Clinical trials: Alcoholism
Alcohol Use Disorder
Pharmacogenomics and Pharmacometabolomics of Acamprosate Treatment Outcome
AUDs are difficult to treat, and relapse rates are high, with an estimated 80% of individuals with AUDs returning to alcohol use after completing addictions treatment.
- Trial name
- NCT03818191
- Testing
- Acamprosate
- Where
- 3 sites in United States
- Volunteers
- 288 people
- Sponsor
- Mayo Clinic
Alcohol Use Disorders
Oxytocin Suppresses Substance Use Disorders Associated With Chronic Stress
In comparison to the general population, military personnel and veterans are at increased risk of developing both substance use disorders (SUDs) and post-traumatic stress disorder (PTSD).
- Trial name
- NCT02058251
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Medical University of South Carolina
Alcohol Dependence, Alcohol Abuse
Carisbamate as a Potential Treatment for Alcohol Dependence
The purpose of this study is to determine the effects of treatment with carisbamate compared to treatment with placebo, on alcohol-induced stimulant and subjective effects in non-treatment seeking alcohol-dependent human…
- Conditions
- Alcohol Dependence, Alcohol Abuse, Substance Abuse
- Trial name
- NCT02435381
- Testing
- Carisbamate
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Baylor College of Medicine
Alcohol Dependence
Study of Campral (Acamprosate) for Alcohol Dependence in a Family Medicine Clinic
This is a study of a medication, acamprosate, which is an FDA approved medication for alcohol problems. We will be examining whether acamprosate compared to a sugar pill (placebo) is more effective for helping with drinking in a…
- Trial name
- NCT00381043
- Testing
- Acamprosate (Campral)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Alcohol Abuse
Puerarin Effects on Alcohol Drinking
This research is designed to assess the impact of pretreatment with puerarin (NPI-031G), a major ingredient in the plant kudzu, on alcohol drinking.
- Trial name
- PAD (NCT00854724)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Alcohol Dependence
Effectiveness of Naltrexone Versus Placebo to Reduce Craving for Alcohol With Evaluation of Genetic Variability.
The purpose of this study is to determine whether naltrexone (an opiate blocking agent approved for the treatment of alcohol dependence) is more effective in the reduction of alcohol craving and drinking compared to placebo in…
- Trial name
- NCT00366626
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder, HIV-infection/Aids
Development of an Intervention to Reduce Heavy Drinking and Improve HIV Care Engagement Among Fisherfolk in Uganda
Fisherfolk are a high risk population for HIV and are prioritized to receive antiretroviral treatment (ART) in Uganda, but risky alcohol use among fisherfolk is a barrier to HIV care engagement; multilevel factors influence…
- Trial name
- NCT03919695
- Testing
- Kisoboka: Behavioral and Structural Intervention, Screening and Referral
- Where
- Uganda
- Volunteers
- 160 people
- Sponsor
- San Diego State University
Alcohol Use Disorder
Non-invasive Vagal Nerve Stimulation in Alcohol Use Disorder
Alcohol use disorder (AUD) is a major health concern amongst Veterans as it causes poor health, lost days at work, impaired psychosocial functioning, and decreased quality of life.
- Trial name
- NCT05226130
- Testing
- Cervical transcutaneous vagus nerve stimulation (active comparator)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- VA Office of Research and Development
Smoking Cessation, Alcohol-Related Disorders
Effectiveness of Bupropion for Smokers Recovering From Alcohol Dependence
Smoking is often a problem for alcohol dependent individuals. Many people who seek treatment for alcohol dependence are unable to quit smoking.
- Trial name
- NCT00304707
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Drinking
Naltrexone and Memantine Effects on Alcohol Drinking Behaviors
The purpose of this study is to evaluate the combined effects of the study medications naltrexone and memantine on alcohol drinking behaviors.
