Clinical trials: Alcoholic Liver Disease
Obesity, Morbid, Bariatric Surgery Candidate
Investigation of Microbiome-based Prognostical Biomarkers in Patients With Morbid Obesity and Bariatric Surgery
Morbid obesity leads to non-alcoholic fatty liver disease (NAFLD), and not all NAFLD cases benefit from weight loss e.g. after bariatric surgery.
- Conditions
- Obesity, Morbid, Bariatric Surgery Candidate, NAFLD, Microbiome
- Trial name
- NCT03391401
- Testing
- Bariatric surgery
- Where
- 2 sites in Germany
- Volunteers
- 204 people
- Sponsor
- St. Franziskus Hospital
Non-Alcoholic Fatty Liver Disease
Role of Vitagliptin and Vitamin D in the Treatment of Non Alcoholic Fatty Liver Disease (NAFLD)
Sedentary lifestyle and poor dietary choices are leading to a weight gain epidemic and increasing the risk for developing nonalcoholic fatty liver disease (NAFLD).
- Trial name
- NCT01083992
- Testing
- Galvus (vitagliptin), Galvus + vitamin D
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Ziv Hospital
Fatty Liver, Hepatitis
Orlistat (Xenical) in the Treatment of Overweight Patients With Nonalcoholic Steatohepatitis (NASH)
The purpose of this study is to determine if orlistat (Xenical) therapy in overweight patients with NASH leads to enhanced weight loss over time, with subsequent improvement in the underlying necroinflammatory and fibrotic…
- Trial name
- NCT00160407
- Testing
- Orlistat (Xenical), 1400 kcal diet (30% fat)
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- St. Louis University
Fatty Liver
The Effect of Pentoxifylline on Liver Function Tests in Fatty Liver Disease
This randomized double blind clinical trial was performed in patients with non-alcoholic fatty liver disease.They were randomly assigned to lifestyle modification alone or lifestyle modification plus Pentoxifylline groups.
- Trial name
- NCT02283710
- Testing
- Pentoxifylline, Lifestyle modification
- Where
- Iran
- Volunteers
- 120 people
- Sponsor
- Tehran University of Medical Sciences
Non-Alcoholic Fatty Liver Disease
Measuring Fatty Liver With Ultrasound and MRS in Children With Overweight or Obesity
Obesity is associated with a variety of comorbidities, amongst which non-alcoholic fatty liver disease (NAFLD). A recent meta-analysis has shown that the prevalence of NAFLD in obese pediatric populations is around 35%, compared…
- Trial name
- NCT03787108
- Testing
- Magnetic resonance spectroscopy measurement
- Where
- Netherlands
- Volunteers
- 53 people
- Sponsor
- Maastricht University Medical Center
Chronic Hepatitis b, Non-alcoholic Fatty Liver Disease
Risk Factors for Hepatic Inflammation, Fibrosis and Prognosis in Patients With CHB and NAFLD
Chronic hepatitis B (CHB) affects an estimated 292 million people, and causes approximately 800,000 people deaths per year from liver-related complications including cirrhosis and hepatocellular carcinoma, remaining a major…
- Trial name
- NCT05766449
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Obesity, Nonalcoholic Fatty Liver Disease
Long-term Investigation of Resveratrol on Fat Metabolism in Obese Men With Nonalcoholic Fatty Liver Disease
The purpose of this study is to investigate potential metabolic effects of resveratrol in obese healthy men with non-alcoholic fatty liver disease.
- Trial name
- NCT01446276
- Testing
- Resveratrol
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- University of Aarhus
Non Alcoholic Fatty Liver Disease (NAFLD)
Potential Role of n-3 Fatty Acids in the Treatment of NAFLD in Pediatric Patients
Nonalcoholic hepatic steatosis (NASH) is defined as the amount greater than 5% of the total liver volume fat. Commonly known as NASH, it includes 4 stages histological ranging from the mere presence of fat to the existence of…
- Trial name
- NCT02201160
- Testing
- omega 3
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- St. Justine's Hospital
Fatty Liver Disease
Effect of Thyroid Disorders in Liver Diseases
Aims of the Research 1. To detect correlation between hyperthyroidism and non alcoholic fatty liver disease (NAFLD). 2. To detect hepatic risk in subclinical and clinical hypothyroidism . 3.
- Trial name
- NCT06071923
- Testing
- Fibroscan
- Volunteers
- 140 people
- Sponsor
- Assiut University
NAFLD Cirrhosis
Dapagliflozin in Non Alcoholic Fatty Liver Disease Associated Cirrhosis and Its Role in Preventing Development of Chronic Kidney Disease.
