Clinical trials: Aldosteronism
Insulinoma; Pancreas, MEN1
Endoscopic Ultrasound-guided Radiofrequency Ablation for Upper Gastrointestinal Tract Lesions
The goal of this observational study is to evaluate the long-term clinical effectiveness of EUS-RFA and quality of life in patients with pancreatic or adrenal tumors recieving EUS-RFA.
- Conditions
- Insulinoma; Pancreas, MEN1, NETs, Radiofrequency Ablation
- Trial name
- EURAGIL (NCT07272187)
- Testing
- observational study
- Where
- Denmark
- Volunteers
- 138 people
- Sponsor
- Herlev Hospital
Primary Aldosteronism, Super Selective Adrenal Arterial Embolization
Super Selective Adrenal Artery Embolization for Primary Aldosteronism: a Prospective Cohort Study(SAAE-PA)
The objective of this study was to evaluate the efficacy and safety of adrenal vein blood extraction for primary aldosteronism classification and adrenal artery embolization in the treatment of primary aldosteronism, to provide…
- Trial name
- NCT06513676
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xinjiang Medical University
Primary Aldosteronism, Secondary Hypertension
PETAL Trial: Impact of Gallium-68 Pentixafor PET-CT on Surgical Outcomes in Primary Aldosteronism
This study is a randomized controlled trial to assess the clinical utility of gallium-68 pentixafor PET/CT in the management of primary aldosteronism (PA).
- Conditions
- Primary Aldosteronism, Secondary Hypertension, Aldosterone-Producing Adenoma, Idiopathic Hyperaldosteronism
- Trial name
- NCT07027254
- Testing
- 68Ga-pentixafor PET/CT
- Where
- 2 sites in South Korea
- Volunteers
- 90 people
- Sponsor
- Seoul National University Hospital
Primary Aldosteronism
Finerenone for Patients With Primary Aldosteronism (FAIRY)
Using spironolactone as the control, to assess the efficacy and safety of finerenone in patients with primary aldosteronism(PA).
- Trial name
- NCT06457074
- Testing
- Finerenone Oral Tablet, Spironolactone Oral Tablet
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Chongqing Medical University
Primary Aldosteronism
[11C]Metomidate PET-CT vs Usual Care for People With Primary Aldosteronism: a Proof-of-concept Study
The goal of this randomised open-label controlled study is to compare the biochemical and clinical responses following [11C]Metomidate-PET CT(MTO-PET) versus usual care with adrenal venous sampling as first lateralisation…
- Trial name
- NCT07814105
- Testing
- [11C] Metomidate PETCT, Adrenal Venous Sampling
- Where
- Hong Kong
- Volunteers
- 32 people
- Sponsor
- Chinese University of Hong Kong
Hyperaldosteronism
Primary Aldosteronism in Western Norway
In this study the investigators aim to identify and include consecutively patients with primary aldosteronism (PA) diagnosed in the Western and Mid-parts of Norway, to describe the characteristics of these patients, to explore…
- Trial name
- NCT02832388
- Where
- 2 sites in Norway
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Primary Aldosteronism
Simplification of Oral Sodium Loading Test in the Diagnosis of Primary Aldosteronism: 2-day Replacing 3-day Method
To compare the consistency of 24-hour urinary aldosterone in the diagnosis of primary aldosteronism by oral sodium loading test between the second day method and the third day method
- Trial name
- NCT06750172
- Testing
- The oral sodium loading test
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Hypertension
SPIRO-First: A Pragmatic Primary Care-Embedded Pilot Trial of Renin-Guided First-Line Antihypertensive Therapy
The goal of this clinical trial is to determine whether a renin-guided antihypertensive treatment strategy is feasible to implement in community primary care clinics and to explore whether spironolactone improves blood pressure…
- Trial name
- SPIRO-First (NCT07687160)
- Testing
- Spironolactone (drug), Candesartan 8mg, Hydrochlorothiazide (HCTZ) 25 milligrams.
- Where
- 4 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute
Apparent Mineralocorticoid Excess Syndrome
Natural History of Apparent Mineralocorticoid Excess Syndrome
Apparent mineralocorticoid excess (AME) is a rare inherited disease that can cause severe high blood pressure and low blood potassium in children and adults. It is caused by abnormal hormone metabolism and can be fatal.
- Trial name
- NCT00474942
- Where
- 4 sites in United States, Brazil and 1 more
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Primary Aldosteronism
Subtyping Primary Aldosteronism With Para-chloro-2-[18F]Fluoroethyl-etomidate
The goal of this clinical trial is to investigate the uptake characteristics of [18F]CETO in adrenal tissue in patients with two different subtypes of primary aldosteronism.
