducing HIV-risk behavior and revictimization among adult women survivors of childhood sexual abuse (CSA).
- Conditions
- Alcoholism, Child Abuse, Sexual, Sexual Abuse, Sexual Behavior
- Trial name
- NCT00220597
- Testing
- Trauma-focused group therapy
- Where
- United States
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Stanford University
Hepatitis, Alcoholic
Safety and Efficacy of IMM 124-E for Patients With Severe Alcoholic Hepatitis
Hypothesis: Oral administration of hyperimmune bovine colostrum enriched with anti-LPS antibodies will reduce endotoxemia, and improve pathophysiological and clinical parameters related to severe alcoholic hepatitis (SAH).
- Trial name
- TREAT (NCT01968382)
- Testing
- IMM 124-E (Hyperimmune Bovine Colostrum)
- Where
- 3 sites in United States
- Volunteers
- 57 people
- Sponsor
- Virginia Commonwealth University
Healthy
PET Imaging of DHA Metabolism
This study will examine the use of positron emission tomography (PET) for measuring docosahexaenoic acid (DHA) absorption from the blood into the brain. DHA is a type of fatty acid found in fish and other seafood.
- Trial name
- NCT00074503
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Domestic Violence, Mental Health Impairment
Trial of a Multi-pronged Intervention to Address Prevention of Violence in Zambia
This study evaluates the effectiveness of a multi-pronged intervention in reducing and preventing violence against women and children compared to a treatment as usual control group among families living in Lusaka, Zambia.
- Conditions
- Domestic Violence, Mental Health Impairment, Child Abuse, Alcoholism
- Trial name
- NCT02790827
- Testing
- CETA, Treatment as usual
- Where
- Zambia
- Volunteers
- 626 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Alcoholism
Medication Development in Alcoholism: Investigating PPAR Agonists
The primary hypotheses under test are that alcohol dependent subjects treated with fenofibrate will report decreased craving for alcohol following cue-exposure in the laboratory and report less drinking post treatment relative to…
- Trial name
- NCT02158273
- Testing
- Sugar Pill, TRICOR (fenofibrate)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Scripps Research Institute
Alcohol-dependence
Electrophysiological Correlates of Emotional and Crossmodal Stimuli Processing Among Alcohol-dependent Participants
Alcohol-dependence is the most widespread addiction in Western countries and leads to a wide range of impairments at cerebral and cognitive levels.
- Trial name
- ALCOLAT (NCT01633905)
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Alcohol Dependence, in Remission, Addiction, Alcohol
Virtual Reality-Assisted Cognitive Behavioral Therapy for Alcohol Dependence (CRAVR)
The study is a single-blinded, randomized, controlled, 12 months clinical trial. The objective is to investigate the feasibility, effects and side-effects of virtual reality-assisted cognitive behavioral therapy (VR-CBT) vs.
- Trial name
- NCT05042180
- Testing
- Virtual Reality Cognitive Behavioral Therapy (CRAVR), CBT
- Where
- Denmark
- Volunteers
- 102 people
- Sponsor
- Psychiatric Centre Rigshospitalet
HIV, Alcohol Use Disorders
Understanding Longitudinal Clinical Outcomes and Post-release Retention in Care Among HIV-infected Prisoners in Lusaka, Zambia
To inform the design of a future transitional HIV care intervention for releasees, the study proposes to prospectively assess clinical outcomes for HIV-infected prisoners after release; explore factors from health behavior theory…
- Trial name
- NCT02905162
- Testing
- Transitional HIV care for prison releasees
- Where
- Zambia
- Volunteers
- 300 people
- Sponsor
- University of North Carolina, Chapel Hill
Substance-Related Disorders
The Road to Recovery Initiative (R2RI)
Despite substance use causing significant harms and cost to our health care system, British Columbia's (BC) current addiction treatment system remains under-resourced and fragmented.
- Trial name
- R2RI (NCT06639373)
- Testing
- Specialized clinical service access
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- BC Centre on Substance Use
Alcohol Use Disorder
Broccoli Extract Supplementation in Older Adults With Alcohol Use Disorder
Chronic alcohol consumption leads to perturbations in gut microbiome balance (dysbiosis) and disruption of gut barrier integrity.
- Trial name
- NCT05902754
- Testing
- Generally Recognized as Safe - Sulforaphane
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
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