- Trial name
- NCT01519063
- Testing
- Naltrexone and memantine first
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Yale University
Alcohol Dependence
An Exploratory Study of Naltrexone Plus Aripiprazole for Alcohol Dependence
The principal aim of this exploratory study is to examine whether the addition of aripiprazole to naltrexone will enhance efficacy over naltrexone alone in a 16-week randomized, placebo-controlled clinical trial, in which all…
- Trial name
- NALAPZ (NCT00667875)
- Testing
- Naltrexone, Naltrexone + Aripiprazole
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder
Probenecid as Medication for Alcohol Use Disorder (PROB)
The design is a randomized, within-subject, crossover, double-blind, placebo-controlled human alcohol laboratory study with one oral dose of 2g probenecid or placebo administered in two laboratory sessions.
- Trial name
- PROB (NCT04218357)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Brown University
Alcohol Use Disorder
Brief Online Interventions for Alcohol Use
The purpose of this study is to test the feasibility and acceptability of delivering cognitive training over mTurk. Subjects will be randomized to a 1) inhibitory control training condition, 2) working memory training condition…
- Trial name
- NCT03438539
- Testing
- Normative Feedback, Inhibitory Control Training, Working Memory Training
- Where
- United States
- Volunteers
- 444 people, healthy volunteers welcome
- Sponsor
- Craig Rush
Alcohol Dependence, Dual Diagnosis
Impact of Group Motivational Interviewing and In-Home-Messaging-Devices for Dually Diagnosed Veterans
Two approaches for providing evidence-based substance abuse treatment (EBT), group motivational interviewing (GMI) and the In-Home-Messaging-Device (IHMD), are interventions that have the characteristic ability for increasing…
- Conditions
- Alcohol Dependence, Dual Diagnosis, Drug Dependence
- Trial name
- GMI-IHMDs (NCT00706901)
- Testing
- Arm 1 GMI, Arm 2 IHMD, Arm 3 TCC
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder
Pioglitazone for the Treatment of Alcohol Use Disorder
Alcohol Use Disorder (AUD) is common among Veterans but medication treatment is used infrequently and the impact of these treatments are small to moderate at best.
- Trial name
- PAUSE (NCT03864146)
- Testing
- Brief Behavioral Compliance Enhancement Treatment
- Where
- 2 sites in United States
- Volunteers
- 201 people
- Sponsor
- VA Office of Research and Development
Alcohol Dependence
Safety and Efficacy of Nalmefene in Patients With Alcohol Dependence
The purpose of the study is long-term safety, tolerability and efficacy of nalmefene in patients with alcohol dependence.
- Trial name
- SENSE (NCT00811941)
- Testing
- Nalmefene
- Where
- 60 sites in Czechia, Estonia and 8 more
- Volunteers
- 665 people
- Sponsor
- H. Lundbeck A/S
Alcohol Use Disorder, Post Traumatic Stress Disorder
Cannabidiol as a Treatment for AUD Comorbid With PTSD
This project aims to determine whether cannabidiol (CBD), a compound derived from the cannabis plant, is effective in treating alcohol use disorder (AUD) in individuals with comorbid posttraumatic stress disorder (PTSD).
- Trial name
- NCT03248167
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- NYU Langone Health
Alcohol Dependence, Drug Dependence
LINK: Aftercare Monitoring Project
The prevalence of substance use disorders (SUD) in the VA is rising, making SUD(s) among the most commonly diagnosed disorders in the VA.
- Trial name
- NCT00265512
- Testing
- Telephone Case Monitoring, Continuing Care as Usual
- Where
- 3 sites in United States
- Volunteers
- 667 people
- Sponsor
- VA Office of Research and Development
Alcohol Dependence
CRF1 Antagonist GSK561679 in Alcoholism
Objective: To evaluate GSK561679, an orally available, brain penetrant selective CRH1 antagonist for its ability to reduce alcohol craving in recently detoxified alcohol dependent women in response to stress or alcohol-associated…
- Trial name
- NCT01187511
- Testing
- GSK561679
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorders, Stress Disorders, Posttraumatic
Prazosin Augmentation of Outpatient Treatment of Alcohol Use Disorders in Active Duty Soldiers With and Without PTSD
The purpose of the study is to evaluate if the drug prazosin: will decrease alcohol use in active duty members of the military who served in Iraq and/or Afghanistan and determine if presence or absence of posttraumatic stress…
- Conditions
- Alcohol Use Disorders, Stress Disorders, Posttraumatic, Combat Disorders
- Trial name
- NCT02226367
- Testing
- prazosin hydrochloride
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research