- Trial name
- SPACE (NCT06616142)
- Testing
- [18F]CETO tracer, Dexamethasone oral, Adrenal vein sampling
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- University Medical Center Groningen
Apparent Mineralocorticoid Excess
An Investigation Into the Effect of Liquorice Ingestion on the Salivary Cortisol to Cortisone Molar Ratio
Aldosterone, the major mineralocorticoid hormone and cortisol, the major glucocorticoid hormone are produced in the adrenal gland.
- Trial name
- NCT02939144
- Testing
- Liquorice
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Primary Hyperaldosteronism
Parent Study: A Study to Assess Efficacy and Safety of Baxdrostat in Participants With Primary Aldosteronism Sub-study: A Follow-up Substudy After Completion of the BaxPA Main Study.
Parent study: This is a Phase III, multicentre, randomised, double-blind, placebo-controlled, parallel-group study to evaluate the safety, tolerability, and efficacy of baxdrostat versus placebo, on the reduction of Seated Blood…
- Trial name
- BaxPA (NCT07007793)
- Testing
- Baxdrostat
- Where
- 76 sites in United States, Australia and 10 more
- Volunteers
- 212 people
- Sponsor
- AstraZeneca
Primary Aldosteronism, Hypertension
The Diagnostic Performance of 24-hour Urinary Aldosterone for Primary Aldosteronism
This is an observational study to define the cut-off value of 24-hour urinary aldosterone for diagnosing primary aldosteronism in hypertensive patients in our center.
- Trial name
- NCT06236698
- Testing
- 24-hour urinary aldosterone measurement
- Where
- China
- Volunteers
- 999 people
- Sponsor
- Zhiming Zhu
Primary Aldosteronism
The Effect of SAAE on Vascular Endothelial Function in PA Patients
The study aims to assess the effect of superselective adrenal arterial embolization on vascular endothelial function in patients with primary aldosteronism based on brachial artery flow-mediated relaxation
- Trial name
- NCT05561361
- Testing
- Super selective adrenal artery embolization, Spironolactone
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Primary Aldosteronism
REnin-guided TherApy With MinEralocorticoid Receptor Antagonists in Primary Aldosteronism - Feasibility Study
High blood pressure, or hypertension, can be caused by a condition called Primary Aldosteronism (PA), where the body produces too much of a hormone called aldosterone.
- Trial name
- RETAME-PA (NCT06108427)
- Testing
- Renin measurements
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Primary Aldosteronism
Primary Aldosteronism LC-MS/MS-specific Cutoffs
Aims to evaluation the LC-MS/MS-specific cutoffs of PA screening and CCT test.
- Trial name
- PM (NCT05959863)
- Testing
- Captopril Challenge Test
- Where
- 2 sites in China
- Volunteers
- 396 people
- Sponsor
- Chongqing Medical University
Hyperaldosteronism, Angiography
Adrenal Venous Sampling Via an Antecubital Approach
Currently, adrenal venous sampling (AVS) serves as the gold standard for subtyping of PA. Right adrenal vein catheterization is often difficult due to unfavorable anatomy of the vein including small vein size, short length…
- Trial name
- AVSA (NCT03778645)
- Testing
- Adrenal Venous Sampling
- Where
- 10 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Hyperaldosteronism
China National Study of Adrenal Venous Sampling
This multicenter study intends to combine retrospective analysis and prospective registry to evaluate the success rate and safety of adrenal venous sampling (AVS) via antecubital and femoral approach for patients with primary…
- Trial name
- CNAVS (NCT06192238)
- Testing
- adrenal venous sampling
- Where
- 48 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Primary Aldosteronism
Chongqing Primary Aldosteronism Study
We intends to conduct a series of original clinical research about PA, and establish a large cohort of PA and essential hypertension patients with long-term follow-up of cardiovascular events, renal end points etc.
- Trial name
- NCT03224312
- Testing
- no intervention
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Chongqing Medical University
Hyperaldosteronism
Antecubital Versus Femoral Approach for Adrenal Venous Sampling
Subtype diagnosis is crucial for the treatment of primary aldosteronism (PA), which conducts the appropriate treatment strategy. Currently, adrenal venous sampling (AVS) serves as the gold standard for subtyping of PA.
- Trial name
- AFAVS (NCT06029803)
- Testing
- Adrenal Venous Sampling via Antecubital Approach, Adrenal Venous Sampling via Femoral Approach
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital