Clinical trials: Alcohol-related Liver Disease
Drug Induced Liver Injury
Acetaminophen Adduct Formation in Non-Drinkers Taking Therapeutic Doses of Acetaminophen for Ten Consecutive Days
Acetaminophen is commonly used to treat fever or pain. Your body clears acetaminophen by processing it in the liver. During the processing, some of the acetaminophen may bind to proteins in the liver.
- Trial name
- Non-Drinker (NCT00616018)
- Testing
- acetaminophen
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Kennon Heard
Liver Cirrhosis, Alcoholic
SMS-based Lifestyle Intervention for Patients With Liver Cirrhosis With Previous Hepathic Encephalopathy
To investigate whether simple reminders about healthy lifestyle sent via mobile phone text messages can improve the liver cirrhosis severity and prognosis (as assessed by the MELD score supported by the Child-Pugh score) among…
- Trial name
- SMILE (NCT02811887)
- Testing
- Supervised exercise, Usual Care, SMS-messages
- Where
- Denmark
- Volunteers
- 9 people
- Sponsor
- Marius Henriksen
Alcoholic Liver Disease
French National MICMAF Cohort
Excessive alcohol consumption is a major public health problem, particularly in France. It is the leading cause of cirrhosis and hepatocellular carcinoma.
- Trial name
- MICMAF (NCT05895890)
- Testing
- Sequential sampling (stool, saliva, serum) .
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alcoholic Liver Disease, Alcohol Dependence
Baclofen in the Treatment of Alcohol Dependence With or Without Alcoholic Liver Disease
To explore the effectiveness and biobehavioural basis of baclofen in improving treatment outcomes for alcohol dependence in people with or without alcoholic cirrhosis in a double-blind randomised placebo-controlled trial.
- Trial name
- BacALD (NCT01711125)
- Testing
- Baclofen 30mg/day, Baclofen 75mg/day
- Where
- Australia
- Volunteers
- 104 people
- Sponsor
- South West Sydney Local Health District
Lysosomal Acid Lipase Deficiency, Wolman Disease
Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Sebelipase Alfa in Children With Growth Failure Due to Lysosomal Acid Lipase Deficiency
This was an open-label, repeat-dose, intra-participant dose-escalation study of SBC-102 (sebelipase alfa) in children with growth failure due to lysosomal acid lipase (LAL) Deficiency.
- Trial name
- NCT01371825
- Testing
- Sebelipase alfa (SBC-102)
- Where
- 7 sites in United States, Egypt and 3 more
- Volunteers
- 9 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Steatotic Liver Disease, MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis)
Long-term Follow-up to Determine Outcome in Liver Disease (LOVE Study)
The rational to conduct the LOVE study builds on the lack of available data on outcomes in steatotic liver disease in well characterized patients over a time frame of several years.
- Conditions
- Steatotic Liver Disease, MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis), Steatotic Liver Disease of Mixed Origin (MetALD), ALD - Alcoholic Liver Disease
- Trial name
- LOVE (NCT06907563)
- Where
- 4 sites in France, Germany and 2 more
- Volunteers
- 30,000 people
- Sponsor
- Universität des Saarlandes
Liver Fibroses, Alcohol-Induced Disorders
Alcohol Challenge On Liver and Gut Measured by Liver Vein Catheterization. A Pathophysiological Intervention Trial
To investigate the effects of acute alcohol challenge on the gut and liver axis.
- Trial name
- NCT03018990
- Testing
- Ethanol
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Alcohol-related Liver Disease, Liver Diseases
Enhancing Alcohol Treatment Engagement in Associated Liver Disease (ALD) Patients
The purpose of this trial is to see if providing patients with alcohol-related liver disease with tailored alcohol use treatment options will increase engagement with treatment and correct possible misconceptions.
- Trial name
- ENGAGE-ALD (NCT06269510)
- Testing
- ENGAGE-ALD Application (APP), Treatment Facilitation bundle, Enhanced Usual Care
- Where
- United States
- Volunteers
- 268 people
- Sponsor
- Henry Ford Health System
Alcoholic Hepatitis
Pegfilgrastim in Patients With Alcoholic Hepatitis
This is a multi-center, prospective, randomized trial of standard of care vs. standard of care + pegfilgrastim (Neulasta®) among patients with a clinical diagnosis of alcoholic hepatitis and DF≥32.
- Trial name
- NCT02776059
- Testing
- Standard of care + pegfiltrastim, Standard of care
- Where
- 5 sites in United States
- Volunteers
- 34 people
- Sponsor
- Timothy Morgan, MD
Alcoholic Hepatitis
Treatment of Alcohol-Related Hepatitis With Arginine
The purpose of this study is to test the effectiveness of the amino acid arginine in reducing liver injury in individuals with alcohol-related hepatitis.
