Clinical trials: Alcoholism
Alcohol Dependence
ALK21-014: Efficacy and Safety of Medisorb® Naltrexone (VIVITROL®) After Enforced Abstinence
VIVITROL is indicated for the treatment of alcohol dependence in patients who are able to abstain from alcohol in an outpatient setting prior to initiation of treatment with VIVITROL.
- Trial name
- NCT00501631
- Testing
- VIVITROL 380 mg
- Volunteers
- 300 people
- Sponsor
- Alkermes, Inc.
Alcohol Abuse
Puerarin Effects on Alcohol Drinking
This research is designed to assess the impact of pretreatment with puerarin (NPI-031G), a major ingredient in the plant kudzu, on alcohol drinking.
- Trial name
- PAD (NCT00854724)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Alcoholism
Study of the Medication Prazosin for Alcohol Dependence
The purpose of this study is to determine whether the drug prazosin is effective for the treatment of alcohol dependency.
- Trial name
- NCT00762710
- Testing
- Prazosin medication
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Unhealthy Alcohol Use, Alcohol Use Disorder
Relational Agent for Alcohol Screening and Treatment
This project will involve the development and initial evaluation of a promising computer-based intervention to improve the primary care management of risky alcohol use among Veterans.
- Conditions
- Unhealthy Alcohol Use, Alcohol Use Disorder, Alcohol Disorders
- Trial name
- RAAST (NCT02030288)
- Testing
- Relational Agent Intervention
- Where
- United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cocaine Dependence, Alcohol Dependence
VIVITROL as a Treatment for Cocaine and Alcohol Dependence
To evaluate the efficacy of VIVITROL (naltrexone for extended-release injectable suspension) for the treatment of co-occurring cocaine and alcohol dependence
- Trial name
- NCT00777062
- Testing
- VIVITROL (Naltrexone extended-release injectable suspension)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Alcohol Use Disorder, Alcohol Drinking
Human Laboratory Study of ASP8062 for Alcohol Use Disorder
The primary objective of this study is to evaluate the effects of ASP8062, 25 mg once a day and matched placebo, on alcohol cue-elicited alcohol craving during a human laboratory paradigm after 2 weeks of daily dosing among…
- Conditions
- Alcohol Use Disorder, Alcohol Drinking, Alcohol Use Disorder (AUD)
- Trial name
- NCT05096117
- Testing
- ASP8062
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol; Use, Problem
Probiotics, Immune Function, and the Brain in Alcohol Consumers
This pilot project is a brief, open-label clinical trial of probiotics as an intervention in heavy drinkers. Heavy drinkers who do not yet show significant signs of liver disease may stand to benefit from probiotics, but no…
- Trial name
- NCT05232682
- Testing
- Seed DS-01 Daily Synbiotic
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcoholism
ALK21-006: Long-Term Study of Medisorb® Naltrexone (VIVITROL®)
This was a Phase 3 multicenter randomized, open-label, safety study assessing the safety of repeat doses of Medisorb® naltrexone 380 mg (VIVITROL®) administered for up to 1 year to adults with alcohol and/or opioid dependence as…
- Trial name
- NCT01218997
- Testing
- Medisorb naltrexone 380 mg, Oral naltrexone 50 mg
- Volunteers
- 436 people
- Sponsor
- Alkermes, Inc.
Alcohol Drinking, Alcohol Abuse
A Gamified, Social Media Inspired Personalized Normative Feedback Alcohol Intervention for Sexual Minority Women
Sexual minority women in the United States are more likely to drink alcohol, engage in heavy drinking, and experience alcohol-related problems than are heterosexual women.
- Conditions
- Alcohol Drinking, Alcohol Abuse, Alcohol; Harmful Use
- Trial name
- NCT03884478
- Testing
- Personalized Normative Feedback
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Loyola Marymount University
Alcohol Use Disorder
Development of Ivermectin for Alcohol Use Disorders
Current pharmacotherapies for alcohol use disorders (AUDs) have limited efficacy. Thus, the development of effective treatments for AUDs represents an important public health objective. Repositioning, i.e.
