Clinical trials: Alcoholism
Alcohol Use Disorder
Brief Family-involved Treatment for Alcohol Use Disorder
Family-involved treatments for alcohol use disorders (AUDs) hold considerable promise to improve engagement and compliance with treatment and improve treatment outcomes.
- Trial name
- B-FIT (NCT05545644)
- Testing
- Brief Family-Involved Treatment for Alcohol Use Disorder
- Volunteers
- 35 people
- Sponsor
- University of New Mexico
Alcohol Use Disorder
Effects of Cortical Dopamine Regulation on Drinking, Craving, and Cognitive Control
The purpose of this study is to determine whether the catechol-O-methyltransferase (COMT) inhibitor tolcapone, relative to placebo, reduces alcohol drinking and alcohol cue-elicited brain activation and increases brain activation…
- Trial name
- NCT02949934
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Medical University of South Carolina
Substance Use Disorders, Alcohol Use Disorder
W-SUDs for COVID-19
The purpose of this study is to test the efficacy of a substance use disorder intervention delivered via a mobile application in an adult population during the COVID-19 pandemic.
- Trial name
- NCT04460027
- Testing
- Woebot Substance Use Disorder
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Woebot Health
Cocaine Dependence, Alcohol Dependence
VIVITROL as a Treatment for Cocaine and Alcohol Dependence
To evaluate the efficacy of VIVITROL (naltrexone for extended-release injectable suspension) for the treatment of co-occurring cocaine and alcohol dependence
- Trial name
- NCT00777062
- Testing
- VIVITROL (Naltrexone extended-release injectable suspension)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Substance Related Disorders
Screening and Brief Advice to Reduce Teen Substance Use
The purpose of this study is to test the effectiveness of a brief intervention for alcohol and drug use in adolescents that a primary care doctor can give in his/her office.
- Trial name
- NCT00227877
- Testing
- cSBA - New England, USA, cSBA - Prague, CZR
- Where
- 6 sites in United States, Czechia
- Volunteers
- 2,695 people
- Sponsor
- Boston Children's Hospital
Alcohol Use Disorder, Alcohol Drinking
Pitolisant Effects on Alcohol Self-Administration in Heavy Drinkers
This is a double-blind, randomized, placebo-controlled, crossover design trial that will test the effect of pitolisant on alcohol self-administration and craving following a priming dose of alcohol.
- Trial name
- NCT04596267
- Testing
- Pitolisant
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Boston Medical Center
Alcohol Dependence
Prometa Protocol for Alcohol Dependence
This is a placebo controlled trial (some people receive active and some people receive inactive medication) to evaluate the effectiveness of a new protocol to treat alcohol dependence.
- Trial name
- NCT00262639
- Testing
- Flumazenil and Gabapentin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder
Neural Mechanisms of Disulfiram Effects
This study combines functional MRI with medication treatment in order to understand the neural mechanisms by which disulfiram, a currently approved medication for alcohol use disorder, changes behavior.
- Trial name
- NCT02735577
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- New York State Psychiatric Institute
Alcohol Abuse, Posttraumatic Stress Disorder
Prazosin for Alcohol Dependence and Posttraumatic Stress Disorder
The purpose of this study is to determine whether the drug prazosin is effective for the treatment of alcohol dependency and symptoms of Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT01518972
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Suicidal Ideation, Depression
Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse
This project aims to evaluate the potential rapid and sustained antisuicidal and antidepressant effects of a single intranasal dose of ketamine in inpatients during a mood episode in Major Depressive Disorder (MDD) or Bipolar…
- Conditions
- Suicidal Ideation, Depression, Alcohol Abuse
- Trial name
- NCT03539887
- Testing
- Intranasal ketamine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- The University of Texas Health Science Center, Houston
Alcohol Dependence
Effects of Omegas 3 and 6 on Alcohol Dependence
Context: The treatment of alcoholism is a challenge for psychiatrists and patients. Some studies have shown that alcohol alters the environment of the membranes, mainly by modifying their permeability through the lipid fraction.
- Trial name
- NCT01211769
- Testing
- Naltrexone, PUFAs
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Federal University of São Paulo
Alcoholism
Modulation of Pharmacologically Induced Alcohol Craving in Recently Detoxified Alcoholics
This study will determine if acamprosate, a drug approved to treat alcoholism, decreases alcohol cravings in alcohol-dependent subjects following infusions of yohimbine and mCPP.
- Trial name
- NCT00605904
- Testing
- Acamprosate, Yohimbine, mCPP
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcoholism
Examination of Zinc, S-adenosylmethionine, and Combination Therapy Versus Placebo in Alcoholics
This is a randomized, placebo controlled trial of dietary zinc and S-adenosylmethionine (SAMe) in otherwise healthy alcoholic US Veterans.
- Trial name
- ExZACTO (NCT01899521)
- Testing
- Bronchoscopy, Zinc sulfate 220 mg once daily, S-adenosylmethionine 400 mg twice daily
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder
Treatment Parameters for the Empower Neuromodulation System (ENS)
The subject will be administered a treatment at a treatment location and then be asked if he/she believes it is the active treatment, sham treatment, or does not know.
- Trial name
- AUD1 (NCT03807544)
- Testing
- TENS
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Theranova, L.L.C.
Alcohol Use Disorder
Cognitive Enhancement Through Computerized Training
Alcohol use disorder is characterized by widespread neurocognitive impairments, however despite substantial advances in the intervention and treatment of alcohol use disorders, exceptionally few studies have been directed to…
- Trial name
- NCT04244032
- Testing
- Working Memory Training, Inhibitory Control Training, Bias Modification Training
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Florida
PTSD and Alcohol Use Disorder
Topiramate and Prolonged Exposure
Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) frequently co-occur, and having both disorders is associated with greater psychological and functional impairment than having either disorder alone.
- Trial name
- TOP (NCT03176953)
- Testing
- topiramate, prolonged exposure
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder, Alcohol Use Disorders
CAP: Doxazosin in the Treatment of Co-Occurring PTSD and Alcohol Use Disorders
The proposed study will examine the efficacy of doxazosin in the treatment of PTSD and alcohol use disorder or substance use disorders.
- Trial name
- Doxazosin (NCT02500602)
- Testing
- doxazosin
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder, Injury Traumatic
PRACT to Investigate Controlling Alcohol Related Harms in a Low-Income Setting; Emergency Department BIs in Tanzania
Alcohol use is rapidly increasing in low- and middle-income countries, where it is inexpensive, readily available, poorly regulated, and there are few resources devoted to promoting safe alcohol use.
- Conditions
- Alcohol Use Disorder, Injury Traumatic, Trauma
- Trial name
- PRACT (NCT04535011)
- Testing
- PPKAY (brief intervention), Standard Booster, Personalized Booster
- Where
- Tanzania
- Volunteers
- 673 people
- Sponsor
- Duke University
HIV/AIDS, Alcohol Abuse
An Economic and Relationship-strengthening Intervention for HIV-affected Couples Who Drink Alcohol in Malawi
A couples-based alcohol-reduction and economic and relationship-strengthening intervention for HIV-affected couples in Malawi.
- Trial name
- NCT04906616
- Testing
- Mlambe
- Where
- Malawi
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Nicotine Dependence, Alcohol Dependence
Topiramate to Aid Smoking Cessation in Alcohol Dependent Men
The purpose of this study is to determine whether topiramate is effective as an aid to smoking cessation for recovering alcohol dependent men.
- Trial name
- NCT00802412
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- VA Office of Research and Development