- Trial name
- NCT00200746
- Testing
- Arginine
- Where
- United States
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Alcohol Abuse
Effectiveness and Safety of Probiotics in Protecting Liver Function
To evaluate the effectiveness and safety of using probiotics to protect the liver function of long-term alcohol consumers
- Trial name
- NCT06607562
- Testing
- Probiotic group
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Alcoholic Hepatitis
Alcoholic Hepatitis: A Multicenter, Observational Study by the TREAT Consortium
To conduct a prospective, multicenter, observational study of patients with well-characterized alcoholic hepatitis (AH) and frequency matched individuals (by age, gender, and race) with comparable history of alcohol consumption…
- Trial name
- NCT02172898
- Where
- 2 sites in United States
- Volunteers
- 454 people
- Sponsor
- Indiana University
Severe Alcoholic Hepatitis
Assessment of the Predictive Value of Fecal Calprotectin for the Outcome of Severe Alcoholic Hepatitis
Severe alcoholic hepatitis, defined by a "Maddrey discriminant function" above 32, is associated with significant short-term mortality.
- Trial name
- CALPRO-HAA (NCT02808663)
- Testing
- fecal calprotectin concentration, blood collection
- Where
- France
- Volunteers
- 6 people
- Sponsor
- CHU de Reims
Hepatitis, Alcoholic
Alcohol Diet and Drug Use Preceding Alcoholic Hepatitis
ADDUP is an observational study of patients with alcoholic hepatitis. A structured interview is used to quantitatively estimate: 1. Alcohol use 2. Dietary intake 3.
- Trial name
- ADDUP (NCT02404636)
- Testing
- Interview
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospital Birmingham
Chronic Liver Disease, Alcohol Use Disorder
Nottingham Community Liver Biomarkers Cohort
Deaths due to advanced liver scarring (liver cirrhosis) continue to increase, and liver disease is now the 3rd leading cause of premature death in the United Kingdom.
- Conditions
- Chronic Liver Disease, Alcohol Use Disorder, Type 2 Diabetes, Persistently Elevated ALT
- Trial name
- NCT02037867
- Testing
- Fibrosis Biomarkers
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- University of Nottingham
Liver Cirrhosis
Faecal Microbiota Transplantation for Liver Cirrhosis
The purpose is to investigate the effect of faecal microbiota transplantation (FMT) on complications, progression, and mortality of patients with liver cirrhosis.
- Trial name
- CHiFT (NCT04932577)
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 220 people
- Sponsor
- University of Aarhus
Acute on Chronic Hepatic Failure, Acute Liver Failure
Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF
The study will evaluate the pharmacokinetics, pharmacodynamics, safety and preliminary efficacy of IDN-6556 in subjects with cirrhosis of the liver who are hospitalized for more than 24 hours due to acute deterioration of liver…
- Conditions
- Acute on Chronic Hepatic Failure, Acute Liver Failure, Liver Cirrhosis, Acute Alcoholic Hepatitis
- Trial name
- NCT01937130
- Testing
- IDN-6556
- Where
- 26 sites in United States, United Kingdom
- Volunteers
- 23 people
- Sponsor
- Conatus Pharmaceuticals Inc.
Alcohol Use Disorder, Alcohol-associated Liver Disease
Pomegranate Dietary Supplements in AUD and ALD
The goal of this project is to determine an individual's ability to generate active gut microbial metabolites called urolithins upon consumption of pomegranate dietary supplements.
- Conditions
- Alcohol Use Disorder, Alcohol-associated Liver Disease, Alcoholic Cirrhosis, Healthy
- Trial name
- NCT07678567
- Testing
- Pomegranate Dietary Ssupplement
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Alcoholism, Alcohol Abuse
Health Behavior Feedback Study for Veterans With Hepatitis C
The purpose of this study was to explore whether a brief (3 session) intervention would impact health behavior of veterans with hepatitis C.
- Conditions
- Alcoholism, Alcohol Abuse, Hepatitis C, Liver Disease
- Trial name
- NCT00229580
- Testing
- 3 session brief intervention with health behavior feedback, treatment as usual
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Washington
HIV/AIDS, Alcoholic Hepatitis
Immunology of HIV and Alcoholic Hepatitis
This is prospective, longitudinal cohort study involving HIV-positive, antiretroviral (ART)-treated, heavy alcohol drinking participants who have and do not have alcoholic hepatitis.
- Trial name
- NCT03951662
- Testing
- Alcoholic Hepatitis Group, Heavy Drinking Controls without Hepatitis
- Where
- United States
- Sponsor
- Indiana University