- Trial name
- NCT02046200
- Testing
- Ivermectin, Alcohol
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of California, Los Angeles
Alcohol Abuse
Smartphone Based Continuing Care for Alcohol
Investigators will recruit 280 alcohol dependent patients in treatment programs in the Philadelphia area to test the efficacy and cost efficiency of a smartphone based application for treating alcohol addiction (ACHESS) with…
- Trial name
- NCT02681406
- Testing
- ACHESS, TMC
- Where
- United States
- Volunteers
- 262 people
- Sponsor
- University of Pennsylvania
Alcoholism
Treatment With Mecamylamine in Smoking and Non-smoking Alcohol Dependent Patients
The purpose of the study will be to evaluate the efficacy of mecamylamine in reducing alcohol consumption in smoking and non-smoking alcohol dependent patients.
- Trial name
- NCT00342563
- Testing
- mecamylamine
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Yale University
Alcohol Dependence, Major Depression
Acamprosate in Alcoholics With Comorbid Anxiety or Depression
STUDY OBJECTIVES: The primary objective of this study is to compare the safety and efficacy of acamprosate versus placebo in the treatment of alcohol dependence in adults with co-occurring mood or anxiety disorders (specifically…
- Conditions
- Alcohol Dependence, Major Depression, Social Anxiety Disorder, Generalized Anxiety Disorder
- Trial name
- NCT00330174
- Testing
- Acamprosate
- Where
- 3 sites in United States
- Volunteers
- 90 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder, Posttraumatic Stress Disorder
Adapting and Piloting Behavioral Activation for Veterans With Alcohol Use Disorder and Posttraumatic Stress Disorder
The goal of this clinical trial is to compare an adaptation of Behavioral Activation, a behavioral intervention, to Relapse Prevention treatment, another behavioral intervention, in a sample of U.S.
- Trial name
- NCT06249386
- Testing
- Behavioral Activation (BA), Relapse Prevention (RP)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- RTI International
Alcohol Dependence, Schizophrenia
Treatment With Acamprosate in Patients With Schizophrenia and Comorbid Alcoholism
The aim of this study is to evaluate the safety and efficacy of acamprosate for patients with alcohol dependence and comorbid schizophrenia spectrum disorders.
- Trial name
- NCT00463346
- Testing
- Acamprosate
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Yale University
PTSD, Alcohol Abuse
Topiramate Treatment of Alcohol Use Disorders in Veterans With Post Traumatic Stress Disorder (PTSD): A Pilot Controlled Trial of Augmentation Therapy
The proposed project aims to: 1. Obtain a preliminary assessment of the efficacy of topiramate treatment in reducing alcohol use in veterans with Post Traumatic Stress Disorder (PTSD) and alcohol dependence; 2.
- Conditions
- PTSD, Alcohol Abuse, Alcoholism
- Trial name
- TAP (NCT01087736)
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Alcohol Abuse, Tobacco Use Disorder
Screening to Augment Referral to Treatment- Project START
The investigators propose to use obstetric-gynecological clinics to conduct a randomized clinical trial that would compare two SBIRTS (Screening, Brief Intervention, Referral and Treatment), delivered either by a trained nurse or…
- Conditions
- Alcohol Abuse, Tobacco Use Disorder, Marijuana Abuse, Substance-Related Disorders
- Trial name
- ProjectSTART (NCT01539525)
- Testing
- Motivational Interview, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 439 people
- Sponsor
- Yale University
Alcohol Use Disorder, Alcohol Misuse
Intranasal Oxytocin for the Treatment of Alcohol Use Disorder
Primary: The primary objective of the study is to compare the efficacy of intranasal oxytocin in reducing the weekly percentage of heavy drinking days over the 10 weeks of maintenance treatment among subjects with moderate to…
- Trial name
- NCT03878316
- Testing
- Instranasal Oxytocin
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder
Manipulating Ghrelin Signaling Via GOAT Inhibition in Alcohol Use Disorder
Background: People with alcohol use disorder (AUD) have trouble controlling their drinking. Medications can help some people with AUD but are not effective for many others.
- Trial name
- NCT03896516
- Testing
- GLWL-01
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Use Disorder
Preliminary Effectiveness of Remotely Monitored Blood Alcohol Concentration Device as Treatment Modality
State the scientific aim(s) of the study, or the hypotheses to be tested. The purpose of the current study is to evaluate the usage and acceptability of the Soberlink's blood alcohol concentration (BAC) unit in collaboration with…
- Trial name
- Soberlink (NCT04380116)
- Testing
- Soberlink
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Yale University