The role of Dapagliflozin in the improvement in CKD in both diabetic and non-diabetic patients has been evaluated in the past. SGLT2i have also been found to be beneficial in NAFLD patients in improving the liver function…
- Trial name
- NCT05849220
- Testing
- Dapagliflozin, Standard of Care
- Where
- India
- Volunteers
- 144 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
NAFLD, Obesity, Morbid
Integrated Multi-omics Data for Personalized Treatment of Obesity-associated Fatty Liver Disease
The investigators seek to analyze the samples provided by patients with obesity-associated fatty liver disease at the multi-omics level and to integrate the results with clinical information, genotypic variants, and factors…
- Conditions
- NAFLD, Obesity, Morbid, Comorbidities and Coexisting Conditions
- Trial name
- NCT05554224
- Testing
- To propose diagnostic tests for liver diseases before surgical decisions.
- Where
- Spain
- Volunteers
- 1,104 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis
Investigation on the Role of Gut-liver Axis for Non-alcoholic Steatohepatitis Through Bariatric Surgery
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Non-alcoholic steatohepatitis (NASH) is an aggressive form of NAFLD with remarkable inflammatory features which may cause advanced fibrosis and…
- Conditions
- Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis, Bariatric Surgery
- Trial name
- NCT04501042
- Testing
- Bariatric surgery
- Where
- Taiwan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
NAFLD
Treatment of NAFLD With Two Different Diets
The impact of popular diets on liver-related health is unclear. In this randomized, controlled trial, patients with NAFLD will be randomized to one of two popular diets or a placebo diet.
- Trial name
- TREND (NCT03118310)
- Testing
- 5:2 diet, LCHF
- Where
- Sweden
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Alcoholic Liver Disease, Alcohol Dependence
Baclofen in the Treatment of Alcohol Dependence With or Without Alcoholic Liver Disease
To explore the effectiveness and biobehavioural basis of baclofen in improving treatment outcomes for alcohol dependence in people with or without alcoholic cirrhosis in a double-blind randomised placebo-controlled trial.
- Trial name
- BacALD (NCT01711125)
- Testing
- Baclofen 30mg/day, Baclofen 75mg/day
- Where
- Australia
- Volunteers
- 104 people
- Sponsor
- South West Sydney Local Health District
Metabolic Dysfunction-Associated Steatotic Liver Disease, Hypothyroidism
Hypothyroidism and Liver Fibrosis Severity in MASLD
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide, characterized by excess fat accumulation in the liver associated with metabolic risk factors such as obesity and…
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Hypothyroidism, Liver Cirrhosis, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT07793279
- Volunteers
- 85 people
- Sponsor
- Assiut University
NAFLD- Non Alcoholic Fatty Liver Disease
Study of Neutrophils and Circulating Platelets in Correlation With the Activity of T Lymphocytes in Patients With NAFLD (Nonalcoholic Fatty Liver Disease)
The aim of the study is to define the relationship between neutrophils, platelets and the activity of T lymphocytes in patients with NAFLD (nonalcoholic fatty liver disease).
- Trial name
- NAFLD (NCT05358496)
- Testing
- Data collection
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of L'Aquila
Fatty Liver, Steatohepatitis
Efficacy of Rifaximin on Hepatosteatosis and Steatohepatitis Patients
Non alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease, it encompasses from simple steatosis to non alcoholic steatohepatitis (NASH) and, eventually leads to cirrhosis and hepatocellular carcinoma…
- Trial name
- NCT02009592
- Testing
- Rifaximin
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Bezmialem Vakif University
Severe Alcoholic Hepatitis
Intensive Enteral Nutrition and Acute Alcoholic Hepatitis
To evaluate the effect of an intensive enteral nutrition (compared to clinical routine) in association with corticosteroïds in patients with severe acute alcoholic hepatitis.
- Trial name
- NCT01801332
- Testing
- intensive nutrition, usual meals
- Where
- 19 sites in Belgium, France
- Volunteers
- 136 people
- Sponsor
- Erasme University Hospital
Fatty Liver, Nonalcoholic, Meal Time
Hepatic Glycogen and Fat Oxidation
Excessive fat in the liver is associated with impairments in metabolic health. Low levels of DNL and high levels of hepatic fat oxidation are considered to be protective.
- Conditions
- Fatty Liver, Nonalcoholic, Meal Time, Fasting, Glycogen Depletion
- Trial name
- NCT03593343
- Testing
- Overnight fasting duration
- Where
- Netherlands
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Non-alcoholic Fatty Liver Disease (NAFLD)
Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease
This short-term, randomized, placebo-controlled, investigator-initiated trial aims to establish metabolic improvements in NAFLD subjects by dietary supplementation with cofactors N-acetylcysteine, L-carnitine tartrate…
- Trial name
- NAFLD (NCT04330326)
- Testing
- Metabolic Cofactor Supplementation, Sorbitol
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- ScandiBio Therapeutics AB
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